CN103091253A - Method for eliminating interference side lobe signal, system thereof and blood cell analyzer - Google Patents
Method for eliminating interference side lobe signal, system thereof and blood cell analyzer Download PDFInfo
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- CN103091253A CN103091253A CN2011103375496A CN201110337549A CN103091253A CN 103091253 A CN103091253 A CN 103091253A CN 2011103375496 A CN2011103375496 A CN 2011103375496A CN 201110337549 A CN201110337549 A CN 201110337549A CN 103091253 A CN103091253 A CN 103091253A
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Abstract
The invention is suitable for the technical field of medical signal processing, and provides a method for eliminating an interference side lobe signal, a system thereof and a blood cell analyzer. The method comprises the following steps: receiving a diffusion light signal obtained through irradiating a cell by laser, converting the diffusion light signal into a digital signal, and acquiring the signal characteristic information in the digital signal; searching the interference side lobe signal in the digital signal according to the signal characteristic information; and rejecting the interference side lobe signal in the digital signal. The interference side lobe signal is eliminated without improving optical element parameters when an optical diffusion process is used to identify cells, such as a platelet cell, so requirements on the optical element parameters are reduced, thereby the material cost is reduced, and the accuracy of the cell identification using the optical diffusion process is improved.
Description
Technical field
The invention belongs to the medical signals processing technology field, relate in particular to a kind of method, system and blood cell analyzer that disturbs side-lobe signal of eliminating.
Background technology
The method that blood cell analyzer carries out the haemocyte detection mainly contains two kinds: a kind of is impedance method, and another kind is optical method.Early stage blood analyser majority all adopts impedance method to measure haemocyte, and the concrete principle of impedance method is Coulter principle, and when utilizing haemocyte to flow through aperture, the variation of aperture two terminal impedances detects.Progress along with the cell detection technology, optical method arises at the historic moment, its concrete principle be Ear Mucosa Treated by He Ne Laser Irradiation with specific wavelength to the haemocyte that flows through irradiated region, by collecting scattered light or the combined with fluorescent of a plurality of angles of haemocyte, realize detection to haemocyte with multidimensional information.With respect to traditional impedance method, optical method sensitivity when detecting haemocyte is higher, affected by blood sample less, and accuracy is also higher.Therefore, high-end blood analyser generally all possesses the ability that optical method detects haemocyte.
Adopt the blood cell analyzer of optical method when measuring haemocyte, mainly distinguish the volume size of cell by low-angle scattered light, and in conjunction with scattered light or the fluorescence of other angles, cell is distinguished.When detecting the cell of some small sizes, as platelet cell, due to its volume ratio red blood cell and leucocyte much smaller, therefore, the main lobe peak value of the low angle scattered light that produces when such stream of cells is crossed laser irradiation area is also less.Due to optical element self parameter, differ as limited aperture and the ripple of lens, generally all can there be secondary lobe near the main lobe of scattered light, size and optical element self parameter of the size of side lobe peak and main lobe peak value are closely related.Under the not high condition of optical component parameter index, the cell that volume is larger, for example, red blood cell and leucocyte, near the low-angle scattered light main lobe that produces side lobe peak and the cell of small volume, for example, platelet cell, the low angle scattered light main lobe peak value that produces is comparatively approaching, and difference is little.When measuring, above-mentioned secondary lobe can disturb the detection accuracy of small size cell.As when measuring blood platelet, above-mentioned secondary lobe can be divided into platelet cell, causes the hematoblastic measured value of optical method higher.
Prior art is by improving the parameter request of optical element, so that the scattered light side lobe peak that the large volume cell produces much smaller than the scattered light main lobe peak value of small size cell, differs as the aperture that enlarges lens, the ripple that reduces lens etc.But the technical scheme that provides according to prior art, find to exist in prior art following technical matters: prior art is eliminated the interference side-lobe signal by improving the optical component parameter performance requirement, because the parameter request to optical element is higher, cause cost significantly to rise.
Summary of the invention
The purpose of the embodiment of the present invention is to provide a kind of method of disturbing side-lobe signal of eliminating, be intended to solve prior art and eliminate the interference side-lobe signal by improving the optical component parameter performance requirement, because the parameter request to optical element is higher, the problem that causes cost significantly to rise.
