CN103040768B - Powder mixing technology for compound antibiotic - Google Patents
Powder mixing technology for compound antibiotic Download PDFInfo
- Publication number
- CN103040768B CN103040768B CN201310031633.4A CN201310031633A CN103040768B CN 103040768 B CN103040768 B CN 103040768B CN 201310031633 A CN201310031633 A CN 201310031633A CN 103040768 B CN103040768 B CN 103040768B
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- China
- Prior art keywords
- antibiotic
- sodium
- powder mixing
- hours
- compound recipe
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- 230000003115 biocidal effect Effects 0.000 title claims abstract description 27
- 150000001875 compounds Chemical class 0.000 title claims abstract description 23
- 239000000843 powder Substances 0.000 title abstract description 12
- 239000011812 mixed powder Substances 0.000 claims abstract description 22
- NKZMPZCWBSWAOX-IBTYICNHSA-M Sulbactam sodium Chemical group [Na+].O=S1(=O)C(C)(C)[C@H](C([O-])=O)N2C(=O)C[C@H]21 NKZMPZCWBSWAOX-IBTYICNHSA-M 0.000 claims abstract description 19
- 229960000614 sulbactam sodium Drugs 0.000 claims abstract description 19
- YRMCBQLZVBXOSJ-PCFSSPOYSA-N (e)-3-[(6r,6as)-4-hydroxy-6-methoxy-3-methyl-11-oxo-5,6,6a,7-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-8-yl]prop-2-enamide Chemical compound CO[C@H]1NC2=C(O)C(C)=CC=C2C(=O)N2C=C(\C=C\C(N)=O)C[C@@H]12 YRMCBQLZVBXOSJ-PCFSSPOYSA-N 0.000 claims abstract description 11
- 238000004108 freeze drying Methods 0.000 claims abstract description 11
- KCVTVKMPZQSSNU-UHFFFAOYSA-N 2-pyridin-4-ylethanethioyl chloride Chemical compound ClC(=S)CC1=CC=NC=C1 KCVTVKMPZQSSNU-UHFFFAOYSA-N 0.000 claims abstract description 8
- NCFTXMQPRQZFMZ-WERGMSTESA-M Cefoperazone sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC(O)=CC=1)C(=O)N[C@@H]1C(=O)N2C(C([O-])=O)=C(CSC=3N(N=NN=3)C)CS[C@@H]21 NCFTXMQPRQZFMZ-WERGMSTESA-M 0.000 claims abstract description 8
- 229960002417 cefoperazone sodium Drugs 0.000 claims abstract description 8
- 229960001994 mezlocillin sodium Drugs 0.000 claims abstract description 8
- 229960002793 amoxicillin sodium Drugs 0.000 claims abstract description 4
- ILVPFTMKCHREDJ-UHFFFAOYSA-N methyl 5-amino-2-fluorobenzoate Chemical compound COC(=O)C1=CC(N)=CC=C1F ILVPFTMKCHREDJ-UHFFFAOYSA-N 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 6
- 238000010792 warming Methods 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 2
- 239000012982 microporous membrane Substances 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- 239000006067 antibiotic powder Substances 0.000 claims 6
- 238000002360 preparation method Methods 0.000 abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 238000004090 dissolution Methods 0.000 abstract description 4
- 238000001035 drying Methods 0.000 abstract description 4
- 239000003242 anti bacterial agent Substances 0.000 abstract description 3
- 229940088710 antibiotic agent Drugs 0.000 abstract description 3
- 239000003960 organic solvent Substances 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 229960005264 piperacillin sodium Drugs 0.000 abstract 1
- WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 abstract 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
- 239000000463 material Substances 0.000 description 6
- 229940027019 amoxicillin / sulbactam Drugs 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000005374 membrane filtration Methods 0.000 description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 description 4
- 238000001291 vacuum drying Methods 0.000 description 4
- 239000008215 water for injection Substances 0.000 description 4
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 150000003951 lactams Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310031633.4A CN103040768B (en) | 2013-01-28 | 2013-01-28 | Powder mixing technology for compound antibiotic |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310031633.4A CN103040768B (en) | 2013-01-28 | 2013-01-28 | Powder mixing technology for compound antibiotic |
Publications (2)
Publication Number | Publication Date |
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CN103040768A CN103040768A (en) | 2013-04-17 |
CN103040768B true CN103040768B (en) | 2014-03-05 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201310031633.4A Active CN103040768B (en) | 2013-01-28 | 2013-01-28 | Powder mixing technology for compound antibiotic |
Country Status (1)
Country | Link |
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CN (1) | CN103040768B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103655578B (en) * | 2013-12-26 | 2015-08-26 | 湖南天圣药业有限公司 | The powder mixing method of a kind of cefoperazone sodium and sulbactam sodium |
CN104856997A (en) * | 2014-02-21 | 2015-08-26 | 杭州长典医药科技有限公司 | Special piperacillin sodium-tazobactam sodium ultra-fine powder preparation and preparation method thereof |
CN104382899B (en) * | 2014-11-20 | 2021-02-12 | 重庆福安药业(集团)股份有限公司 | Compound pharmaceutical composition of mezlocillin sodium and sulbactam sodium |
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2013
- 2013-01-28 CN CN201310031633.4A patent/CN103040768B/en active Active
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Publication number | Publication date |
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CN103040768A (en) | 2013-04-17 |
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Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20200331 Address after: 274199 east side of dongwaihuan Road, Dingtao District, Heze City, Shandong Province (north of Runxin Fine Chemical Co., Ltd.) Patentee after: Shandong Erye Pharmaceutical Co.,Ltd. Address before: 212000 Jiangsu city of Suzhou Province Huang Dai Zhen An min Lu, Xiangcheng District Patentee before: SUZHOU ERYE PHARMACEUTICAL Co.,Ltd. |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Mixing technology of a compound antibiotic Granted publication date: 20140305 Pledgee: Shandong Dingtao Rural Commercial Bank Co.,Ltd. Pledgor: Shandong Erye Pharmaceutical Co.,Ltd. Registration number: Y2024980009202 |