CN103018430B - Serially-connected blood vessel grooves for blood vessel perfusion system - Google Patents
Serially-connected blood vessel grooves for blood vessel perfusion system Download PDFInfo
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- CN103018430B CN103018430B CN201210475805.2A CN201210475805A CN103018430B CN 103018430 B CN103018430 B CN 103018430B CN 201210475805 A CN201210475805 A CN 201210475805A CN 103018430 B CN103018430 B CN 103018430B
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- blood vessel
- perfusion
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Abstract
The invention relates to a pair of serially-connected blood vessel grooves for a blood vessel perfusion system. The serially-connected blood vessel grooves for a blood vessel perfusion system are provided with two serially-connected and independent blood vessel perfusion grooves, namely, an upstream perfusion groove and a downstream perfusion groove; the upstream perfusion groove is connected with the downstream perfusion groove via a rubber tube; the upstream perfusion groove and the downstream perfusion groove are provided with a perfusate inlet channel and a perfusate outlet channel respectively; two upstream/downstream glass microtubules are arranged in the upstream/downstream perfusion groove respectively; the upstream/downstream glass microtubule at one side stretches out of the perfusion groove, as well as is fixed by a screw fixing bolt and connected with an upstream/downstream glass microtubule connection tube; and the upstream/downstream glass microtubule at the other side is connected with the rubber tube between the two perfusion grooves. The serially-connected blood vessel grooves for a blood vessel perfusion system disclosed by the invention has the advantages of being capable of being used for searching the influence of the vasoactive substances released by one blood vessel on another blood vessel, and capable of being used for searching the influence of the vasoactive substances released by one blood vessel in case of external intervention on another blood vessel.
Description
Technical field
The present invention relates to a kind of experiment apparatus, specifically, is a kind of for studying the physiological series connection blood vessel of blood vessel perfusion system blood vessel groove.
Background technology
Only be useful at present single groove blood vessel perfusion system blood vessel groove of research single vessel, there is no the blood vessel perfusion system blood vessel groove of series connection.1. single groove blood vessel perfusion system blood vessel groove cannot be studied the impact on another blood vessel of vaso-active substance that blood vessel discharges; 2. single groove blood vessel perfusion system blood vessel groove cannot be studied the impact on another blood vessel of vaso-active substance that a blood vessel discharges in foreign intervention situation.
Summary of the invention
The object of the invention is for deficiency of the prior art, a kind of series connection blood vessel perfusion system blood vessel groove is provided.
For achieving the above object, the technical scheme that the present invention takes is: a kind of series connection blood vessel perfusion system blood vessel groove, described series connection blood vessel perfusion system blood vessel groove is provided with the independently blood vessel perfusion groove of upstream perfusion groove and two series connection of downstream perfusion groove, between upstream perfusion groove and downstream perfusion groove, connect by rubber tube, described upstream perfusion groove and downstream perfusion groove are respectively provided with respectively a perfusate admission passage and a perfusate flow pass, in the groove of described upstream/downstream perfusion groove, be respectively equipped with two upstream/downstream glass-micropipes, the upstream/downstream glass-micropipe of one side stretches out outside perfusion groove, be screwed fasten fixing, and be connected with upstream/downstream glass-micropipe connecting pipe, rubber tube between the upstream/downstream glass-micropipe of opposite side and two perfusion grooves is connected.
Below described perfusion groove, be also provided with the water bath of heating, described upstream/downstream perfusion groove, perfusate admission passage, upstream/downstream glass-micropipe are all arranged on heats in water bath, and the water bath of heating is provided with heat water bath admission passage and the water bath flow pass of heating.
The end of described upstream glass-micropipe connecting pipe connects boost pump and pressure control device by three-way pipe.
Described perfusate admission passage is designed to tortuous bend.
The invention has the advantages that:
1, the present invention can be used for studying the impact on another blood vessel of vaso-active substance that a blood vessel discharges;
2, the present invention can be used for studying the impact on another blood vessel of vaso-active substance that a blood vessel discharges in foreign intervention situation.
