CN103006917A - Preparation method of heat-clearing toxicity-removing medicament - Google Patents
Preparation method of heat-clearing toxicity-removing medicament Download PDFInfo
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- CN103006917A CN103006917A CN2012105716875A CN201210571687A CN103006917A CN 103006917 A CN103006917 A CN 103006917A CN 2012105716875 A CN2012105716875 A CN 2012105716875A CN 201210571687 A CN201210571687 A CN 201210571687A CN 103006917 A CN103006917 A CN 103006917A
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Abstract
The invention provides a preparation method of a heat-clearing toxicity-removing medicament. According to the preparation method of the medicament, the extraction rate of effective components can be remarkably improved, the extraction time can be shortened, drug resource and energy consumption can be effectively utilized, and production cost can be greatly saved.
Description
Technical field
The present invention relates to a kind of preparation method of heat-clearing and toxic substances removing medicine.
Background technology
Anti-sense detoxification particles is compound Chinese medicinal preparation, and the 15 of Ministry of Health of the People's Republic of China's " drug standard " Traditional Chinese medicine historical preparation begins to be stated from.It is to be made by the 11 flavor medicines such as Radix Puerariae, the Radix Angelicae Dahuricae, Flos Lonicerae, Flos Chrysanthemi, and heat-clearing and toxic substances removing is used for anemopyretic cold.This drug oral, one time 10 gram, 3 times on the one.
At present, the preparation method that anti-sense detoxification particles is put down in writing in Traditional Chinese medicine historical preparation is: above ten simply, and Flos Lonicerae, Flos Chrysanthemi, the Radix Angelicae Dahuricae, Fructus Forsythiae were soaked 1 hour, extracts volatile oil, and medicinal residues and extracting solution are for subsequent use; Herba Artemisiae Scopariae adds 60% ethanol 900ml, soaks 1 hour, and reflux 1 hour filters filtrate for later use; Radix Puerariae, Radix Scutellariae, Radix Isatidis, Folium Isatidis, Fructus Gardeniae, Rhizoma Osmundae add medicinal residues and extracting solution, soak again 1 hour after, decoct with water 1 hour for the first time three times, each 45 minutes collecting decoction of second and third time filters, and filtrate is concentrated into approximately 300ml, adds ethanol 300ml, stir evenly, left standstill 12 hours, filter, get filtrate and Herba Artemisiae Scopariae extracting solution and merge, Recycled ethanol also is concentrated into approximately 200ml, adds the Icing Sugar mixing, granulation, drying sprays into volatile oil, make 1000g, mixing, and get final product.
Yet the inventor studies discovery, and in the traditional handicraft, the volatile oil extraction efficiency is low, and extracts active ingredients is abundant not, is unfavorable for the saving to resource, has caused higher production cost.
Summary of the invention
The object of the present invention is to provide the new preparation method of anti-sense detoxification particles.
The invention provides a kind of preparation method of heat-clearing and toxic substances removing medicine, it comprises following operating procedure:
(1) by following weight proportion weighting raw materials:
150 parts of 150 parts of Rhizoma Osmundae of 150 portions of Herba Artemisiae Scopariaes of 150 portions of Folium Isatidiss of 100 parts of Radix Isatidis of 150 portions of Fructus Gardeniaes of 100 parts of Radix Scutellariaes of 150 parts of Fructus Forsythiaes of 150 parts of Flos Chrysanthemis of 100 portions of Flos Loniceraes of 150 parts of Radixs Angelicae Dahuricae of Radix Puerariae;
(2) extracting honeysuckle, Flos Chrysanthemi, the Radix Angelicae Dahuricae and Fructus Forsythiae powder are broken into coarse powder, extracting in water volatile oil, and medicinal residues and extracting solution are for subsequent use;
(3) Herba Artemisiae Scopariae adds 60%v/v ethanol 65-85 ℃ of extraction, filters, and gets filtrate and namely gets the Herba Artemisiae Scopariae extracting solution;
(4) Radix Puerariae, Radix Scutellariae, Radix Isatidis, Folium Isatidis, Fructus Gardeniae, Rhizoma Osmundae are ground into coarse powder, add medicinal residues and the extracting solution of step (2), add water 65-85 ℃ extraction again, merge water extraction liquid, filter, it is 4.5g crude drug/ml that filtrate is concentrated into concentration, add the isopyknic 95%v/v ethanol of concentrated solution, stir evenly, leave standstill, filter, get the merging of filtrate and Herba Artemisiae Scopariae extracting solution, Recycled ethanol and to be concentrated into concentration be 7.5g crude drug/ml, add the dextrine powder mixing, granulate drying, spray into volatile oil, mixing, and get final product.
