CN102935017B - Large and small Mus breathing mask Universal fixer - Google Patents
Large and small Mus breathing mask Universal fixer Download PDFInfo
- Publication number
- CN102935017B CN102935017B CN201210360998.7A CN201210360998A CN102935017B CN 102935017 B CN102935017 B CN 102935017B CN 201210360998 A CN201210360998 A CN 201210360998A CN 102935017 B CN102935017 B CN 102935017B
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- breathing mask
- face shield
- holder
- small mus
- base
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Abstract
Large and small Mus breathing mask has played important effect preparing in chronic myocardial ischemia model, solve bottleneck problem prepared by model, survival rate prepared by model brings up to more than 90% by 40%, work efficiency improves more than 4 times, this holder is specially for the fixing of large and small Mus breathing mask and design and manufacture, be one of our serial experiment achievement in research, there is not been reported both at home and abroad at present.Face shield Universal fixer is fixed two parts by base and face shield and is formed (figure).Base is made up of jawbone holder entrance (figure 1.), jawbone holder locker (figure 2.), sliding tray (figure 3.), operating-table fixing hole (figure 4.); Face shield standing part is made up of breathing mask bar entrance (figure 5.), face shield rod locking device (figure 6.), sliding tray unlock button (figure 7.).This holder has the features such as easy and simple to handle, stable performance, is easy to be extended and applied, has market application foreground widely.
Description
Technical field
This holder is specially for large and small Mus breathing mask is fixed and design and manufacture.The development and application of large and small Mus breathing mask, (rat breathing mask obtains invention patent mandate can well to solve bottleneck problem prepared by large and small Mus chronic myocardial ischemia model, the patent No. is: ZL 200810150927.8), be applicable in medical science cardiovascular field with the basic research that is platform of large and small Mus acute and chronic myocardial ischemia model, applied research and the research of mechanism of drug action and the evaluation etc. of therapeutic effect.
Background technology
Myocardial ischemia, myocardial infarction and heart failure are the large killers of one in human diseases, cause the great attention of domestic and international medical circle already, and its research is also constantly being goed deep into, and achieves gratifying achievements.But a large amount of study mechanism and drug research are all based on acute myocardial ischemia, and it is fewer for the research of chronic myocardial ischemia, one of them topmost reason is: success rate prepared by large and small Mus chronic myocardial ischemia model is low, mortality rate is high, experimental period is long, these have become the bottleneck problem of restriction chronic myocardial ischemia research, are not well solved for a long time.In the face of these problems, We conducted a large amount of zooperies, to in large and small Mus art and postoperative death reason analyze and study, find in large dead mouse 90% to be because respiratory tract obstruction/suffocating caused, the subject matter of Mus postoperative death sized by one-tenth, the large and small Mus breathing mask that we develop in earlier stage fundamentally can solve the problem of postoperative respiratory tract obstruction.
Through the experimentation in early stage, the rat breathing mask of development, success rate prepared by rat chronic myocardial infarction and ischemia model is increased to more than 90% by original less than 50%, fundamentally solve the postoperative problem of death caused because of dyspnea of rat, technique obtained invention patent mandate in 2010.Mouse breathing face shield, through zoopery, is also confirmed, is now just setting about the associated materials preparing to declare patent.The large and small Mus chronic myocardial ischemia model novel preparation method that we set up, solve the key issue in model preparation, for the ease of the promotion and application of this technical method, Aided design manufactures large and small Mus breathing mask Universal fixer.The development of large and small Mus breathing mask Universal fixer, can solve the problems such as breathing mask and head be fixing, easily for the application of large and small Mus breathing mask provides strong supporting role.
Because the development of Universal fixer has no report at home and abroad, also without like product, belong to original innovation technology, there is good application prospect, therefore, special patent protection.
Summary of the invention
Large mice breathing mask Universal fixer is fixed two parts by base and face shield and is formed (Fig. 1).Base is made up of jawbone holder entrance (Fig. 1 1.), jawbone holder locker (Fig. 1 2.), sliding tray (Fig. 1 3.), operating-table fixing hole (Fig. 1 4.); Face shield standing part is made up of breathing mask bar entrance (Fig. 1 5.), face shield rod locking device (Fig. 1 6.), sliding tray unlock button (Fig. 1 7.).Jawbone holder is that metal material is made, and front end is the ellipse of opening, its diameter scalable, and rear end is the hand-hole of two parallel tinsel inserted base front ends, and be fixed by locker, Main Function is the head (Fig. 2) of fixed size Mus.Be provided with the fixing hole be connected with operating-table in the rear end of base, used fixing hole face shield holder base and operating-table to be fixed, and played the effect of firm holder.The both sides of respiratory surface cover body are provided with face shield fixed bar, fixed bar are inserted face shield holder entrance, are fixed by locker, and Main Function combines breathing mask and face shield holder together (Fig. 3).Press sliding tray unlock button, face shield holder can be movable on base along sliding tray, and the optimum state that adjustment breathing mask and head coincide unclamps sliding tray unlock button and can fix (Fig. 4).Detailed method of operation is shown in detailed description of the invention.
