CN103070677B - Portable physiological parameter remote measuring device with sampling and medicine perfusion functions - Google Patents
Portable physiological parameter remote measuring device with sampling and medicine perfusion functions Download PDFInfo
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- CN103070677B CN103070677B CN201210594905.7A CN201210594905A CN103070677B CN 103070677 B CN103070677 B CN 103070677B CN 201210594905 A CN201210594905 A CN 201210594905A CN 103070677 B CN103070677 B CN 103070677B
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Abstract
The invention discloses a portable physiological parameter remote measuring device with sampling and medicine perfusion functions. The device comprises a flow passage body, a wireless sensor unit, an inlet end conduit and an outlet end conduit, wherein the flow passage body is of a flow structure and is provided with inlet and outlet end mounting holes and a fluid cavity on the middle part of the body; the wireless sensor unit is arranged in the body for detecting a state of fluid entering the fluid cavity and is wirelessly communicated with exterior; one end of the inlet end conduit is communicated with a fluid source of a remote measuring object, and the other end of the inlet end conduit is connected with the inlet end mounting hole in a matching manner; and one end of the outlet end conduit is connected with the outlet end mounting hole in a matching manner, and the other end of the outlet end conduit is connected with a three-way valve. The invention also discloses other structural forms of the device. According to the device, bubbles can be effectively prevented from being detained in the device, the stability for fluid state transfer and the pressure measuring precision are guaranteed; and in addition, the device can also realize functions such as sampling and medicine perfusion, and has the advantages of small size, light weight, wide application range and the like.
Description
Technical field
The invention belongs to armarium technical field, more specifically, relate to a kind of portable physiological parameter telemetering equipment that has both sampling and drug infusion function, it, can also be by realizing other functions such as sampling and drug infusion in realizing smoothly the wireless telemetering of the multinomial physiological parameters such as the pressure cvd of human body or animal, blood flow, blood oxygenation to the adjustment of assembly.
Background technology
In the diagnosis and therapeutic process of disease, often need the multinomial physiological parameter of human body to measure, to provide important reference data according to the variation state of physiological parameter for medical diagnosis on disease and treatment.Taking blood pressure parameter as example, blood pressure is important vital sign, is also to judge hypertension and the most frequently used index of cardiovascular function.Existing blood pressure measuring method is divided into the direct method of measurement of wound and the noninvasive indirect method of measurement.To be percutaneous puncture import special conduit artery and vein and chamber and record pressure value the direct method of measurement, and the indirect method of measurement is to adopt cuff pressurization to measure arteriotony value.Although the indirect method of measurement possesses noninvasive advantage, but can not Real-Time Monitoring blood pressure, therefore (the Intensive Care Unit at present in intensive care unit, ICU) in, extensively adopted wired catheter pressure sensor main equipment directly to measure operation and critical and cardiovascular intervention patient, like this can continuous real-time monitoring blood pressure, and according to the instant direction of medication usage of the variation of blood pressure or interventional therapy.But, this wired catheter pressure sensor main equipment is not only expensive, and because conduit and electric wire interweave, make moving patients and medical worker's operation of diagnosis and treatment inconvenience, make patient activity and sick bed mobile restricted, medical worker's operation of diagnosis and treatment is extremely inconvenient and exist conduit surprisingly to deviate from system risk.
In addition, in the research and new drug development process of disease incidence mechanism, often also need the multinomial physiological parameter of laboratory animal to measure, to determine pathogenesis or disposition of drug effect according to its variation state.Equally taking blood pressure parameter as example, Small rodents (as Mouse and rat) is widely used in research and the new drug development etc. of the cardiovascular disease incidence mechanism such as mankind's hypertension at present, this just requires to adopt high-tech means to ensure that animal is under best physiological condition and studies, and wherein more vitally will avoid using exactly anesthetized animal.Along with the needs of research, a large amount of new techniques arise at the historic moment, such as Millar conduit, kinetocardiogram, implantable blood pressure telemetry etc., these technology have been widely used in Small rodents, but still there is larger limitation in these technology, accuracy and verity to in-vivo measurement have a negative impact, and as Millar conduit and ultrasoundcardiogram all must use on anesthetized animal, and anesthesia can reduce contraction and the diastolic function of heart rate, blood pressure and heart.
