CN103070881B - A kind of vagina is antibacterial, virucidal compositions and application thereof - Google Patents
A kind of vagina is antibacterial, virucidal compositions and application thereof Download PDFInfo
- Publication number
- CN103070881B CN103070881B CN201310003118.5A CN201310003118A CN103070881B CN 103070881 B CN103070881 B CN 103070881B CN 201310003118 A CN201310003118 A CN 201310003118A CN 103070881 B CN103070881 B CN 103070881B
- Authority
- CN
- China
- Prior art keywords
- weight portion
- vagina
- antibacterial
- hydroxyethyl
- glycerol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses that a kind of vagina is antibacterial, virucidal compositions and application thereof.A kind of vagina bacteria inhibiting composition, comprises hexamethylene 0.01 ~ 3 weight portion, disodiumedetate 0.01 ~ 3 weight portion, glycerol 0.2 ~ 60 weight portion, hydroxyethyl-cellulose 0.06 ~ 1.8 weight portion, sodium chloride 0.015 ~ 4.5 weight portion, lactic acid 0.02 ~ 6 weight portion.The normal parasitic lactobacillus of vagina is not killed, the microecosystem balance of protection vagina while that this compositions being antibacterial, antiviral.Can be used for medicine, medical apparatus and instruments, the disinfectant of the vagina preparing treatment antibacterial and viral infection, contribute to vagina and recover normal physiological function.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, medicine or the disinfectant that are directly used in vaginadouche, specifically, relate to a kind of vagina bacteria inhibiting composition and application thereof.
Background technology
In clinical practice, the treatment of genital infection is based on antibiotic or the administering mode based on antiseptic.But antibiotic can be used for whole body or topical therapeutic, antiseptic may be only applicable to topical therapeutic.For bacterial vaginitis, antibiotic therapy method due to Formulations for systemic administration limited or bring side effect often.Polihexanide is one and infects the very promising medicine of disease, especially at bacterial vaginitis and vaginitis for treatment local reproductive device.
Hexamethylene (PHMB), is also referred to as Polyhaxemethylenguanidine Hydrochloride, is a kind of biguanide compound, and molecular formula is C8H17N5.Polyhaxemethylenguanidine Hydrochloride raw produce is colourless transparent liquid, and content is 200g/L, and solution ph is 6.25.Polyhaxemethylenguanidine Hydrochloride is one of biguanides disinfectant, has stronger antibacterial and bactericidal activity, is widely used in the formula for a product such as contact lens care solution, skin antiseptic, sanitary washing liquid, oral nursing liquid, belongs to low effect disinfectants.The compositions for vaginadouche based on this product, for novelty is attempted, for gynecological antibacterial, treatment of viral infections provide new method.
Summary of the invention
Object of the present invention provides a kind of vagina antibacterial, viricidal compositions.
Another object of the present invention is to provide the application of said composition.
Object of the present invention realizes by following technical scheme:
A kind of vagina is antibacterial, virucidal compositions, comprises hexamethylene 0.01 ~ 3 weight portion, disodiumedetate 0.01 ~ 3 weight portion, glycerol 0.2 ~ 60 weight portion, hydroxyethyl-cellulose 0.06 ~ 1.8 weight portion, sodium chloride 0.015 ~ 4.5 weight portion, lactic acid 0.02 ~ 6 weight portion.
Described vagina is antibacterial, also comprise water in virucidal compositions, and described water can be selected from pure water, distilled water or deionized water.
Described vagina is antibacterial, virucidal compositions, preferably comprise hexamethylene 0.05 ~ 1 weight portion, disodiumedetate 0.05 ~ 1 weight portion, glycerol 1 ~ 30 weight portion, hydroxyethyl-cellulose 0.1 ~ 1.2 weight portion, sodium chloride 0.05 ~ 1.5 weight portion, lactic acid 0.1 ~ 1 weight portion, water 30 ~ 100 weight portion.
Described vagina is antibacterial, virucidal compositions, preferably comprise hexamethylene 0.10 weight portion further, disodiumedetate 0.10 weight portion, glycerol 2 weight portion, hydroxyethyl-cellulose 0.6 weight portion, sodium chloride 0.15 weight portion, lactic acid 0.2 weight portion, water 45 ~ 100 weight portion.
Vagina of the present invention is antibacterial, the application of virucidal compositions in preparation vaginadouche medicine, medical apparatus and instruments, disinfectant.
Described virus refers to the HIV1 type virus and HPV virus that can cause gynecological infection.
A kind of medicine for vaginadouche, medical apparatus and instruments, disinfectant, prepare by the following method: get hexamethylene 0.01 ~ 3g, disodiumedetate 0.01 ~ 3g, glycerol 0.2 ~ 60g, hydroxyethyl-cellulose 0.06 ~ 1.8g, sodium chloride 0.015 ~ 4.5g, lactic acid 0.02 ~ 6g, add water to 100ml, mixing.