Accompanying drawing explanation
Accompanying drawing 1 is the structural representation of single vessel perfusion system.
Accompanying drawing 2 is structural representations of series connection blood vessel perfusion system blood vessel groove of the present invention.
Accompanying drawing 3 is structural representations that cover is pricked the series connection blood vessel perfusion system blood vessel groove after blood vessel.
Accompanying drawing 4 is use constitutional diagrams of series connection blood vessel perfusion system blood vessel groove.
Embodiment
Below in conjunction with accompanying drawing, embodiment provided by the invention is elaborated.
The Reference numeral and the ingredient that in accompanying drawing, relate to are as follows:
1. upstream perfusion groove 2. downstream perfusion grooves
3. perfusate admission passage 4. perfusate flow pass
5. the water bath 6. of the heating water bath admission passage of heating
7. the water bath flow pass 8. upstream glass-micropipes of heating
9. downstream glass-micropipe 10. upstream glass-micropipe connecting pipes
11. downstream glass-micropipe connecting pipe 12. screws are fixedly fastened
13. rubber tube 14. upstream blood vessels
15. downstream blood vessels
The single vessel perfusion system of prior art is single independently perfusion groove, please refer to accompanying drawing 1, accompanying drawing 1 is the structural representation of single vessel perfusion system, and perfusion groove connects perfusate input pipe and efferent duct, perfusate flows into perfusion groove by input pipe, then flows out by efferent duct.In perfusion groove, be provided with two glass-micropipes, glass-micropipe is connected with effuser with the perfusate inflow pipe outside groove, blood vessel two ends cover can be pricked on glass-micropipe, perfusate is by inflow pipe and the glass-micropipe lumen of vessels of flowing through, then flowed out by effuser, single vessel perfusion system is mainly used in single vessel shrinkability mensuration and blood vessel is cultivated perfusion.
Series connection blood vessel perfusion system blood vessel groove of the present invention, is mainly used in studying the impact on blood vessel in the perfusion groove of downstream of vaso-active substance that upstream blood vessel discharges, conveniently sets up control group simultaneously, makes experimental result more accurate.Please refer to accompanying drawing 2, accompanying drawing 2 is structural representations of series connection blood vessel perfusion system blood vessel groove of the present invention.Described series connection blood vessel perfusion system blood vessel groove is provided with the independently blood vessel perfusion groove of upstream perfusion groove 1 and 2 two series connection of downstream perfusion groove, between upstream perfusion groove 1 and downstream perfusion groove 2, connects by rubber tube 13.Described upstream perfusion groove 1 and downstream perfusion groove 2 are respectively provided with respectively a perfusate admission passage 3 and a perfusate flow pass 4, perfusate can flow into perfusion groove by perfusate admission passage 3, and then discarded perfusate flows out by perfusate flow pass 4.When use, in upstream/downstream perfusion groove, all fill the physiological salt solusion (perfusate) flowing to by perfusate admission passage 3, for maintaining vasoactive.
In the groove of described upstream perfusion groove 1, be provided with two upstream glass-micropipes 8, the upstream glass-micropipe 8 of one side stretches out outside perfusion groove, be screwed fasten 12 fixing, and be connected with upstream glass-micropipe connecting pipe 10, the end of upstream glass-micropipe connecting pipe 10 connects boost pump and pressure control device (not shown in FIG.) by three-way pipe, be used for upstream glass-micropipe connecting pipe 10 and inject perfusate in blood vessel, and simultaneously by pressure control device control tube cavity pressure; Rubber tube 13 between the upstream glass-micropipe 8 of opposite side and two perfusion grooves is connected.In the groove of downstream perfusion groove 2, be provided with two downstream glass-micropipes 9, the rubber tube 13 between downstream glass-micropipe 9 and two perfusion grooves of downstream perfusion groove 2 one sides is connected, thereby realizes the series connection of two perfusion grooves; The downstream glass-micropipe 9 of opposite side stretches out outside perfusion groove, is screwed to fasten 12 fixingly, and is connected with downstream glass-micropipe connecting pipe 11, and in blood vessel, perfusate can flow out by downstream glass-micropipe connecting pipe 11.Described upstream, downstream glass- micropipe connecting pipe 10 and 11 are rubber tubes, identical with rubber tube 13 materials.
It should be noted that, when use, need under dissecting microscope, blood vessel two ends be overlapped respectively and prick on two glass-micropipes of same perfusion groove, vessel lumen is communicated with the glass-micropipe at two ends, in the time that in upstream/downstream perfusion groove, cover is pricked upstream/downstream blood vessel respectively, can be by upstream glass-micropipe connecting pipe 10, upstream glass-micropipe 8, upstream blood vessel 14, rubber tube 13, downstream glass-micropipe 9, downstream blood vessel 15 and downstream glass-micropipe connecting pipe 11 UNICOMs get up, for perfusate in Perfused vessel, the impact of the vaso-active substance that research upstream blood vessel discharges on blood vessel in the perfusion groove of downstream, upstream glass-micropipe connecting pipe 10 can also be served as the research of method of administration for pharmaceutical intervention simultaneously.Please refer to accompanying drawing 3, accompanying drawing 3 is structural representations that cover is pricked the series connection blood vessel perfusion system blood vessel groove after blood vessel.
It should be noted that, can transposition when described upstream perfusion groove 1 and downstream perfusion groove 2 use, two perfusion grooves can be served as upstream perfusion groove or downstream perfusion groove, do not have directive restriction.
Below described perfusion groove, be also provided with the water bath 5 of heating, described upstream, downstream perfusion groove 1 and 2, perfusate admission passage 3, upstream and downstream glass- micropipe 8 and 9 are all arranged on heats in water bath 5, and object is at the blood vessel needed physiological temp of surviving by liquid-retentive in perfusion groove.The water bath 5 of heating is provided with heat water bath admission passage 6 and the water bath flow pass 7 of heating, and by circulating of warm water in passage 6 and 7, realizes the constant of temperature in the water bath 5 of heating, thereby maintains the blood vessel needed physiological temp of surviving.
It should be noted that, described perfusate admission passage 3 can be designed to tortuous bend, and as shown in accompanying drawing 2,3, object is in order to provide time enough to make the temperature of the perfusate that just flows to perfusion groove reach physiological temp.
When the present invention uses, can under dissecting microscope, blood vessel two ends be overlapped respectively and prick on two glass-micropipes of same perfusion groove.Please refer to accompanying drawing 3 and accompanying drawing 4, accompanying drawing 4 is use constitutional diagrams of series connection blood vessel perfusion system blood vessel groove.Blood vessel 14 two ends in upstream are overlapped respectively on two upstream glass-micropipes 8 that are tied in upstream perfusion groove 1, blood vessel 15 two ends in downstream are overlapped respectively on two downstream glass-micropipes 9 that are tied in downstream perfusion groove 2.Accurately control perfusate flow by the boost pump being arranged on upstream glass-micropipe connecting pipe 11, pressure control device control tube cavity pressure, perfusate enters upstream blood vessel 14 by upstream glass-micropipe connecting pipe 10 and upstream glass-micropipe 8, upstream glass-micropipe 8, rubber tube 13 and the downstream glass-micropipe 9 of opposite side of flowing through enters downstream blood vessel 15, with after flow out through the downstream of opposite side glass-micropipe 9 and downstream glass-micropipe connecting pipe 11.Now can detect the impact that active substance that upstream blood vessel 14 discharges produces downstream blood vessel 15, or using upstream glass-micropipe connecting pipe 10 as method of administration for the research of pharmaceutical intervention.