Consider above problem, from the Data Science International(DSI of the U.S.) company discloses a kind of implantable blood pressure telemetering equipment in US Patent No. 6033366 and US6379308, it has been developed to product, and can be used for the blood pressure remote measurement of animal and human's body.The advantage of this implantable telemetering equipment is 24 hours blood pressures that can the free moving object of Real-Time Monitoring, heart rate and diurnal periodicity situation of change thereof, but still following defect or the deficiency of existence: first, concerning being less than the mice of 17 grams, this telemetering equipment is still too large, too heavy (even minimum DIS blood Pressure Telemetric conveyer PA-C-10 implant, still have 1.4 grams, cumulative volume is 1.1 milliliters), when for zoopery, can have influence on diet and the physical ability activity of implanted mice, make Mouse Weight and blood pressure drops, and then the impact zoopery (such as observation of the blood pressure such as hypertension and cardiovascular disease animal model) relevant with blood pressure, especially the last fortnight after implanting, the second, because frequency response is inadequate, the model that in this telemetering equipment, precision is the highest can not accurately be measured the left ventricular contraction ability (LVdP/dt that implants object
maxand LVdP/dt
min), applicable surface is limited, the 3rd, this implanted telemetering device is a kind of non-negotiable formula hematodinamics telemeter system, therefore can not carry out blood sample collection and drug infusion experiment, the 4th, its displacement battery costliness, (as A-C-10 implant, new battery of every displacement needs 420 Euros, be 45 days the continuous service life of battery), and must be responsible for displacement by DSI company, and the corresponding deficiencies such as cost is high, operation inconvenience that exist, at present domestic only have a few studies personnel can use this blood pressure telemetry system, the 5th, a little less than the pressure transducer of the barrier film of this implanted telemetering device is highly brittle, in the time reusing implant, likely can in the transmission medium stowing operation of the catheter tip of implant, damage pressure sensing barrier film, in addition, in the time that blood pressure is long, in continuous record process, once catheter tip transmission medium is replaced by blood, can forms sludged blood or bubble, and then blood pressure signal is weakened or disappear.Correspondingly, be necessary to develop a kind of novel physiological parameter telemetering equipment, it both can be used for can the accurate remote measurement of embedding little rodentine left ventricle, be used for freely movable clear-headed little rodent to carry out left ventricular blood hydraulic coupling parameter (as left ventricular pressure, the left chamber heart terminal pressure that relaxes, left ventricular contraction maximum capacity, LV Diastolic maximum capacity, and diastolic time etc.) long-term precise monitoring in real time, can be applicable to again human cardiovascular disease, the safety of medicine and preclinical phase animal experiment study, and the cardiovascular function that can be applied to critically ill patient after suitable structure of modification is guarded purposes.
Summary of the invention
For above defect or the technical need of prior art, the object of the present invention is to provide a kind of portable physiological parameter telemetering equipment that has both sampling and drug infusion function, wherein by the improvement to sensor self structure, sensing unit set-up mode, can effectively avoid bubble device in delay and the formation of sludged blood, ensure stability and pressure measurement accuracy that fluid state transmits, while reducing embed-type measurement, bubble enters the risk in organism; In addition, by the adjustment to its associated component, can realize sampling and the function such as drug infusion, and possess that volume is little, lightweight, cost is low, convenient operation and the advantage such as widely applicable.
According to one aspect of the present invention, a kind of portable physiological parameter telemetering equipment that has both sampling and drug infusion function is provided, this device comprises runner body, wireless sensor unit, entrance point conduit and port of export conduit, it is characterized in that:
Described runner body is through-flow structure, and be respectively arranged with entrance point installing hole and port of export installing hole at its two ends, and being positioned at the fluid cavity in the middle part of body interior, the two ends of this fluid cavity keep the fluid between entrance point installing hole and port of export installing hole to be communicated with via transition runner respectively;
Described wireless sensor unit is arranged on runner body interior and is made up of sensor and radio communication circuit, detects, and realize communication by radio frequency signal and outside for the endoceliac fluid state of convection current;
One end of described entrance point conduit is for being connected with the fluid source of teleobjective, and one end is connected by the entrance point installing hole of entrance point connection tube and runner body in addition;
One end of described port of export conduit is connected by the port of export installing hole of port of export connection tube and runner body, and one end is for being connected with three-way valve in addition.
By above design, in the time that employing is carried out embed-type or external measurement according to telemetering equipment of the present invention to measuring object, three-way valve sealing, and entrance point conduit is directly connected with biological fluid, such as blood source, now can utilize the equivalent transmitting characteristic of liquid, biofluid flows into and is enclosed in fluid cavity via entrance point conduit, various states such as the pressure of fluid source, flows etc. are the corresponding fluid cavity that is passed to also, then obtain its relevant information by sensor, and send to outside information collecting device in the mode of radio frequency signal, complete thus Real-time Collection and the record of animal or human's body physiological parameter, and avoid the use of a large amount of conduits and electric wire etc., significantly improve the convenience of medical care precess, in the time that needs are carried out biofluid sampling or carried out the operations such as drug infusion, flushing, now three-way valve is opened, and syringe is connected with port of export conduit by three-way valve, thereby is convenient to carry out sampling or perfusion operation, and is easy to control.
As further preferably, described fluid cavity is elliposoidal, and it is imported and exported between the inwall at two ends and the inwall of corresponding transition runner and forms obtuse angles more than 145 degree.
As further preferably, described runner body interior also comprises that fluid state transmits window and sensor resettlement groove: this fluid state transmits window and is positioned at the bottom of fluid cavity, and contacts with the sensing element of sensor; This sensor resettlement groove is positioned at the bottom of fluid state transmission window, and for holding wireless sensor unit.
As further preferably, described runner body is double-deck platy structure, wherein the inside of upper strata platy structure is used to form described entrance point installing hole, port of export installing hole, transition runner, fluid cavity and fluid state thereof and transmits window, and the inside of its lower floor's platy structure is used to form described sensor resettlement groove.
As further preferably, the monnolithic case of described telemetering equipment is of a size of long 20mm, wide 14mm, high 4.6mm; The external diameter of described entrance point connection tube and port of export connection tube is that 0.6mm, internal diameter are 0.4mm; Described fluid cavity is 2.8mm along the maximum gauge of short transverse, and it is 6.7mm along the curved wall radius from arrival end to port of export direction.
As further preferably, described fluid cavity by hemispheric top and vertical axes to cylindrical lower portion jointly form, wherein the interface of upper and lower part is positioned at the horizontal central plane position of transition runner, and forms obtuse angles more than 90 degree between the inwall at fluid cavity import and export end two ends and corresponding transition runner inwall.
As further preferably, the bottom of described runner body is provided with the substrate for holding wireless sensor unit, and by clad, whole runner body and substrate is given to embedding protection.
As further preferably, the monnolithic case of described telemetering equipment is of a size of diameter 12mm, high 5mm.
As further preferably, between described import and export end connection tube and its corresponding import and export end installing hole, be interference fit, and between them, coordinate the length of section to account for separately the more than 1/3 of import and export end connection tube self total length.
As further preferably, described runner body is made up of transparent organic glass material, described entrance point conduit and port of export conduit are made up of the medical material such as PU or PE50, and described entrance point connection tube and port of export connection tube are made by biocompatible materialses such as rustless steels.
According to another aspect of the present invention, a kind of portable physiological parameter telemetering equipment is also provided, this device comprises runner body, wireless sensor unit and entrance point conduit, it is characterized in that:
Described runner body is through-flow structure, and is provided with entrance point installing hole in its one end, and is positioned at the fluid cavity of body interior, and this fluid cavity keeps the fluid between entrance point installing hole to be communicated with via transition runner;
Described wireless sensor unit is arranged on runner body interior and is made up of sensor and radio communication circuit, detects, and realize communication by wireless radio frequency mode and outside for the endoceliac fluid state of convection current;
One end of described entrance point conduit is for being connected with the pressure source of teleobjective, and one end is connected by the entrance point installing hole of entrance point connection tube and runner body in addition.
As further preferably, described fluid cavity is elliposoidal, and forms obtuse angles more than 145 degree between the inwall of its entrance point and the inwall of transition runner.
As further preferably, described runner body interior also comprises that fluid state transmits window and sensor resettlement groove: this fluid state transmits window and is positioned at the bottom of fluid cavity, and contacts with the sensing element of sensor; This sensor resettlement groove is positioned at the bottom of fluid state transmission window, and for holding described wireless sensor unit.
As further preferably, described runner body is double-deck platy structure, wherein the inside of upper strata platy structure is used to form described entrance point installing hole, transition runner, fluid cavity and fluid state thereof and transmits window, and the inside of its lower floor's platy structure is used to form described sensor resettlement groove.
As further preferably, described fluid cavity by hemispheric top and vertical axes to cylindrical lower portion jointly form, wherein the interface of upper and lower part is positioned at the horizontal central plane position of transition runner, and forms obtuse angles more than 90 degree between the inwall of fluid cavity entrance point and transition runner inwall.
As further preferably, the bottom of described runner body is provided with the substrate for holding wireless sensor unit, and by clad, whole runner body and substrate is given to embedding protection.
As further preferably, between described entrance point connection tube and import installing hole, be interference fit, and between them, coordinate the length of section to account for entrance point connection tube self the more than 1/3 of total length.
As further preferably, the monnolithic case of described telemetering equipment is of a size of diameter 12mm, high 5mm.
As further preferably, described runner body is made up of transparent organic glass material, and described entrance point conduit is made up of the medical material such as PU or PE50, and described entrance point connection tube is made up of biocompatible materialses such as rustless steels.
For above two kinds of portable physiological parameter telemetering equipments, as further preferably, described sensor is a kind of or its combination in pressure transducer, blood flow sensor or oxygen saturation sensor.
For above two kinds of portable physiological parameter telemetering equipments, as further preferably, described pressure transducer is piezo-resistive pressure sensor, for detected pressure signal is converted to the signal of telecommunication; Described radio communication circuit is passive type RFID radio circuit, for accepting energy from signal relay, the signal of telecommunication is sent to signal relay with RF-wise simultaneously, then passes to computer terminal via signal relay.
For above two kinds of portable physiological parameter telemetering equipments, as further preferably, in the time measuring for arteriotony and left ventricular pressure, the internal diameter of described entrance point conduit is greater than 0.2mm, its external diameter is suitable with the internal diameter of puncture tremulous pulse, and the frequency sound of conduit is greater than 100Hz.
For above two kinds of portable physiological parameter telemetering equipments, as further preferably, this telemetering equipment can be applicable to external and embed-type operation simultaneously.
For above two kinds of portable physiological parameter telemetering equipments, as further preferably, this telemetering equipment can with communication network realize grid-connected, to realize long-range remote sensing monitoring.
According to another aspect of the present invention, also provide described telemetering equipment for laboratory rodent being carried out to the purposes of left ventricular blood hydraulic coupling parameter monitoring; And carry out the purposes of remote sensing monitoring for the fluid pressure such as the chamber pressure to comprising arteriovenous blood pressure, heart, hydronephrosis pressure, bladder pressure, Ppl, middle ear pressure, hydrocrania pressure.
In general, according to portable physiological parameter telemetering equipment of the present invention compared with prior art, mainly possess following technological merit:
1,, by adopting the cooperation of wireless senser and other assemblies, wireless penetration that can implement device, avoids the use of a large amount of conduits and electric wire, reduces the misery of measuring object, and has reduced manually-operated safety operation requirement; In addition, in realizing physiological parameter measurement, can also be according to specific needs, carry out biofluid sampling or carry out the operations such as drug infusion, flushing, easy and simple to handle and be easy to control;
2, by the shape of fluid cavity being designed to the shape of elliposoidal or similar yurt, more test practice shows, it can effectively avoid the delay of bubble in device, ensure the stability that fluid state transmits, and then reduced bubble while carrying out embed-type physiological parameter measurement and enter the risk in organism;
3, according to flow through structure of the present invention, be beneficial to existing animal or human's body intubate and be connected, without measuring object is carried out to extra operation technique, and device compact overall structure, volume is little lightweight, both can directly be embedded in animal or human's body body, even if the external burden that also can not increase measuring object is simply portable, even can mobile phone.
4, by replacement fluid intracavity sensor type and radio communication circuit is adjusted, both the measurements such as the chamber pressure, hydronephrosis pressure, bladder pressure, Ppl, middle ear pressure, cranium pressure of fluid pressure such as arteriovenous blood pressure, heart can be realized according to device of the present invention, the remote sensing monitoring to other physiological parameters such as oxygen saturation, blood flow, electrocardiogram (ECG) can also be realized; Therefore widely applicable, be convenient to promote, and be particularly suited for the use of intensive care unit (ICU) and so on environment.In addition,, after this telemetering equipment and communication network are grid-connected, can also implement long-range remote sensing monitoring intensive care patient.
Brief description of the drawings
Fig. 1 is the population structure schematic diagram of the portable physiological parameter telemetering equipment that obtains according to the present invention's the first preferred implementation;
Fig. 2 is the structure cutaway view of fluid cavity shown in Fig. 1;
Fig. 3 is the population structure schematic diagram of the portable physiological parameter telemetering equipment that obtains according to the present invention's the second preferred implementation;
Fig. 4 is the structure cutaway view of fluid cavity shown in Fig. 3;
Fig. 5 a is for showing the system schematic when monitoring for mouse core vascular pressure according to telemetering equipment of the present invention;
Fig. 5 b is for showing the system schematic during for human body artery monitoring of blood pressure according to telemetering equipment of the present invention.
In institute's drawings attached, identical Reference numeral is used for representing identical element or structure, wherein:
1-sensor 2-fluid state transmits window 3-fluid cavity 4-radio communication circuit 5-entrance point conduit 6-port of export connection tube 7-entrance point installing hole 8-transition runner 9-port of export connection tube 10-runner body 11-sensor resettlement groove 12-substrate 13-clad 15-port of export installing hole 16-port of export connection tube 17-hemispherical top 18-cylindrical lower portion
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
Fig. 1 is the population structure schematic diagram of the portable physiological parameter telemetering equipment that obtains according to the present invention's the first preferred implementation.As shown in fig. 1, provide a kind of portable physiological parameter telemetering equipment that has both sampling and drug infusion function, this device mainly comprises the members such as runner body 1, wireless sensor unit, entrance point conduit 5 and port of export conduit 9.
Runner body 10 is through-flow structure, and two ends (in Fig. 1 and Fig. 2, being shown as two ends, left and right) is respectively arranged with entrance point installing hole 7 and port of export installing hole 15 therein, and be positioned at the fluid cavity 3 at the inner middle part of body 10, the two ends of this fluid cavity 3, respectively via two sections of transition runners 8, keep respectively the fluid between entrance point installing hole 7 and port of export installing hole 15 to be communicated with.Wireless sensor unit is arranged on the inside of runner body 10 equally, and formed by sensor 1 and radio communication circuit 4, detect for convection current endoceliac fluid state (including, but not limited to pressure, flow, oxygen saturation etc.), and realize communication by wireless radio frequency mode and outside.One end of entrance point conduit 5 for example can directly be connected with the biological fluid, such as blood source of teleobjective, and one end is connected by entrance point connection tube 6 and the entrance point installing hole 7 of runner body in addition.Similarly, one end of port of export conduit 9 is connected by port of export connection tube 16 and the port of export installing hole 15 of runner body 10, and one end is for being connected with three-way valve (not shown) in addition.
Specifically as shown in fig. 1, according to the preferred a kind of structural form of the present invention, the inside of runner body 10 also comprises that fluid state transmits window 2 and sensor resettlement groove 11, and wherein fluid state transmission window 2 is positioned at the bottom of fluid cavity 3, and contacts with the sensing element of sensor 1; Sensor resettlement groove 11 is positioned at the bottom of fluid state transmission window 2, and for holding wireless sensor unit.For the integrality of runner body 10, it is for example rendered as double-deck platy structure, the inside of the upper strata platy structure that wherein width is relatively little is used for being processed to form entrance point installing hole 7, port of export installing hole 15, transition runner 8, fluid cavity 3 and fluid state transmits window 2, and the inside of the relatively large lower floor's platy structure of width is used for being processed to form sensor resettlement groove 11.The monnolithic case of the telemetering equipment that this double-deck platy structure forms is preferably dimensioned to be long 20mm, wide 14mm, high 4.6mm, the external diameter of entrance point connection tube 6 and port of export connection tube 16 is 0.6mm, internal diameter is 0.4mm, and made by biocompatible materialses such as rustless steels, its size is identical with the external diameter of medical 35G syringe needle like this, thereby the connection of pipeline while being convenient to measure, and the microminiaturization of device and the versatility of interface are ensured.
To the operating process of said apparatus be described as an example of pressure monitoring example below.In the time that employing is carried out embed-type or external measurement according to this telemetering equipment to measuring object, three-way valve sealing, and entrance point conduit 5 can directly be connected with biological fluid, such as blood source, now can utilize the equivalent transmitting characteristic of liquid, biofluid via entrance point conduit 5 flow into and be enclosed in fluid cavity 3(now this fluid cavity become pressure chamber) in, the pressure of fluid source is the corresponding fluid cavity 3 that is passed to also, then by sensor 1(now, can adopt the pressure transducer of varistor type) obtain its relevant information, and send to outside information collecting device in the mode of radio frequency signal, complete thus Real-time Collection and the record of physiological parameter, and in the time that needs are carried out biofluid sampling or carried out the operations such as drug infusion, flushing, now three-way valve is opened, syringe is connected with port of export conduit 9 by three-way valve, thereby is convenient to carry out sampling or perfusion operation, and is easy to control.
Consider fluid cavity 3 be sensor 1 for experiencing and monitor the critical component of fluid state, need to ensure that fluid state can nondestructively transmit, to further improve the accuracy of monitoring as far as possible.Still describe as an example of pressure monitoring process example below, because the pressure-sensitive film of pressure transducer is planar structure, and stock size (1.2mmx1.2mm) is all much larger than importing and exporting conduit, therefore pressure chamber can not directly be designed to and the cylindrical runner of importing and exporting conduit same inner diameter, otherwise the pressure that cannot offer enough areas transmits window, build-up of pressure monitoring misalignment.Correspondingly, according to a preferred embodiment of the present invention, as shown in concrete in Fig. 2, fluid cavity/pressure chamber in the present invention can be designed to substantially be elliposoidal or the fairshaped shape of rugby, and it imports and exports the obtuse angle that forms 145 degree above (preferably 146.3 °) between the inwall at two ends and the inwall of corresponding transition runner 8.The eddy current equal pressure disturbance that so both can effectively avoid pipeline sudden enlargement or dwindle the pressure loss causing and cause, the pressure that can utilize again middle part expanded position to offer enough areas simultaneously transmits window.In addition, in a preferred embodiment, described fluid cavity is 2.8mm along the maximum gauge of short transverse (above-below direction in Fig. 2), and it is along from arrival end to port of export direction, the curved wall radius of (left and right directions Fig. 2) is 6.7mm.
More specifically, in the time that fluid flows through sudden enlargement pipeline, due to runner sudden enlargement, flow velocity reduces, the corresponding increase of pressure, and very easily there is boundary layer separation in fluid, produce vortex in this contrary pressure flow process; And, be difficult for arriving at right angle corner location fluid, easily cause the delay of bubble.And in the time that fluid flows into tubule by bassoon, stream strand dwindles suddenly, after this due to inertial flow, stream strand dwindles continuing, and a stream burst cross section is reduced to minimum, is called vena contracta herein.After vena contracta, stream strand starts to expand gradually, until refill whole tube section.Fluid was moving along baric flow before vena contracta, and similar with sudden enlargement situation after vena contracta is that contrary baric flow is moving, thereby can produce boundary layer separation and eddy current after vena contracta, and bubble is easily detained in same right angle area.Notice just above problem, in the present invention, adopt elliposoidal or Fructus Canarii albi ball-type pressure chamber, right angle area and low-angle region are avoided on the one hand, realize harmless the flowing of fluid turnover pressure chamber, and can ensure to have in time bubble be also easy to be discharged from pressure chamber and can not be detained therein, also the step thicknesses that makes on the other hand pressure that pressure chamber centre bottom offers transmit window reduces to the thinnest, avoids equally the unexpected variation of cross section of fluid channel, thereby realizes stable delivery and the Measurement accuracy of pressure.
Fig. 3 is the population structure schematic diagram of the portable physiological parameter telemetering equipment that obtains according to the present invention's the second preferred implementation.As shown in Figure 3, it is similar that the structures such as entrance point conduit 5, entrance point connection tube 6, entrance point installing hole 7, transition runner 8, port of export conduit 9, wireless sensor unit, port of export installing hole 15 and port of export connection tube 16 in this preferred implementation are the first preferred implementation, and main distinction part is the structure aspects of fluid cavity 3 and runner body 10 thereof.Specifically as shown in Figures 3 and 4, now fluid cavity 3 is designed to be similar to the shape of yurt, its by hemispherical top 17 and vertical axes to cylindrical lower portion 18 jointly form, wherein the interface of upper and lower part is positioned at the horizontal central plane position of transition runner 8, and forms obtuse angles more than 90 degree between the inwall at fluid cavity import and export end two ends and the inwall of corresponding transition runner.In addition, in runner body 10, do not have sensor resettlement groove to place and protect radio-circuit and sensor, but increased substrate 12 and clad 13 to support and holding circuit part.Substrate can adopt silica gel material, also can adopt the other biological compatibility materials such as PVC.Clad can adopt water white transparency medical silica-gel to carry out embedding shaping, and the monnolithic case of the telemetering equipment forming is of a size of diameter 12mm × 5mm.
If above-mentioned design is mainly to consider directly to adopt hemispherical, acute angle corner can be formed at the import and export bottom that is for example rendered as the fluid cavity of pressure chamber form, easily causes the delay of bubble, therefore adopts cylindrical transition in hemispherical bottom.But cylindrical structural causes base pressure window and pressure chamber directly to form right angle area, for reduce the impact of right angle area as far as possible, cylindrical structural should should as far as possible little its hemispheric the first half be conducive to the unimpeded of fluid by height in the situation that meeting structural strength requirement, avoids the delay of bubble.In addition, because the pressure-sensitive film of pressure transducer is a plane, if pressure chamber is directly made hemisphere face, will cause forming acute angle with pressure-sensitive film contact position, easily cause the delay of bubble.Therefore, increase the latter half cylindrical structural, to a certain degree alleviate the retention effect of bubble, the thickness simultaneously increasing has also improved the intensity of substrate.
According to a preferred embodiment of the present invention, between entrance end connection tube 6,16 and its corresponding import and export installing hole 7,15, be interference fit (and can adopt medical Instant cement to connect), and between them, coordinate the length of section to account for separately more than 1/3, to ensure bonding strength of import and export end connection tube self total length.In addition, entrance end connection tube 6,16 can adopt rustless steel or the similar biocompatible materials that possesses some strength to make.Gather at another one preferred embodiment, in order whether to contain bubble in Real Time Observation runner, runner body 10 is made up of transparent organic glass material, and simultaneously owing to belonging to medical, this material should meet bio-compatibility.Entrance point conduit 5 and port of export conduit 9 are for example made up of the medical material such as PU or PE50.
Should be understood that, when be used for arteriotony and left ventricular pressure measurement according to telemetering equipment of the present invention, in order to ensure certainty of measurement, the internal diameter of the entrance point conduit 5 that leads to pressure source that adopts is greater than 0.2mm, be preferably 0.3mm～0.4mm, its external diameter is with suitable with the internal diameter of puncture tremulous pulse, and the frequency response of conduit is greater than 100Hz.In the time monitoring for a long time, the conduit adopting need possess antiinflammatory and anticoagulant characteristic.
In addition, sensor 1 can be rendered as a kind of or its combination in pressure transducer, blood flow sensor, ECG sensor or oxygen saturation sensor.By the adjustment to sensor type and radio communication circuit thereof, can realize the Real-Time Monitoring to polytype physiological fluid parameter like this.Radio communication circuit in these sensor units is preferably passive type RFID radio circuit, like this can be for accepting energy from signal relay, the signal of telecommunication is sent to signal relay with RF-wise simultaneously, then for example pass to computer terminal or mobile phone terminal by bluetooth approach via signal relay, complete thus Real-time Collection and the record of detection signal, and without using battery.
Illustrate according to telemetering equipment of the present invention in the application process aspect pressure monitoring below with reference to Fig. 5 a and 5b.
Fig. 5 a is for showing the system schematic when monitoring for mouse core vascular pressure according to telemetering equipment of the present invention, as shown in Fig. 5 a, can be by telemetering equipment heeling-in of the present invention at mouse web portion, mouse heart is inserted by strength tremulous pulse in cardiovascular inlying catheter one end, one end is connected with fluid inlet end conduit, thereby form from mouse heart to the pressure port apparatus of the present invention pressure chamber, the pressure signal transmission of heart, to pressure transducer, is converted into the signal of telecommunication.Pressure transducer radio-circuit sends to Bluetooth signal relay station by this signal by radiofrequency signal, and relay station is realized and being communicated by letter with computer terminal by Bluetooth signal again, thereby in terminal, obtains left ventricular pressure and the arterial blood pressure signal of mice.
Fig. 5 b is for showing the system schematic during for human body artery monitoring of blood pressure according to telemetering equipment of the present invention, as shown in Fig. 5 b, now adopt external, pressure chamber entrance point conduit is communicated with Hematological System of Professional Workers by arterial cannulation, the pressure transducer by pressure signal transmission to apparatus of the present invention.Pressure transducer radio-circuit sends to Bluetooth signal relay station by this signal by radiofrequency signal, and relay station is realized and being communicated by letter with computer terminal by Bluetooth signal again, thereby obtains the arteriotony information of human body.
Without the place of considering the purposes such as sampling and drug infusion, can also further simplify its structure according to portable remote monitoring device of the present invention for some.For example, runner body interior can not be processed to form port of export installing hole, and fluid cavity only keeps the fluid between entrance point installing hole to be communicated with via transition runner; Runner body interior is provided with the wireless sensor unit being made up of sensor and radio communication circuit.In runner body exterior, one end of entrance point conduit is for being connected with the pressure source of teleobjective, and one end is connected by the entrance point installing hole of entrance point connection tube and runner body in addition.
For the portable physiological parameter telemetering equipment after above-mentioned simplified structure, its with simplify before the main distinction be not provide sampling and drug infusion function, and otherwise design or improvement, it is evident that the various means that provide according to the present invention's the first and second preferred implementations all can be provided, therefore do not repeat them here.
Those skilled in the art will readily understand; the foregoing is only preferred embodiment of the present invention; not in order to limit the present invention, all any amendments of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (13)
1. one kind is had both the portable physiological parameter telemetering equipment of sampling and drug infusion function, this device comprises runner body (10), wireless sensor unit, entrance point conduit (5) and port of export conduit (9), it is characterized in that:
Described runner body (10) is through-flow structure, and be respectively arranged with entrance point installing hole (7) and port of export installing hole (15) at its two ends, and being positioned at the fluid cavity (3) in the middle part of body interior, the two ends of this fluid cavity (3) keep the fluid between entrance point installing hole (7) and port of export installing hole (15) to be communicated with via transition runner (8) respectively; In addition, the shape of this fluid cavity (3) is designed to elliposoidal, and forms obtuse angles more than 145 degree between the inwall at its import and export two ends and the inwall of corresponding transition runner (8); Or the shape of this fluid cavity (3) be designed to by hemispheric top and vertical axes to cylindrical lower portion jointly form, wherein the interface of upper and lower part is positioned at the horizontal central plane position of transition runner (8), and forms obtuse angles more than 90 degree between the inwall at fluid cavity import and export end two ends and the inwall of corresponding transition runner;
Described wireless sensor unit is arranged on runner body (10) inside and is made up of sensor (1) and radio communication circuit (4), detect for the fluid state in convection current body cavity (3), and realize communication by wireless radio frequency mode and outside;
One end of described entrance point conduit (5) is for being connected with the fluid source of teleobjective, and one end is connected with entrance point installing hole (7) interference fit of runner body by entrance point connection tube (6) in addition;
One end of described port of export conduit (9) is connected with port of export installing hole (15) interference fit of runner body by port of export connection tube (16), and one end is for being connected with three-way valve in addition.
2. device as claimed in claim 1, is characterized in that, described sensor (1) is a kind of or its combination in pressure transducer, blood flow sensor, oxygen saturation sensor or electrocardiography transducer.
3. device as claimed in claim 1, it is characterized in that, in the time that the shape of fluid cavity (3) is designed to elliposoidal, described runner body (10) inside also comprises that fluid state transmits window (2) and sensor resettlement groove (11): this fluid state transmits window (2) and is positioned at the bottom of fluid cavity (3), and contacts with the sensing element of sensor (1); This sensor resettlement groove (11) is positioned at the bottom of fluid state transmission window (2), and for holding wireless sensor unit.
4. device as claimed in claim 3, it is characterized in that, described runner body (10) is double-deck platy structure, wherein the inside of upper strata platy structure is used to form described entrance point installing hole (7), port of export installing hole (15), transition runner (8), fluid cavity (3) and fluid state thereof and transmits window (2), and the inside of its lower floor's platy structure is used to form described sensor resettlement groove (11).
5. device as claimed in claim 4, is characterized in that, the monnolithic case of described telemetering equipment is of a size of long 20mm, wide 14mm, high 4.6mm; The external diameter of described entrance point connection tube (6) and port of export connection tube (16) is that 0.6mm, internal diameter are 0.4mm; Described fluid cavity (3) is 2.8mm along the maximum gauge of short transverse, and it is 6.7mm along the curved wall radius from arrival end to port of export direction.
6. device as claimed in claim 1; it is characterized in that; when the shape of fluid cavity (3) be designed to by hemispheric top and vertical axes to cylindrical lower portion while jointly forming; the bottom of described runner body (10) is provided with the substrate (12) for holding wireless sensor unit, and by clad (13), whole runner body (10) and substrate (12) is given to embedding protection.
7. device as claimed in claim 6, is characterized in that, the monnolithic case of described telemetering equipment is of a size of diameter 10mm-14mm, high 3mm-6mm.
8. the device as described in claim 1-7 any one, is characterized in that, this device and communication network are realized grid-connected, to realize long-range remote sensing monitoring.
9. a portable physiological parameter telemetering equipment, this device comprises runner body (10), wireless sensor unit and entrance point conduit (5), it is characterized in that:
Described runner body (10) is through-flow structure, and be provided with entrance point installing hole (7) in its one end, and being positioned at the fluid cavity (3) of body interior, this fluid cavity (3) keeps the fluid between entrance point installing hole (7) to be communicated with via transition runner (8); In addition, the shape of this fluid cavity (3) is designed to elliposoidal, and forms obtuse angles more than 145 degree between the inwall at its import and export two ends and the inwall of corresponding transition runner (8); Or the shape of this fluid cavity (3) be designed to by hemispheric top and vertical axes to cylindrical lower portion jointly form, wherein the interface of upper and lower part is positioned at the horizontal central plane position of transition runner (8), and forms obtuse angles more than 90 degree between the inwall at fluid cavity import and export end two ends and the inwall of corresponding transition runner;
Described wireless sensor unit is arranged on runner body (10) inside and is made up of sensor (1) and radio communication circuit (4), detect for the fluid state in convection current body cavity (3), and realize communication by wireless radio frequency mode and outside;
One end of described entrance point conduit (5) is for being connected with the pressure source of teleobjective, and one end is connected with entrance point installing hole (7) interference fit of runner body by entrance point connection tube (6) in addition.
10. device as claimed in claim 9, is characterized in that, described sensor (1) is a kind of or its combination in pressure transducer, blood flow sensor, oxygen saturation sensor or electrocardiography transducer.
11. devices as claimed in claim 10, is characterized in that, described pressure transducer is piezo-resistive pressure sensor, for detected pressure signal is converted to the signal of telecommunication; Described radio communication circuit (4) is passive type RFID radio circuit, for accepting energy from signal relay, the signal of telecommunication is sent to signal relay with RF-wise simultaneously, then passes to computer terminal via signal relay.
12. devices as claimed in claim 11, it is characterized in that, when for arteriotony and left ventricular pressure measurement, the internal diameter of described entrance point conduit (5) is greater than 0.2mm, its external diameter is suitable with the internal diameter of puncture tremulous pulse, and the frequency response of conduit is greater than 100Hz.
13. devices as described in claim 9-12 any one, is characterized in that, this device and communication network are realized grid-connected, to realize long-range remote sensing monitoring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210594905.7A CN103070677B (en) | 2012-12-31 | 2012-12-31 | Portable physiological parameter remote measuring device with sampling and medicine perfusion functions |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210594905.7A CN103070677B (en) | 2012-12-31 | 2012-12-31 | Portable physiological parameter remote measuring device with sampling and medicine perfusion functions |
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| CN103070677A CN103070677A (en) | 2013-05-01 |
| CN103070677B true CN103070677B (en) | 2014-10-29 |
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| CN201210594905.7A Expired - Fee Related CN103070677B (en) | 2012-12-31 | 2012-12-31 | Portable physiological parameter remote measuring device with sampling and medicine perfusion functions |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106388799B (en) * | 2016-09-26 | 2023-06-06 | 柳州市人民医院 | Invasive pressure monitoring sensor liquid injection tube and needle tube matched with same |
| CN112294279A (en) * | 2020-10-29 | 2021-02-02 | 江西理工大学 | Integrated invasive blood pressure sensor |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5097841A (en) * | 1988-09-22 | 1992-03-24 | Terumo Kabushiki Kaisha | Disposable pressure transducer and disposable pressure transducer apparatus |
| US6033366A (en) * | 1997-10-14 | 2000-03-07 | Data Sciences International, Inc. | Pressure measurement device |
| CN1201700C (en) * | 2002-03-29 | 2005-05-18 | 浙江大学 | Method and device for measuring blood flow using catheter |
| EP3093039A1 (en) * | 2008-11-03 | 2016-11-16 | Advanced Catheter Therapies, Inc. | Occlusion perfusion catheter |
| DE102009017034B3 (en) * | 2009-04-09 | 2010-06-17 | Pulsion Medical Systems Ag | Device for measuring the bubble pressure |
| US20130006130A1 (en) * | 2009-12-28 | 2013-01-03 | Gambro Lundia Ab | Device and method for monitoring a fluid flow rate in a cardiovascular system |
| CN203252641U (en) * | 2012-12-31 | 2013-10-30 | 王青 | Portable physiological parameter remote measuring device with sampling and medicine filling functions |
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