The embodiment of the present invention is achieved in that a kind of method of disturbing side-lobe signal of eliminating, and described method comprises the steps:
Receive cell through the scattered light signal of Ear Mucosa Treated by He Ne Laser Irradiation, convert described scattered light signal to digital signal, and obtain the signal characteristic information in described digital signal;
According to described signal characteristic information, search the interference side-lobe signal in described digital signal;
Reject the interference side-lobe signal in described digital signal.
The embodiment of the present invention also provides a kind of system that disturbs side-lobe signal of eliminating, and described system comprises:
Information acquisition unit is used for receiving cell through the scattered light signal of Ear Mucosa Treated by He Ne Laser Irradiation, converts described scattered light signal to digital signal, and obtains the signal characteristic information in described digital signal;
Secondary lobe is searched the unit, is used for according to described signal characteristic information, searches the interference side-lobe signal in described digital signal;
Culling unit is used for the interference side-lobe signal of rejecting described digital signal.
The embodiment of the present invention also provides a kind of blood cell analyzer, and described blood cell analyzer comprises the system of above-mentioned elimination interference side-lobe signal.
In the present embodiment, by receiving cell through the scattered light signal of Ear Mucosa Treated by He Ne Laser Irradiation, convert described scattered light signal to digital signal, and obtain signal characteristic information in described digital signal, according to described signal characteristic information, search the interference side-lobe signal in described digital signal, reject the interference side-lobe signal in described digital signal.Realization is when using optical scattering method identification cell, for example platelet cell, do not need just can eliminate the interference side-lobe signal by improving optical component parameter, reduces the optical component parameter requirement, thereby reduced Material Cost, and improved the accuracy of using optical scattering method identification cell.
Description of drawings
Fig. 1 is the process flow diagram of the realization of the elimination that provides of the embodiment of the present invention one method of disturbing side-lobe signal;
Fig. 2 is the process flow diagram of the realization of the elimination that provides of the embodiment of the present invention two method of disturbing side-lobe signal;
Fig. 3 is the digital signaling diagram that the embodiment of the present invention two provides;
Fig. 4 is the design sketch that does not use the method thromboblast measurement of eliminating the interference side-lobe signal that the embodiment of the present invention two provides;
Fig. 5 is the use that provides of the embodiment of the present invention two eliminates the design sketch that blood platelet is measured after the method for disturbing side-lobe signal;
Fig. 6 is the system construction drawing of the application scenarios that provides of the embodiment of the present invention three;
Fig. 7 is the structural drawing that the system of side-lobe signal is disturbed in the elimination that provides of the embodiment of the present invention three;
Fig. 8 is the structural drawing that the system of side-lobe signal is disturbed in the elimination that provides of the embodiment of the present invention four;
Fig. 9 is the structural drawing that the system of side-lobe signal is disturbed in the elimination that provides of the embodiment of the present invention five.
Embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, is not intended to limit the present invention.
The embodiment of the present invention by cell is processed through the scattered light signal of Ear Mucosa Treated by He Ne Laser Irradiation, according to signal characteristic information, is searched the interference secondary lobe in digital signal, and near the secondary lobe the main lobe signal is removed.
The embodiment of the present invention provides a kind of method of disturbing side-lobe signal of eliminating, and described method comprises the steps:
Receive cell through the scattered light signal of Ear Mucosa Treated by He Ne Laser Irradiation, convert described scattered light signal to digital signal, and obtain the signal characteristic information in described digital signal;
According to described signal characteristic information, search the interference side-lobe signal in described digital signal;
Reject the interference side-lobe signal in described digital signal.
The embodiment of the present invention also provides a kind of system that disturbs side-lobe signal of eliminating, and described system comprises:
Information acquisition unit is used for receiving cell through the scattered light signal of Ear Mucosa Treated by He Ne Laser Irradiation, converts described scattered light signal to digital signal, and obtains the signal characteristic information in described digital signal;
Secondary lobe is searched the unit, is used for according to described signal characteristic information, searches the interference side-lobe signal in described digital signal;
Culling unit is used for the interference side-lobe signal of rejecting described digital signal.
