CN102944516A - Circuit for carrying out biochemical detection by multiple light sources and multiple pore channels - Google Patents
Circuit for carrying out biochemical detection by multiple light sources and multiple pore channels Download PDFInfo
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- CN102944516A CN102944516A CN2012104556455A CN201210455645A CN102944516A CN 102944516 A CN102944516 A CN 102944516A CN 2012104556455 A CN2012104556455 A CN 2012104556455A CN 201210455645 A CN201210455645 A CN 201210455645A CN 102944516 A CN102944516 A CN 102944516A
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Abstract
The invention relates to a circuit for carrying out biochemical detection by multiple light sources and multiple pore channels, which comprises a light emitting loop and a photovoltaic conversion loop. The light emitting loop further comprises a current regulating circuit; the photovoltaic conversion loop further comprises a zero current regulating circuit; a negative feedback amplifier circuit comprises a digital potentiometer RPot3; the current regulating circuit is connected in series with a light emitting diode LED1; the zero current regulating circuit is connected to a joint of the negative end of a silicon photocell cell1 of the photovoltaic conversion loop and the negative input end of an integrated operational amplifier U1A; and the digital potentiometer RPot3 is connected in parallel to the output and negative input ends of the integrated operational amplifier U1A. According to the invention, the light emitting intensities of the light sources are dynamically regulated by adding the current regulating circuit; the influence of a dark current of the silicon photocell is neutralized by adding the current regulating circuit; an amplification factor of a silicon photocell signal is regulated by the digital potentiometer RPot3; and by simultaneously regulating parameters of the circuits, the consistency of all the pore channels is achieved and the differences among the pore channels are reduced.
Description
Technical field
The invention belongs to the medical science photoelectric detecting technology, mainly is spectrophotometric method multiple light courcess multi-pore channel detection field, is specifically related to the circuit that a kind of multiple light courcess multi-pore channel carries out biochemistry detection.
Background technology
Related biochemistry detection is optical detection substantially in the modern medical service check, take fluorometry and spectrophotometric method as main.Wherein in the spectrophotometric method normal operation tungsten lamp and deuterium lamp as light source.Although these light sources meet the demands in performance, they are expensive, and volume and heat dissipation capacity are larger, and aging speed is fast, need often to detect and change.So and be not suitable for the realization of miniature instrument and low-power consumption instrument.
Therefore a lot of checkout equipments have adopted light emitting diode (LED) as detection light source, because light emitting diode has stable luminescence, low in energy consumption, thermal value is little, be difficult for aging characteristic, so deeply be subjected to modern photoelectricity research staff's approval.The receiver of LED source is photoelectric diode and silicon photocell.
Because the light emitting diode characteristic, they can be made into the equipment that the multi-pore channel multiple light courcess detects simultaneously, can improve detection efficiency like this, have also avoided affecting with the integrated moving component of single light source the problem of reliability.Although this kind method advantage is a lot, this hardware design but runs into the problem that detects homogeneity.
As shown in Figure 1, be the simultaneously single branch road electrical schematic diagram of checkout equipment of present multi-pore channel multiple light courcess, it comprises luminous loop, tested product and opto-electronic conversion loop, wherein:
Luminous loop comprises LED1 and the current-limiting resistance R1 of series connection, and voltage is constant in this loop, but the size of electric current is uncontrollable.At first, owing to the internal resistance of each LED1 of reason of LED1 manufacturing process is different, therefore the size with electric current under the voltage is also different, and therefore the current value for a plurality of luminous loop LED1 of multi-pore channel multiple light courcess is unequal.
The opto-electronic conversion loop comprises silicon photocell cell1 and negative feedback amplifier circuit, and the AD conversion port that the outputting analog signal in opto-electronic conversion loop directly accesses microprocessor is used for reading.In the opto-electronic conversion loop, at first silicon photocell is because dark current is different, and therefore the signal of electric current is just different under dark condition, affects consistance and accuracy in the detection signal in the situation that the sensed light signal dark current can be superimposed upon.Photronic sensitivity also is different in addition, that is to say under equal change in optical signal the different phenomenon of current value also to occur, will amplify this difference like this in the process of light signal through amplification, affects consistance and accuracy.
