CN1029660C - Drug non-plane membranous agent and its preparation technology - Google Patents
Drug non-plane membranous agent and its preparation technology Download PDFInfo
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- CN1029660C CN1029660C CN 93101422 CN93101422A CN1029660C CN 1029660 C CN1029660 C CN 1029660C CN 93101422 CN93101422 CN 93101422 CN 93101422 A CN93101422 A CN 93101422A CN 1029660 C CN1029660 C CN 1029660C
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- membranous
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- medicine
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Abstract
The present invention discloses a drug non-plane membranous agent and a preparation technology thereof. The drug non-plane membranous agent belongs to a drug preparation product with the characteristic of a special physical shape. The macroscopic area of the drug non-plane membranous agent is identical with that of an ordinary plane membranous agent; the microscopic area of the drug non-plane membranous agent is increased; the surface has the drug non-plane membranous agent; the drug non-plane membranous agent can have a single-surface circular arc convex shape or a double-surface circular arc convex shape or a through hole shape or an irregular shape. The preparation method comprises: mixed solution of membranous forming material and drugs is dried by hot wind on a crawler type metal plate with carved flower of a membranous forming machine, or after the plane membranous agent is prepared, a laser punching machine is used for punching a hole, or alloy flower carving is used for forming a rolling machine by hot pressure. The drug non-plane membranous agent accelerates drug membranous dissolution and drug release, and is a new variety of a drug membranous agent.
Description
The present invention relates to a kind of drug non-plane membranous agent and preparation technology thereof, belong to the pharmaceutical product that is shaped as feature with specific physical.
Medicine plane membrane is one of present common drug dosage form, be a kind of be that adjuvant adds a kind of pharmaceutical dosage form that medicine is made with filmogens such as polyvinyl alcohol, as the nonoxynolum contraceptive film used clinically, medicine membrane of oral cavity, ophthalmic film, externally-used pain-relieving medicine film etc., all belong to plane medicine film, face is smooth smooth.When manufacturing, medicine, cellulose, acrylate etc. are added in the poly-vinyl alcohol solution, stir, be uniformly coated on the planar metal band that film-forming machine moves by the thickness that mixes up, the hot air drying film forming is rolled and is sheared packing.Such medicine plane membrane has not only become street drug, and " pharmaceutics " write in 1985 in pharmaceutics teaching and research group of Nanjing pharmaceutical college, and the existing full and accurate description of " Chinese Hospitals pharmaceutical journal " nineteen ninety.The Europe patent relates to prescription, the proportioning that a kind of thin film that is applied to oral mucosa also discloses this patent for No. 90101919.0.
Certainly, onesize, above-mentioned plane its dissolution time of medicine membrane and the release amount of medicine of same use are identical.
Purpose of the present invention is exactly in order to provide a kind of macroscopical area identical with plane membrane size, and the microcosmic area increases, and can shorten dissolution time, brings into play the drug non-plane membranous agent and the preparation technology thereof of its curative effect as early as possible, therefore, the present invention has any different in prior art.
The present invention realizes by following scheme.
Adopting polyvinyl alcohol, cellulose, acrylate and medicine to be adjusted to the membrane surface that solution makes and be non-planar, can be the pedion circular arc convex, or two-sided circular arc convex, or single face right angle convex, or perforate, or irregular type.
The preparation technology of drug non-plane membranous agent is adjusted to solution with polyvinyl alcohol, cellulose, acrylate and medicine, is uniformly coated on the film-forming machine crawler type texturing metallograph, and hot air drying becomes drug non-plane membranous agent.
The preparation technology of drug non-plane membranous agent also can be that medicine plane membrane is punched through laser-beam drilling machine, becomes the perforate drug non-plane membranous agent; Or medicine plane membrane ECDC gold texturing are made drug non-plane membranous agent after to roller hot pressing.
The drug non-plane membranous agent macroscopic view area of making like this is identical with plane membrane size, and the microcosmic area obviously increases, accelerated medicine film dissolution velocity and drug releasing rate, controlled membrane Chinese medicine burst size artificially, reached ideal curative effect by changing the long-pending realization of membrane microcosmic surface.For the medicine membrane increases new varieties.
Below in conjunction with drawings and Examples shape and structure of the present invention and technology characteristics are done detailed description.
Fig. 1 is a pedion circular arc convex membrane sketch map.
Fig. 2 is two-sided circular arc convex membrane sketch map.
Fig. 3 is a single face right angle convex membrane sketch map
Fig. 4 is a perforate membrane sketch map.
Fig. 5 is an irregular type membrane sketch map.
Drug non-plane membranous agent is with preparation medicine plane membrane raw material and proportioning are identical at present, and made medicine membrane surface is non-planar, as pedion circular arc convex, two-sided circular arc convex, single face right angle convex, perforate and irregular type.
Its manufacture technology is that polyvinyl alcohol, cellulose, acrylate and medicine are adjusted to solution, stirs, and leaves standstill, degasser removes bubble, be uniformly coated on the film-forming machine crawler type texturing metallograph by the thickness that mixes up, hot air drying becomes non-plane membranous agent, rolls, shears packing.The floral designs of crawler type texturing metallograph, can be pedion circular arc matrix version or two-sided circular-arc concave version or single face right angle matrix version or irregular concavo-convex stencilling, so just can make pedion circular arc convex or two-sided circular arc convex or single face right angle convex or irregular type drug non-plane membranous agent.
The manufacture technology of perforate drug non-plane membranous agent is that the solution that utilizes same raw material and proportioning to mix up is made the plane membrane earlier, treats that its cooling back imports perforation in the laser-beam drilling machine, gets final product;
Also the plane membrane that makes earlier can be imported the alloy texturing in the roller, the alloy texturing are 30-36 ℃ to the roller surface temperature, and the surface is coated with antitack agents such as Polyethylene Glycol, glycerol or other surfactants, through being hot pressed into non-plane membranous agent.The alloy texturing can be selected pedion circular arc convex or two-sided circular arc convex or single face right angle convex or irregular type to roller for use as required to the annular knurl stricture of vagina.
The drug non-plane membranous agent of making like this is the plane membrane relatively, under the equirotal situation of macroscopical area, has increased the microcosmic area, has accelerated dissolution time, obtains satisfied curative effect.
Table 1 contraceptive (NP-9) non-plane membranous agent and plane membrane are relatively
Dosage form surface area cm dissolution time min clinical effective rate %
Plane membrane 60.5 12 91
Nonplanar film 105-270 4-10 97(circular arc type)
The comparison of table 2 pelliculae pro cavo oris medicine (VA) dissolution
Dosage form time min 35 10 30 60 90 120 240
Plane membrane % 1.1 2.4 4.2 5.7 17.8 24.5 46.5 70.2
Nonplanar film % 4.1 6.9 11.2 22.4 38.5 51.4 77.3 98.1
(perforation formula)
Claims (5)
1, a kind of drug non-plane membranous agent is to be adjusted to solution by polyvinyl alcohol, cellulose, acrylate and medicine to make membrane, it is characterized in that this membrane surface is non-planar.
2, membrane according to claim 1 is characterized in that the membrane surface that is non-planar can be the pedion circular arc convex, or two-sided circular arc convex, or single face right angle convex, or perforate, or irregular type.
3, a kind of manufacture technology of drug non-plane membranous agent is adjusted to solution with polyvinyl alcohol, cellulose, acrylate and medicine, it is characterized in that the solution that will mix up is uniformly coated on the film-forming machine crawler type texturing metallograph, and hot air drying forms.
4, a kind of manufacture technology of drug non-plane membranous agent, polyvinyl alcohol, cellulose, acrylate and medicine are adjusted to solution make medicine plane membrane earlier, it is characterized in that medicine plane membrane is punched through laser-beam drilling machine, make the perforate drug non-plane membranous agent.
5, a kind of manufacture technology of drug non-plane membranous agent is adjusted to solution with polyvinyl alcohol, cellulose, acrylate and medicine and makes medicine plane membrane earlier, it is characterized in that medicine plane membrane ECDC gold texturing are made drug non-plane membranous agent after to roller hot pressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93101422 CN1029660C (en) | 1993-02-17 | 1993-02-17 | Drug non-plane membranous agent and its preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93101422 CN1029660C (en) | 1993-02-17 | 1993-02-17 | Drug non-plane membranous agent and its preparation technology |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1091003A CN1091003A (en) | 1994-08-24 |
| CN1029660C true CN1029660C (en) | 1995-09-06 |
Family
ID=4983582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93101422 Expired - Fee Related CN1029660C (en) | 1993-02-17 | 1993-02-17 | Drug non-plane membranous agent and its preparation technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1029660C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4416926C2 (en) * | 1994-05-13 | 2000-01-13 | Lohmann Therapie Syst Lts | Process for the manufacture of devices for the controlled release of active substances |
| DE19646836B4 (en) * | 1996-11-13 | 2006-06-14 | Lts Lohmann Therapie-Systeme Ag | Preparation, consisting of a planar, film or wafer-like dosage form |
| CN101849926B (en) * | 2009-06-12 | 2012-10-03 | 上海现代药物制剂工程研究中心有限公司 | Zolpidem tartrate film |
| CN109077937A (en) * | 2018-07-31 | 2018-12-25 | 刘经校 | A kind of long-acting slow-release facial mask and preparation method thereof |
-
1993
- 1993-02-17 CN CN 93101422 patent/CN1029660C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1091003A (en) | 1994-08-24 |
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| CF01 | Termination of patent right due to non-payment of annual fee |