The embodiment of the present invention also provides a kind of blood cell analyzer, and described blood cell analyzer comprises the system of above-mentioned elimination interference side-lobe signal.
Below in conjunction with specific embodiment, realization of the present invention is described in detail:
Embodiment one
the application scenarios of the present embodiment can for: adopt the blood cell analyzer of optical method when cell is measured in identification, platelet cell for example, the scattered light signal that cell produces after Ear Mucosa Treated by He Ne Laser Irradiation carries out opto-electronic conversion by sensor, change electric analoging signal into by light signal, electric analoging signal after conversion is carried out signal shaping, for example, amplify, filtering or amplitude limit etc., so that the frequency of electric signal and amplitude all are defined within the specific limits, electric analoging signal after signal shaping is carried out digital quantization, obtain corresponding digital signal, by this digital signal is processed, to remove secondary lobe to the impact of measured cell, for example, red blood cell or leukocytic side-lobe signal are the interference secondary lobe of platelet cell, be specifically described by the following examples, Fig. 1 shows the process flow diagram of realization that the method for side-lobe signal is disturbed in elimination that the embodiment of the present invention one provides, details are as follows:
In step S101, receive cell through the scattered light signal of Ear Mucosa Treated by He Ne Laser Irradiation, convert described scattered light signal to digital signal, and obtain the signal characteristic information in described digital signal.
In the present embodiment, described signal characteristic information is the combination in any of peak value of pulse, peak value of pulse time or pulse base, but is not limited to above three kinds of signal characteristic informations.
In the present embodiment, described digital signal be scattered light signal through opto-electronic conversion, signal shaping, and digital quantization after signal.
In step S102, according to described signal characteristic information, search the interference side-lobe signal in described digital signal.
In the present embodiment, in the process of the undesired signal of searching digital signal, need to use the signal characteristic information of a plurality of pulse signals, therefore, usually pulse signal in chronological sequence arrives respectively, and when needs were recalled the pulse signal feature that arrives before, the feature of these pulse signals was not as carrying out buffer memory, may cause pulse signal to lose, therefore, in order to address the above problem, optional, can also comprise the steps the signal characteristic information that buffering receives before step S102.
In the present embodiment, the process that step S102 searches can be in the following ways:
Mode one: according to the time order and function order of pulse arrival, and according to described signal characteristic information, successively each pulse signal is searched the interference secondary lobe, be specially: searched after near the secondary lobe prepulse, judgement works as whether prepulse is last pulse, if not last pulse, searches secondary lobe near next pulse, when arriving last pulse, stop searching.
Mode two: in order to improve seek rate, can search the interference secondary lobe to a plurality of pulse signals simultaneously according to signal characteristic information, for example can search simultaneously two pulses, three pulses can certainly be searched the interference secondary lobe simultaneously to all pulse signals of current arrival.
In step S103, reject the interference side-lobe signal in described digital signal.
Optionally, can often find one and disturb secondary lobe, reject this and disturb side-lobe signal in described digital signal.
Optionally, also can be after having searched all interference side-lobe signals of digital signal, unified all that reject in digital signal are disturbed side-lobe signal, at this moment, disturb side-lobe signal for the ease of unified deletion, can also comprise the steps: to identify interference secondary lobe in the described digital signal that finds at step S102, perhaps store the signal characteristic information of the interference secondary lobe in the described digital signal that finds, for example, disturb the peak value of pulse information of secondary lobe, perhaps peak value of pulse temporal information etc.
The present embodiment method can realize the identification to haemocyte, and is therefore optional such as the molecule in platelet cell, blood etc. especially to the identification of small size cell, after step S103, can also comprise the steps:
According to the digital signal after rejecting interference side-lobe signal, identification haemocyte.
In the present embodiment, by receiving cell through the scattered light signal of Ear Mucosa Treated by He Ne Laser Irradiation, convert described scattered light signal to digital signal, and obtain signal characteristic information in described digital signal, according to described signal characteristic information, search the interference side-lobe signal in described digital signal, reject the interference side-lobe signal in described digital signal.Realization is when using optical scattering method identification cell, for example platelet cell, do not need just can eliminate the interference side-lobe signal by improving optical component parameter, reduces the optical component parameter requirement, thereby reduced Material Cost, and improved the accuracy of using optical scattering method identification cell.