The described medicine for vaginadouche, medical apparatus and instruments, disinfectant, prepare preferably by following method: get hexamethylene 0.05 ~ 1g, disodiumedetate 0.05 ~ 1g, glycerol 1 ~ 30g, hydroxyethyl-cellulose 0.1 ~ 1.2g, sodium chloride 0.05 ~ 1.5g, lactic acid 0.1 ~ 1g, add water to 100ml, mixing.
The described medicine for vaginadouche, medical apparatus and instruments, disinfectant, prepare preferably by following method further: get hexamethylene 0.10g, disodiumedetate 0.10g, glycerol 2g, hydroxyethyl-cellulose 0.6g, sodium chloride 0.15g, lactic acid 0.2g, add water to 100ml, mixing.
The described medicine for vaginadouche, medical apparatus and instruments, disinfectant, filter after mixing, fill, inspection.
The suggestion usage and dosage of the medicine for vaginadouche of the present invention:
Use front jolting bottle at least 15 seconds; Adopt the position position that is seated, administrator is inserted vagina and squeeze bottle until sky; Keep liquid to stop a few minutes in intravaginal, allow liquid play curative effect.It is just much of that a usual single dose is used for vaginadouche.Repeat once after 4 days if necessary.
Between the present composition mechanism of action and each component about the effect with each component:
Hexamethylene is cationic surfactant, is combined with the anionic sites of acidic phospholipid and memebrane protein thus plays bactericidal action.The EDTA-2Na complexation Ca+2 on bacterial membrane surface, protects the activity of hexamethylene.Lactic acid adjust ph, the normal parasitic lactobacillus of protection vagina.Glycerol plays hydrotropy effect, and hydroxyethyl-cellulose plays suspending effect; Sodium chloride scalable osmotic pressure; Pure water, distilled water or deionized water are as diluent.Above component is composite with specific proportioning, maintains the isotonic environment of pH4.0 ~ 4.6, does not kill the normal parasitic lactobacillus of vagina, the microecosystem balance of protection vagina while playing antibacterial, antivirus action.
Beneficial effect:
Because the acid-base value of the vaginal environment of health is about 4.0 ~ 4.6, in faintly acid, the pH value of medicine of the present invention, close to intravaginal sour environment, can reduce the stimulation to health, and protects the physiological environment of vagina; In addition, the present composition is directly used in vaginadouche, can effectively suppress multiple pathogen, fungus, virus etc., thus to diseases such as cervicitis, vaginal infection (as antibacterial, infusorian and mould microbial leucorrhoea grow in quantity) or pruritus vulvaes, there is good therapeutic effect, use this product after can be used for the treatment of the vagina for the treatment of antibacterial and HIV1 and HPV viral infection or naturopathy, contribute to vagina and recover normal physiological function.
Detailed description of the invention
Embodiment 1
Get hexamethylene 0.10g, disodiumedetate 0.10g, glycerol 2g, hydroxyethyl-cellulose 0.6g, sodium chloride 0.15g, lactic acid 0.2g, add to 100ml with pure water or distilled water, fill after stirring, inspection, obtains the vaginal lotion that pH4.0 is isotonic.
Embodiment 2
Get hexamethylene 0.05g, disodiumedetate 1g, glycerol 5g, hydroxyethyl-cellulose 1.0g, sodium chloride 0.05g, lactic acid 0.1g, adds to 100ml with pure water, fill after stirring, and inspection, obtains the vaginal lotion that pH4.2 is isotonic.
Embodiment 3
Get hexamethylene 1g, disodiumedetate 0.05g, glycerol 10g, hydroxyethyl-cellulose 0.1g, sodium chloride 1.5g, lactic acid 0.5g, adds to 100ml with distilled water, fill after stirring, and inspection, obtains the vaginal lotion that pH4.4 is isotonic.
Embodiment 4
Get hexamethylene 0.5g, disodiumedetate 0.5g, glycerol 3g, hydroxyethyl-cellulose 0.8g, sodium chloride 0.5g, lactic acid 0.25g, add to 100ml with pure water or distilled water, fill after stirring, inspection, obtains the vaginal lotion that pH4.1 is isotonic.
Embodiment 5
With the obtained vaginal lotion of embodiment 1 ~ 4 for sample, with JIEERYIN draft bacteriostatic lotion (125ml fills, Chengdu En Wei pharmaceutical Co. Ltd) for contrast, measure its MIC to multiple vagina pathogen respectively
90, result is as shown in table 1.
Table 1
Claims (3)
1. a compositions kills application in the flushing medicine of HPV virus preparing vagina; Described compositions comprises hexamethylene 0.01 ~ 3 weight portion, disodiumedetate 0.01 ~ 3 weight portion, glycerol 0.2 ~ 60 weight portion, hydroxyethyl-cellulose 0.06 ~ 1.8 weight portion, potassium chloride 0.015 ~ 4.5 weight portion, lactic acid 0.02 ~ 6 weight portion.
