CN103007205A - Oral liquid for treating chronic pharyngitis - Google Patents

Abstract

The invention relates to the field of Chinese herba preparations and in particular relates to oral liquid for treating chronic pharyngitis. The oral liquid for treating the chronic pharyngitis is prepared by the following components: Zhejiang white atractylodes rhizome, poria cocos, orange peel, pinellia tenata breit, mangnolia officinalis, liquorice, cyperus rotundus, radix curcumae, lindera aggregate, costusroot, radix ophiopogonis, platycodon grandiflorum, radix sophorae tonkinensis, burdock, blackberry lily and fennel. The oral liquid has the effects of tonifying spleen and stomach, soothing the liver, and promoting the circulation of qi and relieving sore-throat, completely reflects the characteristics of combining integral diagnosis and prescription with local channel tropism treatment, and tonifying deficiency to reach the effect of treating both symptoms and root causes, and has the advantages of a quick effect, low cost and a clear curative effect.

Description

A kind of oral liquid for the treatment of chronic pharyngitis

Technical field

The present invention relates to belong to field of traditional Chinese, be specifically related to a kind of oral liquid for the treatment of chronic pharyngitis.

Background technology

Chronic pharyngitis is common clinically refractory disease, is equivalent to " sore throat ", " globus hystericus " in the Chinese medicine, and main clinical manifestation is pharyngeal sense of discomfort, such as symptoms such as pharyngeal sense of obstruction, the sticking expectorant sense of foreign body sensation, burning sensation, pharyngalgia.Along with climatic variation, atmospheric pollution increases the weight of in recent years, and the primary disease sickness rate is in rising trend.Its symptom repeatedly, the course of disease is long, is difficult to cure, and has a strong impact on Quality of Life, doctor trained in Western medicine there is no specific medicament at present.

Summary of the invention

The objective of the invention is to overcome the prior art deficiency and provide that a kind of instant effect, expense are low, the oral liquid of the treatment chronic pharyngitis of determined curative effect.

For realizing purpose of the present invention, existing according to following technical scheme.This medicine is to be made by the raw material of following weight portion proportioning:

10 parts of the Zhejiang Rhizoma Atractylodis Macrocephalaes, 12 parts in Poria, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Pinelliae, 10 parts of Cortex Magnoliae Officinalis, 3 parts in Radix Glycyrrhizae, 10 parts of Rhizoma Cyperi, 10 parts of Radix Curcumaes, 10 parts of the Radixs Linderae, 10 parts of the Radix Aucklandiae, 15 parts of Radix Ophiopogonis, 10 parts of Radix Platycodoniss, 12 parts of Radix Sophorae Tonkinensiss, 10 parts of Fructus Arctiis, 10 parts of Rhizoma Belamcandae, 10 parts of Fructus Foeniculi.

Preparation method of the present invention is:

(1), takes by weighing above-mentioned each component raw material by prescription;

(2), with the Zhejiang Rhizoma Atractylodis Macrocephalae that takes by weighing with soil, Rhizoma Cyperi, Radix Curcumae vinegar, Fructus Arctii is concocted with conventional method;

(3), the Zhejiang Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, Radix Curcumae and the Pericarpium Citri Reticulatae that takes by weighing, Rhizoma Pinelliae, the Radix Aucklandiae, the Cortex Magnoliae Officinalis vapor distillation 3h that will concoct through step (2), then collect volatile oil after, with the medicinal residues filtration, get water solution A;

(4), will be through step (3) medicinal residues that filter and the Poria, Radix Glycyrrhizae, the Radix Linderae, Radix Ophiopogonis, Radix Platycodonis, Radix Sophorae Tonkinensis, Rhizoma Belamcandae, the Fructus Foeniculi that take by weighing, the Fructus Arctii of the process of preparing Chinese medicine decocts with water three times, each 1 hour, merges three times decocting liquid, filtration gets liquor B;

(5), water solution A and liquor B are merged, be concentrated in right amount, leave standstill, centrifugal, add sodium benzoate and cyclamate an amount of, stir evenly, add again the volatile oil of collecting through step (3), mixing adds water to 1000ml, stirs evenly, fill, sterilization, and get final product.

The present invention gives full play to motherland's tcm characteristic according to the dialectical theory of the traditional Chinese medical science, thinks that primary disease shows as the card of deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive more in clinical, and its phlegm and qi stasis is the mark of disease, and insufficiency of the spleen stagnation of liver-QI is basis of disease.Fall ill often unsuccessful because of feelings will, liver is lost bar and reaches, mechanism of qi pent-up, and the strongly fragrant soil of taking advantage of of wood makes spleen lose transporting, gives birth in the phlegm-damp, and expectorant and the gas phase knot of fighting mutually with upward invasion of liver-QI, gathers in throat; Or eating and drinking without temperance, impairing the spleen and stomach, dysfunction of the spleen in transportation, retention of water-damp in the body, accumulatively wet raise phlegm, stagnation of phlegm-damp, it is strongly fragrant that soil is stopped up wood, makes upward invasion of liver-QI, and mental disorder is handed over resistance, ties in throat; Though the two cause of disease is different, its result causes liver-spleen disharmony, the mental disorder knot of fighting, and follows through superinverse, and tying in throat and sending out is primary disease.We's invigorating the spleen and regulating the stomach is soothing the liver, the circulation of qi promoting sore-throat relieving, and has embodied integral syndrome differentiation medication and part and has returned through the treatment characteristic that combines full side, mends its void and control in fact, to reach the effect for the treatment of both the principal and secondary aspects of a disease.

