CN103007112B - Traditional medicinal composition for preventing and treating infantile eczema and preparation method thereof - Google Patents
Traditional medicinal composition for preventing and treating infantile eczema and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional medicinal composition for preventing and treating infantile eczema and a preparation method of the traditional medicinal composition, and belongs to the field of traditional Chinese medicines. The traditional medicinal composition comprises the raw materials in parts by weight: 5-8 parts of herba portulacae, 3-7 parts of herba patriniae, 1-5 parts of broom cypress fruits, 1-5 parts of golden cypress, 1-5 parts of rhizoma smilacis glabrae, 1-5 parts of common cnidium fruits, 1-5 parts of rhizoma atractylodis, 0.2-1.8 parts of refined mirabilite powder and 0.2-1.8 parts of indigo naturalis. The traditional medicinal composition has the beneficial effects that infantile eczema can be prevented and treated well, and the composition is safe and reliable.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to Chinese medicine composition of a kind of prevention and treatment infant eczema and preparation method thereof.
Background technology
Infant eczema is one of common dermatosis in infant period, usually betides Head And Face.Disease is main mainly with very itching, and therefore infant repeatedly scratches and rubs when antipruritic under uncontrollable situation, can make tender and lovely skin diabrosis, forms the erosion of large stretch of flushing, thereby has had a strong impact on the healthy of infant.
At present, doctor trained in Western medicine there is no specific short to eczema, adopts symptomatic treatment more.Treat as many to take antihistamine drug (17-hydroxy-11-dehydrocorticosterone) orally, external-use drug form is determined according to clinical skin lesion performance, mostly is ointment.And long-time or the heavy dose of external hormone preparation of short-term, also can addiction cause the series of side effects such as steroid-dependent dermatitis, as thinning of skin, fragility, atrophy, telangiectasis, purpura, fungal infection, acne sample dermatitis, hirsutism, hyperhidrosis, subcutaneous hemorrhage and wound healing difficulty etc.And Chinese medicine and preparation thereof can reduce or stop side effect in the time for the treatment of eczema, can, for a long time for preventing and treat obstinate eczema, greatly demonstrate its superiority.Its usage mostly is for oral administration and external.But for infant patient, decoction difficulty for oral administration, even more dangerous, external drug application meeting brings inconvenience to life, the another method that Chinese medicine is decocted that adopts, its process is very loaded down with trivial details, thereby and cannot grasp best decocting time and affect therapeutic effect.
Summary of the invention
Main purpose of the present invention is to provide the Chinese medicine composition of a kind of safe and effective prevention and treatment infant eczema.
Another object of the present invention is to provide the preparation method of this prevention and treatment infant eczema Chinese medicine composition.
The technical solution used in the present invention is the Chinese medicine composition of a kind of prevention and treatment infant eczema, and its raw material comprises in weight portion: 5～8 parts of Herba Portulacaes, 3～7 parts of Herba Patriniae, 1～5 part of the Fructus Kochiae, 1～5 part of Cortex Phellodendri, 1～5 part of Rhizoma Smilacis Glabrae, 1～5 part of Fructus Cnidii, 1～5 part of Rhizoma Atractylodis, 0.2～1.8 part of Matrii Sulfas Exsiccatus, 0.2～1.8 part of Indigo Naturalis.
As preferably, its raw material comprises in weight portion: 6～7 parts of Herba Portulacaes, 4～6 parts of Herba Patriniae, 2～4 parts of the Fructus Kochiae, 2～4 parts of Cortex Phellodendris, 2～4 parts of Rhizoma Smilacis Glabraes, 2～4 parts of Fructus Cnidiis, 2～4 parts of Rhizoma Atractylodis, 0.5～1.5 part of Matrii Sulfas Exsiccatus, 0.5～1.5 part of Indigo Naturalis.
As preferably, its raw material comprises in weight portion: 6 parts of Herba Portulacaes, 5 parts of Herba Patriniae, 3 parts of the Fructus Kochiae, 3 parts of Cortex Phellodendris, 3 parts of Rhizoma Smilacis Glabraes, 3 parts of Fructus Cnidiis, 3 parts of Rhizoma Atractylodis, 1 part of Matrii Sulfas Exsiccatus, 1 part of Indigo Naturalis.