The large mice breathing mask that we carry out and large mice breathing mask Universal fixer serial experiment research work, its object is exactly to solve rat in art and postoperatively ductus nasopharyngeus can be kept to have air-flow to pass through and not blocked, the problem of the dyspnea that effective prevention of postoperative occurs or the serious respiratory tract obstruction such as to suffocate, considerably improve success rate, stability and work efficiency prepared by large mice myocardial infarction and ischemia model, sized by Mus chronic myocardial ischemia research built reliable zoopery platform.Because this research work has no report both at home and abroad, we when without any data can reference, the completely independent design and fabrication work carrying out large mice face shield Universal fixer.
In design and fabrication, emphasis solves following three critical problems:
(1) breathing mask Universal fixer base designs
The jawbone holder that 1, will be applicable to varying in size fixing.In order to address this problem, we devise rat mandible holder entrance and mice jawbone holder entrance respectively before face shield holder base, being provided with locker in the both sides of base, after jawbone holder inserts from entrance, good fixed effect can being played by regulating locker.
2, face shield Universal fixer base and operating-table is fixing.In order to convenient to operation, we are at back end design fixing hole and the locker of face shield holder base, and operating-table is provided with fixed bar, inserted by fixed bar, play the fixation of base and operating-table by locker after being locked from the fixing hole base.
3, the connection of base and top breathing mask standing part.Can move forward and backward on base to make face shield standing part, we are provided with the mobile chute of strip in the centre of submounts, be connected with the sliding tray unlock button on face shield holder with pull bar, play face shield standing part on base movement and fixation.
(2) breathing mask Universal fixer functional design
1, the fixing of large mice breathing mask will be applicable to.The different diameters of large mice respiratory surface is very large, in order to realize the general fixing of large mice breathing mask, we are in the front end of face shield holder, devise applicable large mice breathing mask fixed bar patchhole respectively, side is provided with locker, after face shield fixed bar inserts from entrance, played the fixation of face shield by the locker of side.
2, breathing mask and large mouse head is fixing.After breathing mask is fixing, the fixing of face shield and head can be realized by sliding tray unlock button, press sliding tray unlock button, can driven forward face shield holder, breathing mask also moves forward thereupon, when after face shield and head close contact, unclamping sliding tray unlock button can play fixation.
(3) design that constant breathing mask and head are fixing.
The hard contact that fixedly belongs to of the breathing mask of setting forth above and head is fixed, this fixing means is along with the change of large mice head position, the seal of breathing mask and head contact can be affected, can not ensure that animal is opening the positive pressure respiration in breast situation, even can cause the death of animal.For this problem, we are through repeatedly zoopery, finally between breathing mask connecting rod and face shield holder, increase elastic pressure buffer unit, this device can when animal head position changes, still can ensure respiration the seal of face shield and head contact, maintains the positive pressure respiration function of animal in open chest surgery situation.
Large and small Mus breathing mask Universal fixer has reasonable in design, easy and simple to handle, reliable and stable, its Developing Application, for the application of large and small Mus breathing mask provides strong supporting role, fundamentally solve Problems existing in the application of large and small Mus breathing mask, simplify operation sequence, ensure that the stability that breathing mask uses, improve stability and postoperative survival rate prepared by large and small Mus chronic myocardial ischemia model, be easy to be extended and applied, market prospect is had an optimistic view of.
Accompanying drawing explanation
Fig. 1 breathing mask holder schematic diagram.
Fig. 2 jawbone holder and scheme of installation
Fig. 3 face shield and holder scheme of installation
Fig. 4 face shield and Head And Face connection diagram
Detailed description of the invention
1. numb acid anhydride: adopt 3% pentobarbital sodium (40-50mg/kg) lumbar injection, treats to be fixed on rat operation platform by it with dorsal position after rat anesthesia, and extremity connect electrocardio and lead line and carry out cardiac monitoring.
2. the installation method of jawbone holder: the opening of jawbone holder is inserted in cervical region along large and small Mus bilateral jawbone angle lower edge, inserts the entrance of Universal fixer base after adjusting elasticity, fixed (see Fig. 2) by the locker of bilateral.Cut off the hair in thoracic operation region and carry out disinfection.
3. the installation of breathing mask is with fixing: the face shield holder entrance large and small Mus breathing mask bar being inserted Universal fixer top, is fixed by the locker of bilateral; Press sliding tray unlock button, push ahead face shield holder, and after large and small Mus Head And Face close contact, unclamp the installation and fixing (see Fig. 3,4) that sliding tray unlock button just completes breathing mask.Open respirator on and off switch after adjusting the tolerance of respirator and frequency, maintain large and small Mus positive pressure respiration.
