CN102994009A - Hydrocolloid adhesive and hydrocolloid dressing - Google Patents
Hydrocolloid adhesive and hydrocolloid dressing Download PDFInfo
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- CN102994009A CN102994009A CN2012104922273A CN201210492227A CN102994009A CN 102994009 A CN102994009 A CN 102994009A CN 2012104922273 A CN2012104922273 A CN 2012104922273A CN 201210492227 A CN201210492227 A CN 201210492227A CN 102994009 A CN102994009 A CN 102994009A
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Abstract
The invention provides a hydrocolloid adhesive and a hydrocolloid dressing prepared from the hydrocolloid adhesive. The hydrocolloid adhesive comprises 15-60 wt% of adhesive substrate, 1-10wt% of acrylic acid segmented copolymer, 5-60wt% of hdrophilic polymer and 0-50wt% of tackifying resin. The acrylic acid segmented copolymer is used as an enhancing agent to obtain the hydrocolloid adhesive which has good integrity, low cold flow property and better flexibility.
Description
Technical field
The present invention relates to a kind of hydrocolloid adhesives and bearing hydrocolloid dressing prepared therefrom, particularly a kind of hydrocolloid adhesives and bearing hydrocolloid dressing that is applicable to enterostomal nursing and is used for the negative pressure drainage iatrotechnics.
Background technology
Hydro-colloid because of have water absorption character, to the viscosity of skin with from the debridement performance, be the very important wound dressings of a class that uses in the clinical care.Hydrocolloid adhesives also can be used as surgical appliance adhesive and is used for the protection that patients with ostomies is made mouthful surrounding skin.When being used for making mouthful surrounding skin protection, require hydro-colloid to have suitable pliability, so that hydrocolloid adhesives can be complied with patient's daily routines.
Traditional hydrocolloid adhesives is by the sticking polymeric substrates of tool and water miscible polymer beads, such as pectin, gelatin and carboxymethyl cellulose etc. composition.There is the problem that integrity (shape-holding property) is relatively poor, cold flow properties is higher in most of traditional hydro-colloids, thereby hydrocolloid adhesives overflowing from release solid support material edge occurs before use.
For solving the problem that integrity is poor, cold flow properties is high, can in hydrocolloid adhesives, add toughener, as passing through the crosslinked vinyl-vinyl acetate copolymer (EVA) of ionic fluid.But the toughener that uses in the prior art tends to sacrifice other beneficial characteristics of hydro-colloid, such as pliability and water-absorbent when improving integrity, reducing cold flow properties.
Therefore, need to provide a kind of have good integrity and low cold flow properties, keep simultaneously the hydro-colloid of better pliability.
Summary of the invention
The invention provides a kind of hydrocolloid adhesives, wherein by using acrylate block copolymer as toughener, give the cold flow properties that the hydrocolloid adhesives integrity also can reduce hydrocolloid adhesives, keep simultaneously preferably pliability.The hydro-colloid that provides among the present invention is particularly suitable for preparing Leakproof strip, is used for making mouth skin care on every side, or is used for the negative pressure drainage iatrotechnics as sealing agent.
On the one hand, the invention provides a kind of hydrocolloid adhesives, comprise:
At the bottom of the adhesive group of 15-60 % by weight,
The acrylic block copolymers of 1-10 % by weight,
The hydrophilic polymer of 5-60 % by weight, and
The tackifying resin of 0-50 % by weight.
On the other hand, the invention provides a kind of bearing hydrocolloid dressing, comprising:
Base material; With
The hydrocolloid adhesives layer, it is formed by aforesaid hydrocolloid adhesives.
Description of drawings
Fig. 1 is the side-view of bearing hydrocolloid dressing in one embodiment of the invention.
Fig. 2 is the dynamic modulus-frequency plot of hydro-colloid in the embodiment of the invention and the comparative example.
Fig. 3 is the loss tangent-frequency plot of hydro-colloid in the embodiment of the invention and the comparative example.
Embodiment
The invention provides a kind of hydrocolloid adhesives, wherein by using acrylate block copolymer to obtain simultaneously good integrity, low cold flow properties as toughener, and pliability preferably.
In this article, term " hydro-colloid " refers to contain jelling agent, thereby has a kind of viscose glue of absorbent function, often is used to wound care.