As preferably, the dosage form that Chinese medicine composition of the present invention and pharmaceutically acceptable excipient can be made, comprises lotion, unguentum, liniment or liniment.
As preferably, Chinese medicine composition of the present invention can be made to the external-use lotion of medicine bag.
Chinese medicine composition of the present invention can adopt the conventional preparation method of Chinese medicine to prepare.And above-mentioned each raw material of Chinese medicine is made to the preferred preparation method of Chinese medicine composition of the present invention, comprise the following steps:
A, get Rhizoma Atractylodis and pulverize, obtain Rhizoma Atractylodis powder for subsequent use;
B, by Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii extracting in water, extracting solution filter, get filtrate simmer down to extractum;
C, by described extractum in stir under add ethanol, leave standstill, get supernatant reclaim ethanol, be evaporated to thick paste;
D, add mix homogeneously in described thick paste after described Matrii Sulfas Exsiccatus, Indigo Naturalis and Rhizoma Atractylodis powder are mixed, dry, pulverize rear for subsequent use.
As preferably, the granularity of the Rhizoma Atractylodis powder in described step a is 10～40 orders.
As preferably, described step b is specially and gets the water extraction 3 times that Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii add 10～12 times of amounts, each 1 hour, extracting solution merged filtration, is evaporated to the extractum that extracted raw material weight is 1 times of amount under the condition of 50～60 DEG C.
As preferably, described step c is specially and in described extractum, under stirring, adds 1 times of 95% ethanol that amount is heavy, and hold over night, gets supernatant and reclaim ethanol, is evaporated to proportion and is 1.20～1.30 thick paste under the condition of 50～60 DEG C.
As preferably, described thick paste is that under 50～60 DEG C of conditions, to measure proportion be 1.25 thick paste.
As preferably, described steps d is specially mixes described Matrii Sulfas Exsiccatus, Indigo Naturalis and Rhizoma Atractylodis powder after 10 minutes, join again in described thick paste and mix 10～20 minutes, make its mix homogeneously, under the condition of 50～60 DEG C, be dried to moisture≤10%, after pulverizing is 10～40 object powder, sealing is preserved, for subsequent use.
Chinese medicine composition of the present invention is taking Herba Portulacae as monarch drug, and Herba Patriniae is ministerial drug, and the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae, Fructus Cnidii and Rhizoma Atractylodis are adjuvant drug, and Matrii Sulfas Exsiccatus and Indigo Naturalis are for making medicine.The collaborative compatibility in full side, gathers heat clearing and damp drying, eliminating carbuncle eliminating stagnation, antipruritic effect altogether, for prevention with treat various eczema, particularly infant eczema.
Preparation method of the present invention, technical maturity is reasonable, has fully taken into account the abundant extraction of various ingredients in compositions, can make crude drug give full play to the effect of prevention and treatment disease.Wherein, adopt concentrating under reduced pressure under the condition of 50～60 DEG C, be in order to ensure better in Chinese medicine that effective ingredient can be because of concentrated decomposition under hot conditions for a long time, thereby improve the therapeutic effect of medicine.
Chinese medicine composition result in clinical application of the present invention shows there is following advantage:
(1) to select Chinese medicine be raw material in the present invention, is natural drug, and or not containing hormone, safety non-toxic, does not produce dependency.
(2) Chinese medicine composition of the present invention is made the external-use lotion of medicine bag, can avoid Chinese medicine extract and Chinese medicine powder to float on the water surface, and more Effective Component of Chinese Medicine is dissolved in water, and therapeutic effect is good, also facilitates infant bathing.
(3) Chinese medicine composition of the present invention is made the external-use lotion of medicine bag, is easy to industrialization, easy to use, and can adjust consumption according to symptom.
(4) for proving that the present composition has the effect of good prevention and treatment infant eczema, the present invention is through 100 routine system clinical observations, and select infant eczema patient that medical history, the state of an illness, age, sex and former Therapeutic Method are suitable for the object of observation, wherein male 42 examples, female's 58 examples.Observing time: 7 days.Using method and consumption: get the medicine bag of embodiment mono-, clean once a day affected part, each 2 bags.The specification of this medicine bag is: 20 grams/bag.
