CN103027968A - Preparation method of medicinal preparation for preventing and treating chronic pelvic inflammation - Google Patents
Preparation method of medicinal preparation for preventing and treating chronic pelvic inflammation Download PDFInfo
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Abstract
The invention relates to a preparation method of a medicinal preparation for preventing and treating chronic pelvic inflammation. The preparation method comprises the following steps: crushing medicinal materials of scorpion, centipede and corydalis tuber in fine powder according to a prescription proportion, adding water in other medicinal materials for decocting, merging a decoction, filtrating, concentrating a filtrate into an extract; adding 70-90wt% of ethanol in the extract, adding the alcohol containing amount to 60-80%, standing for 8-12 hours, filtrating, recovering ethanol by the filtrate to no alcohol taste, performing pressure reduction and concentration to the temperature of 60 DEG C to obtain the extract of which the relative density is 1.10-1.20; and employing spray drying for drying to prepare various preparations. The preparation method of the medicinal preparation provided by the invention has simple preparation method, the medicament active ingredient has high extraction rate, general production equipments can satisfy the requirements of the production of the medicinal preparation, no specific equipment requirement is generated, the production cost is reduced, and the patient burden can be reduced.
Description
Technical field
The present invention relates to the preparation method of the pharmaceutical preparation of a kind of prevention and treatment chronic pelvic inflammatory disease, belong to medical technical field.
Background technology
Pelvic inflammatory disease particularly chronic pelvic inflammatory disease is the common and frequently-occurring disease of gynecological, and this disease symptoms is various, can repeatedly show effect because of fatigue or emotion changes etc., does not with the passing of time heal, and becomes the pertinacious disease of gynecological, has a strong impact on women's life, work and physical and mental health.Acute pelvic inflammatory disease fails appropriately thoroughly to treat or patient's body constitution is relatively poor, course of disease delay also can cause chronic pelvic inflammatory disease.According to the investigation rough estimates of Chongqing gynecological of the academy of traditional Chinese medicine, primary disease accounts for the 20-30% of the rate of just diagnosing a disease.Chronic inflammatory disease causes pelvic congestion, menorrhagia, and the ovarian function infringement time menoxenia can occur, and fallopian tube adhesion can cause infertility when blocking, and has the expert to confirm with laparoscopy, and about 40% infertile main cause just is due to the fallopian tube inflammatory lesion.
Plain Questions of Huangdi's Internal Classic is said: " excess syndrome of blood should be treated by blood letting " " treatise on blood trouble " said: " card that all are not controlled, always by be not good at blood stasis removing so, all persons that controls blood, must be first take blood stasis removing for will ".Again " reading random notes " " the Ye Tianshi meaning: prolonged illness must be controlled network.It says that the implementation of the sick for a long time QI and blood of meaning is unfavorable.Must there be the stasis of blood solidifying among the blood network.So disease causes to twine to prolong and do not go, must dredge its network and pathogenic QI in the body can be use up also." the another feature of this disease: the course of disease is touching, and with the passing of time delay is easy to recurrence, belongs to the card of refractory.In sum, the primary disease method for the treatment of is worked as blood circulation promoting and blood stasis dispelling, and removing summer-heat is hot and suffocating.Blood stasis does not go then fresh blood not give birth to, and hot and suffocating difficulty is clear.So need adopt simultaneously the method for blood circulation promoting and blood stasis dispelling and heat clearing away resolving depression, can suit blood stasis and hold hot and suffocating pathogenesis under the arm, it is then newborn hot and suffocating except then bitterly certainly pacifying to reduce phlegm.
Motherland's medical science is thought primary disease because menstrual period, miscarriage, minute puerperium, damp and hot taking advantage of a weak point in opponent's defence, and the visitor is after uterus, collaterals of the uterus or acute pelvic inflammatory disease, and pathogen will be use up, and heresy of cold and heat fought mutually with QI and blood, makes disorder of QI movement, and meridian qi and blood is obstructed, and rushes a dai channel functional disorder and causes a disease.
Pharmaceutical preparation preparation method of the present invention is simple, and the effective ingredient extraction ratio is high, and general production equipment can satisfy the needs of producing this pharmaceutical preparation, does not have specific equipment requirements, reduces production costs, and reduces patient's burden.