Wherein, coarse powder is the 8-14 order described in step (2), (4).
Further, coarse powder is the 10-14 order described in step (2), (4).
Wherein, in the step (2), soak after 1 hour and extract volatile oil;
In the step (3), Herba Artemisiae Scopariae adds 60%v/v ethanol, soaks 1 hour, and 65-85 ℃ was extracted 1 hour, and the w/v of Herba Artemisiae Scopariae and 60%v/v ethanol is 1:6;
In the step (4), add the medicinal residues and extracting solution of step (2) after, soaked again 1 hour, add water in 65-85 ℃ of lower the extraction three times, 1 hour for the first time, second and third time each 45 minutes.
Wherein, in the step (4), described granulation adopts the compressing grains machine to carry out, and the operational factor of compressing grains machine is: chilling temperature 5-15 ℃, and more than the granulation extruding force 2000kg.
Further, when adopting compressing grains mechanism grain, take soybean oil as lubricant.
Further, the consumption of described soybean oil accounts for the 2-5%w/w of granule total amount.
Further, the compressing grains machine is Chinese patent application number: the compressing grains machine described in 201110089002.9.
The preparation method of medicine of the present invention can obviously improve the extraction ratio of effective ingredient, shortens extraction time, has effectively utilized herb resource and energy consumption, has greatly saved production cost.
The specific embodiment
The preparation of embodiment 1 medicine of the present invention
(1) by following prescription weighting raw materials:
Radix Puerariae 150g Radix Angelicae Dahuricae 100g Flos Lonicerae 150g Flos Chrysanthemi 150g Fructus Forsythiae 100g Radix Scutellariae 150g Fructus Gardeniae 100g Radix Isatidis 150g Folium Isatidis 150g Herba Artemisiae Scopariae 150g Rhizoma Osmundae 150g;
(2) above ten simply, and Flos Lonicerae, Flos Chrysanthemi, the Radix Angelicae Dahuricae, Fructus Forsythiae powder are broken into coarse powder (10 order) and soaked 1 hour, extracts volatile oil, and medicinal residues and extracting solution are for subsequent use; Herba Artemisiae Scopariae adds 60% ethanol 900ml, soaks 1 hour, and 65-85 ℃ was extracted 1 hour, filtered filtrate for later use; Radix Puerariae; Radix Scutellariae; Radix Isatidis; Folium Isatidis; Fructus Gardeniae; Rhizoma Osmundae is ground into coarse powder (10 order) and adds medicinal residues and extracting solution, soak again 1 hour after, add water 65-85 ℃ and extract three times; 1 hour for the first time, second; merged water extraction liquid, and filtered in three times each 45 minutes; filtrate is concentrated into approximately 300ml; add ethanol 300ml, stir evenly, left standstill 12 hours; filter; get filtrate and Herba Artemisiae Scopariae extracting solution and merge, Recycled ethanol also is concentrated into approximately 200ml, adds the dextrine powder mixing; add again an amount of soybean oil; adopt the compressing grains machine, granulation, drying; spray into volatile oil; make 200g, mixing, and get final product.
Wherein, the operational factor of compressing grains machine is: chilling temperature 5-15 ℃, and more than the granulation extruding force 2000kg.The compressing grains machine that the present invention uses can obtain by buying the commercial goods, also can be with reference to Chinese patent application number: 201110089002.9 preparations.