Embodiment two
Fig. 2 shows the process flow diagram of realization that the method for side-lobe signal is disturbed in elimination that the embodiment of the present invention two provides, and details are as follows:
In step S201, receive cell through the scattered light signal of Ear Mucosa Treated by He Ne Laser Irradiation, convert described scattered light signal to digital signal, and obtain the signal characteristic information in described digital signal, described signal characteristic information is peak value of pulse, peak value of pulse time and pulse base.
In step S202, remove the pulse base that comprises in described peak value of pulse, obtain the pulse relative peak.
In the present embodiment, step S202 is specifically as follows and deducts described pulse base from described peak value of pulse, obtain the pulse relative peak, wherein, can deduct described pulse base by signal processing mode from described peak value of pulse, perhaps also can remove the pulse base that comprises in peak value of pulse by hardware circuit, for example, can pass through subtraction circuit, certainly, be not limited to above-mentioned implementation.
In step S203, according to described pulse relative peak, determine the secondary lobe discrimination threshold.
In the embodiment of the present invention, step S203 specifically can realize in the following ways:
Mode one: according to amassing of each pulse relative peak and secondary lobe scale-up factor, determine the secondary lobe discrimination threshold of each pulse, be specially each pulse relative peak and secondary lobe scale-up factor are multiplied each other as the secondary lobe discrimination threshold of each pulse, for example, if the secondary lobe scale-up factor is 15%, after each peak value of pulse all being multiply by 15%, as the secondary lobe discrimination threshold, wherein, the secondary lobe scale-up factor can obtain by the ratio of secondary lobe and main lobe in the optical signalling of adding up reality, is specifically as follows the side-lobe pulse relative peak divided by main lobe pulse relative peak.
Mode two: in order to overcome the larger problem of calculated amount in mode one, can be according to statistical value or the measured value of pulse relative peak, determine that preset value is the secondary lobe discrimination threshold of all pulses, that is, all pulses are all used a fixing threshold value to carry out secondary lobe as the secondary lobe discrimination threshold and are searched.
In step S204, according to described secondary lobe discrimination threshold, in the Preset Time before and after described peak value of pulse, search the interference side-lobe signal in described digital signal.
In the present embodiment, can be before and after current peak value of pulse in Preset Time, for example: Preset Time can be 3us, searches the pulse relative peak less than the pulse of pulse secondary lobe discrimination threshold.
In step S205, reject the signal characteristic information of the described interference side-lobe signal in described digital signal.
In the present embodiment, the signal characteristic information of the interference secondary lobe of rejecting specifically comprises: the peak value of pulse and the peak value of pulse time data that disturb side-lobe signal.
In the present embodiment, the implementation of the step S103 in the execution of step S205 and above-described embodiment one is similar, and details are referring to the description of above-described embodiment one.
for the ease of understanding, below describe with the technical scheme of a concrete realization example to the present embodiment, but the situation with the present embodiment is not limited, Fig. 3 is a digital signaling diagram, wherein, horizontal ordinate is time value, ordinate is pulse amplitude values, the below illustrates the concrete process of searching secondary lobe with this figure: at first, feel the pulse to wash open from 1 and begin to carry out secondary lobe and search, calculate 1 relative peak of feeling the pulse and rushing, 1 relative peak of feeling the pulse punching be multiply by secondary lobe ratio K obtain the 1 secondary lobe discrimination threshold (THR1) of feeling the pulse and rushing, feel the pulse 1 and seek the pulse relative peak less than the pulse of THR1 in the secondary lobe critical region of punching, wherein the secondary lobe critical region is 1 to feel the pulse and rush Preset Time before and after peak value.Whole 1 feels the pulse only has a pulse to satisfy criterion in the secondary lobe discriminate interval of punching, i.e. 2 punchings of feeling the pulse are therefore 2 feel the pulse to rush and can be marked as the interference secondary lobe.Although 2 punchings of feeling the pulse are marked as secondary lobe, to feel the pulse after near secondary lobe punching search to 1 finishing, the pulse that the next one is searched secondary lobe remains 2 and feels the pulse and rush rather than 3 punchings of feeling the pulse.The same near 2 method and 1 of the searching secondary lobe punching punchings of feeling the pulse of feeling the pulse, feel the pulse after the searching of the side-lobe signal that rushes annex to 2 completing, begin to search 3 and feel the pulse and rush near side-lobe signals.Whole process of searching side-lobe signal just so successively one by one pulse go on, until complete searching all pulse side-lobe signals.
Fig. 4 and Fig. 5 are that wherein, horizontal ordinate FL is fluorescence to the effect contrast figure of identical data before and after the operation of using the present embodiment elimination interference side-lobe signal, and ordinate FSC is the low angle scattered light.Fig. 4 does not use the present embodiment to eliminate the design sketch of the method thromboblast measurement of interference side-lobe signal, can see in Fig. 4, be designated and comprised in the zone of A because disturb side-lobe signal to miss the blood platelet of identifying, abnormal noise spot has appearred in the left side that can obviously see normal blood platelet zone from regional A, and mix with blood platelet, be difficult to distinguish; Fig. 5 is that identical data has used the present embodiment to eliminate the design sketch that blood platelet is measured after the method for disturbing side-lobe signal, can see the noise spot that has not disturbed secondary lobe to bring in regional B in Fig. 5.
Eliminate the effect of the method for disturbing side-lobe signal in order to further illustrate the present embodiment, below describe with concrete measurement data, see also table 1, table 1 be to same blood sample adopt respectively impedance method, and optical method and adopt Fig. 4 and Fig. 5 in the blood platelet measurement result calculated of measurement data:
Table 1
As can be seen from Table 1, when adopting Fig. 4 to reject to disturb data before secondary lobe to calculate the blood platelet measured value, cause result more higher than actual value among due to meeting, the part noise spot being counted blood platelet in the lump.And, generally, due to the discrimination specific impedance Fa Genggao of optical method to platelet cell, can with impedance method identification less than blood platelet give and to be identified, therefore the result that general identical blood sample uses optical method to record is wanted the slightly higher of specific impedance method.Table 1 shows that the blood platelet value that the same blood sample of use is tested is 204 * 10 under impedance method
9/ L, according to the characteristics of optical method, the result of using the optical method test to obtain should be than 204 * 10
9/ L is more higher.By contrasting the result of upper table, can clearly find out: before rejecting the interference secondary lobe, the hematoblastic measured value of optical method has reached more than 2 times of the hematoblastic measured value of impedance method, serious distortion; After rejecting the interference secondary lobe, optical method blood platelet measured value returns to normal level, and is comparatively approaching with impedance method blood platelet measured value.
the present embodiment passes through according to described peak value of pulse and pulse base, calculate the pulse relative peak, according to described pulse relative peak, determine the secondary lobe discrimination threshold, and according to described secondary lobe discrimination threshold, in Preset Time before and after described peak value of pulse, search the interference side-lobe signal in described digital signal, and reject peak value of pulse and the peak value of pulse time data of the interference side-lobe signal in described digital signal, realization is when using optical scattering method identification haemocyte, do not need just can eliminate the interference side-lobe signal by improving optical component parameter, reduction is to the optical component parameter requirement, thereby reduced Material Cost, and improved the accuracy of using optical scattering method identification haemocyte.
Embodiment three
Fig. 6 is the system construction drawing of the application scenarios of the present embodiment: at the blood cell analyzer that adopts optical method when measuring cell, platelet cell for example, the scattered light signal that cell produces after Ear Mucosa Treated by He Ne Laser Irradiation carries out opto-electronic conversion by sensor 61, change electric signal into by light signal, electric analoging signal after conversion is carried out signal shaping through signal conditioning circuit 62, for example, amplify, filtering or amplitude limit etc., so that the frequency of electric signal and amplitude all are defined within the specific limits, electric analoging signal after signal shaping is carried out digital quantization through analog to digital conversion circuit 63, obtain corresponding digital signal, digital signal enters the system 64 that disturbs side-lobe signal of eliminating, this system processes this digital signal, to remove one-level secondary lobe or the multistage secondary lobe of the measured cell of impact, for example, red blood cell or leukocytic side-lobe signal are the interference secondary lobe of platelet cell, below specifically to being specifically described by embodiment, the structural drawing of the system of side-lobe signal is disturbed in the elimination that Fig. 7 shows the embodiment of the present invention three to be provided, for convenience of explanation, only show the part relevant to the embodiment of the present invention, this device can be the software unit that is built in blood cell analyzer, hardware cell or soft or hard combining unit.
The present embodiment is eliminated and disturbed the system of side-lobe signal specifically can comprise: information acquisition unit 71, secondary lobe are searched unit 72, culling unit 73.
Secondary lobe is searched unit 72, is used for according to described signal characteristic information, searches the interference side-lobe signal in described digital signal.
Culling unit 73 is used for the interference side-lobe signal of rejecting described digital signal.
The elimination that the embodiment of the present invention provides disturbs the system of side-lobe signal can use in the embodiment of the method one of aforementioned correspondence, and details do not repeat them here referring to the description of above-described embodiment one.
In the present embodiment, by receiving cell through the scattered light signal of Ear Mucosa Treated by He Ne Laser Irradiation, convert described scattered light signal to digital signal, and obtain signal characteristic information in described digital signal, according to described signal characteristic information, search the interference side-lobe signal in described digital signal, reject the interference side-lobe signal in described digital signal.Realization is when using optical scattering method identification cell, for example platelet cell, do not need just can eliminate the interference side-lobe signal by improving optical component parameter, reduces the optical component parameter requirement, thereby reduced Material Cost, and improved the accuracy of using optical scattering method identification cell.
Embodiment four
The structural drawing of the system of side-lobe signal is disturbed in the elimination that Fig. 8 shows the embodiment of the present invention four to be provided, for convenience of explanation, only show the part relevant to the embodiment of the present invention, this device can be software unit, hardware cell or the soft or hard combining unit that is built in blood cell analyzer.
The present embodiment is eliminated and disturbed the system of side-lobe signal specifically can comprise: information acquisition unit 81, buffer unit 82, secondary lobe are searched unit 83, culling unit 84 and recognition unit 85.
Optionally, buffer unit 82 is used for the described signal characteristic information of buffer memory.
Secondary lobe is searched unit 83, is used for according to described signal characteristic information, searches the interference side-lobe signal in described digital signal.
Culling unit 84 is used for the interference side-lobe signal of rejecting described digital signal.
Optionally, secondary lobe is searched unit 83, the concrete time order and function order that is used for according to pulse, and according to described signal characteristic information, successively each pulse signal is searched the interference secondary lobe.Perhaps secondary lobe is searched unit 83, concrete being used for according to described signal characteristic information, simultaneously a plurality of pulse signals is searched the interference secondary lobe.
The elimination that the embodiment of the present invention provides disturbs the system of side-lobe signal can use in the embodiment of the method one of aforementioned correspondence, and details do not repeat them here referring to the description of above-described embodiment one.
Embodiment five
The structural drawing of the system of side-lobe signal is disturbed in the elimination that Fig. 9 shows the embodiment of the present invention five to be provided, for convenience of explanation, only show the part relevant to the embodiment of the present invention, this device can be software unit, hardware cell or the soft or hard combining unit that is built in blood cell analyzer.
The present embodiment is eliminated and disturbed the system of side-lobe signal specifically can comprise: information acquisition unit 91, buffer unit 92, secondary lobe are searched unit 93, culling unit 94 and recognition unit 95.
Described secondary lobe is searched unit 93 and specifically comprised: baseline is removed module 931, determination module 932 and is searched module 933.
Baseline is removed module 931, is used for removing the pulse base that described peak value of pulse comprises, and obtains the pulse relative peak.
In the present embodiment, baseline removal module 931 is specifically as follows and deducts described pulse base from described peak value of pulse, obtain the pulse relative peak, wherein, can deduct described pulse base by signal processing mode from described peak value of pulse, perhaps also can remove the pulse base that comprises in peak value of pulse by hardware circuit, for example, can pass through subtraction circuit, certainly, be not limited to above-mentioned implementation.