4. conventional Thoracotomy in Management operation: along left border of sternum incision skin parallel with breastbone, blunt separation subcutaneous tissue and muscle expose rib, select, by xiphoid-process upwards fourth from the last root bone, to wear the ligation of two-wire two ends and cut off rib from centre, fully expose heart.
5. following coronary artery occlusion: can observe down left anterior descending coronary artery under stereoscope, passes coronary artery with the line of 5-6 zero band pin, at once causes myocardial ischemia after following coronary artery occlusion.Electrocardiogram occurs that myocardial ischemic changes, and the myocardium color in heart ischemia region is thin out, and contractility obviously weakens
6. synthorax withdraws breathing mask: first clear up intrathoracic secretions before synthorax, placing drainage in thoracic cavity, then layer-by-layer suture, drainage tube is extracted after eliminating breast intracavity gas, press sliding tray unlock button to move round about, after departing from the contact of face shield and Head And Face, after about a few second, large and small Mus just recovers autonomous respiration.Skin suture also carries out disinfection, and withdraws operating-table, and rat puts into rearging cage with lateral position posture.
7. clinical follow: postoperative large and small Mus breathes steadily, can regain consciousness after 1-2 hour, freely, feed of can intaking, just can recover through 3-4 days wounds the large and small Mus activity after clear-headed.If there is dyspnea, may be relevant with following factors.When 1. closing breast, breast intracavity gas is not drained.2. airtight bad in thoracic cavity.3. have progressive hemorrhage in thoracic cavity.Above-mentioned several situation all can cause negative pressure in thoracic cavity to reduce, and causes pulmonary atelectasis and causes dyspnea even dead.
Claims (1)
1. the large and small Mus breathing mask Universal fixer for fixing large and small Mus breathing mask, this Universal fixer is fixed two parts by base and face shield and is formed, and it is characterized in that: base is made up of jawbone holder entrance, jawbone holder locker, sliding tray, operating-table fixing hole; Face shield standing part is made up of breathing mask bar entrance, face shield rod locking device, sliding tray unlock button.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201210360998.7A CN102935017B (en) | 2012-09-25 | 2012-09-25 | Large and small Mus breathing mask Universal fixer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201210360998.7A CN102935017B (en) | 2012-09-25 | 2012-09-25 | Large and small Mus breathing mask Universal fixer |
Publications (2)
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CN102935017A CN102935017A (en) | 2013-02-20 |
CN102935017B true CN102935017B (en) | 2015-10-21 |
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CN201210360998.7A Expired - Fee Related CN102935017B (en) | 2012-09-25 | 2012-09-25 | Large and small Mus breathing mask Universal fixer |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103445881B (en) * | 2013-09-25 | 2015-07-29 | 深圳市瑞沃德生命科技有限公司 | Anesthetic gases reclaims face shield experimental provision |
CN108113776A (en) * | 2018-03-01 | 2018-06-05 | 重庆市中医院 | Rat fixing device and atomization test equipment |
CN108670497B (en) * | 2018-06-05 | 2020-10-23 | 电子科技大学 | Canned type rat respirator |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6079980A (en) * | 1999-01-11 | 2000-06-27 | Durand; Cecile M. | Dental patient face mask |
US6612776B1 (en) * | 2002-11-01 | 2003-09-02 | Jan Erik Jansson | Manufacture of articulated, predominantly concrete mat |
CN101357082A (en) * | 2008-09-12 | 2009-02-04 | 中国人民解放军第四军医大学 | Rat breathing mask |
CN201643310U (en) * | 2010-05-04 | 2010-11-24 | 曹晓霞 | Simple fixer of breathing mask |
WO2011014908A1 (en) * | 2009-08-03 | 2011-02-10 | Colin Dunlop | An improved method and apparatus for delivering a fluid to a patient |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US20070272245A1 (en) * | 2006-05-17 | 2007-11-29 | Stephen Ripple | System and method for an anesthesia breathing circuit |
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2012
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6079980A (en) * | 1999-01-11 | 2000-06-27 | Durand; Cecile M. | Dental patient face mask |
US6612776B1 (en) * | 2002-11-01 | 2003-09-02 | Jan Erik Jansson | Manufacture of articulated, predominantly concrete mat |
CN101357082A (en) * | 2008-09-12 | 2009-02-04 | 中国人民解放军第四军医大学 | Rat breathing mask |
WO2011014908A1 (en) * | 2009-08-03 | 2011-02-10 | Colin Dunlop | An improved method and apparatus for delivering a fluid to a patient |
CN201643310U (en) * | 2010-05-04 | 2010-11-24 | 曹晓霞 | Simple fixer of breathing mask |
Non-Patent Citations (1)
Title |
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"心肌缺血模型的制作方法研究进展";卢志强 等;《中国药理学通报》;20120831;第28卷(第8期) * |
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