In use procedure, upstream, downstream perfusion groove 1 and 2 are inputted perfusate by perfusate admission passage 3 respectively, and perfusate is flowed through after perfusion groove, is flowed out by perfusate flow pass 4., flow by heat water bath admission passage 6 and water bath flow pass 7 circulator baths of heating meanwhile, make the temperature of perfusion groove and Endovascular maintain the blood vessel needed physiological temp (Fig. 4) of surviving.
The present invention is mainly applicable to study the impact of a kind of blood vessel on another kind of blood vessel.When use, a kind of vascular cuffing can be pricked in the blood vessel groove of upstream, another kind of vascular cuffing is pricked in downstream blood tube seat, after such two blood vessels communicate, the vaso-active substance that upstream blood vessel discharges will enter in the tube chamber of downstream blood vessel, and then downstream blood vessel is exerted an influence.In addition, the present invention also can pass through boost pump reagent intravasation tube chamber, and the vaso-active substance that upstream blood vessel discharges the in the situation that of reagent intervention like this flows to downstream blood vessel, and downstream blood vessel is exerted an influence.
At present, this field only has single groove blood vessel perfusion system blood vessel groove, obviously cannot realize above-mentioned requirements.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, do not departing under the prerequisite of the inventive method; can also make some improvement and supplement, these improvement and the supplementary protection scope of the present invention that also should be considered as.
Claims (1)
1. a series connection blood vessel perfusion system blood vessel groove, it is characterized in that, described series connection blood vessel perfusion system blood vessel groove is provided with the independently blood vessel perfusion groove of upstream perfusion groove and two series connection of downstream perfusion groove, between upstream perfusion groove and downstream perfusion groove, connect by rubber tube, described upstream perfusion groove and downstream perfusion groove are respectively provided with respectively a perfusate admission passage and a perfusate flow pass, in the groove of described upstream/downstream perfusion groove, be equipped with a upstream glass-micropipe and a downstream glass-micropipe, the upstream/downstream glass-micropipe of one side stretches out outside perfusion groove, be screwed fasten fixing, and be connected with upstream/downstream glass-micropipe connecting pipe, rubber tube between the upstream/downstream glass-micropipe of opposite side and two perfusion grooves is connected, below described perfusion groove, be also provided with the water bath of heating, described upstream/downstream perfusion groove, perfusate admission passage, upstream/downstream glass-micropipe is all arranged on heats in water bath, the water bath of heating is provided with heat water bath admission passage and the water bath flow pass of heating, described perfusate admission passage is designed to tortuous bend, the end of described upstream glass-micropipe connecting pipe connects boost pump and pressure control device by three-way pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210475805.2A CN103018430B (en) | 2012-11-22 | 2012-11-22 | Serially-connected blood vessel grooves for blood vessel perfusion system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210475805.2A CN103018430B (en) | 2012-11-22 | 2012-11-22 | Serially-connected blood vessel grooves for blood vessel perfusion system |
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| Publication Number | Publication Date |
|---|---|
| CN103018430A CN103018430A (en) | 2013-04-03 |
| CN103018430B true CN103018430B (en) | 2014-07-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210475805.2A Expired - Fee Related CN103018430B (en) | 2012-11-22 | 2012-11-22 | Serially-connected blood vessel grooves for blood vessel perfusion system |
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Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2420286Y (en) * | 2000-03-20 | 2001-02-21 | 上海中路生物工程有限公司 | New organized irrigation device |
| AU2001278714A1 (en) * | 2000-08-11 | 2002-02-25 | Chugai Seiyaku Kabushiki Kaisha | Vascular relaxation agents |
| CN201729835U (en) * | 2010-07-14 | 2011-02-02 | 中国人民解放军第四军医大学 | Cell constant temperature perfusion device |
| CN203037652U (en) * | 2012-11-22 | 2013-07-03 | 上海交通大学医学院附属仁济医院 | Tandem blood vessel perfusion system |
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| CN103018430A (en) | 2013-04-03 |
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Granted publication date: 20140702 Termination date: 20161122 |