Determination module 932 is used for according to described pulse relative peak, determines the secondary lobe discrimination threshold.
Search module 933, be used for according to described secondary lobe discrimination threshold, in the Preset Time before and after described peak value of pulse, search the interference side-lobe signal in described digital signal.
Described culling unit 94, the signal characteristic information of concrete described interference side-lobe signal for rejecting described digital signal
Wherein, determination module 932, concrete being used for determined the secondary lobe discrimination threshold of each pulse according to the amassing of each pulse relative peak and secondary lobe scale-up factor;
Perhaps described determination module 932, concrete for statistical value or measured value according to the pulse relative peak, determines that preset value is the secondary lobe discrimination threshold of all pulses.
The elimination that the embodiment of the present invention provides disturbs the system of side-lobe signal can use in the embodiment of the method two of aforementioned correspondence, and details do not repeat them here referring to the description of above-described embodiment two.
It should be noted that in said apparatus and system embodiment, included unit is just divided according to function logic, but is not limited to above-mentioned division, as long as can realize corresponding function; In addition, the concrete title of each functional unit also just for the ease of mutual differentiation, is not limited to protection scope of the present invention.
In addition, one of ordinary skill in the art will appreciate that all or part of step that realizes in the various embodiments described above method is to come the relevant hardware of instruction to complete by program, corresponding program can be stored in a computer read/write memory medium, described storage medium is as ROM/RAM, disk or CD etc.
The above is only preferred embodiment of the present invention, not in order to limiting the present invention, all any modifications of doing within the spirit and principles in the present invention, is equal to and replaces and improvement etc., within all should being included in protection scope of the present invention.
Claims (17)
1. eliminate the method for disturbing side-lobe signal for one kind, it is characterized in that, described method comprises the steps:
Receive cell through the scattered light signal of Ear Mucosa Treated by He Ne Laser Irradiation, convert described scattered light signal to digital signal, and obtain the signal characteristic information in described digital signal;
According to described signal characteristic information, search the interference side-lobe signal in described digital signal;
Reject the interference side-lobe signal in described digital signal.
2. the method for claim 1, is characterized in that, after the step of the interference side-lobe signal in the described digital signal of described rejecting, described method also comprises the steps:
According to the digital signal after rejecting interference side-lobe signal, identification haemocyte.
3. the method for claim 1, is characterized in that, and is described according to described signal characteristic information, and before searching the step of the interference side-lobe signal in described digital signal, described method also comprises the steps:
The described signal characteristic information of buffer memory.
4. the method for claim 1, is characterized in that, described signal characteristic information is the combination in any of peak value of pulse, peak value of pulse time or pulse base.
5. method as claimed in claim 4, is characterized in that, when signal characteristic information was peak value of pulse, peak value of pulse time and pulse base, described according to described signal characteristic information, the step of searching the interference side-lobe signal in described digital signal was specially:
Remove the pulse base that comprises in described peak value of pulse, obtain the pulse relative peak;
According to described pulse relative peak, determine the secondary lobe discrimination threshold;
According to described secondary lobe discrimination threshold, in the Preset Time before and after described peak value of pulse, search the interference side-lobe signal in described digital signal;
The step of the interference side-lobe signal in the described digital signal of described rejecting is specially:
Reject the signal characteristic information of the described interference side-lobe signal in described digital signal.
6. method as claimed in claim 5, is characterized in that, and is described according to described pulse relative peak, determines that the step of secondary lobe discrimination threshold is specially:
According to amassing of each pulse relative peak and secondary lobe scale-up factor, determine the secondary lobe discrimination threshold of each pulse; Perhaps
According to statistical value or the measured value of pulse relative peak, determine that preset value is the secondary lobe discrimination threshold of all pulses.
7. method as claimed in claim 5, is characterized in that, the pulse base that comprises in described removal peak value of pulse, and the step that obtains the pulse relative peak is specially:
Deduct described pulse base from described peak value of pulse, obtain the pulse relative peak.
