CN103048479B - Reagent sample system used for full-automatic chemiluminescence analyzer - Google Patents
Reagent sample system used for full-automatic chemiluminescence analyzer Download PDFInfo
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- CN103048479B CN103048479B CN201210540386.6A CN201210540386A CN103048479B CN 103048479 B CN103048479 B CN 103048479B CN 201210540386 A CN201210540386 A CN 201210540386A CN 103048479 B CN103048479 B CN 103048479B
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Abstract
The present invention relates to a reagent sample system used for a full-automatic chemiluminescence analyzer. The system includes a cooling mechanism, a reagent sample storing mechanism and a magnetic particle mixing mechanism. The system integrates the functions of sample reagent automatic sampling, sample reagent low temperature storage and magnetic particle mixing as one. The system is small in volume, clever in structure, simple and reliable, and improves the overall reliability and reduces the manufacturing costs. The system of the present invention is simple and reliable in magnetic particle mixing way and good in mixing effect, has no risk of cross contamination and can meanwhile mix a plurality of magnetic particle boxes.
Description
technical field:
The present invention relates to a kind of Full-automatic chemiluminescence analyser module, more precisely, relate to a kind of reagent sample system of Full-automatic chemiluminescence analyser.
background technology:
Sample bin and the agent bin ingredient that is absolutely necessary in Full-automatic chemiluminescence analytical instrument, the auto arrangement input that it has comprised sample, the preservation storage of various reagent and magnetic response particulate the function such as mix.On domestic and international market, most instruments is all sample bin and agent bin separately design separately at present; and set up separately the mixing mechanism of magnetic particle; magnetic particle requires CONCENTRATION DISTRIBUTION even while using; but while not using at ordinary times, magnetic particle can normally not be deposited in bottle bottom, so magnetic particle need to be mixed to rear use.Common way is to use to mix rod and probe under magnetic bead box liquid level and stir and mix, and this blending manner need to have mixing arm and needing wiper mechanism in order to avoid cross pollution between reagent of a set of independent Telescopic rotary.This project organization is complicated and have a risk of cross pollution.Another kind of mode is that the kit that holds magnetic particle is mixed by the mode of rotor vibrations, or it taking-up is placed on shaking table and is mixed, or have a set of Design of vibration table that can move up and down in magnetic bead box bottom, in this design complex structure and practice, amiss risk is larger.
For full-automatic instrument, modular design is overstepping the bounds of propriety loose, and structure is more complicated, and instrument reliability of operation will reduce, and the cost of the manufacturing will increase,
summary of the invention:
The present invention is in order to overcome deficiency of the prior art; design a kind of reagent sample system of Full-automatic chemiluminescence analyser; sample reagent automatic sampling, sample reagent cryopreservation and magnetic particle are mixed to three partial functions and be integrated, and can mix several magnetic bead boxes simultaneously.
The present invention adopts a kind of reagent sample system for Full-automatic chemiluminescence apparatus device, and described system comprises band refrigeration mechanism, reagent sample holding structure and magnetic particle mixing mechanism; Described system integrates sample reagent automatic sampling, sample reagent cryopreservation and magnetic particle and mixes three partial functions.
Further, described refrigeration mechanism comprises blower fan, heat radiator, semiconductor chilling plate, refrigeration storehouse and insulation construction; Described reagent sample holding structure comprises reagent sample dish, reagent cassette holder, kit, dilution box, bottom Upper shaft sleeve, reagent disc central axle sleeve, reagent sample dish synchronizing belt gear, reagent sample dish Timing Belt and motor; Described magnetic particle mixing mechanism comprises that rotation magnetic bead box, rotary seat, magnetic mix gear, mix axle, magnetic bead rotation belt wheel, magnetic bead rotary synchronous band and mix motor.
Further, the heating face of described semiconductor chilling plate is attached to heatsink upper surface, and the chill surface of semiconductor cooling piece processed is attached to refrigeration storehouse lower surface, and blower fan is lowered the temperature to heat radiator by down draught box.
Further, described insulation construction comprises refrigeration storehouse stay-warm case, reagent sample dish upper cover and reagent sample dish lower cover, and this insulation construction is bonded in outside, refrigeration storehouse.
Further, described stay-warm case is used the foaming material shaped making of EVA, described upper cover liner heat-preservation cotton.
Further; in described magnetic particle mixing mechanism, mix motor by magnetic bead rotary synchronous band drive magnetic bead rotation belt wheel and mix axle and rotate; mix axle upper end installation magnetic and mix gear; magnetic mixes gear and coordinates with the gear of rotary seat; rotary seat is rotated, and turning axle is arranged on rotary seat, and rotation magnetic bead box the latter half is placed on turning axle; and the impeller that utilizes magnetic bead box both sides makes the liquid in rotation of magnetic bead box inside, reach the object that magnetic bead mixes.