The preparation of embodiment 2 medicines of the present invention
(1) by following prescription weighting raw materials:
Radix Puerariae 150g Radix Angelicae Dahuricae 100g Flos Lonicerae 150g Flos Chrysanthemi 150g Fructus Forsythiae 100g Radix Scutellariae 150g Fructus Gardeniae 100g Radix Isatidis 150g Folium Isatidis 150g Herba Artemisiae Scopariae 150g Rhizoma Osmundae 150g;
(2) above ten simply, and Flos Lonicerae, Flos Chrysanthemi, the Radix Angelicae Dahuricae, Fructus Forsythiae powder are broken into coarse powder (10 order) and soaked 1 hour, extracts volatile oil, and medicinal residues and extracting solution are for subsequent use; Herba Artemisiae Scopariae adds 60% ethanol 900ml, soaks 1 hour, and 65-85 ℃ was extracted 1 hour, filtered filtrate for later use; Radix Puerariae, Radix Scutellariae, Radix Isatidis, Folium Isatidis, Fructus Gardeniae, Rhizoma Osmundae are ground into coarse powder (10 order) and add medicinal residues and extracting solution, after soaking again 1 hour, add water 65-85 ℃ and extract three times, 1 hour for the first time, second and third time merged water extraction liquid in each 45 minutes, filter, filtrate is concentrated into approximately 300ml, adds ethanol 300ml, stir evenly, left standstill 12 hours, and filtered, get filtrate and Herba Artemisiae Scopariae extracting solution and merge, Recycled ethanol also is concentrated into approximately 200ml, add the dextrine powder mixing, granulation, drying, spray into volatile oil, make 200g, mixing, and get final product.
Beneficial effect of the present invention is mainly reflected in following several respects:
(1) yield of coarse powder extraction volatile oil is higher.By contrast, extract the more former technique of volatile oil with coarse powder approximately high by about 12%, and extraction time shortens 30%.
(2) add water or add ethanol extraction with coarse powder, extract temperature and can be reduced to 65-85 ℃, significantly saved energy consumption (reducing approximately 50% than decocting method); Extract under these process conditions, the loss of drug volatilization composition is few, can also improve the recovery rate of extractum simultaneously, approximately improves 30-50% than former technique extractum recovery rate, to improving the curative effect to Reducing Cost in Enterprises, raising medicine, all has significant meaning.
In addition, adopt coarse powder to extract, if excess Temperature, material can produce gel or gelatinizing, realizes large production and can't filter.
(3) in the leaching process, coarse granularity should be in 8-14 order scope, and granularity is excessive little to improving extractum recovery rate and energy-saving significance, and undersized is difficult to filter, and can't implement large production.
When (4) adopting the compressing grains machine to granulate, must add an amount of soybean oil and be lubricated, otherwise when granulating, can affect large production output and efficient; and the operation stability of equipment; its consumption is 2-5%, the excessively low lubricant effect that do not reach, the too high melting that can affect granule.Can not adopt magnesium stearate, affect the melting of granule because it can not leach, also be not suitable for the operation of compressing grains machine and use.
Simultaneously, soybean oil belongs to the kind that pharmacopeia is recorded, and is quality controllable, free from extraneous odour.
Claims (8)
1. the preparation method of a heat-clearing and toxic substances removing medicine, it is characterized in that: it comprises following operating procedure:
(1) by following weight proportion weighting raw materials:
150 parts of 150 parts of Rhizoma Osmundae of 150 portions of Herba Artemisiae Scopariaes of 150 portions of Folium Isatidiss of 100 parts of Radix Isatidis of 150 portions of Fructus Gardeniaes of 100 parts of Radix Scutellariaes of 150 parts of Fructus Forsythiaes of 150 parts of Flos Chrysanthemis of 100 portions of Flos Loniceraes of 150 parts of Radixs Angelicae Dahuricae of Radix Puerariae;
(2) extracting honeysuckle, Flos Chrysanthemi, the Radix Angelicae Dahuricae and Fructus Forsythiae powder are broken into coarse powder, extracting in water volatile oil, and medicinal residues and extracting solution are for subsequent use;
(3) Herba Artemisiae Scopariae adds 60%v/v ethanol 65-85 ℃ of extraction, filters, and gets filtrate and namely gets the Herba Artemisiae Scopariae extracting solution;
(4) Radix Puerariae, Radix Scutellariae, Radix Isatidis, Folium Isatidis, Fructus Gardeniae, Rhizoma Osmundae are ground into coarse powder, add medicinal residues and the extracting solution of step (2), add water 65-85 ℃ extraction again, merge water extraction liquid, filter, it is 4.5g crude drug/ml that filtrate is concentrated into concentration, add the isopyknic 95%v/v ethanol of concentrated solution, stir evenly, leave standstill, filter, get the merging of filtrate and Herba Artemisiae Scopariae extracting solution, Recycled ethanol and to be concentrated into concentration be 7.5g crude drug/ml, add the dextrine powder mixing, granulate drying, spray into volatile oil, mixing, and get final product.
