CN103030952B - Infusion device tee-junction valve/drug feeding device degradation material and method for making - Google Patents
Infusion device tee-junction valve/drug feeding device degradation material and method for making Download PDFInfo
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- CN103030952B CN103030952B CN201110293642.1A CN201110293642A CN103030952B CN 103030952 B CN103030952 B CN 103030952B CN 201110293642 A CN201110293642 A CN 201110293642A CN 103030952 B CN103030952 B CN 103030952B
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- Prior art keywords
- feeding device
- drug feeding
- tee
- base material
- junction valve
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- 239000003814 drug Substances 0.000 title claims abstract description 29
- 229940079593 drug Drugs 0.000 title claims abstract description 29
- 239000000463 material Substances 0.000 title claims abstract description 28
- 238000001802 infusion Methods 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 10
- 230000015556 catabolic process Effects 0.000 title abstract description 7
- 238000006731 degradation reaction Methods 0.000 title abstract description 7
- 238000002347 injection Methods 0.000 claims abstract description 17
- 239000007924 injection Substances 0.000 claims abstract description 17
- 239000004615 ingredient Substances 0.000 claims abstract description 5
- 229920002521 macromolecule Polymers 0.000 claims abstract description 5
- 239000012744 reinforcing agent Substances 0.000 claims abstract description 5
- 230000006835 compression Effects 0.000 claims abstract description 4
- 238000007906 compression Methods 0.000 claims abstract description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 13
- 239000000843 powder Substances 0.000 claims description 9
- 239000008188 pellet Substances 0.000 claims description 8
- 238000001291 vacuum drying Methods 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 238000001125 extrusion Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000005453 pelletization Methods 0.000 claims description 2
- 239000004626 polylactic acid Substances 0.000 claims description 2
- 230000007613 environmental effect Effects 0.000 abstract description 4
- 238000001746 injection moulding Methods 0.000 abstract description 2
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000000593 degrading effect Effects 0.000 abstract 1
- 239000004033 plastic Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- HGUFODBRKLSHSI-UHFFFAOYSA-N 2,3,7,8-tetrachloro-dibenzo-p-dioxin Chemical compound O1C2=CC(Cl)=C(Cl)C=C2OC2=C1C=C(Cl)C(Cl)=C2 HGUFODBRKLSHSI-UHFFFAOYSA-N 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Landscapes
- Injection Moulding Of Plastics Or The Like (AREA)
Abstract
The invention provides a kind of infusion device tee-junction valve/drug feeding device degradation material and method for making. Degradation-type infusion device tee-junction valve/drug feeding device is made into by the degradable macromolecule major ingredient of base material of degrading, reinforcing agent, and its injection molding process is: charging aperture 155-165 DEG C, 160-170 DEG C, compression section, metering section 160-175 DEG C, 155-170 DEG C of nozzle; Mold temperature is: 20-30 DEG C; Injection pressure is: 55-90Mpa; Injection time is: the 40-45 second; Dwell time is: the 0-4 second; Screw speed is: 180 revs/min; Just can obtain degradation-type infusion device tee-junction valve/drug feeding device, after using without burn can pass through fill in natural environment complete biodegradable, reach low-carbon (LC), energy-saving and environmental protection, purpose.
Description
Technical field
The present invention relates to the technical field of bioengineering of medical apparatus and instruments, particularly relate to a kind of infusion device tee-junction valve/drug feeding device degradation material and method for making.
Background technology
" three-way valve/drug feeding device " of existing disposable transfusion device, it is entirely with the making of nondegradable petroleum-based plastics, because its price comparison is cheap, especially " three-way valve/drug feeding device " is used for single use as the accessory of disposable transfusion device and stops the advantages such as cross infection of disease and be widely used, but the clinical practice through decades proves, there is many problems in plastics disposable transfusion device " three-way valve/drug feeding device ", it is well known that need by reclaiming and burning disposal after using, and plastics can produce a large amount of black smoke when burning, hydrogen chloride can be discharged simultaneously, dioxin etc. are poisonous and carcinogen, severe contamination environment, compromise human health. for this, research and development infusion device tee-junction valve/drug feeding device degradation material and method for making, can not only single use, and burning disposal after avoiding again use, avoid again contaminated environment simultaneously, protect human health, but also it is greatly saved the energy, the present invention with the addition of pure halobiontic oyster shell powder, and achieving environmental protection and energy saving, and reduces manufacturing cost. but up to now, at home and abroad there is no the research about infusion device tee-junction valve/drug feeding device degradation material and method for making and report.
Summary of the invention
First purpose of the present invention is to provide degradation-type infusion device tee-junction valve/drug feeding device.
Second purpose of the present invention is to provide the method for making of infusion device tee-junction valve/drug feeding device degradation material.
Infusion device tee-junction valve/drug feeding device of the present invention, it is characterised in that be made up of degradable base material, its composition and weight proportion be:
Degradable macromolecule major ingredient 100 parts, reinforcing agent 2-6 part;
Described macromolecule major ingredient is: polylactic acid (PLA);
Described reinforcing agent is: EMFORCEBIO, modified calcium carbonate, calcium carbonate superfine powder, oyster shell powder or their mixture;
Described oyster shell powder is the oyster shell powder of 100-300 order.
The present invention provides the method for making of degradation-type infusion device tee-junction valve/drug feeding device, and step and condition are as follows:
The first step: the base material good by proportioning, sends in homogenizer, and rotating speed 600-900 rev/min mixes 5-8 minute, makes uniform base material or base material compound;
Second step: the base material that the first step is made or base material compound; respectively at 60-85 DEG C; vacuum drying 4-8 hour, sends in single screw extrusion machine, and temperature controls: feeding section 65-110 DEG C; batch mixing segment 80-125 DEG C; fluxing zone 125-180 DEG C, head 100-170 DEG C, screw speed 30-100 rev/min; after pelleter pelletizing, prepare the pellet of above-mentioned base material respectively.
3rd step: by above-mentioned base material pellet, at 50 DEG C, vacuum drying 4-5 hour, stand-by;
4th step: by the pellet of above-mentioned drying, joins injection machine, for making the injection mo(u)lding of the degradation-type infusion device tee-junction valve/various types of drug feeding device, all size;
Barrel temperature is set as: charging aperture 155-165 DEG C, 160-170 DEG C, compression section, metering section 160-175 DEG C, 155-170 DEG C of nozzle;
Mold temperature is: 20-30 DEG C;
Injection pressure is: 55-90Mpa;
Injection time is: the 40-45 second;
Dwell time is: the 0-4 second;
Screw speed is: 180 revs/min;
After injection mo(u)lding, just can be made into the infusion device tee-junction valve/drug feeding device of degradable various model, all size.
Table 1 gives the biodegradation base material formula used by part model infusion device tee-junction valve/drug feeding device.
Table 1
Obviously, overcome the defect of prior art according to the degradation-type infusion device tee-junction valve/drug feeding device of the present invention, demonstrate very big advantage simultaneously:
When one, producing, the injection temperature for degradable material is lower than petroleum-based plastics, has saved productive power amount;
Two, original disposable transfusion device three-way valve/drug feeding device mould can be adopted to produce, need not again make mould, save the input cost of mould;
Three, making because degradation-type infusion device tee-junction valve/drug feeding device is the environment-friendly materials adopting Wholly-degradable, can reaching degradable by modes such as concentration landfills after therefore using, thus realizing environmental protection, energy-conservation purpose.
Detailed description of the invention
The formula that following example adopt, is the formula of above-mentioned table 1.
The injection molding forming method of embodiment 1 degradation-type infusion device tee-junction valve/drug feeding device:
The first step, vacuum drying: by the degradable base material pellet of formula 1, formula 2 or formula 3 at 50-55 DEG C, vacuum drying 4 hours, stand-by.
Second step, injection mo(u)lding: the degradable base material pellet of the formula 1 of drying, formula 2 or formula 3 is joined injection machine and carries out injection mo(u)lding.
Barrel temperature is set as: charging aperture 155-165 DEG C, 160-170 DEG C, compression section, metering section 160-175 DEG C, 155-170 DEG C of nozzle;
Mold temperature is: 20-30 DEG C;
Injection pressure is: 55-90Mpa;
Injection time is: the 40-45 second;
Dwell time is: the 0-4 second;
Screw speed is: 180 revs/min;
Obtain the infusion device tee-junction valve/drug feeding device adopting the degradable base material of formula 1, formula 2 or formula 3 to make.
Biodegradable infusion device tee-junction valve/drug feeding device is described in detail by above-described embodiment, not only preparation technology is detailed rationally, and production cost is relatively low, therefore, the degradation-type infusion device tee-junction valve/drug feeding device of the present invention has good commercial application and promotional value, jointly realize environmental protection and energy saving, will significantly promote the well-being of mankind.
Applicant's design and embodiment to the present invention is made that detailed description; those skilled in the art can make various conversion and improvement on this basis; but these convert and improve the spirit all without departing from the present invention, all within claims and description protection defined.
Claims (1)
1. degradation-type infusion device tee-junction valve/drug feeding device, it is characterised in that composition and the weight proportion of preparing the degradable base material of described infusion device tee-junction valve/drug feeding device be:
Degradable macromolecule major ingredient 100 parts, reinforcing agent 2-6 part;
Described macromolecule major ingredient is: polylactic acid (PLA);
Described reinforcing agent is: EMFORCEBIO, modified calcium carbonate, calcium carbonate superfine powder, oyster shell powder mixture;
Described oyster shell powder is the oyster shell powder of 100-300 order;
The method for making of degradation-type infusion device tee-junction valve/drug feeding device, step and condition are as follows:
The first step: the base material good by proportioning, sends in homogenizer, and rotating speed 600-900 rev/min mixes 5-8 minute, makes uniform base material compound;
Second step: the base material compound that the first step is made; at 60-85 DEG C; vacuum drying 4-8 hour, sends in single screw extrusion machine, and temperature controls: feeding section 65-110 DEG C; batch mixing segment 80-125 DEG C; fluxing zone 125-180 DEG C, head 100-170 DEG C, screw speed 30-100 rev/min; after pelleter pelletizing, prepare the pellet of above-mentioned base material.