Further, in described reagent sample holding structure, by motor, by reagent sample dish Timing Belt, drive reagent sample dish synchronizing belt gear to rotate, then make reagent disc central axle sleeve drive the rotation of bottom Upper shaft sleeve, make reagent sample disc spins.
Further, described reagent sample dish is mounted with reagent cassette holder, and described reagent cassette holder is mid-kit and dilution box; Described reagent sample dish is placed in the inside in described refrigeration storehouse.
Further, there are 4 support column and 2 whole reagent sample systems of reagent sample dish seat supports are installed.
The present invention has converged sample reagent automatic sampling, sample reagent cryopreservation and magnetic particle and has mixed the system that three partial functions are integrated, and volume is little, and structure is ingenious and simple and reliable, and has improved complete machine operational reliability and reduced manufacturing cost; And magnetic bead blending manner of the present invention is simple and reliable, and Blending Efficiency of Blending is good, without cross contamination risk and can mix several magnetic bead boxes simultaneously.
accompanying drawing explanation:
?fig. 1 is the schematic perspective view of the embodiment of the present invention;
Fig. 2 is the elevated bottom perspective schematic diagram of the embodiment of the present invention;
Fig. 3 is exploded view embodiment illustrated in fig. 1;
Fig. 4 is the A-A cut-open view of the embodiment shown in Fig. 1;
Fig. 5 is the schematic diagram of the kit of the embodiment of the present invention;
Fig. 6 is the schematic diagram of the magnetic bead box of the embodiment of the present invention.
reference numeral:1, refrigeration storehouse; 2, cold storehouse stay-warm case; 3, reagent sample dish lower cover; 4, mix axle; 5, bottom Upper shaft sleeve; 6, reagent disc central axle sleeve; 7, magnetic mixes gear; 8, reagent sample dish; 9, reagent sample dish upper cover; 10, heat radiator; 11 down draught boxes; 12, blower fan; 13 motors; 14, magnetic bead rotation belt wheel; 15, support column; 16, reagent sample dish seat; 17, mix motor; 18, synchronizing belt gear; 19, magnetic bead rotary synchronous band Timing Belt; 20, reagent sample dish Timing Belt; 21, semiconductor cooling piece processed; 22, rotary seat; 23, rotation magnetic bead box; 24, turning axle; 25, impeller; 26, reagent cassette holder; 27, kit; 28 dilution boxes.
embodiment:
Below in conjunction with accompanying drawing, instructions embodiment is described in detail:
The invention provides a kind of reagent sample system for Full-automatic chemiluminescence apparatus device, comprise the refrigeration mechanism with insulation construction, reagent sample holding structure and the magnetic particle mixing mechanism of kit is housed, integrate reagent sample and magnetic particle evenly mixing device.
Referring to Fig. 1-Fig. 6, wherein refrigeration mechanism comprises blower fan 12, heat radiator 10, semiconductor chilling plate 21, refrigeration storehouse 1 and insulation construction.Wherein the heating face of semiconductor chilling plate 21 is attached to heat radiator 10 upper surfaces, the chill surface of semiconductor cooling piece 21 processed is attached to refrigeration storehouse 1 lower surface, blower fan 12 gives heat radiator 10 coolings by down draught box 11, so just allow semiconductor chilling plate 21 continuously the heat in refrigeration storehouse 1 be led away, thereby the temperature in the storehouse that makes to freeze reduces, and utilizes this principle to reach our needed cryogenic temperature.
Insulation construction comprises refrigeration storehouse stay-warm case 2, with reagent sample dish upper cover 9 and the reagent sample dish lower cover 3 of the liner heat-preservation cotton of pin thief hole, be bonded in inner 1 outside, refrigeration storehouse of being processed into for aluminum, the storehouse 1 that makes to freeze is able to heat-insulation and heat-preservation comprehensively.Stay-warm case 2 is used the foaming material shaped making of EVA, is circle framework, and effectively isolating exterior heat, reaches required low temperature requirement.
Magnetic particle mixing mechanism comprises that rotation magnetic bead box 23, rotary seat 22, magnetic mix gear 7, mix axle 4, magnetic bead rotation belt wheel 14, magnetic bead rotary synchronous band 19 and mix motor 17.Wherein mixing motor 17 is driven magnetic bead rotation belt wheel 14 and is mixed axle 4 rotations by magnetic bead rotary synchronous band 19, mix axle 4 upper ends installation magnetic and mix gear 7, magnetic mixes gear 7 and coordinates with the gear of rotary seat 22, rotary seat 22 is rotated, turning axle 24 is arranged on rotary seat 22, rotation magnetic bead box 23 the latter halfs are placed on turning axle 24, and utilize the impeller 25 of magnetic bead box 23 both sides to make the liquid in rotation of magnetic bead box 23 inside, finally reach the object that magnetic bead mixes.
