CN102952152A - Method for synthesising cobalt ion probe - Google Patents
Method for synthesising cobalt ion probe Download PDFInfo
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- CN102952152A CN102952152A CN 201210389131 CN201210389131A CN102952152A CN 102952152 A CN102952152 A CN 102952152A CN 201210389131 CN201210389131 CN 201210389131 CN 201210389131 A CN201210389131 A CN 201210389131A CN 102952152 A CN102952152 A CN 102952152A
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- cobalt ion
- ion probe
- reduced pressure
- probe
- cobalt
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Abstract
The invention discloses a method for synthesising a cobalt ion probe, comprising the following steps of: dissolving BODIPY fluorescent dye and N,N'-m-phenylene-bismaleimide in the mixed solution of ethylbenzene and N,N-dimethylformamide at room temperature; adding dibasic lead phosphate as a catalyst, and performing heating reflux; performing reduced pressure evaporation on a solvent, tracking by a spot board until the raw materials are completely reacted; performing column chromatography; and performing reduced pressure distillation to remove the solvent, thus obtaining a reddish brown product, namely, the cobalt ion probe, wherein according to the invention, a novel cobalt ion probe is synthesised by taking BODIPY as a fluorescent matrix, and taking 4-N,N-diacetyl amide alcohol benzaldehyde as a receptor. Based on no need of a complex pre-treatment, the cobalt ion probe presents high selectivity and sensitivity to Co<2+> in aqueous solution; and researches show that the cobalt ion probe is insensitive to common transition metal ions and heavy metal ions, and represents great selective fluorescence enhancement identification to Co<2+> only.
Description
Technical field
The present invention relates generally to a kind of method of synthesising probing needle, relates in particular to a kind of method of synthetic cobalt ion probe.
Background technology
The English name of cobalt " Cobalt " comes from the Kobold of German, means " bad smart ", because cobalt ore is poisonous, miner, smelter catch an illness when being everlasting work, and cobalt also can pollute other metal, and these ill effects all are counted as smart mischief in the past.Cobalt ore is mainly arsenide, oxide compound and sulfide.In addition, radioactive cobalt-60 can carry out cancer therapy.
Summary of the invention
The object of the invention just provides a kind of method of synthetic cobalt ion probe.
The present invention is achieved by the following technical solutions:
A kind of method of synthetic cobalt ion probe may further comprise the steps:
At ambient temperature, get fluorine boron two pyrroles's fluorescence dye and N, a N '-penylene bismaleimides is dissolved in ethylbenzene and N, in the mixing solutions of N-dimethyl formamide, then add dibasic lead phosphite and make catalyzer, reflux, some plate track to raw material reaction fully after, after the solvent evaporated under reduced pressure, column chromatography, after the underpressure distillation desolventizing, obtain the reddish-brown product, be described cobalt ion probe.
Advantage of the present invention is:
The present invention is take fluorine boron two pyrroles as fluorescence parent, 4-N, and N-diethylamide alcohol phenyl aldehyde is that acceptor has synthesized a kind of novel cobalt ion probe.Do not needing on the complicated pre-treatment basis, in the aqueous solution, Co2+ is shown selectivity and the susceptibility of height, find that it is insensitive to common transition metal and heavy metal ion (Hg2+, Pb2+, Ag+, Zn2+, Pt2+, Cu2+, Ni2+ etc.), only Co2+ is shown fabulous selectivity fluorescence and strengthen identification; Test finds that this probe and cobalt ion have formed 1: 1 complex compound; Cell after experiment has also been obtained nutrient solution through adding cobalt ion and cultivated by fluorescent microscope and the photo of probe effect.In view of single-minded selectivity and the highly sensitive to cobalt ion of this probe, there is clear and definite fluorescence to strengthen response to the cobalt ion in water body, the cell, can predict this probe has good application prospect.
Embodiment
Embodiment 1
A kind of method of synthetic cobalt ion probe may further comprise the steps:
At ambient temperature, get fluorine boron two pyrroles's fluorescence dye and N, a N '-penylene bismaleimides is dissolved in ethylbenzene and N, in the mixing solutions of N-dimethyl formamide, then add dibasic lead phosphite and make catalyzer, reflux, some plate track to raw material reaction fully after, after the solvent evaporated under reduced pressure, column chromatography, after the underpressure distillation desolventizing, obtain the reddish-brown product, be described cobalt ion probe.
Claims (1)
1. the method for a synthetic cobalt ion probe is characterized in that may further comprise the steps:
At ambient temperature, get fluorine boron two pyrroles's fluorescence dye and N, a N '-penylene bismaleimides is dissolved in ethylbenzene and N, in the mixing solutions of N-dimethyl formamide, then add dibasic lead phosphite and make catalyzer, reflux, some plate track to raw material reaction fully after, after the solvent evaporated under reduced pressure, column chromatography, after the underpressure distillation desolventizing, obtain the reddish-brown product, be described cobalt ion probe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210389131 CN102952152A (en) | 2012-10-15 | 2012-10-15 | Method for synthesising cobalt ion probe |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210389131 CN102952152A (en) | 2012-10-15 | 2012-10-15 | Method for synthesising cobalt ion probe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102952152A true CN102952152A (en) | 2013-03-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210389131 Pending CN102952152A (en) | 2012-10-15 | 2012-10-15 | Method for synthesising cobalt ion probe |
Country Status (1)
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| CN (1) | CN102952152A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106632290A (en) * | 2016-11-16 | 2017-05-10 | 淮阴师范学院 | Benzoate compound and synthesis method and application thereof |
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2012
- 2012-10-15 CN CN 201210389131 patent/CN102952152A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106632290A (en) * | 2016-11-16 | 2017-05-10 | 淮阴师范学院 | Benzoate compound and synthesis method and application thereof |
| CN106632290B (en) * | 2016-11-16 | 2019-09-27 | 淮阴师范学院 | A kind of benzoate compounds and its synthetic method and application |
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| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Application publication date: 20130306 |