Efficacy determination: cure: skin lesion all disappears, no conscious sympton, occurs without new skin lesion; Effective: skin lesion disappears more than 70%, the dry incrustation of part, even feel skin pruritus; Effective: skin lesion disappears more than 50%, often feel skin pruritus; Invalid: the skin lesion less than 50% that disappears, skin pruritus is not improved, and still has vesicle sepage, even worsens.
Observed result: cure 40 examples, cure rate is 40%.Effective 32 examples, obvious effective rate is 32%.Effective 18 examples, effective percentage is 18%.Invalid 10 examples, inefficiency is 10%.
Chinese medicine composition of the present invention, in the time of prevention infant eczema, is got the medicine bag of embodiment mono-, cleans once a day affected part, each 1 bag.The specification of this medicine bag is: 20 grams/bag.After using 3 days continuously, there is good preventive effect, the phenomenon of eczema can not occur substantially.
Detailed description of the invention
For making those skilled in the art understand in detail production technology of the present invention and technique effect, further introduce application of the present invention and technique effect with concrete production instance below.
Embodiment mono-: prepare Chinese medicine composition of the present invention
Raw material is counted with weight portion:
6 parts of Herba Portulacaes, 5 parts of Herba Patriniae, 3 parts of the Fructus Kochiae, 3 parts of Cortex Phellodendris, 3 parts of Rhizoma Smilacis Glabraes, 3 parts of Fructus Cnidiis, 3 parts of Rhizoma Atractylodis, 1 part of Matrii Sulfas Exsiccatus, 1 part of Indigo Naturalis.
Get Rhizoma Atractylodis and pulverize, obtain granularity and be 10 object Rhizoma Atractylodis powder, for subsequent use; Get the water extraction 3 times that Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii add 11 times of amounts, each 1 hour, extracting solution merged and filters, and is evaporated to the extractum that extracted raw material weight is 1 times of amount under the condition of 50 DEG C; In extractum, under stirring, add 1 times of heavy 95% ethanol of amount, hold over night, gets supernatant and reclaims ethanol, and under the condition of 50 DEG C, being evaporated to proportion is to measure under 1.25(60 DEG C of condition) thick paste; Get Matrii Sulfas Exsiccatus, Indigo Naturalis and Rhizoma Atractylodis powder and mix after 10 minutes, then join in thick paste and mix 15 minutes, make its mix homogeneously, under the condition of 50 DEG C, being dried to moisture is 8%, and after pulverizing is 10 object powder, sealing is preserved, for subsequent use; Then pack with heat-sealing type tea filter paper, to obtain final product.
Embodiment bis-: prepare Chinese medicine composition of the present invention
Raw material is counted with weight portion:
5 parts of Herba Portulacaes, 4 parts of Herba Patriniae, 2 parts of the Fructus Kochiae, 2 parts of Cortex Phellodendris, 2 parts of Rhizoma Smilacis Glabraes, 2 parts of Fructus Cnidiis, 2 parts of Rhizoma Atractylodis, 0.5 part of Matrii Sulfas Exsiccatus, 0.5 part of Indigo Naturalis.
Get Rhizoma Atractylodis and pulverize, obtain granularity and be 40 object Rhizoma Atractylodis powder, for subsequent use; Get the water extraction 3 times that Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii add 10 times of amounts, each 1 hour, extracting solution merged and filters, and is evaporated to the extractum that extracted raw material weight is 1 times of amount under the condition of 60 DEG C; In extractum, under stirring, add 1 times of heavy 95% ethanol of amount, hold over night, gets supernatant and reclaims ethanol, and under the condition of 50 DEG C, being evaporated to proportion is to measure under 1.30(50 DEG C of condition) thick paste; Matrii Sulfas Exsiccatus, Indigo Naturalis and Rhizoma Atractylodis powder were mixed after 10 minutes, then join in thick paste and mix 10 minutes, make its mix homogeneously, under the condition of 50 DEG C, being dried to moisture is 7%, and after pulverizing is 20 object powder, sealing is preserved, for subsequent use; Then pack with heat-sealing type tea filter paper, to obtain final product.