3rd step: by above-mentioned base material pellet, at 50 DEG C, vacuum drying 4-5 hour, stand-by;
4th step: by the pellet of above-mentioned drying, joins injection machine, for making the injection mo(u)lding of the degradation-type infusion device tee-junction valve/various types of drug feeding device, all size;
Barrel temperature is set as: charging aperture 155-165 DEG C, 160-170 DEG C, compression section, metering section 160-175 DEG C, 155-170 DEG C of nozzle;
Mold temperature is: 20-30 DEG C;
Injection pressure is: 55-90MPa;
Injection time is: the 40-45 second;
Dwell time is: the 0-4 second;
Screw speed is: 180 revs/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110293642.1A CN103030952B (en) | 2011-09-29 | 2011-09-29 | Infusion device tee-junction valve/drug feeding device degradation material and method for making |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110293642.1A CN103030952B (en) | 2011-09-29 | 2011-09-29 | Infusion device tee-junction valve/drug feeding device degradation material and method for making |
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| Publication Number | Publication Date |
|---|---|
| CN103030952A CN103030952A (en) | 2013-04-10 |
| CN103030952B true CN103030952B (en) | 2016-06-08 |
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| CN201110293642.1A Expired - Fee Related CN103030952B (en) | 2011-09-29 | 2011-09-29 | Infusion device tee-junction valve/drug feeding device degradation material and method for making |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152588A (en) * | 2007-10-30 | 2008-04-02 | 中国科学院长春应用化学研究所 | Degradation type disposable syringe and method of producing the same |
| CN101177537A (en) * | 2007-11-06 | 2008-05-14 | 中国科学院长春应用化学研究所 | Degraded resin base material for medical injector and preparation method thereof |
| CN101468215A (en) * | 2007-12-29 | 2009-07-01 | 上海林静医疗器械有限公司 | Technique for producing degradable medical apparatus |
| CN101506278A (en) * | 2006-08-31 | 2009-08-12 | 金伯利-克拉克环球有限公司 | Highly breathable biodegradable films |
| CN101918485A (en) * | 2007-12-17 | 2010-12-15 | 密执安特种矿石公司 | Surface treated inorganic particle additive for increasing the toughness of polymers |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6838403B2 (en) * | 2000-12-28 | 2005-01-04 | Kimberly-Clark Worldwide, Inc. | Breathable, biodegradable/compostable laminates |
| US7354656B2 (en) * | 2002-11-26 | 2008-04-08 | Michigan State University, Board Of Trustees | Floor covering made from an environmentally friendly polylactide-based composite formulation |
-
2011
- 2011-09-29 CN CN201110293642.1A patent/CN103030952B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101506278A (en) * | 2006-08-31 | 2009-08-12 | 金伯利-克拉克环球有限公司 | Highly breathable biodegradable films |
| CN101152588A (en) * | 2007-10-30 | 2008-04-02 | 中国科学院长春应用化学研究所 | Degradation type disposable syringe and method of producing the same |
| CN101177537A (en) * | 2007-11-06 | 2008-05-14 | 中国科学院长春应用化学研究所 | Degraded resin base material for medical injector and preparation method thereof |
| CN101918485A (en) * | 2007-12-17 | 2010-12-15 | 密执安特种矿石公司 | Surface treated inorganic particle additive for increasing the toughness of polymers |
| CN101468215A (en) * | 2007-12-29 | 2009-07-01 | 上海林静医疗器械有限公司 | Technique for producing degradable medical apparatus |
Non-Patent Citations (2)
| Title |
|---|
| 《碳酸钙填充聚乳酸复合材料的制备和性能研究》;周凯等;《中国塑料》;20090626;第23卷(第6期);第27-30页 * |
| 《纳米碳酸钙改性聚乳酸材料性能的研究》;曹延生等;《中国塑料》;20071026;第21卷(第10期);第45-48页 * |
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Inventor after: Zhang Xingxing Inventor after: Wu Qianqian Inventor after: Lin Jing Inventor before: Zhang Xingxing |
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Inventor after: Lin Jing Inventor after: Zhang Xingxing Inventor after: Wu Qianqian Inventor before: Zhang Xingxing Inventor before: Wu Qianqian Inventor before: Lin Jing |
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Effective date of registration: 20181008 Address after: 224200 Jiangsu Dongtai machinery and Electronics Industrial Park 3 Jinfeng Road Patentee after: JIANGSU AOBOJIN PHARMACEUTICAL TECHNOLOGY CO.,LTD. Address before: 201600 No. 37, Yu Jia Road, Songjiang District, Shanghai. Patentee before: SHANGHAI LINJING MEDICAL EQUIPMENT Co.,Ltd. |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160608 |