CN102988832B - 一种治疗小儿哮喘的中药组合物 - Google Patents
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Abstract
本发明公开了一种治疗小儿哮喘的中药组合物。祖国医学认为哮喘是因小儿“脾常不足”、“肺常不足”，水湿不化，易成痰饮；感受外邪是小儿哮喘反复发作的主要原因。为此，本发明选择具有补肾健脾、温肺散寒、化痰止咳、宣肺平喘的中药黄栎、山药、小叶枇杷、麻黄、响铃草、薏苡仁、显子草、白术、大叶沿阶草、澜江百合、桑叶、白芥子、细辛、五味子、甘草水煎成汤剂，经我院临床试验，总有效率达到97.9％，明显优于对照组，而且每年复发率也远远低于对照组，值得临床推广应用。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗小儿哮喘的中药组合物。
背景技术
小儿哮喘发病率在世界范围内近年有逐步上升的趋势，哮喘是儿童时期常见的反复发作的慢性病，本病是由多种细胞和细胞因子参与的慢性气道炎症反应和气道高反应性而导致反复喘鸣发作、呼吸困难、胸闷或咳嗽，可恢复的气流受阻是其特征，哮喘治疗不当给家庭和社会带来经济负担，更重要的是严重影响了患者的生命质量；目前尽管肾上腺皮质激素作为哮喘治疗的有效药物而广泛使用，但近年发现长期吸入糖皮质激素仍不能降低支气管哮喘的发病率和死亡率。
发明内容
本发明的目的是提供一种治疗小儿哮喘的中药组合物。祖国医学认为哮喘是因小儿“脾常不足”、“肺常不足”，水湿不化，易成痰饮；感受外邪是小儿哮喘反复发作的主要原因，中医在治疗上以补肾健脾、温肺散寒、化痰止咳、宣肺平喘为治则。
本发明的目的是通过以下技术方案实现的，该治疗小儿哮喘的中药组合物由以下重量份的中药制成：黄栎7-9份、山药10-12份、小叶枇杷5-7份、麻黄4-6份、响铃草13-15份、薏苡仁14-16份、显子草7-9份、白术5-7份、大叶沿阶草9-11份、澜江百合8-10份、桑叶9-11份、白芥子7-9份、细辛4-6份、五味子4-6份、甘草3-5份。
优选的，黄栎8份、山药11份、小叶枇杷6份、麻黄5份、响铃草14份、薏苡仁15份、显子草8份、白术6份、大叶沿阶草10份、澜江百合9份、桑叶10份、白芥子8份、细辛5份、五味子5份、甘草4份。
制备方法：按传统方法水煎成汤剂。
方中：黄栎平喘；山药补脾养胃，生津益肺，补肾涩精；五味子敛肺滋肾，生津收汗，涩精；小叶枇杷止咳平喘，祛痰；麻黄发汗解表，宣肺平喘，利水消肿；响铃草敛肺气，补脾肾；显子草补虚健脾，活血调经；薏苡仁利水渗湿，健脾除痹，清热排脓；白术补气健脾，燥湿利水；大叶沿阶草安心安神，止咳化痰；澜江百合润肺止咳，清热安神；桑叶疏散风热，清肺润燥，平肝明目；白芥子温肺化痰，利气散结；细辛祛风散寒，通窍止痛，温肺化饮；甘草益气补中，清热解毒，祛痰止咳，缓解止痛。
临床资料
一般资料所选的192例患儿均为我院妇女儿童医疗中心儿童院区中医科2009年2月～2010年11月门诊及住院病人。将192例患儿随机分为治疗组和对照组。治疗组96例，男54例，女42例；1.5岁～3岁22例，4～6岁者46例，7～15岁者28例。对照组96例，男50例，女46例；2～4岁21例，5～7岁者45例，8～16岁者30例。两组患儿病情轻重程度基本相同。发病后最短2天就诊，最长1周就诊；两组患儿一般资料经统计学处理，无统计学意义，具有可比性(P＞0.05)。
诊断标准小儿哮喘诊断标准参照2006版GINA方案，中医哮喘病和哮喘缓解期诊断参照国家中医药管理局1994年发布的《中医病证诊断疗效标准·中医儿科病证诊断疗效标准》，共纳入病例192例。
治疗方法治疗组服用以上所述的中药组合物，每日一剂，分2-3次分服；对照组：急性发作期静脉点滴抗生素，每日氨茶碱10mg·kg，强的松1mg·kg，分3次E1服；恢复期必可酮气雾剂100mg·d，晨起1次吸入；两组均1个月为1个疗程，随访1年。
疗效标准(1)显效：哮喘基本不发作，平时无明显症状，听诊两肺无喘鸣音；(2)有效：哮喘发作次数明显减少，症状减轻，听诊两肺偶闻及喘鸣音；(3)无效：哮喘发作次数及症状均无改善，听诊两肺常闻及喘鸣音。
治疗结果(1)一年内发作次数比较见表1。
表1一年内发作次数比较
分析：发作次数组间比较，差别有高度统计学意义(P＜0.01)，治疗组疗效明显优于对照组。
(2)综合疗效比较见表2。
表2两组综合疗效比较
分析：发作次数组间比较，差别有高度统计学意义(P＜0.01)，治疗组疗效明显优于对照组。
(3)两组治疗两个疗程后疗效比较见表3。
表3两组治疗两个月后疗效比较。
治疗组显效率、总有效率明显高于对照组，差异有统计学意义(P＜0.05)。
具体是实施方式
实施例一：称取黄栎8g、山药11份、小叶枇杷6g、麻黄5g、响铃草14份、薏苡仁15g、显子草8g、白术6g、大叶沿阶草10g、澜江百合9g、桑叶10g、白芥子8g、细辛5g、五味子5g、甘草4g，将上述中药水煎成汤剂，每日一剂，分2-3次分服。
实施例二：称取黄栎7g、山药10份、小叶枇杷5g、麻黄4g、响铃草13份、薏苡仁14g、显子草7g、白术5g、大叶沿阶草9g、澜江百合8g、桑叶9g、白芥子7g、细辛4g、五味子6g、甘草3g，将上述中药水煎成汤剂，每日一剂，分2-3次分服。
实施例三：称取黄栎9g、山药12份、小叶枇杷7g、麻黄6g、响铃草15份、薏苡仁16g、显子草9g、白术7g、大叶沿阶草11g、澜江百合10g、桑叶11g、白芥子9g、细辛6g、五味子4g、甘草5g，将上述中药水煎成汤剂，每日一剂，分2-3次分服。
Claims (1)
1.一种治疗小儿哮喘的中药组合物，其特征在于该中药组合物由以下重量的中药制成：黄栎8g、山药11份、小叶枇杷6g、麻黄5g、响铃草14份、薏苡仁15g、显子草8g、白术6g、大叶沿阶草10g、澜江百合9g、桑叶10g、白芥子8g、细辛5g、五味子5g、甘草4g。
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