Embodiment tri-: prepare Chinese medicine composition of the present invention
Raw material is counted with weight portion:
7 parts of Herba Portulacaes, 6 parts of Herba Patriniae, 4 parts of the Fructus Kochiae, 4 parts of Cortex Phellodendris, 4 parts of Rhizoma Smilacis Glabraes, 4 parts of Fructus Cnidiis, 4 parts of Rhizoma Atractylodis, 1.5 parts of Matrii Sulfas Exsiccatus, 1.5 parts of Indigo Naturaliss.
Get Rhizoma Atractylodis and pulverize, obtain granularity and be 20 object Rhizoma Atractylodis powder, for subsequent use; Get the water extraction 3 times that Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii add 12 times of amounts, each 1 hour, extracting solution merged and filters, and is evaporated to the extractum that extracted raw material weight is 1 times of amount under the condition of 60 DEG C; In extractum, under stirring, add 1 times of heavy 95% ethanol of amount, hold over night, gets supernatant and reclaims ethanol, and under the condition of 50 DEG C, being evaporated to proportion is to measure under 1.30(50 DEG C of condition) thick paste; Matrii Sulfas Exsiccatus, Indigo Naturalis and Rhizoma Atractylodis powder were mixed after 10 minutes, then join in thick paste and mix 20 minutes, make its mix homogeneously, under the condition of 50 DEG C, being dried to moisture is 10%, and after pulverizing is 40 object powder, sealing is preserved, for subsequent use; Then pack with heat-sealing type tea filter paper, to obtain final product.
Embodiment tetra-: prepare Chinese medicine composition of the present invention
Raw material is counted with weight portion:
8 parts of Herba Portulacaes, 3 parts of Herba Patriniae, 1 part of the Fructus Kochiae, 1 part of Cortex Phellodendri, 1 part of Rhizoma Smilacis Glabrae, 1 part of Fructus Cnidii, 2 parts of Rhizoma Atractylodis, 0.2 part of Matrii Sulfas Exsiccatus, 0.2 part of Indigo Naturalis.
Get Rhizoma Atractylodis and pulverize, obtain granularity and be 10 object Rhizoma Atractylodis powder, for subsequent use; Get the water extraction 3 times that Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii add 10 times of amounts, each 1 hour, extracting solution merged and filters, and is evaporated to the extractum that extracted raw material weight is 1 times of amount under the condition of 55 DEG C; In extractum, under stirring, add 1 times of heavy 95% ethanol of amount, hold over night, gets supernatant and reclaims ethanol, and under the condition of 55 DEG C, being evaporated to proportion is to measure under 1.25(60 DEG C of condition) thick paste; Matrii Sulfas Exsiccatus, Indigo Naturalis and Rhizoma Atractylodis powder were mixed after 10 minutes, then join in thick paste and mix 15 minutes, make its mix homogeneously, under the condition of 55 DEG C, being dried to moisture is 6%, and after pulverizing is 20 object powder, sealing is preserved, for subsequent use; Then pack with heat-sealing type tea filter paper, to obtain final product.
Claims (10)
1. a Chinese medicine composition for prevention and treatment infant eczema, its raw material is made up of 0.2～1.8 part of 5～8 parts of Herba Portulacae, 3～7 parts of Herba Patriniae, 1～5 part of the Fructus Kochiae, 1～5 part of Cortex Phellodendri, 1～5 part of Rhizoma Smilacis Glabrae, 1～5 part of Fructus Cnidii, 1～5 part of Rhizoma Atractylodis, 0.2～1.8 part of Matrii Sulfas Exsiccatus, Indigo Naturalis in weight portion.
2. Chinese medicine composition according to claim 1, is characterized in that: its raw material is made up of 0.5～1.5 part of 6～7 parts of Herba Portulacae, 4～6 parts of Herba Patriniae, 2～4 parts of the Fructus Kochiae, 2～4 parts of Cortex Phellodendris, 2～4 parts of Rhizoma Smilacis Glabraes, 2～4 parts of Fructus Cnidiis, 2～4 parts of Rhizoma Atractylodis, 0.5～1.5 part of Matrii Sulfas Exsiccatus, Indigo Naturalis in weight portion.