8. the described method of claim as arbitrary in claim 1 to 7, is characterized in that, according to described signal characteristic information, the step of searching the interference side-lobe signal in described digital signal is specially:
According to the time order and function order of pulse, and according to described signal characteristic information, successively each pulse signal is searched the interference secondary lobe; Perhaps
According to described signal characteristic information, simultaneously a plurality of pulse signals are searched the interference secondary lobe.
9. eliminate the system that disturbs side-lobe signal for one kind, it is characterized in that, described system comprises:
Information acquisition unit is used for receiving cell through the scattered light signal of Ear Mucosa Treated by He Ne Laser Irradiation, converts described scattered light signal to digital signal, and obtains the signal characteristic information in described digital signal;
Secondary lobe is searched the unit, is used for according to described signal characteristic information, searches the interference side-lobe signal in described digital signal;
Culling unit is used for the interference side-lobe signal of rejecting described digital signal.
10. system as claimed in claim 9, is characterized in that, described system also comprises:
Recognition unit is used for according to the digital signal after rejecting interference side-lobe signal, identification haemocyte.
11. system as claimed in claim 9 is characterized in that, described system also comprises:
Buffer unit is used for the described signal characteristic information of buffer memory.
12. system as claimed in claim 9 is characterized in that, described signal characteristic information is the combination in any of peak value of pulse, peak value of pulse time or pulse base.
13. system as claimed in claim 12 is characterized in that, described secondary lobe is searched the unit and is specifically comprised:
Baseline is removed module, is used for removing the pulse base that described peak value of pulse comprises, and obtains the pulse relative peak;
Determination module is used for according to described pulse relative peak, determines the secondary lobe discrimination threshold;
Search module, be used for according to described secondary lobe discrimination threshold, in the Preset Time before and after described peak value of pulse, search the interference side-lobe signal in described digital signal;
Described culling unit, the signal characteristic information of concrete described interference side-lobe signal for rejecting described digital signal.
14. system as claimed in claim 13 is characterized in that, described determination module, and concrete being used for determined the secondary lobe discrimination threshold of each pulse according to the amassing of each pulse relative peak and secondary lobe scale-up factor;
Perhaps described determination module, concrete for statistical value or measured value according to the pulse relative peak, determines that preset value is the secondary lobe discrimination threshold of all pulses.
15. system as claimed in claim 13 is characterized in that, described baseline is removed module and specifically is used for:
Deduct described pulse base from described peak value of pulse, obtain the pulse relative peak.
16. system as described in claim 9 to 15 is characterized in that secondary lobe is searched the unit, the concrete time order and function order that is used for according to pulse, and according to described signal characteristic information, successively each pulse signal is searched the interference secondary lobe; Perhaps
According to described signal characteristic information, simultaneously a plurality of pulse signals are searched the interference secondary lobe.
17. a blood cell analyzer is characterized in that, described blood cell analyzer comprises the system of the described elimination interference of the arbitrary claim of claim 9 to 16 side-lobe signal.
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| CN109283121A (en) * | 2018-10-11 | 2019-01-29 | 迈克医疗电子有限公司 | Pulse recognition method and apparatus, analysis instrument, storage medium |
| CN114674729A (en) * | 2022-03-02 | 2022-06-28 | 迈克医疗电子有限公司 | Pulse recognition method, pulse recognition device, storage medium, apparatus, and blood cell analyzer |
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| CN109283121A (en) * | 2018-10-11 | 2019-01-29 | 迈克医疗电子有限公司 | Pulse recognition method and apparatus, analysis instrument, storage medium |
| CN109283121B (en) * | 2018-10-11 | 2021-04-09 | 迈克医疗电子有限公司 | Pulse recognition method and device, analysis instrument and storage medium |
| CN114674729A (en) * | 2022-03-02 | 2022-06-28 | 迈克医疗电子有限公司 | Pulse recognition method, pulse recognition device, storage medium, apparatus, and blood cell analyzer |
| CN114674729B (en) * | 2022-03-02 | 2023-11-21 | 迈克医疗电子有限公司 | Pulse identification method, pulse identification device, pulse identification storage medium, pulse identification equipment and blood cell analyzer |
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| CN103091253B (en) | 2016-03-02 |
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