Reagent sample holding structure comprises reagent sample dish 8, reagent cassette holder 26, kit 27, dilution box 28, bottom Upper shaft sleeve 5, reagent disc central axle sleeve 6, reagent sample dish synchronizing belt gear 18, reagent sample dish Timing Belt 20 and motor 13.By motor 13, by reagent sample dish Timing Belt 20, drive synchronizing belt gear 18 rotations, then make reagent disc central axle sleeve 6 drive 5 rotations of bottom Upper shaft sleeve, make 8 rotations of reagent sample dish.According to Chemiluminescence Apparatus main control software, handle, reagent and sample are rotated on request to sampling place, reagent got by confession sampling probe or sample carries out analysis operation.
Wherein reagent sample dish 8 is mounted with reagent cassette holder 26, is equipped with kit 27 and dilution box 28 in reagent cassette holder 26; Central authorities at reagent sample dish 8 have a magnetic to mix gear 7; What both sides distributed is to drive the motor 13 of reagent sample dish 8 rotations and drive magnetic to mix mixing motor 17, reagent sample dish synchronizing belt gear 18, synchronous pulley 19 and mixing the parts such as axle 4, reagent disc central axle sleeve 6 of gear 7 rotations, and temperature sensor and temperature control module.
Reagent sample dish 8 is placed in refrigeration 1 inside, storehouse.4 support column 15 and 2 reagent sample dish seats 16 support whole systems are installed.
The present invention has converged sample reagent automatic sampling, sample reagent cryopreservation and magnetic particle and has mixed the system that three partial functions are integrated, and volume is little, and structure is ingenious and simple and reliable, and has improved complete machine operational reliability and reduced manufacturing cost; And magnetic bead blending manner of the present invention is simple and reliable, and Blending Efficiency of Blending is good, without cross contamination risk and can mix several magnetic bead boxes simultaneously.
The foregoing is only preferred embodiment of the present invention, be not limited to the present invention, all any modifications of making within the spirit and principles in the present invention, are equal to replacement and improvement etc., all should be included in protection scope of the present invention.
Claims (7)
1. for a reagent sample system for Full-automatic chemiluminescence apparatus device, it is characterized in that, described system comprises refrigeration mechanism, reagent sample holding structure and magnetic particle mixing mechanism, described system integrates sample reagent automatic sampling, sample reagent cryopreservation and magnetic particle and mixes three partial functions, wherein said refrigeration mechanism comprises blower fan (12), heat radiator (10), semiconductor chilling plate (21), refrigeration storehouse (1) and insulation construction, described reagent sample holding structure comprises reagent sample dish (8), reagent cassette holder (26), kit (27), dilution box (28), bottom Upper shaft sleeve (5), reagent disc central axle sleeve (6), reagent sample dish synchronizing belt gear (18), reagent sample dish Timing Belt (20) and motor (13), described magnetic particle mixing mechanism comprises that rotation magnetic bead box (23), rotary seat (22), magnetic mix gear (7), mix axle (4), magnetic bead rotation belt wheel (14), magnetic bead rotary synchronous band (19) and mix motor (17), in described magnetic particle mixing mechanism, mixing motor (17) is driven magnetic bead rotation belt wheel (14) and is mixed axle (4) rotation by magnetic bead rotary synchronous band (19), mix axle (4) upper end installation magnetic and mix gear (7), magnetic mixes gear (7) and coordinates with the gear of rotary seat (22), rotary seat (22) is rotated, turning axle (24) is arranged on rotary seat (22), rotation magnetic bead box (23) the latter half is placed on turning axle (24), and the impeller (25) that utilizes magnetic bead box (23) both sides makes the inner liquid in rotation of magnetic bead box (23), reach the object that magnetic bead mixes.
2. system according to claim 1, it is characterized in that, the heating face of described semiconductor chilling plate (21) is attached to heat radiator (10) upper surface, the chill surface of semiconductor cooling piece processed (21) is attached to refrigeration storehouse (1) lower surface, and blower fan (12) is given heat radiator (10) cooling by down draught box (11).
3. system according to claim 2, is characterized in that, described insulation construction comprises refrigeration storehouse stay-warm case (2), reagent sample dish upper cover (9) and reagent sample dish lower cover (3), and this insulation construction is bonded in outside, refrigeration storehouse (1).
