CN103099901B - Traditional Chinese medicine enema for treating endometriosis - Google Patents
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Abstract
The invention relates to a preparation method of a traditional Chinese medicine enema for treating endometriosis. The traditional Chinese medical science considers that the pathogenesis of endometriosis comprises the symptoms of organs disorders, Qi-stagnation and blood stasis, chills with yang asthenia, turbidity hysteresis at lower abdomen, blood stasis block, collaterals impassability, stagnation leading to pain and dysmenorrheal. The traditional Chinese medicine enema comprises salvia chinensis, mock-strawberry, Stellaria media, willow herb, radices lithospermi, campsis grandiflora, Securidaca inappendiculata Hassk, arachnoid cyanotis root, Viola orientalis, obcordateleaf raspberry root, beautyberry leaf, Begonia Yunnanensis Levl, piper cubeba, sandalwood and licorice, and the enema is prepared by a manufacturing laboratory of our hospital. According to the clinical test, the total effective rate is 96.3%, the recurrence rate is 18.3%, which are superior to 81.3% and 33.3% of a control group.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicinal enema for the treatment of endometriosis.
Background technology
Endometriosis is current common gynecological disease, frequently-occurring disease, sickness rate 10%～15% in the childbearing age.For a long time, be the Important cause of disease of infertile, metrorrhagia and dysmenorrhea.This disease makes clinician be at a loss always, although kinds of schemes can be treated Endometriosis, but result is dissatisfied, particularly middle-older patient, Drug therapy and abdominal all have weak point, recurrence and the probability of again performing the operation are all higher, herbal drug enema in treatment endometriosis passes through topical administration, the untoward reaction and the relapse rate that have effectively reduced patient have improved patient's tolerance degree simultaneously, easy to patients, herbal enema, medicine directly acts on diseased region, and not only curative effect is higher compared with oral Chinese medicine, and onset is faster.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicinal enema for the treatment of endometriosis.Endometriosis belongs to the categories such as the traditional Chinese medical science " dysmenorrhea " " lump in the abdomen ".The pathogenesis of endometriosis is zang-fu disharmony, qi depression to blood stasis, and yang deficiency is cold, turbid stagnant in lower abdomen, stagnation of blood stasis, channels is obstructed, " stagnation of QI and blood may bring about pain " and cause patient's lower abdomen pain, the symptoms such as dysmenorrhea.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicinal enema of this treatment endometriosis is made up of the Chinese medicine of following weight portion: Herba Salviae Chinensis 5-10 part, Herba Duchesneae Indicae 3-6 part, Herba malachii aquatici 10-15 part, Herba Lythri Salicariae 7-15 part, Radix Arnebiae (Radix Lithospermi) 5-10 part, Flos Campsis 6-9 part Radix securidacae 10-15 part, Radix Cyanotis arachnoideae 4-6 part, Radix violae delavayi 7-10 part, Radix Rubi obcordati 9-15 part, Folium Callicarpae Formosanae 10-15 part, Herba Begoniae Yunnanensis 9-12 part, Fructus Litseae 1.5-3.5 part, Lignum Santali Albi 1-2.5 part, Radix Glycyrrhizae 3-5 part.
Preferably, 7 parts of Herba Salviae Chinensiss, 5 parts of Herba Duchesneae Indicaes, 12 parts of Herba malachii aquaticis, 12 parts of Herba Lythri Salicariae, 7 parts of Radix Arnebiae (Radix Lithospermi)s, 8 parts of Flos Campsiss, 12 parts of Radix securidacae, 5 parts of Radix Cyanotis arachnoideaes, 8 parts of Radix violae delavayis, 13 parts of Radix Rubi obcordatis, 12 parts of Folium Callicarpae Formosanaes, 10 parts of Herba Begoniae Yunnanensis, 2.5 parts of Fructus Litseae, 2 parts, Lignum Santali Albi, 4 parts, Radix Glycyrrhizae.