In this article, term " acrylic block copolymers " and " acrylate block copolymer " are used interchangeably, refer to acrylic block copolymer, it comprises at least one by acrylic monomer, such as the block of acrylate or methacrylate monomer formation.
In this article, term " cold flow properties " refers to that hydro-colloid is under certain temperature (such as envrionment temperature) and less external force (such as self gravitation) effect, deformation increases and the character that increases in time, change of shape easily occurs in the hydro-colloid that cold flow properties is high, can overflow from release solid support material edge before use.
In the situation that do not specify, per-cent herein, umber, ratio, concentration etc. are all based on weighing scale.
The invention provides a kind of hydrocolloid adhesives, comprise:
At the bottom of the adhesive group of 15-60 % by weight,
The acrylic block copolymers of 1-10 % by weight,
The hydrophilic polymer of 5-60 % by weight, and
The tackifying resin of 0-50 % by weight.
The below is described in more detail each component in the hydrocolloid adhesives.
Be used for providing the bond properties of tackiness agent at the bottom of the adhesive group.
Binding agent based gross weight meter, the content at the bottom of the adhesive group in hydrocolloid adhesives is the 15-60 % by weight, is preferably the 15-50 % by weight, more preferably the 20-40 % by weight.
Can use polymer elastomer at the bottom of the adhesive group, such as polyolefine, the example includes but not limited to polyisobutene, polybutene and polyhutadiene, and the multipolymer that comprises at least one olefin polymer block poly-(vinylbenzene/alkene/vinylbenzene) segmented copolymer for example, such as poly-(styrene/isobutylene/styrene), poly-(vinylbenzene/butylene/styrene), poly-(styrene/butadiene/styrene), poly-(styrene/isoprene/styrene), poly-(styrene/ethylene/butylene/styrene) etc.The preferred polyisobutene that uses.
Can regulate viscosity by the polymkeric substance with different molecular weight.The lower viscosity that then provides of polymericular weight of using can be larger.Molecular weight as the polymkeric substance at the bottom of the adhesive group can be at Mn=1,000-80, and in 000 the scope, preferably at Mn=5,000-50, in 000 the scope, more preferably at Mn=10,000-40 is in 000 the scope.The mixture that can use two or more polymkeric substance with different molecular weight as adhesive group at the bottom of.
Can use be purchased product as adhesive group at the bottom of, the example includes but not limited to the BR9000 polyhutadiene (cis-1,4-polybutadiene rubber) of SINOPEC Qilu Petro-Chemical Corp, Hangzhou is along the SDG-8650 polyisobutene that reaches plastic cement company limited (China), the LM-MH of Exxon Mobil Corporation (U.S.), the PIB6H polyisobutene of RitChem (U.S.), the polyisobutene Oppanol B10-B15 of BASF AG (Germany), Glissopal1000, Glissopal1300, Glissopal2300.
In some embodiments, use Glissopal1000 polyisobutene and Oppanol B10 polyisobutene, all available from BASF AG (Germany).
Acrylic block copolymers plays the effect of toughener, provide tackiness agent integrity, reduce its cold flow properties.Herein, " acrylic block copolymers " uses interchangeably with " acrylate block copolymer ".
Binding agent based gross weight meter, the content of acrylate block copolymer in hydrocolloid adhesives is the 1-10 % by weight, is preferably the 2.5-7.5 % by weight, more preferably the 3-6 % by weight.In some embodiments, the content of acrylate block copolymer in hydrocolloid adhesives is the 5-7.5 % by weight.
Acrylic block copolymers comprises at least one polyacrylic ester block and/or polymethacrylate block.In some embodiments, acrylic block copolymers comprises at least one polyacrylic acid C1-C10 alkyl ester block and/or polymethyl acrylic acid C1-C10 alkyl ester block, or comprises at least one polyacrylic acid C1-C6 alkyl ester block and/or polymethyl acrylic acid C1-C6 alkyl ester block.The example of vinylformic acid C1-C10 alkyl ester includes but not limited to methyl acrylate, ethyl propenoate, vinylformic acid n-propyl, isopropyl acrylate, n-butyl acrylate, isobutyl acrylate, tert-butyl acrylate etc.The example of methacrylic acid C1-C10 alkyl ester includes but not limited to methyl methacrylate, β-dimethyl-aminoethylmethacrylate, n propyl methacrylate, isopropyl methacrylate, n-BMA, Propenoic acid, 2-methyl, isobutyl ester, Tert-butyl Methacrylate etc.
In some embodiments, use comprises the acrylic block copolymers of at least one polyacrylic acid C1-C10 alkyl ester block and at least one polymethyl acrylic acid C1-C10 alkyl ester block, or comprises the acrylic block copolymers of at least one polyacrylic acid C1-C6 alkyl ester block and at least one polymethyl acrylic acid C1-C6 alkyl ester block.
In some embodiments, use the acrylate block copolymer that contains polymethylmethacrylablock block, such as poly-(methyl methacrylate-n-butyl acrylate-methyl methacrylate) triblock copolymer; Poly-(methyl methacrylate-n-butyl acrylate) di-block copolymer; Or the mixture of above-mentioned three blocks and di-block copolymer.The preferred use gathered (methyl methacrylate-n-butyl acrylate-methyl methacrylate) triblock copolymer, or the mixture of above-mentioned three blocks and di-block copolymer.
The second-order transition temperature of polyacrylic ester block (Tg) is at least-100 ℃ in the acrylic block copolymers, preferably is at least-70 ℃, more preferably is at least-50 ℃, and is not higher than 0 ℃, preferably is not higher than-20 ℃, more preferably no higher than-40 ℃.If Tg is lower than-100 ℃, then can cause the stickiness of tackiness agent too high, be not easy to use.And if Tg is higher than 0 ℃, then can cause the rising of tackiness agent hardness.
The second-order transition temperature of polymethacrylate block (Tg) is at least 50 ℃ in the acrylic block copolymers, preferably is at least 70 ℃, more preferably is at least 100 ℃, and is not higher than 300 ℃, preferably is not higher than 200 ℃, more preferably no higher than 150 ℃.If Tg is lower than 50 ℃, then can weaken acrylate block copolymer as the effect of toughener, less to the effect that cold flow properties reduces.And if Tg is higher than 300 ℃, then can cause the processing temperature of tackiness agent too high.
The weight-average molecular weight of acrylic block copolymers (Mw) is at least 5,000, preferably is at least 10,000, more preferably is at least 20,000, and is not higher than 500,000, preferably is not higher than 200,000, more preferably no higher than 100,000.If Mw is lower than 5,000, then can cause the stickiness of tackiness agent too high, be not easy to use.And if Mw is higher than 500,000, then can cause tackiness agent excessive at the viscosity that adds man-hour, be unfavorable for processing.
In acrylic block copolymers, the hard and soft property of each block is variant, and wherein the methacrylic ester block is owing to having methyl side groups and sterically hindered larger on the main chain, so that the polymkeric substance chain rigidity increases, acrylate block then relative rigidity is lower.Can further regulate the hard and soft property of each block by selecting different ester groups, the alkyl carbon number on the ester group more at most side chain is longer and mobility is better, so that the polymkeric substance chain rigidity reduces.By being separated, the methacrylic ester block that rigidity is higher in the segmented copolymer such as methyl methacrylate block play the effect of cross-linking set, give tackiness agent essential structural integrity, the motion of polymer molecule at the bottom of the restriction adhesive group, thus reduced the cold flow properties of tackiness agent.Acrylate block in the segmented copolymer such as n-butyl acrylate block then have comparatively soft characteristic, therefore can not cause the rising of tackiness agent hardness.Can obtain by the ratio of regulating two blocks the balance between structural integrity and the pliability.Based on segmented copolymer gross weight meter, the ratio of rigid block in segmented copolymer is at least 5 % by weight, preferably is at least 10 % by weight, more preferably be at least 20 % by weight, and be not higher than 50 % by weight, preferably be not higher than 40 % by weight, more preferably no higher than 30 % by weight.If this ratio is lower than 5 % by weight, then acrylate block copolymer can reduce as the effect of toughener, and the effect that reduces cold flow properties is reduced.And if this ratio is higher than 50 % by weight, then can cause the rising of tackiness agent hardness.
When using as mentioned above the mixture of three blocks and di-block copolymer, wherein the ratio of rigidity and flexible blocks satisfies aforementioned ratio, and the weight ratio of triblock copolymer and di-block copolymer is preferably in 3: 1 to 1: 3 scope.
In some embodiments, the molecular weight of triblock copolymer is 30,000 to 150,000; The molecular weight of di-block copolymer is 20,000 to 100,000; Wherein when rigid block was polymethylmethacrylablock block, its molecular weight was 3,000 to 10,000.