4. system according to claim 3, is characterized in that, described stay-warm case (2) is used the foaming material shaped making of EVA, described upper cover (9) liner heat-preservation cotton.
5. system according to claim 1, it is characterized in that, in described reagent sample holding structure, by motor (13), by reagent sample dish Timing Belt (20), drive reagent sample dish synchronizing belt gear (18) rotation, make again reagent disc central axle sleeve (6) drive bottom Upper shaft sleeve (5) rotation, make reagent sample dish (8) rotation.
6. system according to claim 5, is characterized in that, described reagent sample dish (8) is mounted with reagent cassette holder (26), is equipped with kit (27) and dilution box (28) in described reagent cassette holder (26); Described reagent sample dish (8) is placed in the inside in described refrigeration storehouse (1).
According to claim 1 ?one of 6 described systems, it is characterized in that having 4 support columns (15) to be installed and 2 reagent sample dish seats (16) support whole reagent sample system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210540386.6A CN103048479B (en) | 2012-12-13 | 2012-12-13 | Reagent sample system used for full-automatic chemiluminescence analyzer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210540386.6A CN103048479B (en) | 2012-12-13 | 2012-12-13 | Reagent sample system used for full-automatic chemiluminescence analyzer |
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| CN103048479A CN103048479A (en) | 2013-04-17 |
| CN103048479B true CN103048479B (en) | 2014-03-26 |
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Families Citing this family (14)
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| CN112657568A (en) * | 2014-07-01 | 2021-04-16 | 深圳迈瑞生物医疗电子股份有限公司 | Reagent bottle storage device and blood analyzer |
| CN104849130B (en) * | 2015-06-04 | 2018-08-21 | 宁波海壹生物科技有限公司 | Evenly mixing device and mixing method |
| CN105455458A (en) * | 2015-12-29 | 2016-04-06 | 嘉兴市欣欣仪器设备有限公司 | Improved intelligent multifunctional storage cabinet |
| CN105411217A (en) * | 2015-12-29 | 2016-03-23 | 嘉兴市欣欣仪器设备有限公司 | Intelligent multifunctional storage cabinet |
| CN105651762A (en) * | 2016-02-24 | 2016-06-08 | 南京诺尔曼生物技术有限公司 | Reagent sample plate with refrigeration performance |
| CN105628687B (en) * | 2016-02-24 | 2018-08-07 | 南京诺尔曼生物技术有限公司 | A kind of Full-automatic chemiluminescence analyzer |
| CN108240876B (en) * | 2016-12-26 | 2019-12-20 | 中国空气动力研究与发展中心超高速空气动力研究所 | Temperature-sensitive luminescent material calibrating device based on semiconductor refrigerator |
| CN107121558A (en) * | 2017-03-21 | 2017-09-01 | 迪瑞医疗科技股份有限公司 | It is a kind of to extend the biochemical analyser of the corkage reagent term of validity |
| CN108181287A (en) * | 2018-02-09 | 2018-06-19 | 广州源起健康科技有限公司 | A kind of magnetic bead time-resolved fluoroimmunoassay quantitatively detects H-FABP kits |
| CN108333357A (en) * | 2018-02-09 | 2018-07-27 | 广州源起健康科技有限公司 | A kind of magnetic bead time-resolved fluoroimmunoassay quantitatively detects CK-MB kits |
| CN110361555A (en) * | 2018-03-26 | 2019-10-22 | 成都深迈瑞医疗电子技术研究院有限公司 | Load reagents component, sample reagent loading attachment and chemical illumination immunity analysis instrument |
| CN110479164A (en) * | 2019-09-19 | 2019-11-22 | 南京迪格诺斯生物技术有限公司 | A kind of sample reagent disk double driving mechanism of chemiluminescent analyzer |
| CN112505338A (en) * | 2020-11-23 | 2021-03-16 | 泰州泽成生物技术有限公司 | Refrigerating device for tester and application thereof |
| CN114047329A (en) * | 2021-10-19 | 2022-02-15 | 北京胡曼智造科技有限责任公司 | Reagent disk system |
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Owner name: JIANGSU ZECHENG BIOTECHNOLOGY CO., LTD. Free format text: FORMER NAME: JIANGYIN ZECHENG BIOTECHNOLOGY CO., LTD. |
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Address after: 214434 D405 room, No. 159 middle Chengjiang Road, Jiangyin, Jiangsu, Wuxi Patentee after: JIANGSU ZECHENG BIOLOGICAL TECHNOLOGY CO., LTD. Address before: 214434 D405 room, No. 159 middle Chengjiang Road, Jiangyin, Jiangsu, Wuxi Patentee before: Jiangyin Zecheng Biotechnology Co., Ltd. |