Summary of the invention
Purpose of the present invention aims to provide a kind of bioavailability that improves, and preparation technology is simple, and perfect technology is applicable to the preparation technology of the pharmaceutical preparation of the treatment chronic pelvic inflammatory disease of industrialized great production.
The objective of the invention is to realize by following manner: 250 parts of Radix Angelicae Sinensis, 180 parts of Caulis Loniceraes, 180 parts of Caulis Spatholobis, 180 parts of Herba Patriniae, 80 parts of Radix Salviae Miltiorrhizaes, 80 parts of Rhizoma Chuanxiongs, 80 parts of Radix Paeoniae Rubra, 10 parts of Scorpios, 10 parts of Scolopendras, 80 parts of Rhizoma Corydalis, 50 parts in Radix Glycyrrhizae;
Said pharmaceutical preparation is to prepare by the following method:
One, the preparation method of capsule:
(1), it is for subsequent use to get the crude drug of above-mentioned each weight portion;
(2), Scorpio, Scolopendra, Rhizoma Corydalis are ground into fine powder, mistake 80 mesh sieves;
(3) Radix Angelicae Sinensis, Caulis Lonicerae, Caulis Spatholobi, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Glycyrrhizae 8 flavor medical material mixture are decocted with water 2-4 time, each amount of water be Radix Angelicae Sinensis, Caulis Lonicerae, Caulis Spatholobi, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Glycyrrhizae 8 flavor medical material mixture 4-10 doubly, each 0.5-2 hour, decoct temperature and be controlled at 80 ℃ to boiling; Collecting decoction filters, and relative density was 1.10～1.15 extractum when filtrate was concentrated into 60 ℃;
(4), the extractum in (3) adds the ethanol of 70-90% percentage by weight, regulates to contain alcohol and measures to 60-80%, leaves standstill 8-12 hour, filters, filtrate recycling ethanol is to without the alcohol flavor, relative density is 1.10～1.20 extractum when being evaporated to 60 ℃;
(5), the extractum that obtains after adopting spray drying method to Recycled ethanol carries out drying, in used container, add Scorpio, Scolopendra, Rhizoma Corydalis as bed material, extractum is as binding agent, granulation is dressed up capsule, makes capsule, the control inlet temperature is at 75-90 ℃, temperature of charge is at 70-85 ℃, and atomisation pressure is at 0.1-0.3 Mpa, and the transfusion frequency is at 10-40r/min.
Two, the preparation method of tablet:
(1), it is for subsequent use to get the crude drug of above-mentioned each weight portion;
(2), Scorpio, Scolopendra, Rhizoma Corydalis are ground into fine powder, mistake 80 mesh sieves;
(3) Radix Angelicae Sinensis, Caulis Lonicerae, Caulis Spatholobi, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Glycyrrhizae 8 flavor medical material mixture are decocted with water 2-4 time, each amount of water be Radix Angelicae Sinensis, Caulis Lonicerae, Caulis Spatholobi, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Glycyrrhizae 8 flavor medical material mixture 4-10 doubly, each 0.5-2 hour, decoct temperature and be controlled at 80 ℃ to boiling; Collecting decoction filters, and relative density was 1.10～1.15 extractum when filtrate was concentrated into 60 ℃;
(4), the extractum in (3) adds the ethanol of 70-90% percentage by weight, regulates to contain alcohol and measures to 60-80%, leaves standstill 8-12 hour, filters, filtrate recycling ethanol is to without the alcohol flavor, relative density is 1.10～1.20 extractum when being evaporated to 60 ℃;
(5) extractum that obtains after adopting spray drying method to Recycled ethanol carries out drying, in used container, add Scorpio, Scolopendra, Rhizoma Corydalis as bed material, extractum is as binding agent, granulation, tabletting makes tablet, the control inlet temperature is at 75-90 ℃, temperature of charge is at 70-85 ℃, and atomisation pressure is at 0.1-0.3 Mpa, and the transfusion frequency is at 10-40r/min.