Preparation method is by for subsequent use above-mentioned Chinese medicine decocting extracting juice 100ml.
Fang Zhong: Herba Salviae Chinensis, Herba Duchesneae Indicae, Herba malachii aquatici, Radix securidacae, Folium Callicarpae Formosanae heat-clearing and toxic substances removing, blood circulation promoting regulates qi, dissipating blood stasis for subsidence of swelling Radix Arnebiae (Radix Lithospermi), Flos Campsis, Herba Lythri Salicariae dissipating blood stasis to promote menstruationg, cooling blood, expelling wind, removing toxic substances rash; Radix Cyanotis arachnoideae, Radix violae delavayi, Radix Rubi obcordati promoting the flow of QI in the collateral by warming the meridian, removing damp and stopping pain; Herba Begoniae Yunnanensis, Fructus Litseae, Lignum Santali Albi warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain; The invigorating middle warmer of Radix Glycyrrhizae QI invigorating, alleviates pain relieving.
Clinical data
1, month June physical data in June, 2009 to 2010, Wo Yuan gynecological treated endometriosis patients 160 examples altogether, patient was divided into two groups at random, two groups of patients' basic clinical data: treatment group patient's 80 examples, and the age is at 21～27 years old, 22.8 years old mean age; The routine patient of matched group 80, the age is at 22～28 years old, 23.6 years old mean age.After patient examines, diagnose according to clinical manifestation, ultrasound diagnosis and relevant gynecologial examination result, all patients are all diagnosed as endometrium disease.Further to site of pathological change inspection: treatment group, uterus rear wall lower section 26 examples, cul-de-sac of Douglas place 24 examples, chocolate cyst of ovary 17 examples, posterior fornix of vagina place 13 examples; Matched group, uterus rear wall lower section 29 examples, cul-de-sac of Douglas place 23 examples, chocolate cyst of ovary 13 examples, posterior fornix of vagina place 15 examples.To two groups of patients' the course of disease, marriage situation, fertility condition and the clinical datas such as relevant complication that whether occur together compare, and Epidemiological Analysis by statistics, without the significance difference opposite sex.
2, Therapeutic Method treatment group is used Chinese medicinal enema of the present invention, get Herba Salviae Chinensis 7g, Herba Duchesneae Indicae 5g, Herba malachii aquatici 12g, Herba Lythri Salicariae 12g, Radix Arnebiae (Radix Lithospermi) 7g, Flos Campsis 8g, Radix securidacae 12g, Radix Cyanotis arachnoideae 5g, Radix violae delavayi 8g, Radix Rubi obcordati 13g, Folium Callicarpae Formosanae 12g, Herba Begoniae Yunnanensis 10g, Fructus Litseae 2.5g, Lignum Santali Albi 2g, Radix Glycyrrhizae 4g, decocting becomes enema 100ml.In after menstruation is clean the 5th day, get Chinese medicinal enema 100ml retention enema, specific practice: coloclysis preferably carries out evening just before going to bed, advise patient emptying two just.The medicinal liquid that is 38～42 DEG C by temperature sucks in 100ml syringe, and syringe nipple connects disposal urinary catheter, and catheter front end, with after lubrication of liquid paraffin air-out, inserts approximately 20～25cm of anus by catheter, and medicinal liquid is slowly injected.Medicinal liquid is more than enteral retains 4h, and matched group is taken: with tamoxifen (ShangHai Fudan Fuhua Pharmaceutical Co., Ltd's production), menstruation starts on the 5th day, and each 10mg, every day 2 times, serve on 20 days, and two groups of equal 3 menstrual cycle are a course for the treatment of.
