CN103097363A - 羟基丙二醇类衍生物、其制备方法和其药物组合物与用途 - Google Patents

羟基丙二醇类衍生物、其制备方法和其药物组合物与用途 Download PDF

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Publication number
CN103097363A
CN103097363A CN2011800281777A CN201180028177A CN103097363A CN 103097363 A CN103097363 A CN 103097363A CN 2011800281777 A CN2011800281777 A CN 2011800281777A CN 201180028177 A CN201180028177 A CN 201180028177A CN 103097363 A CN103097363 A CN 103097363A
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CN
China
Prior art keywords
pharmaceutical compositions
hydroxy
preparative method
propanediol derivatives
propanediol
Prior art date
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Pending
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CN2011800281777A
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English (en)
Inventor
韩伟娟
周婉琪
李志永
张翼
陈晓光
尹大力
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Institute of Materia Medica of CAMS
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Institute of Materia Medica of CAMS
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Application filed by Institute of Materia Medica of CAMS filed Critical Institute of Materia Medica of CAMS
Priority to CN2011800281777A priority Critical patent/CN103097363A/zh
Publication of CN103097363A publication Critical patent/CN103097363A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/34—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one hydroxy group bound to another carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

式（I）所示的化合物，其制备方法，含有它们的药物组合物以及作为免疫调节药物的用途。所述化合物可治疗免疫紊乱、免疫抑制、免疫力低下、器官移植后排斥反应和自身免疫病。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN2011800281777A 2010-05-25 2011-05-25 羟基丙二醇类衍生物、其制备方法和其药物组合物与用途 Pending CN103097363A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2011800281777A CN103097363A (zh) 2010-05-25 2011-05-25 羟基丙二醇类衍生物、其制备方法和其药物组合物与用途

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2010101818122A CN102260178A (zh) 2010-05-25 2010-05-25 羟基丙二醇类衍生物、其制备方法和其药物组合物与用途
CN201010181812.2 2010-05-25
CN2011800281777A CN103097363A (zh) 2010-05-25 2011-05-25 羟基丙二醇类衍生物、其制备方法和其药物组合物与用途
PCT/CN2011/074633 WO2011147311A1 (zh) 2010-05-25 2011-05-25 羟基丙二醇类衍生物、其制备方法和其药物组合物与用途

Publications (1)

Publication Number Publication Date
CN103097363A true CN103097363A (zh) 2013-05-08

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CN2010101818122A Pending CN102260178A (zh) 2010-05-25 2010-05-25 羟基丙二醇类衍生物、其制备方法和其药物组合物与用途
CN2011800281777A Pending CN103097363A (zh) 2010-05-25 2011-05-25 羟基丙二醇类衍生物、其制备方法和其药物组合物与用途

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Country Status (2)

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CN (2) CN102260178A (zh)
WO (1) WO2011147311A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9115054B2 (en) 2013-02-21 2015-08-25 Bristol-Myers Squibb Company Tetrahydronaphthalenyl compounds useful as sipi agonists
CN114456053B (zh) * 2021-11-09 2023-12-01 广东海洋大学 海洋真菌产的苯甲醛类化合物及其制备方法和抗炎用途

Citations (3)

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CN1655774A (zh) * 2002-05-27 2005-08-17 诺瓦提斯公司 双芳族链烷醇
CN1777575A (zh) * 2003-04-30 2006-05-24 诺瓦提斯公司 作为1－磷酸－鞘氨醇受体调节剂的氨基－丙醇衍生物
CN1809531A (zh) * 2003-04-30 2006-07-26 诺瓦提斯公司 作为鞘氨醇－1－磷酸受体调节剂的氨基丙醇衍生物

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US2543271A (en) * 1951-02-27 Biphenyl compounds
US5360811A (en) * 1990-03-13 1994-11-01 Hoechst-Roussel Pharmaceuticals Incorporated 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents
GB9508823D0 (en) * 1995-05-01 1995-06-21 Scotia Holdings Plc Drug Derivatives
CN1144779C (zh) * 1999-03-11 2004-04-07 杭州中美华东制药有限公司 制备2-[2-(4-烷基苯基)-乙基]-2-氨基-丙二醇的方法以及其中制得的中间产物
CN100415735C (zh) * 2000-07-13 2008-09-03 三共株式会社 氨基醇衍生物
CN100516024C (zh) * 2002-09-13 2009-07-22 诺瓦提斯公司 氨基-丙醇衍生物
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CN101386580A (zh) * 2007-09-13 2009-03-18 中国医学科学院药物研究所 氨基丙二醇类衍生物、其制备方法和其药物组合物与用途

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CN1777575A (zh) * 2003-04-30 2006-05-24 诺瓦提斯公司 作为1－磷酸－鞘氨醇受体调节剂的氨基－丙醇衍生物
CN1809531A (zh) * 2003-04-30 2006-07-26 诺瓦提斯公司 作为鞘氨醇－1－磷酸受体调节剂的氨基丙醇衍生物

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Publication number Publication date
CN102260178A (zh) 2011-11-30
WO2011147311A1 (zh) 2011-12-01

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Application publication date: 20130508