Three, the preparation method of granule
(1), it is for subsequent use to get the crude drug of above-mentioned each weight portion;
(2), Scorpio, Scolopendra, Rhizoma Corydalis are ground into fine powder, mistake 80 mesh sieves;
(3) Radix Angelicae Sinensis, Caulis Lonicerae, Caulis Spatholobi, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Glycyrrhizae 8 flavor medical material mixture are decocted with water 2-4 time, each amount of water be Radix Angelicae Sinensis, Caulis Lonicerae, Caulis Spatholobi, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Glycyrrhizae 8 flavor medical material mixture 4-10 doubly, each 0.5-2 hour, decoct temperature and be controlled at 80 ℃ to boiling; Collecting decoction filters, and relative density was 1.10～1.15 extractum when filtrate was concentrated into 60 ℃;
(4), the extractum in (3) adds the ethanol of 70-90% percentage by weight, regulates to contain alcohol and measures to 60-80%, leaves standstill 8-12 hour, filters, filtrate recycling ethanol is to without the alcohol flavor, relative density is 1.10～1.20 extractum when being evaporated to 60 ℃;
(5), the extractum that obtains after adopting spray drying method to Recycled ethanol carries out drying, in used container, add Scorpio, Scolopendra, Rhizoma Corydalis as bed material, extractum is as binding agent, granulate, packing makes granule, the control inlet temperature is at 75-90 ℃, temperature of charge is at 70-85 ℃, and atomisation pressure is at 0.1-0.3 Mpa, and the transfusion frequency is at 10-40r/min.
Why the present invention adopts above-mentioned technique to test, and the applicant proves that by the following test of pesticide effectiveness this preparation method is to the effectiveness of medicine:
(1) impact of xylol induced mice ear swelling
1 purpose
Observe the impact of sample xylol induced mice ear swelling acute inflammation model.
2 experiment materials
2.1 control drug
Prednisone: fairy house Pharmacy stock Co., Ltd produces, lot number: 090103.
2.2 laboratory animal
Kunming mouse, 30,18～22g, male and female half and half, cleaning level animal.
2.3 key instrument and reagent
AW220 type electronic balance: Japanese SHIMADZU company produces.
Dimethylbenzene: Chongqing Chuan Dong chemical industry (group) company limited chemical reagent factory is produced, lot number: 20090318.
3 methods and result
Get 30 of 18～22g mices and be divided at random 3 groups, 10 every group, press table 1 gastric infusion, once a day, for three days on end, matched group gives the normal saline of equal volume.After the last administration 1 hour, only smear dimethylbenzene 0.03ml/ in mouse right ear, take off neck after 20 minutes and put to death animal, card punch is laid animal left and right sides ear, precision takes by weighing auricle weight, calculate ear swelling degree (=auris dextra weight-left ear weight) and swelling rate (=swelling/left ear weight * 100%), the results are shown in Table 1.
The impact of table 1 xylol induced mice ear swelling (
)
Each administration group and NS matched group be * P＜0.05 relatively, * * P＜0.01
By table as seen: medicine of the present invention has the effect of obvious anti-inflammation under 40g/kg dosage.
(2) on the swollen impact of rat granuloma
1 purpose
Observe sample to the swollen antiproliferative effect of rat granuloma.
2 test materials
2.1 control drug
Prednisone: fairy house Pharmacy stock Co., Ltd produces, lot number: 090103.
2.2 experimental animal
The Wistar rat, 24, complete male, cleaning level animal.
2.3 key instrument and reagent
AW220 type electronic balance: Japanese SHIMADZU company produces.
Ether: Prospirolboli joannsi pharmaceutical factory in Shanghai produces, lot number: 20090121.
3 methods and result
Get 24 of 150g left and right sides male rats, be divided at random 3 groups, 8 every group, behind the etherization, iodine disinfection is cut an osculum in chest, implants load weighted sterilization cotton balls (20mg/, 2/rats) in the oxter, sews up.Implant cotton balls and rose by table 2 gastric infusion the same day, once a day, continuous 7 days, matched group gave the normal saline of equal volume.Put to death animal in 1 hour after the last administration, take out the cotton balls granulation tissue, weigh immediately (weight in wet base), 100 ℃ of oven dryings took by weighing dry weight in 24 hours again, calculated granulation tissue net weight (=dry weight-cotton balls is heavy), the results are shown in Table 2.