Simultaneously, along with the accumulation of service time, catabiosis can occur in electrical equipment, and aging degree is different, and this has all greatly affected accuracy and consistance that photoelectricity gathers.Nowadays this technical barrier needs to be resolved hurrily.
Summary of the invention
The purpose of patent of the present invention is to overcome the deficiencies in the prior art, provides a kind of multiple light courcess multi-pore channel to carry out the circuit of biochemistry detection.
Patent of the present invention solves its technical matters and takes following technical scheme to realize:
A kind of multiple light courcess multi-pore channel carries out the circuit of biochemistry detection, comprise luminous loop and opto-electronic conversion loop, luminous loop by be connected to+current-limiting resistance R1 between the 5V power supply connects with LED 1 and consists of, the opto-electronic conversion loop comprises silicon photocell cell1 and negative feedback amplifier circuit, and innovative point of the present invention is:
In luminous loop, further include matrix current adjustment circuit; In the opto-electronic conversion loop, further include the zero current Circuit tuning; And in negative feedback amplifier circuit, include digital regulation resistance RPot3.Matrix current adjustment circuit is connected between power supply+5V end and the LED 1; The zero current Circuit tuning is connected on the node of integrated operational amplifier U1A negative input end in silicon photocell cell1 negative terminal and the negative feedback amplifier circuit; Digital regulation resistance RPot3 is connected in parallel in the output and negative input end of integrated operational amplifier U1A.
And described matrix current adjustment circuit adopts the digital regulation resistance RPot1 in parallel at current-limiting resistance R1 two ends.
And, the zero current Circuit tuning comprises: be connected on+5V and-resistance R 2 and resistance R 3 between the 5V, be connected to+5V and-digital regulation resistance RPot2 between the 5V, be connected to the resistance R 4 between the node and integrated operational amplifier negative input end between resistance R 2, the resistance R 3, the link node between an end of resistance R 4 and resistance R 2, the resistance R 3 links to each other with the adjustable side of digital regulation resistance RPot2 jointly.
And digital regulation resistance RPot3 replaces with the simulation potentiometer.
Advantage and the good effect of patent of the present invention are:
1, the present invention is by increasing the zero current Circuit tuning, in and the impact of silicon photocell dark current, remove and detect static interference, strengthen and detect consistance.
2, the present invention adjusts the enlargement factor of silicon photocell signal by digital regulation resistance, and Circuit tuning sensitivity is removed and detected dynamic disturbance, strengthens to detect consistance.
3, the present invention dynamically adjusts light source luminescent intensity by matrix current adjustment circuit, strengthens to detect consistance.
4, to reach all ducts by the circuit parameter of adjusting simultaneously each single channel photoelectricity acquisition system all consistent in the present invention, strengthened greatly the consistance of experiment, and difference has very important significance between the duct to reducing.
Description of drawings
Fig. 1 is the electrical schematic diagram that present multiple light courcess multi-pore channel carries out one of them duct branch road of biochemistry detection equipment;
Fig. 2 is the electrical schematic diagram that multiple light courcess multi-pore channel of the present invention carries out one of them duct branch road of biochemistry detection equipment.
Embodiment
Below in conjunction with accompanying drawing patent working example of the present invention is further described: it is emphasized that embodiments of the invention are illustrative, rather than determinate, can not be with the present embodiment as the restriction to patent of the present invention.
A kind of multiple light courcess multi-pore channel carries out the circuit of biochemistry detection, as shown in Figure 2, comprise luminous loop and opto-electronic conversion loop, luminous loop by be connected to+current-limiting resistance R1 between the 5V power supply connects with LED 1 and consists of, the opto-electronic conversion loop comprises that innovative point of the present invention is among the silicon photocell cell1 and negative feedback amplifier circuit that receives LED 1 light signal in the luminous loop:
In luminous loop, further include matrix current adjustment circuit, in the opto-electronic conversion loop, further include the zero current Circuit tuning, and in negative feedback amplifier circuit, comprise digital regulation resistance RPot3, matrix current adjustment circuit is connected between power supply+5V end and the LED 1, the zero current Circuit tuning is connected on the node of integrated operational amplifier U1A negative input end in silicon photocell cell1 negative terminal and the negative feedback amplifier circuit, and digital regulation resistance RPot3 is connected in parallel in the output and negative input end of integrated operational amplifier U1A.
Example 1
In implementation of the present invention, be connected to described in the luminous loop power supply+matrix current adjustment circuit between 5V end and the LED 1, can adopt the digital regulation resistance RPot 1 in parallel at current-limiting resistance R1 two ends, regulate the electric current of LED 1 by the resistance of regulating digital regulation resistance RPot 1, thereby regulate the light intensity that LED 1 sends.
Example 2
In implementation of the present invention, be connected to described in the luminous loop power supply+matrix current adjustment circuit between 5V end and the LED 1, also can adopt the simulation potentiometer directly to replace current-limiting resistance R1, change the light intensity that LED 1 sends by the adjusting of simulating potentiometer resistance.
Example 3
In implementation of the present invention, describedly be connected to that the zero current Circuit tuning on the integrated operational amplifier U1A negative input end node comprises in silicon photocell cell1 negative terminal and the negative feedback amplifier circuit: be connected on+5V and-resistance R 2 and resistance R 3 between the 5V, be connected to+5V and-digital regulation resistance RPot2 and resistance R 4 between the 5V, link node between resistance R 2, the resistance R 3 links to each other with the adjustable side of digital regulation resistance RPot2, and the link node between resistance R 2, the resistance R 3 is by the negative input end of resistance R 4 access integrated operational amplifiers.
In the zero current Circuit tuning of above implementation, by regulating the position, adjustable side of digital regulation resistance RPot2, can change the electric current that flows out the output of zero current Circuit tuning, this positive and negative size all adjustable electric current can in and silicon photocell self dark current, finally making under the unglazed irradiating state electric current of input negative feedback amplifier circuit negative input end is zero.Certainly, the zero current Circuit tuning of this kind form also can replace with the simulation potentiometer.
Example 4
In implementation of the present invention, be connected in parallel on the output terminal of integrated operational amplifier in the negative feedback amplifier circuit and the digital regulation resistance RPot3 between the negative input end, change the enlargement factor of feedback amplifier by the position of adjusting digital regulation resistance RPot3 adjustable side, certainly, digital regulation resistance RPot3 also can replace with the simulation potentiometer, regulate the enlargement factor that changes feedback amplifier, thereby change the sensitivity that receives signal.
Principle of work of the present invention and step are:
⑴ power up to the opto-electronic conversion loop;
⑵ adjust the resistance value output of the digital regulation resistance RPot2 in the zero current Circuit tuning in whole ducts, is being 0 without the AD conversion delivery outlet that makes the opto-electronic conversion loop under the optical condition at voltage;
⑶ record the resistance value M of whole duct digital regulation resistance RPot2;
⑷ power up for luminous loop;
⑸ the digital regulation resistance RPot1 that adjust in the matrix current adjustment circuit in whole ducts is same resistance value A;
⑹ read the opto-electronic conversion output voltage loop value a in whole ducts, the line number of going forward side by side value record from the AD translation interface;
⑺ the digital regulation resistance RPot1 that adjust in the matrix current adjustment circuit in whole ducts is same resistance value B, B〉A;
⑻ read the opto-electronic conversion output voltage loop value b in whole ducts, the line number of going forward side by side value record from the AD translation interface;
⑼ this moment all ducts are used simultaneously (A, a) value of (B, b) two points is brought the sensitivity curve formula y=kx+d of silicon photocell into, and (bring A, B into x, with a, b brings y into) calculates sensitivity parameter k and constant d;
⑽ with the k phase adduction in all ducts k' that averages to get;
⑾ be replaced by average k' with the k value of the sensitivity curve in all ducts, obtains the sensitivity curve y=k'x+d in each duct, and bring B into curve and obtain the magnitude of voltage Y that should obtain;
⑿ the digital regulation resistance RPot1 that adjust in the matrix current adjustment circuit in whole ducts is same value B;
⒀ adjust the digital regulation resistance RPot3 of negative feedback amplifier circuit, and the opto-electronic conversion output voltage loop value that makes all ducts is all consistent with the Y value that draws with self sensitivity curve, and record the value C of digital regulation resistance RPot3;
⒁ record the value B of the digital regulation resistance RPot1 in all ducts; The value R of RPot2; The value C of RPot3;
⒂ input same resistance value B with the digital regulation resistance RPot1 in all ducts when carrying out the sample experiment; The resistance value R in the separately duct that the digital regulation resistance RPot2 input in the zero current Circuit tuning in all ducts is determined when dark current is debugged; The resistance value C in the separately duct that the digital regulation resistance RPot1 in negative feedback amplifier circuit input was determined when the adjusting stage.To obtain one group and have very high conforming collection duct this moment.
Claims (4)
1. a multiple light courcess multi-pore channel carries out the circuit of biochemistry detection, comprise luminous loop and opto-electronic conversion loop, luminous loop by be connected to+current-limiting resistance R1 between the 5V power supply connects with LED 1 and consists of, the opto-electronic conversion loop comprises silicon photocell cell1 and negative feedback amplifier circuit, it is characterized in that:
In luminous loop, further include matrix current adjustment circuit, in the opto-electronic conversion loop, further include the zero current Circuit tuning, and in negative feedback amplifier circuit, include digital regulation resistance RPot3, matrix current adjustment circuit is connected between power supply+5V end and the LED 1, the zero current Circuit tuning is connected on the node of integrated operational amplifier U1A negative input end in silicon photocell cell1 negative terminal and the negative feedback amplifier circuit, and digital regulation resistance RPot3 is connected in parallel in the output and negative input end of integrated operational amplifier U1A.
2. multiple light courcess multi-pore channel according to claim 1 carries out the circuit of biochemistry detection, it is characterized in that: described matrix current adjustment circuit, adopt the digital regulation resistance RPot1 in parallel at current-limiting resistance R1 two ends.
3. multiple light courcess multi-pore channel according to claim 1 carries out the circuit of biochemistry detection, it is characterized in that: the zero current Circuit tuning comprises: be connected on+5V and-resistance R 2 and resistance R 3 between the 5V, be connected to+5V and-digital regulation resistance RPot2 between the 5V, be connected to the resistance R 4 between the node and integrated operational amplifier negative input end between resistance R 2, the resistance R 3, the link node between an end of resistance R 4 and resistance R 2, the resistance R 3 links to each other with the adjustable side of digital regulation resistance RPot2 jointly.
4. multiple light courcess multi-pore channel according to claim 1 carries out the circuit of biochemistry detection, it is characterized in that: digital regulation resistance RPot3 replaces with the simulation potentiometer.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012104556455A CN102944516A (en) | 2012-11-13 | 2012-11-13 | Circuit for carrying out biochemical detection by multiple light sources and multiple pore channels |
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| CN2012104556455A CN102944516A (en) | 2012-11-13 | 2012-11-13 | Circuit for carrying out biochemical detection by multiple light sources and multiple pore channels |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111562237A (en) * | 2020-05-26 | 2020-08-21 | 中国科学院合肥物质科学研究院 | CO based on double-beam cavity enhanced spectroscopy technology2、N2O stable isotope simultaneous detection device and method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111562237A (en) * | 2020-05-26 | 2020-08-21 | 中国科学院合肥物质科学研究院 | CO based on double-beam cavity enhanced spectroscopy technology2、N2O stable isotope simultaneous detection device and method |
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Application publication date: 20130227 |