3. Chinese medicine composition according to claim 1, is characterized in that: its raw material is made up of 1 part of 6 parts of Herba Portulacae, 5 parts of Herba Patriniae, 3 parts of the Fructus Kochiae, 3 parts of Cortex Phellodendris, 3 parts of Rhizoma Smilacis Glabraes, 3 parts of Fructus Cnidiis, 3 parts of Rhizoma Atractylodis, 1 part of Matrii Sulfas Exsiccatus, Indigo Naturalis in weight portion.
4. comprise the dosage form that Chinese medicine composition and pharmaceutically acceptable excipient are made described in claim 1, this dosage form is the one in lotion, unguentum, liniment or liniment.
5. the preparation method of Chinese medicine composition according to claim 1, comprises following steps:
A, get Rhizoma Atractylodis and pulverize, obtain Rhizoma Atractylodis powder for subsequent use;
B, by Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii extracting in water, extracting solution filter, get filtrate simmer down to extractum;
C, by described extractum in stir under add ethanol, leave standstill, get supernatant reclaim ethanol, be evaporated to thick paste;
D, add mix homogeneously in described thick paste after described Matrii Sulfas Exsiccatus, Indigo Naturalis and Rhizoma Atractylodis powder are mixed, dry, pulverize rear for subsequent use.
6. the preparation method of Chinese medicine composition according to claim 5, is characterized in that: in described step a, the granularity of Rhizoma Atractylodis powder is 10～40 orders.
7. the preparation method of Chinese medicine composition according to claim 5, it is characterized in that: described step b is specially and gets the water extraction 3 times that Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii add 10～12 times of amounts, each 1 hour, extracting solution merges filtration, is evaporated to the extractum that extracted raw material weight is 1 times of amount under the condition of 50～60 DEG C.
8. the preparation method of Chinese medicine composition according to claim 5, it is characterized in that: described step c is specially and in described extractum, under stirring, adds 1 times of 95% ethanol that amount is heavy, hold over night, get supernatant and reclaim ethanol, under the condition of 50～60 DEG C, be evaporated to proportion and be 1.20～1.30 thick paste.
9. the preparation method of Chinese medicine composition according to claim 8, is characterized in that: described thick paste is that under 50～60 DEG C of conditions, to measure proportion be 1.25 thick paste.
10. the preparation method of Chinese medicine composition according to claim 5, it is characterized in that: described steps d is specially mixes described Matrii Sulfas Exsiccatus, Indigo Naturalis and Rhizoma Atractylodis powder after 10 minutes, join again in described thick paste and mix 10～20 minutes, make its mix homogeneously, under the condition of 50～60 DEG C, be dried to moisture≤10%, after pulverizing is 10～40 object powder, sealing is preserved, for subsequent use.
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| CN106309599A (en) * | 2016-11-16 | 2017-01-11 | 宋波 | Traditional Chinese medicine ointment for treating infantile eczema and preparation method thereof |
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| CN105343662A (en) * | 2015-11-10 | 2016-02-24 | 张霞 | Externally-applied traditional Chinese medicine for treating skin eczema and preparation method of externally-applied traditional Chinese medicine |
| CN117159631A (en) * | 2023-04-07 | 2023-12-05 | 上海中医药大学附属曙光医院 | A Chinese medicinal composition for treating psoriasis, and its preparation method |
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| CN101804166B (en) * | 2010-05-05 | 2011-07-27 | 余静 | Traditional Chinese medicine composition for treating dermatitis and eczema of infants |
| CN102178877B (en) * | 2011-04-28 | 2012-09-05 | 尚德信 | External preparation for treating eczema of scrotum and preparation method thereof |
| CN102784340A (en) * | 2012-08-09 | 2012-11-21 | 陈俊梅 | Traditional Chinese medicine composition for treating children eczema |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804166B (en) * | 2010-05-05 | 2011-07-27 | 余静 | Traditional Chinese medicine composition for treating dermatitis and eczema of infants |
| CN102178877B (en) * | 2011-04-28 | 2012-09-05 | 尚德信 | External preparation for treating eczema of scrotum and preparation method thereof |
| CN102784340A (en) * | 2012-08-09 | 2012-11-21 | 陈俊梅 | Traditional Chinese medicine composition for treating children eczema |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106309599A (en) * | 2016-11-16 | 2017-01-11 | 宋波 | Traditional Chinese medicine ointment for treating infantile eczema and preparation method thereof |
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