The impact that table 2 swells on rat granuloma (
)
Each administration group and NS matched group be * P＜0.05 relatively, * * P＜0.01
By table as seen: medicine of the present invention can obviously reduce the swollen hypertrophy (p ﹤ 0.05) of rat granuloma.
(3) impact of Dichlorodiphenyl Acetate induced mice writhing response
1 purpose
Observe sample to the impact of mice chemical stimulation pain.
2 test materials
2.1 control drug
Aspirin: Jiangsu Huang He Pharmaceutical Co., Ltd provides, lot number: 091010.
2.2 experimental animal
Kunming mouse, 70, male and female half and half, cleaning level animal.
2.3 key instrument and reagent
Glacial acetic acid: reagent four factories in Shanghai produce, lot number: 09031014.
3 methods and result
Get 30 of 18～22g mices and be divided at random 3 groups, 10 every group, press table 3 administration, once a day, for three days on end, matched group gives the physiological salt liquid of equal volume.After the last administration 1 hour, the glacial acetic acid liquid 0.2ml/ of lumbar injection 0.7% only recorded mouse writhing number of times and incubation period in 20 minutes.The results are shown in Table 3.
The impact that table 3 reacts mouse writhing (
)
Each administration group and NS matched group be * P＜0.05 relatively, * * P＜0.01
By as seen from Table 3: show that the peripheral pain that medicine of the present invention causes chemical irritation has obvious analgesic activity.
Above experimental result shows: the pharmaceutical preparation that preparation method of the present invention is produced can produce good therapeutic effect.
The specific embodiment
Below with embodiment a kind of preparation method that is used for the treatment of the medicament of chronic pelvic inflammatory disease of the present invention is further described; this will help the present invention and effect thereof are further understood; embodiment does not limit protection scope of the present invention, and its protection domain is decided by claim.
Embodiment 1
The preparation method of capsule: Radix Angelicae Sinensis 250g, Caulis Lonicerae 180g, Caulis Spatholobi 180g, Herba Patriniae 180g, Radix Salviae Miltiorrhizae 80g, Rhizoma Chuanxiong 80g, Radix Paeoniae Rubra 80g, Scorpio 10g, Scolopendra 10g, Rhizoma Corydalis 80g, Radix Glycyrrhizae 50g;
Said pharmaceutical preparation is to prepare by the following method:
(1), it is for subsequent use to get the crude drug of above-mentioned each weight portion;
(2), Scorpio, Scolopendra, Rhizoma Corydalis are ground into fine powder, mistake 80 mesh sieves;
(3) Radix Angelicae Sinensis, Caulis Lonicerae, Caulis Spatholobi, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Glycyrrhizae 8 flavor medical material mixture are decocted with water 2-4 time, each amount of water be Radix Angelicae Sinensis, Caulis Lonicerae, Caulis Spatholobi, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Glycyrrhizae 8 flavor medical material mixture 4-10 doubly, each 0.5-2 hour, decoct temperature and be controlled at 80 ℃ to boiling; Collecting decoction filters, and relative density was 1.10～1.15 extractum when filtrate was concentrated into 60 ℃;
(4), the extractum in (3) adds the ethanol of 70-90% percentage by weight, regulates to contain alcohol and measures to 60-80%, leaves standstill 8-12 hour, filters, filtrate recycling ethanol is to without the alcohol flavor, relative density is 1.10～1.20 extractum when being evaporated to 60 ℃;
(5), the extractum that obtains after adopting spray drying method to Recycled ethanol carries out drying, in used container, add Scorpio, Scolopendra, Rhizoma Corydalis as bed material, extractum is as binding agent, granulation is dressed up capsule, makes capsule, the control inlet temperature is at 75-90 ℃, temperature of charge is at 70-85 ℃, and atomisation pressure is at 0.1-0.3 Mpa, and the transfusion frequency is at 10-40r/min.