Acrylic block copolymers can use and be purchased product, and the example includes but not limited to: the LA2140e of Japanese Kuraray company, LA1114, LA2330, LA2250, LA3270, LA4285, LAM730H, LAB550; The Nanostrength M75 of France Arkema company, M75M, M85, M85M.
In some embodiments, use following two kinds of acrylate block copolymers:
ABC1: Japanese Kuraray company rank is poly-(methyl methacrylate-n-butyl acrylate-methyl methacrylate) triblock copolymer of LA2140e, total molecular weight is 80,000, the molecular weight of polymethylmethacrylablock block is 9,000, the content of polymethylmethacrylablock block is 23 % by weight;
ABC2: Japanese Kuraray company rank is poly-(methyl methacrylate-n-butyl acrylate) di-block copolymer of LA1114, total molecular weight is 70,000, and the molecular weight of polymethylmethacrylablock block is 4,500, the content of polymethylmethacrylablock block is 7 % by weight.
In some embodiments, use the mixture of above-mentioned two kinds of acrylate block copolymers, its weight ratio is ABC1: ABC2=2: 3.
Hydrophilic polymer has the ability that absorbs liquid, and can not dissolve after absorption owing to having crosslinking structure but swelling occurs.
Binding agent based gross weight meter, the content of hydrophilic polymer in hydrocolloid adhesives is the 5-60 % by weight, is preferably the 10-55 % by weight, more preferably the 30-50 % by weight.
Spendable hydrophilic macromolecular compounds comprises natural, semi-synthetic or synthetic hydrophilic macromolecular compounds.Natural hydrophilic macromolecular compounds comprises polyose polymer such as pectin, gum arabic, guar gum, agar, starch, xanthan gum, dextran etc.; With protein or polypeptide family macromolecule such as gelatin, albumin, casein etc.Semisynthetic hydrophilic macromolecular compounds comprises carboxymethyl cellulose, Xylo-Mucine, methylcellulose gum, ethyl cellulose, Natvosol, hydroxypropylcellulose, methylhydroxypropylcellulose, sodium alginate, carboxymethyl starch etc.Synthetic hydrophilic macromolecular compounds comprises acrylic polymers (such as polyacrylic acid, polyacrylamide), polyvinyl alcohol, Polyvinylpyrolidone (PVP), polyoxyethylene glycol, polyvinyl methyl ether etc.Above-mentioned hydrophilic macromolecular compounds can use with single form, or uses with the form of mixtures of two or more hydrophilic macromolecular compounds.
Can use and be purchased product, the example includes but not limited to: the HS100000YP2 Natvosol of Clariant chemical industry (China) company limited, the FH5000 Xylo-Mucine of the happy chemical industry of prestige (Suzhou) company limited (China) or PE32FGX cellulose gum, the croscarmellose sodium of FMC BioPolymer company (U.S.), hypromellose and the Natvosol of Shanghai He Lisi specialization worker company limited (China), the carboxymethyl starch of Gongyi City, Henan Province Fuhua siccative factory (China), the Luquasorb1030 super absorbent polymer of BASF AG (Germany).
In some embodiments, use following hydrophilic macromolecular compounds:
CMC: the PE32FGX cellulose gum of the happy chemical industry of prestige (Suzhou) company limited (China);
The AC-Di-Sol SD-711 croscarmellose sodium of diSol:FMC BioPolymer company (U.S.).
In some embodiments, hydrocolloid adhesives also randomly comprises tackifying resin, with the viscosity of further adjusting product.
Binding agent based gross weight meter, the content of tackifying resin in hydrocolloid adhesives is the 0-50 % by weight, is preferably the 5-40 % by weight, more preferably the 10-30 % by weight.
Tackifying resin can be for being selected from the following one or more: the petroleum line resin such as aliphatics, alicyclic and aromatic copolymer; Terpenoid resin; Terpenes-styrene resin; Coumarone-terpenoid resin; The rosin series resin; The hydrogenation thing of above-mentioned resin etc.Preferred aliphatics and the alicyclic petroleum line resin of using; Terpenoid resin and terpenes-styrene resin most preferably use aliphatics and alicyclic petroleum line resin.
The example that can be used as the commercially available product of tackifying resin includes but not limited to: the Eastotac H-100R Resin of Eastman Chemical Company (U.S.), the Wingtack95 of Cray Valleylad Inc. (France), the Escorez5340 of Exxon Mobil Corporation (U.S.), the Sylvalite RE80HP Rosin Ester of Arizona Chemicals (U.S.).
In some embodiments, use is available from the Escorez5340 tackifying resin of Exxon Mobil Corporation (U.S.).
Hydrocolloid adhesives of the present invention is optional other additives that comprises also, such as antioxidant etc., purpose is to prevent high molecular oxidation or degraded in the tackiness agent preparation process, and its content can be in the scope of 0.1-5%, preferably in the scope of 0.1-2%, more preferably in the scope of 0.1-1%.
The present invention also provides a kind of bearing hydrocolloid dressing, comprising:
Base material; With
The hydrocolloid adhesives layer, it is formed by aforesaid hydrocolloid adhesives.
Base material in the bearing hydrocolloid dressing can be any common used material, and such as film, foam, non-woven fabrics, fabric etc. considered preferred film from bacterium blocking, steam breathability, flexibility and ductility equal angles.The example of film material comprises one or more in urethane, polyester, polymeric amide, polyolefine such as polyethylene or polypropylene, vinylformic acid or acrylic polymer, olefinic copolymer such as the vinyl-vinyl acetate copolymer.Wherein, be preferably urethane, polyester, polyethylene or vinyl-vinyl acetate copolymer, more preferably urethane or vinyl-vinyl acetate copolymer.
The thickness of hydrocolloid adhesives layer and base material can be selected according to actual needs in the bearing hydrocolloid dressing.The thickness of hydro-colloid layer is with water-absorbent and the comfortableness of major effect dressing, and the thickness of base material will affect ventilation property and the comfortableness of dressing.Wherein, the thickness of hydro-colloid layer is the 10-5000 micron, preferred 15-4500 micron, more preferably 25-3500 micron.The thickness of substrate layer is the 4-200 micron, preferred 4-180 micron, more preferably 4-140 micron.
Can include but not limited to as the example that is purchased product of film substrate: the PT6100 of German Bayer AG, PT2202, PT4200 polyurethane film, the Ureamax polyurethane film of China Jiaxing Nanxiong polymer company limited, the LF2500 polyester film of Chinese Zhongshan Breathtex Plastic New Material Co., Ltd..
Being not particularly limited for the method that forms the hydrocolloid adhesives layer at base material, can be hydrocolloid adhesives to be extruded or rolling for sheet material, base material is fitted to method on the sheet material again; The method that directly is expressed into hydrocolloid adhesives on the base material and pressurizes and suppress; Hydrocolloid adhesives extruded or rolling for sheet material, will be dissolved with base material again solution coat on the hydro-colloid sheet material, with the method for baking oven with removal of solvents.Wherein, be preferably and hydrocolloid adhesives extruded or rolling for sheet material, base material is fitted to method on the sheet material again.
In some embodiments, bearing hydrocolloid dressing also comprises protective layer, for example separate-type paper.Separate-type paper contacts with the outside surface of hydrocolloid adhesives layer, namely contacts on the surface of the surface opposite that contacts with base material with the hydrocolloid adhesives layer, can play the effect of protection hydrocolloid adhesives layer.In use, separate-type paper is peeled off, the hydrocolloid adhesives layer is attached to the position that needs to use this dressing.Separate-type paper can be conventional any type of using in this area.The material that can be used as separate-type paper includes but not limited to glassine paper, laminated paper, polyester film, polypropylene film etc., preferably to they silicone-coating.Fig. 1 is the side-view of bearing hydrocolloid dressing in this embodiment, and wherein 11 is base material, and 12 is the hydrocolloid adhesives layer, and 13 is protective layer such as separate-type paper.
More specifically describe the present invention below by embodiment, do not limit the scope of the invention but should not be understood as by any way.
Embodiment
The material that uses among the embodiment is summarized as follows.
1. polyisobutene (PIB1)
Available from BASF AG, the U.S., CAS9003-27-4, rank: Glissopal1000;
2. polyisobutene (PIB2)
Available from BASF AG, the U.S., rank: Oppanol B10;
3. acrylic block copolymers (ABC1)
Available from Kuraray company, Japan, rank: LA2140e, chemical name: poly-(methyl methacrylate-n-butyl acrylate-methyl methacrylate) triblock copolymer, total Mw=80kg/mol, PMMA block M w=9Kg/mol, PMMA content=23wt%;
4. acrylic block copolymers (ABC2)
Available from Kuraray company, Japan, rank: LA1114, chemical name: poly-(methyl methacrylate-n-butyl acrylate) Synthetic rubber, isoprene-styrene, hydrogenated, block, diblock, total Mw=70kg/mol, PMMA block M w=4.5Kg/mol, PMMA content=7wt%;
5. tackifying resin
Available from Exxon Mobil Corporation, the U.S., rank: Escorez5340;
6. carboxymethyl cellulose (CMC)
Available from the happy chemical industry of prestige (Suzhou) company limited, China, trade(brand)name: PE32FGX cellulose gum, sequence number: 11-0018-1575-9;
7. croscarmellose sodium (diSol)
Available from FMC BioPolymer company (U.S.), trade(brand)name: AC-Di-Sol SD-711Croscarmellose Na, sequence number: 11-0011-5152-8.
The instrument that uses among the embodiment is:
Brabender mixing tank: C.W.Brabender Instruments company (U.S.);
ARES dynamic rheometer: TA company (U.S.).
Embodiment 1: the preparation of toughener
8g acrylic block copolymers ABC1 and 12g acrylic block copolymers ABC2 are dropped into Brabender mixing tank (available from C.W.Brabender Instruments company), under 150 ℃ and 40rpm rotating speed, mixed 20 minutes.Mixture is taken out and be cooled to room temperature, the agent that namely is enhanced is for the preparation of the hydrocolloid adhesives among following examples 2-7.
Embodiment 2-7
With the toughener that obtains among the embodiment 1, the proportion of composing that PIB1, PIB2, tackifying resin, CMC, diSol press table 1 drops into the Brabender mixing tank, and mixing is 20 minutes under 150 ℃ and 40rpm rotating speed.Mixture is taken out and is clipped between two organo silicon release paper, be cooled to room temperature.
Comparative example 1
Obtain according to the program identical with embodiment 2-7, difference is the composition of the comparative example 1 shown in the use table 1, does not namely add toughener.
The test of embodiment 8. rheological property
The hydrocolloid adhesives of preparation in embodiment of the invention 2-7 and the comparative example 1 is carried out the rheological property test.Method is as follows: testing tool is the ARES dynamic rheometer of TA company, uses diameter to be the plate jig of 25mm.At 32 ℃, under 5% strain, carry out the frequency sweeping test, range of frequency is 0.01-10Hz, record elasticity (storage) modulus (G ') and loss tangent (tan δ).Under low frequency (0.01-0.1Hz), G ' modulus is less to show that then tested tackiness agent is softer, and tan δ is larger to show that then tested tackiness agent has better flowing property.Tackiness agent is softer, flowability better, and then the stickiness of tackiness agent and skin is just better, and the leak resistance when being used for making mouthful surrounding skin protection is just better, and the sealing effectiveness when being used for the negative pressure drainage iatrotechnics as sealing agent is also just better.
The test result of embodiment 2 and comparative example 1 (see Fig. 2,3 and table 1) illustrate when toughener content 5.0% the time, significant change does not occur in the pliability of hydrocolloid adhesives.After toughener content was increased to 7.5% (embodiment 3), the modulus of hydro-colloid increased, but tan δ remains unchanged substantially.
The hydrocolloid adhesives of table 1. embodiment 2-7 and comparative example 1 forms and modulus
The test of embodiment 9. cold flow properties
The hydrocolloid adhesives of preparation in embodiment of the invention 2-7 and the comparative example 1 is carried out the cold flow properties test.Method is as follows: the use diameter is that 1 inch mould cuts out circular specimen (one side is with separate-type paper).Every kind of hydrocolloid adhesives is cut 5 built-in testing samples, be arranged in equally spacedly on the separate-type paper, above sample, place a plastic sheet (covering 5 built-in testing samples of below fully), on plastic sheet, place again the metal block that weight is 3.3kg.After 24 hours, remove metal block and plastic sheet, measure the diameter of specimen, and calculate it with respect to the per-cent (%) that initial diameter increases, the per-cent of 5 sample gained is averaged, characterize the cold flow properties of sample.
Test result (seeing Table 2) illustrates that the acrylate copolymer toughener has remarkable effect for the cold flow properties that reduces hydro-colloid.
The experimental result of table 2. hydro-colloid cold flow properties
In conjunction with the embodiments 8 and the result of embodiment 9; show when addition within the specific limits the time; the acrylate copolymer toughener can reduce the cold flow properties of hydrocolloid adhesives; simultaneously can significantly not change its pliability again; be suitable for making Leakproof strip or sealing material, be used for making mouthful surrounding skin protection or a negative pressure drainage iatrotechnics.
The hydrocolloid adhesives of preparation among the embodiment 2 is put into forcing machine be extruded into the sheet material that thickness is about 0.5mm, simultaneously, with being purchased from rolling being laminated with on the hydro-colloid sheet material of the PT6100 of German Bayer AG polyurethane film (25 microns), obtain bearing hydrocolloid dressing.
Claims (19)
1. hydrocolloid adhesives comprises:
At the bottom of the adhesive group of 15-60 % by weight,
The acrylic block copolymers of 1-10 % by weight,
The hydrophilic polymer of 5-60 % by weight, and
The tackifying resin of 0-50 % by weight.
2. hydrocolloid adhesives claimed in claim 1, wherein said acrylic block copolymers comprises at least one polyacrylic ester block and/or polymethacrylate block.
3. hydrocolloid adhesives claimed in claim 2, wherein said acrylic block copolymers comprises at least one polyacrylic acid C1-C10 alkyl ester block and/or polymethyl acrylic acid C1-C10 alkyl ester block.
4. hydrocolloid adhesives claimed in claim 3, wherein said acrylic block copolymers is poly-(methyl methacrylate-n-butyl acrylate-methyl methacrylate) triblock copolymer, poly-(methyl methacrylate-n-butyl acrylate) di-block copolymer, or the mixture of described triblock copolymer and di-block copolymer.
5. each described hydrocolloid adhesives among the claim 1-4, the weight-average molecular weight of wherein said acrylic block copolymers is at least 5,000, and is not higher than 500,000.
6. each described hydrocolloid adhesives among the claim 1-5, wherein the ratio of rigid block in acrylic block copolymers is at least 5 % by weight, and is not higher than 50 % by weight.
7. hydrocolloid adhesives claimed in claim 1, the content of wherein said acrylic block copolymers is the 5-7.5 % by weight.
8. each described hydrocolloid adhesives among the claim 1-7 is polymer elastomer at the bottom of the wherein said adhesive group.
9. each described hydrocolloid adhesives among the claim 1-8 is polyolefine or the multipolymer that comprises at least one olefin polymer block at the bottom of the wherein said adhesive group.
10. hydrocolloid adhesives claimed in claim 9, at the bottom of the wherein said adhesive group for being selected from polyisobutene, polybutene, polyhutadiene and poly-(vinylbenzene/alkene/vinylbenzene) segmented copolymer one or more.
11. each described hydrocolloid adhesives among the claim 1-10, the molecular weight at the bottom of the wherein said adhesive group are at Mn=1,000-80 is in 000 the scope.
12. each described hydrocolloid adhesives among the claim 1-11, wherein said hydrophilic polymer are to be selected from the natural, semi-synthetic or synthetic hydrophilic macromolecular compounds one or more.
13. each described hydrocolloid adhesives among the claim 1-12, the content of wherein said tackifying resin in hydrocolloid adhesives is the 5-40 % by weight.
14. each described hydrocolloid adhesives among the claim 1-13, wherein said tackifying resin are to be selected from the following one or more: aliphatics, alicyclic and aromatic copolymer petroleum line resin; Terpenoid resin; Terpenes-styrene resin; Coumarone-terpenoid resin; The rosin series resin; With their hydrogenation thing.
15. each described hydrocolloid adhesives among the claim 1-14 also comprises the antioxidant of 0.1-5 % by weight.
16. a bearing hydrocolloid dressing comprises:
Base material; With
The hydrocolloid adhesives layer, it is formed by each described hydrocolloid adhesives among the claim 1-15.
17. the described bearing hydrocolloid dressing of claim 16, wherein said base material are film, foam, non-woven fabrics or fabric.
18. claim 16 or 17 described bearing hydrocolloid dressings, wherein said base material is the film of urethane, polyester, polymeric amide, polyolefine, vinylformic acid or acrylic polymer or olefinic copolymer.