2. preparation method according to claim 1, it is characterized in that: coarse powder is the 8-14 order described in step (2), (4).
3. preparation method according to claim 2, it is characterized in that: coarse powder is the 10-14 order described in step (2), (4).
4. preparation method according to claim 1 is characterized in that: in the step (2), soak after 1 hour and extract volatile oil;
In the step (3), Herba Artemisiae Scopariae adds 60%v/v ethanol, soaks 1 hour, and 65-85 ℃ was extracted 1 hour, and the w/v of Herba Artemisiae Scopariae and 60%v/v ethanol is 1:6;
In the step (4), add the medicinal residues and extracting solution of step (2) after, soaked again 1 hour, add water in 65-85 ℃ of lower the extraction three times, 1 hour for the first time, second and third time each 45 minutes.
5. preparation method according to claim 1 is characterized in that: in the step (4), described granulation adopts the compressing grains machine to carry out, and the operational factor of compressing grains machine is: chilling temperature 5-15 ℃, and more than the granulation extruding force 2000kg.
6. preparation method according to claim 5 is characterized in that: when adopting compressing grains mechanism grain, take soybean oil as lubricant.
7. preparation method according to claim 6, it is characterized in that: the consumption of described soybean oil accounts for the 2-5%w/w of granule total amount.
8. it is characterized in that according to claim 5 or 6 described preparation methoies: the compressing grains machine is Chinese patent application number: the compressing grains machine described in 201110089002.9.
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| CN2012105716875A CN103006917A (en) | 2012-12-25 | 2012-12-25 | Preparation method of heat-clearing toxicity-removing medicament |
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| CN2012105716875A CN103006917A (en) | 2012-12-25 | 2012-12-25 | Preparation method of heat-clearing toxicity-removing medicament |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108853028A (en) * | 2018-08-15 | 2018-11-23 | 康美保宁（四川）制药有限公司 | A kind of preparation method of anti-influenza detoxification granule |
Citations (3)
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| CN101966244A (en) * | 2010-09-28 | 2011-02-09 | 广西健丰药业有限公司 | Preparation method of sugar-free type anti-cold and antidotal granule |
| CN102727665A (en) * | 2011-04-08 | 2012-10-17 | 四川旭阳药业有限责任公司 | Anti-cold detoxification puffed granule and preparation method thereof |
| CN102727384A (en) * | 2011-04-08 | 2012-10-17 | 四川金岁方药业有限公司 | Compression granulator |
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- 2012-12-25 CN CN2012105716875A patent/CN103006917A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966244A (en) * | 2010-09-28 | 2011-02-09 | 广西健丰药业有限公司 | Preparation method of sugar-free type anti-cold and antidotal granule |
| CN102727665A (en) * | 2011-04-08 | 2012-10-17 | 四川旭阳药业有限责任公司 | Anti-cold detoxification puffed granule and preparation method thereof |
| CN102727384A (en) * | 2011-04-08 | 2012-10-17 | 四川金岁方药业有限公司 | Compression granulator |
Non-Patent Citations (1)
| Title |
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| 张英财: "绿僵菌颗粒剂研制及其贮存活性检测", 《中国优秀硕士学位论文全文数据库（农业科技辑）》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108853028A (en) * | 2018-08-15 | 2018-11-23 | 康美保宁（四川）制药有限公司 | A kind of preparation method of anti-influenza detoxification granule |
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Application publication date: 20130403 |