Embodiment 2
The preparation method of tablet: Radix Angelicae Sinensis 250g, Caulis Lonicerae 180g, Caulis Spatholobi 180g, Herba Patriniae 180g, Radix Salviae Miltiorrhizae 80g, Rhizoma Chuanxiong 80g, Radix Paeoniae Rubra 80g, Scorpio 10g, Scolopendra 10g, Rhizoma Corydalis 80g, Radix Glycyrrhizae 50g;
Said pharmaceutical preparation is to prepare by the following method:
(1), it is for subsequent use to get the crude drug of above-mentioned each weight portion;
(2), Scorpio, Scolopendra, Rhizoma Corydalis are ground into fine powder, mistake 80 mesh sieves;
(3) Radix Angelicae Sinensis, Caulis Lonicerae, Caulis Spatholobi, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Glycyrrhizae 8 flavor medical material mixture are decocted with water 2-4 time, each amount of water be Radix Angelicae Sinensis, Caulis Lonicerae, Caulis Spatholobi, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Glycyrrhizae 8 flavor medical material mixture 4-10 doubly, each 0.5-2 hour, decoct temperature and be controlled at 80 ℃ to boiling; Collecting decoction filters, and relative density was 1.10～1.15 extractum when filtrate was concentrated into 60 ℃;
(4), the extractum in (3) adds the ethanol of 70-90% percentage by weight, regulates to contain alcohol and measures to 60-80%, leaves standstill 8-12 hour, filters, filtrate recycling ethanol is to without the alcohol flavor, relative density is 1.10～1.20 extractum when being evaporated to 60 ℃;
(5) extractum that obtains after adopting spray drying method to Recycled ethanol carries out drying, in used container, add Scorpio, Scolopendra, Rhizoma Corydalis as bed material, extractum is as binding agent, granulation, tabletting makes tablet, the control inlet temperature is at 75-90 ℃, temperature of charge is at 70-85 ℃, and atomisation pressure is at 0.1-0.3 Mpa, and the transfusion frequency is at 10-40r/min.
Embodiment 3
The preparation method of granule: Radix Angelicae Sinensis 250g, Caulis Lonicerae 180g, Caulis Spatholobi 180g, Herba Patriniae 180g, Radix Salviae Miltiorrhizae 80g, Rhizoma Chuanxiong 80g, Radix Paeoniae Rubra 80g, Scorpio 10g, Scolopendra 10g, Rhizoma Corydalis 80g, Radix Glycyrrhizae 50g;
Said pharmaceutical preparation is to prepare by the following method:
(1), it is for subsequent use to get the crude drug of above-mentioned each weight portion;
(2), Scorpio, Scolopendra, Rhizoma Corydalis are ground into fine powder, mistake 80 mesh sieves;
(3) Radix Angelicae Sinensis, Caulis Lonicerae, Caulis Spatholobi, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Glycyrrhizae 8 flavor medical material mixture are decocted with water 2-4 time, each amount of water be Radix Angelicae Sinensis, Caulis Lonicerae, Caulis Spatholobi, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Glycyrrhizae 8 flavor medical material mixture 4-10 doubly, each 0.5-2 hour, decoct temperature and be controlled at 80 ℃ to boiling; Collecting decoction filters, and relative density was 1.10～1.15 extractum when filtrate was concentrated into 60 ℃;
(4), the extractum in (3) adds the ethanol of 70-90% percentage by weight, regulates to contain alcohol and measures to 60-80%, leaves standstill 8-12 hour, filters, filtrate recycling ethanol is to without the alcohol flavor, relative density is 1.10～1.20 extractum when being evaporated to 60 ℃;
(5), the extractum that obtains after adopting spray drying method to Recycled ethanol carries out drying, in used container, add Scorpio, Scolopendra, Rhizoma Corydalis as bed material, extractum is as binding agent, granulate, packing makes granule, the control inlet temperature is at 75-90 ℃, temperature of charge is at 70-85 ℃, and atomisation pressure is at 0.1-0.3 Mpa, and the transfusion frequency is at 10-40r/min.