19. each described bearing hydrocolloid dressing also comprises protective layer among the claim 16-18.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104130434A (en) * | 2013-05-02 | 2014-11-05 | 3M创新有限公司 | Hydrocolloid dressing and preparation method thereof |
| CN104840996A (en) * | 2014-02-13 | 2015-08-19 | 上海巍太医疗器械有限公司 | Novel wet stoma artificial skin and preparation method thereof |
| CN106167683A (en) * | 2015-05-18 | 2016-11-30 | 日东电工株式会社 | The one-piece type adhesive foil of adhesive foil, dicing tape, plural layers, the manufacture method of semiconductor device and semiconductor device |
| CN106381092A (en) * | 2016-08-29 | 2017-02-08 | 无锡万能胶粘剂有限公司 | Environment-friendly all-purpose adhesive |
| CN106822985A (en) * | 2017-03-22 | 2017-06-13 | 嘉好(太仓)新材料股份有限公司 | A kind of medical use hydrocolloid dressing adhesive |
| CN107365563A (en) * | 2017-07-28 | 2017-11-21 | 威海洁瑞医用制品有限公司 | It can suppress or absorb the hydrocolloid adhesives and application of peculiar smell |
| CN107722887A (en) * | 2017-10-18 | 2018-02-23 | 广州市豪特粘接材料有限公司 | A kind of low temperature resistant label PUR and preparation method thereof |
| CN109758293A (en) * | 2019-03-11 | 2019-05-17 | 山东煜和堂药业有限公司 | Postpartum Warn uterus paste and application method and manufacture the equipment that material is organized in the postpartum Warn uterus paste |
| CN112175556A (en) * | 2020-10-26 | 2021-01-05 | 广州鹿山新材料股份有限公司 | Adhesive resin, method for producing the same, and protective film |
| CN112220960A (en) * | 2020-10-26 | 2021-01-15 | 湖北大学 | Double-layer hydrocolloid dressing and preparation method thereof |
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| CN1230124A (en) * | 1996-09-16 | 1999-09-29 | 卫生与营养实验室 | Novel hydrophile adhesive mass |
| EP1260566A2 (en) * | 2001-05-22 | 2002-11-27 | Novacel | Protective adhesive films |
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| CN1142400A (en) * | 1995-03-02 | 1997-02-12 | 庄臣消费品有限公司 | Structured occlusive dressing |
| CN1230124A (en) * | 1996-09-16 | 1999-09-29 | 卫生与营养实验室 | Novel hydrophile adhesive mass |
| EP1260566A2 (en) * | 2001-05-22 | 2002-11-27 | Novacel | Protective adhesive films |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104130434A (en) * | 2013-05-02 | 2014-11-05 | 3M创新有限公司 | Hydrocolloid dressing and preparation method thereof |
| CN104130434B (en) * | 2013-05-02 | 2018-01-12 | 3M创新有限公司 | Bearing hydrocolloid dressing and preparation method thereof |
| CN104840996A (en) * | 2014-02-13 | 2015-08-19 | 上海巍太医疗器械有限公司 | Novel wet stoma artificial skin and preparation method thereof |
| CN106167683A (en) * | 2015-05-18 | 2016-11-30 | 日东电工株式会社 | The one-piece type adhesive foil of adhesive foil, dicing tape, plural layers, the manufacture method of semiconductor device and semiconductor device |
| CN106381092A (en) * | 2016-08-29 | 2017-02-08 | 无锡万能胶粘剂有限公司 | Environment-friendly all-purpose adhesive |
| CN106822985A (en) * | 2017-03-22 | 2017-06-13 | 嘉好(太仓)新材料股份有限公司 | A kind of medical use hydrocolloid dressing adhesive |
| CN107365563A (en) * | 2017-07-28 | 2017-11-21 | 威海洁瑞医用制品有限公司 | It can suppress or absorb the hydrocolloid adhesives and application of peculiar smell |
| CN107722887A (en) * | 2017-10-18 | 2018-02-23 | 广州市豪特粘接材料有限公司 | A kind of low temperature resistant label PUR and preparation method thereof |
| CN109758293A (en) * | 2019-03-11 | 2019-05-17 | 山东煜和堂药业有限公司 | Postpartum Warn uterus paste and application method and manufacture the equipment that material is organized in the postpartum Warn uterus paste |
| CN112175556A (en) * | 2020-10-26 | 2021-01-05 | 广州鹿山新材料股份有限公司 | Adhesive resin, method for producing the same, and protective film |
| CN112220960A (en) * | 2020-10-26 | 2021-01-15 | 湖北大学 | Double-layer hydrocolloid dressing and preparation method thereof |
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