Rhizoma Atractylodis Macrocephalae (parched with earth), Poria, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Radix Glycyrrhizae invigorating the spleen for dissipating phlegm are monarch in the side; The depressed liver-energy dispersing and QI regulating such as Rhizoma Cyperi (processed with vinegar), vinegar Radix Curcumae, the Radix Linderae, the Radix Aucklandiae, Fructus Foeniculi are minister; Radix Ophiopogonis, YIN nourishing and the production of body fluid promoting was assistant in case the warm-dryness syndrome medicine consumes cloudy Tianjin; The clearing throat such as Radix Platycodonis, Radix Sophorae Tonkinensis, and the through disease of priming is done and is made.

Among the modern study we, the Rhizoma Atractylodis Macrocephalae, Poria, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae etc. are monarch drug, modern pharmacological research shows that the Rhizoma Atractylodis Macrocephalae, Poria have raising immunity, the effects such as antiinflammatory, anti-stress, the contained volatile oil of Pericarpium Citri Reticulatae has the passive phlegm-dispelling functions of zest, and sputum is easily brought up.The Pericarpium Citri Reticulatae decoct has faint dilating effect to bronchus, and Pericarpium Citri Reticulatae decoct and vitamin C, vitamin K and usefulness can strengthen antiinflammation.The Rhizoma Pinelliae has antitussive, suppresses the effect of the secretion of body of gland, and Rhizoma Belamcandae has resisting pathogenic microbes, antiinflammatory, and anticancer antioxidation and removing free radical, aldehyde is warded off the reductase inhibitory action, the effects such as Protein kinase C activation.In recent years research is found, the Chinese medicine for the treatment of chronic pharyngitis, and what have has antiinflammatory, pain relieving, a refrigeration function, and what have has a detumescence antitussive action, and what also have can expand local vascular, suppresses or the infiltration of the cell that reduces inflammation, and what have also has an immunoregulation effect etc.

The specific embodiment:

10 parts of the Zhejiang Rhizoma Atractylodis Macrocephalaes, 12 parts in Poria, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Pinelliae, 10 parts of Cortex Magnoliae Officinalis, 3 parts in Radix Glycyrrhizae, 10 parts of Rhizoma Cyperis, 10 parts of Radix Curcumaes, 10 parts of the Radixs Linderae, 10 parts of the Radix Aucklandiae, 15 parts of Radix Ophiopogonis, 10 parts of Radix Platycodoniss, 12 parts of Radix Sophorae Tonkinensiss, 10 parts of Fructus Arctiis, 10 parts of Rhizoma Belamcandae, 10 parts of Fructus Foeniculi.

Preparation method of the present invention is:

(1), takes by weighing above-mentioned each component raw material by prescription;

(2), with the Zhejiang Rhizoma Atractylodis Macrocephalae that takes by weighing with soil, Rhizoma Cyperi, Radix Curcumae vinegar, Fructus Arctii is concocted with conventional method;

(3), the Zhejiang Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, Radix Curcumae and the Pericarpium Citri Reticulatae that takes by weighing, Rhizoma Pinelliae, the Radix Aucklandiae, the Cortex Magnoliae Officinalis vapor distillation 3h that will concoct through step (2), then collect volatile oil after, with the medicinal residues filtration, get water solution A;

(4), will be through step (3) medicinal residues that filter and the Poria, Radix Glycyrrhizae, the Radix Linderae, Radix Ophiopogonis, Radix Platycodonis, Radix Sophorae Tonkinensis, Rhizoma Belamcandae, the Fructus Foeniculi that take by weighing, the Fructus Arctii of the process of preparing Chinese medicine decocts with water three times, each 1 hour, merges three times decocting liquid, filtration gets liquor B;

(5), water solution A and liquor B are merged, be concentrated in right amount, leave standstill, centrifugal, add sodium benzoate and cyclamate an amount of, stir evenly, add again the volatile oil of collecting through step (3), mixing adds water to 1000ml, stirs evenly, fill, sterilization, and get final product.

Drug administration method of the present invention is: every day 1 time, and minute 2 clothes, each 200 milliliters, be a course for the treatment of January.

For showing that the present invention treats the effect of chronic pharyngitis, the inventor is by having carried out clinical observation to clinical 200 cases of Henan College Of Traditional Chinese Medicine one attached institute.

Data and method conclusion

1 physical data

200 examples 1.1 case history is originated, male's 52 examples wherein, women's 148 examples, 18～64 years old age, average 37.6 years old.Course of disease two weeks to 8 year, average 1.8 years.