Claims (6)
1. the preparation method of pharmaceutical preparation of a prevention and treatment chronic pelvic inflammatory disease is characterized in that:
Described Chinese medicine composition is by the crude drug of following weight parts: 250 parts of Radix Angelicae Sinensis, 180 parts of Caulis Loniceraes, 180 parts of Caulis Spatholobis, 180 parts of Herba Patriniae, 80 parts of Radix Salviae Miltiorrhizaes, 80 parts of Rhizoma Chuanxiongs, 80 parts of Radix Paeoniae Rubra, 10 parts of Scorpios, 10 parts of Scolopendras, 80 parts of Rhizoma Corydalis, 50 parts in Radix Glycyrrhizae;
Said Chinese medicine composition is to prepare by the following method:
(1) it is for subsequent use to get the crude drug of above-mentioned each weight portion;
(2) Scorpio, Scolopendra, Rhizoma Corydalis are ground into fine powder, cross 80 mesh sieves;
(3) Radix Angelicae Sinensis, Caulis Lonicerae, Caulis Spatholobi, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Glycyrrhizae 8 flavor medical material mixture are decocted with water, collecting decoction filters, and relative density was 1.10～1.15 extractum when filtrate was concentrated into 60 ℃;
(4) extractum in (3) adds the ethanol of 70-90% percentage by weight, regulates to contain alcohol and measures to 60-80%, leaves standstill 8-12 hour, filters, and filtrate recycling ethanol is to without the alcohol flavor, and relative density is 1.10～1.20 extractum when being evaporated to 60 ℃.
2. the preparation method of pharmaceutical preparation of prevention according to claim 1 and treatment chronic pelvic inflammatory disease, it is characterized in that, the condition that decocting boils is: decoct with water 2-4 time, each amount of water be Radix Angelicae Sinensis, Caulis Lonicerae, Caulis Spatholobi, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Glycyrrhizae 8 flavor medical material mixture 4-10 doubly, each 0.5-2 hour, decoct temperature and be controlled at 80 ℃ to boiling.
3. the preparation method of pharmaceutical preparation of prevention according to claim 1 and treatment chronic pelvic inflammatory disease is characterized in that, filtrate recycling ethanol is 1.10～1.15 extractum to relative density without the alcohol flavor and when being concentrated into 60 ℃.
4. the preparation method of pharmaceutical preparation of prevention according to claim 1 and treatment chronic pelvic inflammatory disease, it is characterized in that the extractum that obtains after adopting spray drying method to Recycled ethanol carries out drying, adds the fine powder of Scorpio, Scolopendra, Rhizoma Corydalis as bed material in used container, extractum is as binding agent, granulation is dressed up capsule, makes capsule, the control inlet temperature is at 75-90 ℃, temperature of charge is at 70-85 ℃, and atomisation pressure is at 0.1-0.3 Mpa, and the transfusion frequency is at 10-40r/min.
5. the preparation method of pharmaceutical preparation of prevention according to claim 1 and treatment chronic pelvic inflammatory disease, it is characterized in that the extractum that obtains after adopting spray drying method to Recycled ethanol carries out drying, adds the fine powder of Scorpio, Scolopendra, Rhizoma Corydalis as bed material in used container, extractum is as binding agent, granulation, tabletting makes tablet, the control inlet temperature is at 75-90 ℃, temperature of charge is at 70-85 ℃, and atomisation pressure is at 0.1-0.3 Mpa, and the transfusion frequency is at 10-40r/min.
6. the preparation method of pharmaceutical preparation of prevention according to claim 1 and treatment chronic pelvic inflammatory disease, it is characterized in that the extractum that obtains after adopting spray drying method to Recycled ethanol carries out drying, adds the fine powder of Scorpio, Scolopendra, Rhizoma Corydalis as bed material in used container, extractum is as binding agent, granulate, packing makes granule, the control inlet temperature is at 75-90 ℃, temperature of charge is at 70-85 ℃, and atomisation pressure is at 0.1-0.3 Mpa, and the transfusion frequency is at 10-40r/min.
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| CN2011102931057A CN103027968A (en) | 2011-10-07 | 2011-10-07 | Preparation method of medicinal preparation for preventing and treating chronic pelvic inflammation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105233088A (en) * | 2015-11-17 | 2016-01-13 | 包莉丽 | Medicine for treating chronic pelvic inflammatory disease |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105233088A (en) * | 2015-11-17 | 2016-01-13 | 包莉丽 | Medicine for treating chronic pelvic inflammatory disease |
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Application publication date: 20130410 |