2. a compositions is preparing vagina and is killing the application in the medical apparatus and instruments of HPV virus; Described compositions comprises hexamethylene 0.01 ~ 3 weight portion, disodiumedetate 0.01 ~ 3 weight portion, glycerol 0.2 ~ 60 weight portion, hydroxyethyl-cellulose 0.06 ~ 1.8 weight portion, potassium chloride 0.015 ~ 4.5 weight portion, lactic acid 0.02 ~ 6 weight portion.
3. a compositions is preparing vagina and is killing the application in the disinfectant of HPV virus; Described compositions comprises hexamethylene 0.01 ~ 3 weight portion, disodiumedetate 0.01 ~ 3 weight portion, glycerol 0.2 ~ 60 weight portion, hydroxyethyl-cellulose 0.06 ~ 1.8 weight portion, potassium chloride 0.015 ~ 4.5 weight portion, lactic acid 0.02 ~ 6 weight portion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310003118.5A CN103070881B (en) | 2013-01-05 | 2013-01-05 | A kind of vagina is antibacterial, virucidal compositions and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310003118.5A CN103070881B (en) | 2013-01-05 | 2013-01-05 | A kind of vagina is antibacterial, virucidal compositions and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103070881A CN103070881A (en) | 2013-05-01 |
| CN103070881B true CN103070881B (en) | 2016-03-09 |
Family
ID=48147728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310003118.5A Active CN103070881B (en) | 2013-01-05 | 2013-01-05 | A kind of vagina is antibacterial, virucidal compositions and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103070881B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103908469B (en) * | 2014-04-10 | 2016-03-23 | 南京明生医药技术有限公司 | A kind of compositions and application thereof regulating microecology in vaginas to balance and/or treat atrophic vaginitis |
| CN106619709A (en) * | 2017-01-05 | 2017-05-10 | 深圳市三方科技有限公司 | Preparation composition for inhibiting HPV viruses and preparation method and application of such preparation composition |
| CN108066376A (en) * | 2017-12-06 | 2018-05-25 | 林良权 | A kind of bacteriostatic lotion of human body privates |
| CN109431984A (en) * | 2018-12-12 | 2019-03-08 | 上海美哈医药科技有限公司 | A kind of female private part is dispelled the preparation method of the sliding massage liquid of black silk |
-
2013
- 2013-01-05 CN CN201310003118.5A patent/CN103070881B/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 苏伟东等.一种聚六亚甲基双胍复方消毒剂杀菌性能及毒性的实验研究.《实用预防医学》.2009, * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103070881A (en) | 2013-05-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI376364B (en) | A pharmaceutical composition comprising an n, n-dihalogenated amino acid or a derivative thereof, and methods for use of the pharmaceutical composition | |
| Kanisavaran | Chlorhexidine gluconate in endodontics: an update review | |
| CN103070881B (en) | A kind of vagina is antibacterial, virucidal compositions and application thereof | |
| CN105362212A (en) | Washing-free sterilizing gel and preparing method thereof | |
| US9662360B2 (en) | Treatment of herpes, pseudomonas, staph, and hepatitis | |
| KR20070092095A (en) | Disinfecting composition and methods of making and using same | |
| CN105055642A (en) | Compound guanidine disinfectant and preparation method of compound guanidine disinfectant | |
| KR20100015767A (en) | Therapeutic agent for infectious skin or mucosal disease | |
| CN106109451A (en) | A kind of antibiotic preparation and preparation method thereof | |
| WO2009093540A1 (en) | Chlorine dioxide liquid preparation composition | |
| US20130171262A1 (en) | Honey based compositions of a consistency that can be delivered to the respiratory system | |
| CN102204880A (en) | Disinfectant gellant for gynaecological external use and its preparation method | |
| WO2008001849A1 (en) | Agent for injection purposes comprising antibiotic, and solution for injection comprising the agent | |
| JP2015535298A (en) | Powder composition for disinfection of dairy nipples | |
| Barillo | Topical antimicrobials in burn wound care: a recent history | |
| RU2368609C1 (en) | Silver salt of n-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulphone)-n'-isonicotinoylhydrazide, which exhibits immunotropic, antimicrobial, antifungal (antimycotic) activity and medicinal agent based on said salt | |
| CN101690836A (en) | Oxygen humidifying liquid | |
| CN104288773A (en) | Preparation method of external sulfanilamide drug, external sulfanilamide drug and application of external sulfanilamide drug | |
| CN101194938A (en) | Chinese medicine disinfection liquid for tunica mucosa infection | |
| JP2014513721A (en) | “RENESSANS”, a pharmaceutical composition having antibacterial, antiulcer and immunomodulating effects | |
| US11351192B2 (en) | De-colonization drug, preparation method therefor, and application thereof | |
| CN101112382A (en) | Povidone iodine wiping sheet | |
| CN101249084B (en) | Disinfection composing prescription of preventability transmitted diseases | |
| CN101837020A (en) | American cockroach medicinal composition for curing oral ulcers and preparation method thereof | |
| CN103719872B (en) | A kind of concentrated type mineral trace element edible alkali additive |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |