CN102944500A - Passageway device and system for detecting viscosity of liquid as well as application thereof - Google Patents

Passageway device and system for detecting viscosity of liquid as well as application thereof Download PDF

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Publication number
CN102944500A
CN102944500A CN2012104412548A CN201210441254A CN102944500A CN 102944500 A CN102944500 A CN 102944500A CN 2012104412548 A CN2012104412548 A CN 2012104412548A CN 201210441254 A CN201210441254 A CN 201210441254A CN 102944500 A CN102944500 A CN 102944500A
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channel
lane device
viscosity
buffer channel
titer
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CN102944500B (en
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蔡绍皙
邹米莎
赵振礼
樊欣
陈龙聪
陈斯佳
赵毅
何腾龙
李博
柯明
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Chongqing University
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Chongqing University
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Abstract

The invention belongs to the field of bioengineering, particularly relates to detection equipment and technology of micro-flow controlled viscosity, and relates to a passageway device for detecting viscosity of liquid. The functional units of the passageway device comprise a measuring main passageway and a buffer passageway, wherein the buffer passageway is connected and in parallel with the measuring main passageway, the diameter of the buffer passageway is larger than that of the measuring main passageway, the length of the buffer passageway is smaller than that of the measuring main passageway, and the measuring main passageway and the buffer passageway are cylindrical passageways; the passageway device comprises at least one functional unit, and a plurality of functional units are preferred and gathered; the determination method of viscosity is based on the Poiseuille principle; the device is a micro-upgrading device, which is provided with high accuracy and precision; and the method has the advantages of high repeatability and small consumption of reagent, thus the device can be used for measuring Newton fluid and non-Newton fluid.

Description

Lane device and system and application thereof for detection of liquid viscosity
Technical field
The invention belongs to the apparatus field, particularly the checkout equipment of micro-fluidic viscosity and technology.
Background technology
Viscosity and many departments of measuring in national economy thereof all have a wide range of applications, for example oil (oil extraction with transport, the grade estimation of petroleum products, the mixing of oil product etc.), chemical industry (paint, coating, bonding agent, three large synthetic material---plastics, rubber, synthon etc.), light industry (weaving, papermaking, cosmetics etc.), food (cream, chocolate, jam etc.), building materials (glass, pottery, cement etc.), coal, metallurgical fields such as (motlten metal and slags etc.), viscosity measurement is related to the production control flow process, guarantees safety in production, the aspects such as control and evaluation product quality; Especially at field of medicaments, hemorheological property (comprises blood viscosity, plasma viscosity etc.) directly have influence on the resistance of blood flow, closely related with the multiple pathological processes of human body, be one of the cardiovascular and cerebrovascular diseases such as headstroke, coronary heart disease, hypertension, high fat of blood, artery sclerosis clinical detection index commonly used at present, viscosity measurements becomes one of important means of medical diagnosis.
In recent years, along with the rise of micro-fluidic chip technology, the application of viscosity measurement in scientific research also more and more is subject to people's attention.Micro-fluidic chip (microfluidic chi p) refers to: become circuit the same the function element image sets such as microchannel, Micropump, little valve, little reservoir, microelectrode, little detecting element window and connector by Micrometer-Nanometer Processing Technology, they are integrated on the chip material; Be intended to the sample preparation that the fields such as biological and chemical is related, biological and chemical reaction, separate with the basic operation unit such as detections and be integrated on more than one square centimeters the chip, react in order to finish different biological or chemicals, and its product is analyzed.The Fluid Flow in A of research in the chip is one of the key factor that affect design of micro-fluidic chip, and the viscosity relationship of fluid is controlled to the precision that flows of inner fluid passage, and therefore, the viscosity measurement technology also becomes one of emphasis of researcher.
The tradition method for detecting viscosity mainly contains capillary tube technique and two kinds of main stream approach of rotary process, and capillary tube technique Main Basis Poiseuille law is measured, and commonly used is gravity-type capillary tube technique (being mainly used in the petroleum products), and the compression type capillary tube technique etc.It is also to measure the important method of polymer substance molecular weight that capillary tube technique is measured Viscosity of Polymer Solutions.The rotary process viscosity measurement also is a kind of relatively ripe measuring method, and the rotating speed difference that acts on the viscosity moment of object or object by test fluid is determined the viscosity of fluid.Having in the world many famous brand names company to develop a series of rotary flow graphs is widely used in the various industrial trades.
For the measurement requirement of different material, also have falling ball method, vibratory drilling method, flat band method, viscosity agar diffusion method and various modification methods on this basis.Development along with science and technology, Viscosity Measurement Methods is also towards microminiaturized and quick, accurate future development, in recent years, there is research to report many emerging microviscometer designs, these microviscometer consumptions only need microlitre and even receive upgrading not, even can measure the rheological properties of Bacterial biofilm, even the viscosity of cell liquid also becomes possibility.
Summary of the invention
The object of the present invention is to provide a kind of viscosity apparatus, described viscosity apparatus is micro updating viscosity detecting device and the system take the Poiseuille law as basic engineering, and degree of accuracy is high, and configuration is simple.
For achieving the above object, technical scheme of the present invention is:
Lane device for detection of liquid viscosity, the functional unit of described lane device comprises measures main channel and buffer channel, one end of described buffer channel connects with described measurement main channel and is parallel, the diameter of described buffer channel is greater than the diameter of measuring the main channel, the length of described buffer channel is less than the length of measuring the main channel, and described measurement main channel and buffer channel are the right cylinder passage.Described lane device contains at least one functional unit, preferably gathers a plurality of described functional units.
Preferably, described lane device is micro fluidic device, and described measurement main channel length is no less than 4 centimetres, and diameter is the 0.15-1 millimeter; The diameter of described buffer channel is 10-20 times of described measurement main channel.Described lane device is prepared from transparent material, selects transparent material to be convenient to observe.When the length of measuring the main channel during less than 4 centimetres, the result precision step-down of test; The diameter of described main channel is selected the 0.15-1 millimeter, has embodied the advantage of " trace "; But diameter is during less than 0.15 millimeter, the result precision step-down of test.
Preferably, described measurement main channel and buffer channel are the horizontal channel.The horizontal channel can reduce the error that the liquid potential difference is brought.But even so, the error brought of the liquid potential difference of trace level itself is less.
Preferably, the other end of described measurement main channel is connected with tension force and offsets passage.
Preferably, the diameter that described tension force is offset passage be buffer channel diameter 0.9-1.1 doubly, the length that described tension force is offset passage be buffer channel length 0.9-1.1 doubly.
Preferably, the other end of described buffer channel is connected with feed tube.The setting of feed tube can avoid liquid to omit on the utility appliance outside the micro-fluidic viscosity apparatus.
Preferably, described lane device is made by transparent material.Transparent material is convenient to observation.
The system that contains described lane device, described system comprise thermostat and the lane device that places thermostat, and the buffer channel of described lane device or feed tube are connected with the constant voltage drive unit, and the top of described buffer channel is equipped with video-unit.
Two of purpose of the present invention is to provide the detection method of liquid viscosity, and the method is based on the Poiseuille law, and the method error is little, expends reagent little, has very high repeatability and high precision.
Measure the method for liquid viscosity based on described lane device, specifically may further comprise the steps:
The parameter measurement of A titer and testing sample
The titer of known-viscosity is added in the described lane device with constant pressure p, and described titer flows to described measurement main channel from described buffer channel, observes described titer flow through described buffer channel apart from l and the time t that needs, and wherein, is designated as l apart from l Mark, the time, t was designated as t MarkTesting sample is added in the described lane device with constant pressure p, and described testing sample flows to described measurement main channel from described buffer channel, observes described titer flow through described buffer channel apart from l and the time t that needs, and wherein, is designated as l apart from l Survey, the time, t was designated as t Survey
The viscosity calculations of B testing sample
The l that steps A is recorded Mark, t Mark, l SurveyAnd t SurveyAmong the substitution formula I, try to achieve the viscosity number of testing sample; Among the described formula I, η MarkBe the viscosity number of described titer, for known; η SurveyViscosity number η for described testing sample;
Figure BDA00002369409400031
I。
Or
Measure the method for liquid viscosity based on described lane device, specifically may further comprise the steps:
The parameter measurement of A titer and testing sample
The titer of known-viscosity is added in the described lane device with constant pressure p, and described titer flows to described measurement main channel from described buffer channel, and observation described titer in official hour t is flowed through described buffer channel apart from l, wherein, is designated as l apart from l MarkTesting sample is added in the described lane device with constant pressure p, and described testing sample flows to described measurement main channel from described buffer channel, and observation described titer in official hour t is flowed through described buffer channel apart from l, wherein, is designated as l apart from l Survey
The viscosity calculations of B testing sample
The l that steps A is recorded MarkAnd l SurveyAmong the substitution formula II, try to achieve the viscosity number of testing sample; Among the described formula II, η MarkBe the viscosity number of described titer, for known; η SurveyViscosity number η for described testing sample;
Figure BDA00002369409400041
II。
Further, in the steps A, the video-unit that is used for catching liquid flow is installed above described buffer channel, described video-unit is equipped with video recording software, described l MarkAnd l SurveyFluid Flow in A situation pixel and calculating by video-unit monitoring and comparison different time sections obtain.
Further, described method is carried out under constant temperature.
Beneficial effect of the present invention is: 1) the detection reagent of micro fluidic device employing is few; 2) this method accuracy is high; 3) this method favorable repeatability; 3) because drive unit can give constant pressure, at pressure one regularly, flowing velocity is certain, and shear rate is also certain, so, can detect the viscosity of the fluid under the specific shear rate, can be used for the detection of Newton and non-Newton fluid; 4) data error of measuring with the shooting acquisition equipment is little; 5) this device manufacture craft is simple, need not by exact instrument; 6) this installation cost is low; 7) this device is suitable for the multisample detection, can reduce to greatest extent the error that space, time and temperature are brought.
Description of drawings
Fig. 1 is the structural representation of this lane device.
Fig. 2 is the system architecture schematic diagram of lane device.
Embodiment
Illustrated embodiment is in order better content of the present invention to be described, but is not that content of the present invention only limits to illustrated embodiment.So those of ordinary skill in the art carry out nonessential improvement and adjustment according to the foregoing invention content to embodiment, still belong to protection scope of the present invention.
Micro fluidic device: the basic operation units such as the sample preparation of biological, chemistry, medical analysis process, reaction, separation, detection are integrated on the chip of a micro-meter scale, automatically finish the analysis overall process.
First is based on the formula of Poiseuille law
Poiseuille law: when fluid is done laminar motion in horizontal pipe, the pressure difference Δ p (p) at its volume flow Q and pipe two ends, the radius r of measurement main channel, (described measurement main channel) length L, and the viscosity number η of fluid has following relation:
Figure BDA00002369409400051
η = π R 4 P 8 QL
(formula III);
(formula IV);
Figure BDA00002369409400054
(formula V)
(formula VI)
(formula I)
When t survey=t timestamp, have formula II as follows:
In the above-mentioned formula, S is the sectional area of described buffer channel 2, v is the average flow velocity of liquid (Newtonian fluid or non-Newtonian fluid) in described buffer channel 2, t is liquid in the described 2 interior needed times of mobile certain distance of buffer channel, and l is the distance of liquid in the described 2 interior mobile t times of buffer channel.
The preparation of the micro-fluidic viscosity apparatus of the embodiment 1-8 of first
Embodiment 1 is for detection of the lane device of liquid viscosity, the functional unit of described lane device 5 comprises measures main channel 1 and buffer channel 2, described buffer channel 2 and described measurement main channel 1 level connection joint, the diameter of described buffer channel 2 is greater than the diameter of measuring main channel 1, the length of described buffer channel 2 is less than the length of measuring main channel 1, and described measurement main channel 1 and buffer channel 2 are the right cylinder passage.
Embodiment 2 is as the preferred embodiment of embodiment 1, and described lane device 5 is micro fluidic device, and described measurement main channel 1 length is no less than 4 centimetres, and diameter is the 0.15-1 millimeter; The diameter of described buffer channel 2 is 10-20 times of described measurement main channel 1.The micro fluidic device of the present embodiment, main channel 1 length is not 6.5 centimetres, diameter is 0.2 millimeter; The diameter of described buffer channel 2 is 12 times of described measurement main channel 1.
Embodiment 3 is as the preferred embodiment of embodiment 2, and described measurement main channel 1 and buffer channel 2 are the horizontal channel.
Embodiment 4 is as the preferred embodiment of embodiment 3, and the other end of described measurement main channel 1 is connected with tension force and offsets passage 3.
Embodiment 5 is as the preferred embodiment of embodiment 4, and the 0.9-1.1 of the diameter of described tension force counteracting passage 3 and the diameter that length is respectively buffer channel 2 and length doubly.The diameter that tension force described in the present embodiment is offset passage 3 and buffer channel 2 is identical with length.
Embodiment 6 is as the preferred embodiment of embodiment 5, and described buffer channel 2 links to each other with feed tube 4.
Embodiment 7 is as the preferred embodiment of embodiment 6, and described lane device is made by transparent material, and the present embodiment is selected dimethyl silicone polymer (PDMS).
Embodiment 8
The system that contains described lane device, described system comprises thermostat 6 and places the lane device 5 (lane device of embodiment 7) of thermostat 6, buffer channel 2 or the feed tube 4 of described lane device 5 are connected with the constant voltage drive unit, described constant voltage drive unit is U-shaped pipe pressure device, and its use principle can be with reference to " the manometric analysis of uncertainty in measurement of U-shaped and the improvement " of Ma Shilong etc.; The top of described buffer channel 2 is equipped with catches liquid at the video-unit 7 of buffer channel mobility status, and described screen device 7 has video recording software.Light source 8 is equipped with in the top of video-unit 7.
The application of second portion lane device
Embodiment 9
(1) method step
8 preparations contain the method for the systematic survey water viscosity of described lane device based on embodiment, specifically may further comprise the steps:
The parameter measurement of A titer and testing sample
The titer of known-viscosity is added in the described lane device 5 with constant pressure p, described titer flows to described measurement main channel (1) from described buffer channel 2, observation is the described titer (water under 20 ℃ of conditions in official hour t, its viscosity number is 1.002mPas) the described buffer channel 2 of flowing through is apart from l, wherein, be designated as l apart from l Mark
With the testing sample (water under the condition of different temperatures, see table 1 for details) add in the described lane device with constant pressure p, described testing sample flows to described measurement main channel 1 from described buffer channel 2, observation described titer in official hour t is flowed through described buffer channel 2 apart from l, wherein, be designated as l apart from l SurveyWhen using the shooting acquisition equipment to l SurveyAnd l MarkWhen measuring, convert by pixel apart from l, write " the MATLAB image/video is processed and used and example " book with reference to Yang Gaobo etc.Except using the shooting acquisition equipment, conventional distance measurement tools all can be used for measuring apart from l.
The viscosity calculations of B testing sample
The l that steps A is recorded MarkAnd l SurveyAmong the substitution formula II, try to achieve the viscosity number of testing sample; Among the described formula II, η MarkBe the viscosity number of described titer, for known; η SurveyViscosity number for described testing sample;
Figure BDA00002369409400081
II。
(2) use screen device to measure l MarkAnd l SurveyValue
See " the MATLAB image/video is processed and used and example " book that Yang Gaobo etc. writes for details.Or Yu Songyu, perigene China, Zhang Rui etc. write " Digital Image Processing " book.
(3) result
Table 1 testing result
Compare with the practical viscosity value of announcing, the measuring error of this chip is less than 1%, and relative error is 0.8986%.
Embodiment 10
(1) method step
Measure the method for liquid viscosity based on lane device claimed in claim 1, specifically may further comprise the steps:
The parameter measurement of A titer and testing sample
The titer of known-viscosity is added in the described lane device with constant pressure p, described titer flows to described measurement main channel 1 from described buffer channel 2, observe the described titer (water under 20 ℃ of conditions, its viscosity number is 1.002mPas) the time t of described buffer channel 2 apart from l and needs flows through, wherein, be designated as l apart from l Mark, the time, t was designated as t MarkTesting sample is added in the described lane device with constant pressure p, and described testing sample flows to described measurement main channel 1 from described buffer channel 2, observes described titer flow through described buffer channel 2 apart from l and the time t that needs, and wherein, is designated as l apart from l Survey, the time, t was designated as t Survey
The viscosity calculations of B testing sample
The l that steps A is recorded Mark, t Mark, l SurveyAnd t SurveyAmong the substitution formula I, try to achieve the viscosity number of testing sample; Among the described formula I, η MarkBe the viscosity number of described titer, for known; η SurveyViscosity number for described testing sample;
Figure BDA00002369409400091
l。
(2) use screen device to measure l MarkAnd l SurveyValue
See " the MATLAB image/video is processed and used and example " book that Yang Gaobo etc. writes for details.
(3) result
Use this method to test DMEM high glucose medium under 37 ℃ of conditions, its viscosity number η is 0.7439 milli handkerchief second (mPas).
Explanation is at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although with reference to preferred embodiment the present invention is had been described in detail, those of ordinary skill in the art is to be understood that, can make amendment or be equal to replacement technical scheme of the present invention, and not breaking away from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.

Claims (12)

1. for detection of the lane device of liquid viscosity, it is characterized in that, described lane device (5) comprises measures main channel (1) and buffer channel (2), one end of described buffer channel (2) connects with described measurement main channel (1) and is parallel, the diameter of described buffer channel (2) is greater than the diameter of measuring main channel (1), the length of described buffer channel (2) is less than the length of measuring main channel (1), and described measurement main channel (1) and buffer channel (2) are the right cylinder passage.
2. lane device according to claim 1 is characterized in that, described measurement main channel (1) length is no less than 4 centimetres, and diameter is the 0.15-1 millimeter; The diameter of described buffer channel (2) is 10-20 times of described measurement main channel (1).
3. lane device according to claim 1 is characterized in that, described measurement main channel (1) and buffer channel (2) are the horizontal channel.
4. lane device according to claim 1 is characterized in that, the other end of described measurement main channel (1) is connected with tension force and offsets passage (3).
5. lane device according to claim 4, it is characterized in that, the diameter that described tension force is offset passage (3) be buffer channel (2) diameter 0.9-1.1 doubly, the length that described tension force is offset passage (3) be buffer channel (2) length 0.9-1.1 doubly.
6. lane device according to claim 1 is characterized in that, the other end connection of described buffer channel (2) is provided with feed tube (4).
7. lane device according to claim 1 is characterized in that, described lane device is made by transparent material.
8. measure the method for liquid viscosity based on lane device claimed in claim 1, it is characterized in that, specifically may further comprise the steps:
The parameter measurement of A titer and testing sample
The titer of known-viscosity is added in the described lane device with constant pressure p, described titer flows to described measurement main channel (1) from described buffer channel (2), observe described titer flow through described buffer channel (2) apart from l and the time t that needs, wherein, be designated as l apart from l Mark, the time, t was designated as t MarkTesting sample is added in the described lane device with constant pressure p, described testing sample flows to described measurement main channel (1) from described buffer channel (2), observe described titer flow through described buffer channel (2) apart from l and the time t that needs, wherein, distance 1 is designated as l Survey, the time, t was designated as t Survey
The viscosity calculations of B testing sample
The l that steps A is recorded Mark, t Mark, l SurveyAnd t SurveyAmong the substitution formula I, try to achieve the viscosity number of testing sample; Among the described formula I, η MarkBe the viscosity number of described titer, for known; η SurveyViscosity number η for described testing sample;
I。
9. measure the method for liquid viscosity based on lane device claimed in claim 1, it is characterized in that, specifically may further comprise the steps:
The parameter measurement of A titer and testing sample
The titer of known-viscosity is added in the described lane device (5) with constant pressure p, described titer flows to described measurement main channel (1) from described buffer channel (2), observation described titer in official hour t described buffer channel (2) distance L of flowing through, wherein, distance L is designated as L MarkTesting sample is added in the described lane device with constant pressure p, described testing sample flows to described measurement main channel (1) from described buffer channel (2), observation described titer in official hour t is flowed through described buffer channel (2) apart from l, wherein, is designated as l apart from l Survey
The viscosity calculations of B testing sample
The l that steps A is recorded MarkAnd l SurveyAmong the substitution formula II, try to achieve the viscosity number of testing sample; Among the described formula II, η MarkBe the viscosity number of described titer, for known; η SurveyViscosity number η for described testing sample;
Figure FDA00002369409300022
II。
10. according to claim 8 or 9 described methods, it is characterized in that: in the steps A, describedly measure with the video-unit (7) of catching liquid flow apart from l, described video-unit is equipped with video recording software.
11. method according to claim 10 is characterized in that: described method is carried out under constant temperature.
12. contain the system of lane device claimed in claim 1, it is characterized in that: described system comprises thermostat (6) and places the lane device (5) of thermostat (6), buffer channel (2) or the feed tube (4) of described lane device (5) are connected with the constant voltage drive unit, and the top of described buffer channel (2) is equipped with video-unit (7).
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