1.2 case is selected

1.2.1 all cases of diagnostic criteria all meet " new that Ministry of Public Health bureau of drug administration formulated in 2002 years

Medicine (Chinese medicine) treatment chronic pharyngitis guideline of clinical investigations " diagnostic criteria, and meet the Chinese medical discrimination person that belongs to the stagnation of liver-QI with deficiency of the spleen, disease is seen: pharyngeal sense of obstruction, dry pharynx be uncomfortable in chest, breathe hard, emotion is not smooth etc.

Diagnose and the Standards of Chinese Medical Syndrome Differentiation person 1.2.2 include all primary disease that meets of case standard in, can include the clinical observation case history in.

1.2.3 Excluded cases standard

1.2.3.1 the person that do not meet the Standards of Chinese Medical Syndrome Differentiation.

1.2.3.2 the age below 18 one full year of life or more than 65, gestation or women breast-feeding their children.Those who are allergic to this drug.

1.2.3.3 be associated with the serious primary disease person such as cardiovascular, lung, liver, kidney and hemopoietic system, the psychotic.

1.2.3.4 all inclusive criterias that do not meet, not in accordance with regulations medication can't be judged that curative effect or data are not congruent to affect the treatment and safety judgement person.

2 Therapeutic Method, take oral liquid of the present invention every day 1 time, minute 2 clothes, are taken January altogether by each 200 milliliters.

3 observation indexs

3.1 curative effect determinate standard

Curative effect determinate standard with reference to " new drug (Chinese medicine) treatment chronic pharyngitis guideline of clinical investigations ".

3.1.1 cure: medication 10 d are with interior sx↓, and 1 month with interior clinical symptoms and sign disappearance, 0. nothing recurrence more than 5 years;

3.1.2 produce effects: nothing recurred more than 3 months with interior clinical symptoms and sign disappearance in 1 month with interior sx↓ in 0.5 month in medication;

3.1.3 effectively: 1 month with interior clinical symptoms and the disappearance of part sign with interior sx↓ in 0.5 month in medication;

3.1.4 invalid: medication 1 month with interior clinical symptoms and sign all without obviously alleviating and improving.

3.2 health giving quality observation index

The 3.2.4 emotion is not smooth 3.2.1 pharyngeal sense of obstruction 3.2.2 dry pharynx 3.2.3 uncomfortable in chest breathes hard

4 results

4.1 clinical efficacy after the treatment: see Table 1

Clinical efficacy (%) after table 1 treatment

The example number	Recovery from illness	Produce effects	Effectively	Invalid	Total effective rate %
						200	90	86	26	8	98

4.2 cardinal symptom changes before and after the treatment: see Table 2

4.3 untoward reaction without.

Claims (2)

1. an oral liquid for the treatment of chronic pharyngitis is characterized in that it is to be made by the raw material of following weight portion proportioning: 10 parts of the Zhejiang Rhizoma Atractylodis Macrocephalaes, 12 parts in Poria, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Pinelliae, 10 parts of Cortex Magnoliae Officinalis, 3 parts in Radix Glycyrrhizae, 10 parts of Rhizoma Cyperi, 10 parts of Radix Curcumaes, 10 parts of the Radixs Linderae, 10 parts of the Radix Aucklandiae, 15 parts of Radix Ophiopogonis, 10 parts of Radix Platycodoniss, 12 parts of Radix Sophorae Tonkinensiss, 10 parts of Fructus Arctiis, 10 parts of Rhizoma Belamcandae, 10 parts of Fructus Foeniculi.

2. a kind of preparation method for the treatment of the oral liquid of chronic pharyngitis according to claim 1 is characterized in that:

(1), takes by weighing above-mentioned each component raw material by prescription;

(2), with the Zhejiang Rhizoma Atractylodis Macrocephalae that takes by weighing with soil, Rhizoma Cyperi, Radix Curcumae vinegar, Fructus Arctii is concocted with conventional method;

(3), the Zhejiang Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, Radix Curcumae and the Pericarpium Citri Reticulatae that takes by weighing, Rhizoma Pinelliae, the Radix Aucklandiae, the Cortex Magnoliae Officinalis vapor distillation 3h that will concoct through step (2), then collect volatile oil after, with the medicinal residues filtration, get water solution A;

(4), will be through step (3) medicinal residues that filter and the Poria, Radix Glycyrrhizae, the Radix Linderae, Radix Ophiopogonis, Radix Platycodonis, Radix Sophorae Tonkinensis, Rhizoma Belamcandae, the Fructus Foeniculi that take by weighing, the Fructus Arctii of the process of preparing Chinese medicine decocts with water three times, each 1 hour, merges three times decocting liquid, filtration gets liquor B;

(5), water solution A and liquor B are merged, be concentrated in right amount, leave standstill, centrifugal, add sodium benzoate and cyclamate an amount of, stir evenly, add again the volatile oil of collecting through step (3), mixing adds water to 1000ml, stirs evenly, fill, sterilization, and get final product.