CN102977022B - (-)-meptazinol phenyl urethan-L-(+)-tartrate IV type crystal - Google Patents
(-)-meptazinol phenyl urethan-L-(+)-tartrate IV type crystal Download PDFInfo
- Publication number
- CN102977022B CN102977022B CN201210473827.5A CN201210473827A CN102977022B CN 102977022 B CN102977022 B CN 102977022B CN 201210473827 A CN201210473827 A CN 201210473827A CN 102977022 B CN102977022 B CN 102977022B
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- CN
- China
- Prior art keywords
- tartrate
- type crystal
- phenyl urethan
- meptazinol phenyl
- meptazinol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000013078 crystal Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 229940095064 tartrate Drugs 0.000 claims description 5
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
- 238000001757 thermogravimetry curve Methods 0.000 claims description 4
- 229960000365 meptazinol Drugs 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000000113 differential scanning calorimetry Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract description 5
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract description 4
- JLICHNCFTLFZJN-OAHLLOKOSA-N 3-[(3s)-3-ethyl-1-methylazepan-3-yl]phenol Chemical compound C=1C=CC(O)=CC=1[C@]1(CC)CCCCN(C)C1 JLICHNCFTLFZJN-OAHLLOKOSA-N 0.000 abstract 2
- LBKPGNUOUPTQKA-UHFFFAOYSA-N ethyl n-phenylcarbamate Chemical compound CCOC(=O)NC1=CC=CC=C1 LBKPGNUOUPTQKA-UHFFFAOYSA-N 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000002329 infrared spectrum Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-L L-tartrate(2-) Chemical compound [O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O FEWJPZIEWOKRBE-JCYAYHJZSA-L 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 238000000646 scanning calorimetry Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 206010048650 Cholinesterase inhibition Diseases 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007707 calorimetry Methods 0.000 description 1
- 238000004455 differential thermal analysis Methods 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- -1 phenol carbanilic acid ester compounds Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210473827.5A CN102977022B (en) | 2012-11-09 | 2012-11-09 | (-)-meptazinol phenyl urethan-L-(+)-tartrate IV type crystal |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210473827.5A CN102977022B (en) | 2012-11-09 | 2012-11-09 | (-)-meptazinol phenyl urethan-L-(+)-tartrate IV type crystal |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102977022A CN102977022A (en) | 2013-03-20 |
CN102977022B true CN102977022B (en) | 2016-09-14 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210473827.5A Expired - Fee Related CN102977022B (en) | 2012-11-09 | 2012-11-09 | (-)-meptazinol phenyl urethan-L-(+)-tartrate IV type crystal |
Country Status (1)
Country | Link |
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CN (1) | CN102977022B (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1850804A (en) * | 2006-03-31 | 2006-10-25 | 复旦大学 | Optical-purity meptazinol orits salts, and preparing method |
CN101020661A (en) * | 2007-03-19 | 2007-08-22 | 复旦大学 | (-)-meptazinol carbamate derivative and/or its salt and their prepn and use |
-
2012
- 2012-11-09 CN CN201210473827.5A patent/CN102977022B/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1850804A (en) * | 2006-03-31 | 2006-10-25 | 复旦大学 | Optical-purity meptazinol orits salts, and preparing method |
CN101020661A (en) * | 2007-03-19 | 2007-08-22 | 复旦大学 | (-)-meptazinol carbamate derivative and/or its salt and their prepn and use |
Also Published As
Publication number | Publication date |
---|---|
CN102977022A (en) | 2013-03-20 |
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Legal Events
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
C41 | Transfer of patent application or patent right or utility model | ||
GR01 | Patent grant | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20160822 Address after: 264205 No. 1 South Qingdao Road, Weihai economic and technological development, Shandong Applicant after: Disha Pharmaceutical Industry Group Corp., Ltd. Applicant after: Weihai Disu Pharmaceutical Co., Ltd. Address before: 264205 No. 1 South Qingdao Road, Weihai economic and technological development, Shandong Applicant before: Disha Pharmaceutical Industry Group Corp., Ltd. Applicant before: Disha Pharmaceutical Group Shandong Disha Pharmaceutical Co., Ltd. Applicant before: Weihai Disu Pharmaceutical Co., Ltd. Applicant before: Weihai Weitai Medical Technology Development Co., Ltd. |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160914 Termination date: 20181109 |