CN1030702A - Blood perfusion instrument - Google Patents
Blood perfusion instrument Download PDFInfo
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- CN1030702A CN1030702A CN 88105307 CN88105307A CN1030702A CN 1030702 A CN1030702 A CN 1030702A CN 88105307 CN88105307 CN 88105307 CN 88105307 A CN88105307 A CN 88105307A CN 1030702 A CN1030702 A CN 1030702A
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- blood
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- purification system
- perfusion
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Abstract
Blood perfusion instrument is a kind of extracorporeal circulation of blood of carrying out, and reaches the expertness electronic medical equipment of blood detoxification and purification.The present invention: (1) blood purification system adopts the agent of direct contact type blood detoxification; (2) adopt the miniature blood delivery pump; (3) adopt New PTC constant temperature heater element thermostatic chamber pyrotoxin; (4) can temperature automatically controlled and control speed.Compared with the prior art, have special use, advantage such as small-sized, efficient, clinical rescue can keep under human body normal arterial pressure and the temperature prerequisite blood being circulated linearly.Be applicable to: the clinical rescue of acute drug excess/poisoning, toxic poisoning, uremia and the traumatic blood infection of wound etc.
Description
The present invention relates to a kind of medical electronic machine, the special-purpose blood perfusion instrument of particularly a kind of automatic control blood heat and flow velocity.
Temperature-control pressure-control type blood perfusion instrument is a kind of expertness medical apparatus and instruments that the blood extracorporeal circulation reaches blood detoxification and purification that carries out.
External once had a report of carrying out blood perfusion technique research, and domestic still do not have this type of special equipment, and the apparatus of only dialysing has similar functions.
There are some shortcomings in these medical apparatus and instruments of prior art, as:
1, blood delivery system
External report, the blood transport pump adopts Σ delivery pump (Sigma pump) more; Domestic in artificial kidney (Kidney Artificial) and heart-lung machine (Heart-Lung Artificial) the blood transport pump mainly be to adopt TX type pump.The major defect of these pumps is that apparatus is too big, and the constant temperature constant speed of blood ground is linear in more can not guaranteeing to perform the operation carries.
2, warming portion
In the prior art, often use nickel reeling (1-2KW) to make heating element heater.Nickel reeling when energising surface temperature is more than 700 ℃, thereby the big shortcoming of pulse amplitude gradient when prior art exists temperature height, intensification, cooling is though have the parts of control temperature, low precision.
3, blood purification part
In the prior art, the flat dialyser of many employings, (Cellophane) makes dialyzer with cellophane paper, by external pipeline, patient blood is incorporated in the dialyser, and blood is just dialysed across dialyzer and dialysis solution, and poisonous substance is transferred in the dialysis solution, it is slow that prior art is not only removed the speed of medicine, and not ideal.
Purpose of the present invention will provide a kind of exactly and simulate human body temperature, constant temperature, constant speed preferably, hemoperfusion special equipment completely detoxifies, purifies the blood.When clinical rescue, purify and auxiliary power for blood in extracorporeal circulation with constant temperature, detoxifcation, it can be circulated under the prerequisite that keeps human body normal arterial pressure and temperature linearly.
The objective of the invention is to adopt following measure to realize
The hemoperfusion apparatus that complete machine is made up of shell, power supply, blood purification system, blood delivery system and constant temperature system the invention is characterized in:
1, blood purification system is direct contact type;
2, blood delivery system is made up of miniature blood transfusion apparatus and ghyristor circuit;
3, constant temperature system is made up of heating element heater and ghyristor circuit.
Wherein:
1, blood purification system is to be made of a cylindrical shell that is loading the blood detoxification agent.In the treatment, the blood that needs to purify directly contacts with the blood detoxification agent, and adsorbed by the blood of blood detoxification device, its quality has reached normal value, can be in the patient's body that backflows.
2, the blood delivery system speed that adopts miniature roller blood transfusion apparatus and be used to detect, control blood flow detects and control circuit is formed, the rotating speed of pump adopts electronic stepless speed regulation, amount of infusion reaches the voltage that the control drive motors adds armature by the SCR control circuit by the control thyristor operating angle, motor speed is changed, making the roller infusion pump rotating speed that is adopted is 1-50r/min, infinitely variable speeds, adjustable continuously.Amount of infusion is controlled in the 30-450ml/min scope adjustable continuously.Speed detects and adopts 555 o'clock base light-operated circuits, shows by control infusion pump rotating speed to show indirectly.
3, constant temperature system adopts temperature detection and the control circuit that temperature-sensitive element is formed.The present invention adopts the PTC temperature-sensitive element to blood heats, Constant Temperature Detection constitutes by temperature-sensitive element bridge for measuring temperature, show by A.C. contactor J control charactron, injects the temperature of blood in human body in liquid in order to strictness control.
The present invention is further elaborated below in conjunction with accompanying drawing
Fig. 1 is a blood perfusion instrument complete machine general assembly sketch map of the present invention.
Fig. 2 is a blood perfusion instrument operation principle block diagram of the present invention.
Fig. 3 is a blood purification system structural representation of the present invention.
Fig. 4 is a blood purification tube structure sketch map of the present invention.
Fig. 5 is blood perfusion instrument circuit theory diagrams of the present invention.
Among Fig. 1: the 1st, thermostatic chamber, the 2nd, blood purification cylindrical shell, the 3rd, bubble stripper, the 4th, infusion pump, the 5th, tachoscope, the 6th, rotational speed regulation, the 7th, on and off switch, the 8th, speed switch, the 9th, temperature detect switch (TDS), the 10th, observation window, the 11st, metal rack, the 12nd, shell.
Among Fig. 2: the 1st, power supply is given, the 2nd, trigger impulse circuit, the 3rd, major loop, the 4th, infusion pump, the 5th connects tremulous pulse, the 6th, negative-feedback circuit, the 7th, tachometer circuit, the 8th, blood purification, the 9th, temperature sensing circuit, the 10th, amplifying circuit, the 11st, executive circuit, the 12nd, heater, the 13rd, bubble stripper, the 14th connects vein.
Among Fig. 3: the 2nd, blood purification cylindrical shell, the 3rd, bubble stripper, the 13rd, motor-driven injection joint, the 14th, medical silicone tube.
Among Fig. 4: the 2nd, blood purification cylindrical shell, the 14th, medical silicone tube, the 15th, cover, the 16th at the bottom of the politef open-type screw thread, politef screw thread enclosing cover, the 17th, the silicone rubber pad connects stainless (steel) wire, the 18th, joint.
Machine shape structure and operation principle are as shown in Figure 1 and Figure 2. Complete machine is made up of following several parts: by a speed given circuit, the trigger impulse formation circuit that its input links to each other with given circuit first output, a major loop that links to each other with trigger impulse formation circuit output end, the infusion pump that its input links to each other with the major loop output, its input and testing the speed and display circuit that infusion pump first output links to each other, its input with test the speed and display circuit links to each other, the negative-feedback circuit that output links to each other with speed given circuit, a temperature sensing circuit, the detection signal amplifying circuit that its input links to each other with temperature sensing circuit, the executive circuit that its input links to each other with the detection signal amplification circuit output end, ptc heater and the blood purification system that its input links to each other with the executive circuit output. Human body artery links to each other with infusion pump, and human vein links to each other with bubble stripper.
The each several part operation principle is described below:
Temperature-control circuit: be by blood, the balanced bridge (temperature sensor that its input links to each other with the blood output, its output is connected on that the temperature setting device of difference amplifier input forms), the output of the temperature sensor in the input of difference amplifier and the balanced bridge links to each other, the input of comparison amplifier links to each other with the difference amplifier output, the input of controller links to each other with the output of comparison amplifier, and display is connected on the node of controller and heater. The input of heater links to each other with the output of controller, and blood links to each other with the output of heater.
Principle: thermistor R7 is as temperature sensor, the temperature of direct feeling blood, R7, R17, R18, R22, R23 consist of balanced bridge, when adjusting R22 makes blood reach design temperature, and bridge balance, amplify through difference R19, R20, R21, BG9, BG10, further amplify through comparison amplifier BG11 again, make BG13 conducting or cut-off, control relay J corresponding actions, thereby control A.C. contactor CJ0-10 action, control heater makes temperature stabilization on setting value.
Speed control circuit: be by speed regulator, the amplifier that its input links to each other with the speed regulator output, the trigger signal generator that its input links to each other with amplifier out, the controllable silicon that its input links to each other with the trigger signal generator output, the motor that its input links to each other with the controllable silicon output, the output of motor are connected on second output of amplifier. Speed is regulated the resistance that changes W4, affect the speed that discharges and recharges of capacitor C 14, amplify through BG21, BG20 amplifier, in triggering signal of BG19 output, the control silicon controlled angle of flow, thus the motor both end voltage changes, the control motor speed, motor terminal voltage feeds back to again amplifier through R35, plays negative feedback, thereby motor speed is stabilized on the speed set point.
Velocity display circuit: be by light pulse signal, its input links to each other with the light pulse signal output, light/electric transducer, its input and the amplifier that light/the electric transducer output links to each other, the pulse shaper that its input links to each other with amplifier out forms with the display that its input links to each other with pulse shaper.
Operation principle: when illumination is mapped on the motor shaft blanking disc, motor shaft rotates and produces light pulse signal, and whenever circling produces six optical signals. Form electric pulse through phototriode, amplify through BG7, pulse signal enters pulse shaper. Each input signal becomes the wide standard electric signal pulse of 1.1RC that is, the input speed table demonstrates its mean value, reads the numerical value of rotating speed at table.
Whole working: after the equipment input operation, at first, the energising of thermostatic chamber PTC element heats up, when temperature rises to 38 ℃, thermistor R24 detects this signal after amplifying, and executing agency's action stops to heat, when temperature is lower than 38 ℃, executing agency moves again, again heats, and so goes round and begins again, make temperature stabilization at 38 ± 2 ℃, guarantee the needs of whole perfusing course.
After perfusion begins, start blood pump, adjusting rotary speed, revolution counter namely demonstrate reading, thereby indirectly obtain blood flow at that time.
Advantage of the present invention:
1, extracts blood from patient's artery, from patient's Venous Reflux blood;
2, blood purification system adopts the agent of novel direct contact type blood detoxification;
What 3, its blood delivery system adopted is the miniature blood delivery pump;
4, constant temperature system has adopted new ceramic material to make heating element heater.
Therefore, compared with the prior art, these facility have special use, small-sized, efficient, easy sterilization, charge and discharge operations conveniently, and can accurately regulate blood flow.Simulation normal human's the blood pressure and the advantage of temperature guarantee that not only blood can be carried linearly in the operation.And the physical property and the chemical of the blood after purifying all reach normal value.
The present invention is applicable to the rescue of following case:
1, this blood perfusion instrument is remarkable to acute severe medicine excess/poisoning effect; Can recover consciousness quickly to II, III degree coma patient, save one's life.
Be used in:
(1) barbiturates hypnotic sedative activity;
(2) non-barbiturates hypnotic sedative activity;
(3) refreshing smart tranquilizer;
(4) antidepressant drug;
(5) other class medicine (as: salicylic acid, isoniazid, digoxin, anticarcinogen etc.).
2, toxic poisoning:
To organophosphorus pesticide and poison
(α-Amanitine) wait toxin that good scavenging action is also arranged can merge with Drug therapy and use the α-amanitine that includes.
3, uremia
The clearance rate of refuses such as the uric acid of the body inner accumulated that uremia is caused, creatinine is better than prior art.
4, other
To acute and chronic liver failure, toxic hepatitis, creating traumatic blood infection etc. also has certain detoxifying effect.
(embodiment)
Press shown in Fig. 1-4, select a suitable element external form of assembling blood perfusion instrument of the present invention as shown in Figure 1, result of use is best.
By shown in Figure 5, audion BG1 adopts 3DD series silicone tube, BG2 among the figure, BG3, BG7, BG9, BG10, BG21, BG20 adopts 3DG series small-power silicone tube, and BG5 is a 3DU series phototriode, and BG11 is a 3DG series high-frequency triode, BG19 is BT31, BT33 unijunction transistor, and BG1 is 3CT103(or other model) controllable silicon 1A/50V-10A/50V.
The resistance of resistance R 1-R35 is respectively:
1.4-2.6K, 0.7-1.3K, 70-130 Ω, 84-156K, 392-728 Ω, 210-330 Ω, 0.84-1.56K, 0.7-1.3K, 8.4-15.6K, 1.4-2.6K, 3.57-6.63K, 3.57-6.63K, 35-65K, 3.57-6.63K, 14-26 Ω, 329-611 Ω (PTC critesistor), 0.7-1.3 Ω, 0.7-1.3K, 3.57-6.63K, 1.4-2.6K, 476-884 Ω, 0.7-1.3K, 37.1-68.9K, 70-130 Ω, 70-130 Ω, 1.4-2.6K, 70-130 Ω, 252-46 Ω, 70-130 Ω, 5.74-10.66 Ω, 3.57-6.63K, 0.7-1.3K, 3.57-6.63K, 5.74-10.66K.
The C1-C14 capacity is as follows:
70-130μF/50V，70-130μF/16V，7-13μF/16V，3.29-6.1μF/16V，329-611μF/16V，0.007-0.013μF，0.07-0.013μF，0.0329-0.0611μF，70-130μF/16V，329-611μF/16V，0.007-0.013μF，0.007-0.013μF，0.7-1.3μF，70-130μF/16V。
Press blood perfusion instrument of said elements assembling, using method is as follows:
1, preparation and sterilization
(1) clear water is cleaned
(2) 5% peracetic acid are handled
(3) 0.5% sodium peroxide solution-treated
(4) 3% hydrogen peroxide are handled
(5) conventional high pressure steam sterilization
2, use
(1) with blood purification cylindrical shell 2, bubble stripper 3 with silica gel tube 14, connects in accordance with regulations;
(2) energized, temperature detect switch (TDS) are beaten " automatic control ";
(3) under the sterile working, the MMAC that handles well is placed blood purification cylindrical shell 2;
(4) normal saline flushing total system;
(5) heparinization;
(6) treat that thermostatic chamber constant temperature reaches regulation after, connect patient's artery and vein, the beginning perfusion mixes up flow according to the treatment needs.
(7) stop perfusion before, with normal saline exchange system inner blood;
(8) withdraw from circulation, shut down.
Claims (10)
1, a kind of blood perfusion instrument of being made up of shell, power supply, blood purification system, blood delivery system and constant temperature system the invention is characterized in:
(1) blood purification system is direct contact type;
(2) blood delivery system is made up of miniature blood transfusion apparatus and ghyristor circuit;
(3) constant temperature system is made up of heating element heater and ghyristor circuit.
2, according to the described blood perfusion instrument of claim 1, it is characterized in that:
(1) blood purification system is that cylindrical shell by the blood detoxification agent of a filling constitutes,
(2) blood delivery system is by miniature blood transfusion apparatus and the speed that is used to survey inspection and control blood flow detects and control circuit is formed;
(3) constant temperature system adopts temperature detection and the control circuit composition that temperature-sensitive element is formed, and flows into the temperature of blood in human body in liquid in order to strictness control.
3, according to the blood purification system of claim 1 or 2 described blood perfusion instruments, it is characterized in that blood purification system is installed in 1 li of thermostatic chamber, it is by cylindrical shell 2, bubble stripper 3, motor-driven syringe adapter 13 and silicone rubber tube 14 are formed.
4, according to the blood purification system of the described blood perfusion instrument of claim 3, the cylindrical shell 2 that it is characterized in that described cleaning system is the bulging abdomen cylinder of the streamlined inwall of a tool, and two ends link to each other with silicone rubber tube 14 with web plate 17, joint 18 by cover 15, screw thread enclosing cover 16, pad at the bottom of the open-type screw thread.
5, according to the blood purification system of the described blood perfusion instrument of claim 4, it is characterized in that loading in the described cylindrical shell 2 direct contact type blood detoxification agent MMAC(Micro in Micro Activated Charcoal).
According to the blood delivery system of the described blood perfusion instrument of claim 1, it is characterized in that 6, the miniature blood delivery pump that is adopted is the roller infusion pump, its type of drive can adopt motor-driven or manual driven.
7, according to the blood delivery system of the described blood perfusion instrument of claim 2, it is characterized in that the miniature blood transfusion apparatus that is adopted is the roller infusion pump, be used to survey the speed detection and the control circuit of inspection and control blood flow, it is to adopt 555 time base circuits that speed detects, and what control circuit adopted is SCR control.
8, according to the blood delivery system of claim 6 or 7 described blood perfusion instruments, it is characterized in that the roller infusion pump rotating speed that is adopted is 1-50r/min, infinitely variable speeds, adjustable continuously.
9, according to the blood constant temperature system of claim 1 or 2 described blood perfusion instruments, it is characterized in that forming by heating element heater, temperature detection and control circuit, heating element heater adopts the PTC critesistor, temperature sensing circuit adopts bridge for measuring temperature, charactron to show that control circuit is made up of temperature signal amplifying circuit and executive circuit.
10,, it is characterized in that it being to extract blood out, from patient's vein blood that backflows from patient's tremulous pulse according to claim 1 or 2 described blood perfusion instruments.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88105307 CN1015149B (en) | 1988-07-11 | 1988-07-11 | Blood perfusion instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88105307 CN1015149B (en) | 1988-07-11 | 1988-07-11 | Blood perfusion instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1030702A true CN1030702A (en) | 1989-02-01 |
| CN1015149B CN1015149B (en) | 1991-12-25 |
Family
ID=4833515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 88105307 Expired CN1015149B (en) | 1988-07-11 | 1988-07-11 | Blood perfusion instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1015149B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108815604A (en) * | 2012-10-29 | 2018-11-16 | 生物技术公司 | The medical system of fluid distribution |
| CN108917167A (en) * | 2018-08-07 | 2018-11-30 | 江苏斯托利仪器仪表有限公司 | A kind of constant temperature perfusion system |
| CN110151295A (en) * | 2017-11-15 | 2019-08-23 | 林斌 | A kind of vena cave bypass blood perfusion Cryoablation system |
-
1988
- 1988-07-11 CN CN 88105307 patent/CN1015149B/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108815604A (en) * | 2012-10-29 | 2018-11-16 | 生物技术公司 | The medical system of fluid distribution |
| CN108815604B (en) * | 2012-10-29 | 2022-07-29 | 生物技术公司 | Medical system for fluid dispensing |
| CN110151295A (en) * | 2017-11-15 | 2019-08-23 | 林斌 | A kind of vena cave bypass blood perfusion Cryoablation system |
| CN108917167A (en) * | 2018-08-07 | 2018-11-30 | 江苏斯托利仪器仪表有限公司 | A kind of constant temperature perfusion system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1015149B (en) | 1991-12-25 |
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