3, criterion of therapeutical effect is according to the criterion of therapeutical effect of health ministry " new Chinese medicine clinical guidance principle " and the research of clinical experience formulation for many years of my institute.Standard is divided into recovery from illness, takes a turn for the better and invalid Three Estate, specific as follows: recovery from illness: patient sign and symptom disappear completely, and menstrual cycle, the color of menstruation, matter, it is normal that amount is all recovered, ultrasound diagnosis, the pathological changes such as hypertrophy all disappear; Take a turn for the better: patient sign and transference cure or obviously alleviate.Ultrasound diagnosis, the pathological changes such as hypertrophy are obviously dwindled; Invalid: patient's S&S is without obviously alleviating or increasing the weight of.Ultrasound diagnosis, the pathological changes such as hypertrophy are not improved or increase the weight of.
4, (1) two group for the treatment of patient curative effect of therapeutic outcome is relatively in table 1.
Table 2 liang group patient clinical curative effect comparison sheet
Treatment group total effective rate is 96.3%; Matched group total effective rate is 81.3%; Patient treatment is followed up a case by regular visits to 3 months relapse rates and is compared after leaving hospital, treatment group has a clear superiority in compared with matched group.Epidemiological Analysis by statistics, has the significance difference opposite sex (P < 0.05).
(2) two groups of patient clinical data are relatively in table 2.
Table 2 liang group patient clinical data comparison sheet
It is slight uncomfortable that treatment group patient only has 2 examples to occur, untoward reaction rate is 2.50%, and matched group patient has 9 examples to occur feeling sick, the symptoms such as vomiting, and bad reflection ratio is 11.3%; In the course for the treatment of, the relatively middle treatment group of the clinical datas such as tolerance degree and patient satisfaction rate all has significant advantage.
5, model case Wang, female, 35 years old.Secondary infertility 5 years, two Nian Qianzeng outer court row right ovary cystectomies, pathological replacement prompting right ovary chocolate cyst.Now suffer from abdominal pain half a year, increase the weight of 3 months.There is the low echological picture of 3.5cm × 4.5cm in B ultrasonic prompting left side attachment district, in it, taking fluidity as main, has a little thin echogenic dots therebetween, and border is still clear.Be diagnosed as right ovary chocolate cyst.Gynaecological examination pudendum is married formula.Vagina is smooth.Cervix uteri is smooth, lifts the pain positive.Position after the body of palace, Chang great, mobility is not good enough.4.5cm enclosed mass can be touched in attachment area, right side, the tenderness positive, left side attachment district feminine gender.Premenstrual distending pain of the breast is obvious, and dark tongue quality has ecchymosis, yellow and thin fur, deep pulse.Dialectical is qi stagnation and blood stasis type.Use Chinese medicinal enema of the present invention, stop using menstrual period, and after 1 month, lower abdominal pain takes a turn for the better, and continues to disappear with B ultrasonic prompting right side adnexa enclosed mass after enema two weeks drug withdrawal menolipsis 40 days after 3 months, the pregnancy tests positive.
Detailed description of the invention
Embodiment mono-: take Herba Salviae Chinensis 7g, Herba Duchesneae Indicae 5g, Herba malachii aquatici 12g, Herba Lythri Salicariae 12g, Radix Arnebiae (Radix Lithospermi) 7g, Flos Campsis 8g, Radix securidacae 12g, Radix Cyanotis arachnoideae 5g, Radix violae delavayi 8g, Radix Rubi obcordati 13g, Folium Callicarpae Formosanae 12g, Herba Begoniae Yunnanensis 10g, Fructus Litseae 2.5g, Lignum Santali Albi 2g, Radix Glycyrrhizae 4g.By for subsequent use above-mentioned Chinese medicine decocting extracting juice 100ml.
Embodiment bis-: take Herba Salviae Chinensis 5g, Herba Duchesneae Indicae 3g, Herba malachii aquatici 10g, Herba Lythri Salicariae 15g, Radix Arnebiae (Radix Lithospermi) 5g, Flos Campsis 9g, Radix securidacae 10g, Radix Cyanotis arachnoideae 4g, Radix violae delavayi 10g, Radix Rubi obcordati 15g, Folium Callicarpae Formosanae 10g, Herba Begoniae Yunnanensis 9g, Fructus Litseae 1.5g, Lignum Santali Albi 2.5g, Radix Glycyrrhizae 3g.By for subsequent use above-mentioned Chinese medicine decocting extracting juice 100ml.
Embodiment tri-: take Herba Salviae Chinensis 10g, Herba Duchesneae Indicae 6g, Herba malachii aquatici 15g, Herba Lythri Salicariae 7g, Radix Arnebiae (Radix Lithospermi) 10g, Flos Campsis 6g, Radix securidacae 15g, Radix Cyanotis arachnoideae 6g, Radix violae delavayi 7g, Radix Rubi obcordati 9g, Folium Callicarpae Formosanae 15g, Herba Begoniae Yunnanensis 12g, Fructus Litseae 3.5g, Lignum Santali Albi 1g, Radix Glycyrrhizae 5g.By for subsequent use above-mentioned Chinese medicine decocting extracting juice 100ml.
Claims (2)
1. treat a Chinese medicinal enema for endometriosis, it is characterized in that this Chinese medicinal enema is made up of the Chinese medicine of following weight portion: Herba Salviae Chinensis 5-10 part, Herba Duchesneae Indicae 3-6 part, Herba malachii aquatici 10-15 part, Herba Lythri Salicariae 7-15 part, Radix Arnebiae (Radix Lithospermi) 5-10 part, Flos Campsis 6-9 part, Radix securidacae 10-15 part, Radix Cyanotis arachnoideae 4-6 part, Radix violae delavayi 7-10 part, Radix Rubi obcordati 9-15 part, Folium Callicarpae Formosanae 10-15 part, Herba Begoniae Yunnanensis 9-12 part, Fructus Litseae 1.5-3.5 part, Lignum Santali Albi 1-2.5 part, Radix Glycyrrhizae 3-5 part.
2. a kind of Chinese medicinal enema for the treatment of endometriosis according to claim 1, is characterized in that this Chinese medicinal enema is made up of the Chinese medicine of following weight portion: 7 parts of Herba Salviae Chinensiss, 5 parts of Herba Duchesneae Indicaes, 12 parts of Herba malachii aquaticis, 12 parts of Herba Lythri Salicariae, 7 parts of Radix Arnebiae (Radix Lithospermi)s, 8 parts of Flos Campsiss, 12 parts of Radix securidacae, 5 parts of Radix Cyanotis arachnoideaes, 8 parts of Radix violae delavayis, 13 parts of Radix Rubi obcordatis, 12 parts of Folium Callicarpae Formosanaes, 10 parts of Herba Begoniae Yunnanensis, 2.5 parts of Fructus Litseae, 2 parts, Lignum Santali Albi, 4 parts, Radix Glycyrrhizae.
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| CN103656224B (en) * | 2013-12-22 | 2016-02-17 | 于厚美 | A kind of Chinese medicine composition for the treatment of syndrome of qi stagnation and blood stasis primary dysmenorrhea |
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| AUPS323902A0 (en) * | 2002-06-27 | 2002-07-18 | Chinese Medicines Scientific Consultants Pty Ltd | Compositions and methods for treating gynaecological disorders |
| CN102671152B (en) * | 2011-03-11 | 2014-11-26 | 上海中医药大学附属曙光医院 | Traditional Chinese medicine compound preparation for treating endometriosis and preparation method of traditional Chinese medicine compound preparation |
| CN102526398A (en) * | 2012-01-17 | 2012-07-04 | 肖文辉 | Externally-used traditional Chinese medicinal preparation for treating chronic pelvic inflammation |
| CN102727808B (en) * | 2012-06-27 | 2014-01-08 | 王忠民 | Drug for rapidly treating dysmenorrheal and abdomen mass |
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