CN102921043B - The preparation method of the absorbable double layer fibre film hernia paster of part - Google Patents
The preparation method of the absorbable double layer fibre film hernia paster of part Download PDFInfo
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- CN102921043B CN102921043B CN201210444924.1A CN201210444924A CN102921043B CN 102921043 B CN102921043 B CN 102921043B CN 201210444924 A CN201210444924 A CN 201210444924A CN 102921043 B CN102921043 B CN 102921043B
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Abstract
The present invention relates to a kind of part and can absorb the preparation method of double layer fibre film hernia paster, use PVDF as material of main part, make to support basic unit and there is the mechanical strength of excellence, good compliance, there is within the implantation phase good biocompatibility and histocompatibility, and can well assist tissue remodeling；Use PLGA and add macromolecule softener so that functional layer has good cellular affinity and histocompatibility, adding small-molecule drug and make functional layer have hemostasis, the antibacterial and effect of anti；Preparation means easily operates, low cost, can scale, end properties is excellent, can extensively be used as internal hernia paster material.
Description
Technical field:
The present invention relates to degradable high polymer material and field of compound material, be specifically related to a kind of be entered by incompatible material
The part that row is combined can absorb the preparation method of double layer fibre film hernia paster.
Background technology:
Hernia paster is a kind of conventional medical embedded timbering material in treating hernia.The support of one-component often due to
Its performance limits and is difficult to meet actual demand, and being developed into of the most compound material designs a big hands of multi-functional material
Section.Such as, in hernia paster material, polypropylene mesh structure adds poly (glycolide-lactide), embedded material can be improved and plant
Enter the histocompatibility at position, reduce the formation of healing early stage cicatrix, thus the safety in utilization of material can be improved with effective
Property.
In recent ten years, electrospinning biocompatible fibres film is widely studied due to the superiority of its structure and performance.Example
As, the most studied confirmation of electricity spinning fibre has the surface compatability of excellence due to the surface texture of its class cytoskeleton；Take
To the bootable cells in situ of electricity spinning fibre film grow in original topological structure and arrange；The knot that fibrous membrane is three-dimensional porous
Structure is conducive to keeping the environment of implant site circulation；The soft characteristic of fibrous membrane light weight can increase embedded material operability and
Comfortableness, etc..According to the development of nearest Electrospinning, composite electrospun cortina makes the performance of electrospun membrane more diversified
And performance-based.Such as, solution blending spining technology and co spun technology can be prepared containing two kinds or many by regulation and control spinning condition
Plant the composite fiber membrane material of different macromolecular materials so that prepared material property variation, more can be according to the actual requirements；Enter
Row regulation and control；Milk thread can realize the embedding in fibrous membrane of Medicine small molecule and gene, RNA, DNA isoreactivity macromole and
Do not destroy structure and the character of embedded object so that the fibrous membrane character function prepared.
But using electrostatic spinning to be combined by the macromolecule that two kinds incompatible, to obtain the method for stabilizing material the rarest, especially
It is not yet to be seen in report in hernia paster field.
Summary of the invention:
It is an object of the invention to provide and a kind of the part that incompatible material carries out being combined is can absorb double layer fibre film
The preparation method of hernia paster.
To achieve these goals, the present invention propose following technical scheme realize:
The absorbable double layer fibre film hernia paster of part, it is characterised in that: double layer fibre film hernia paster by support basic unit,
Functional layer forms；Described support basic unit is with non-degradable macromolecular material as material of main part；Described functional layer is with biodegradable
Macromolecular material is material of main part, adds macromolecule softener；Supporting basic unit, functional layer all uses electrostatic spinning technique to make.
Described double layer fibre film hernia paster thickness is 60 μm～500 μm.
Described non-degradable macromolecular material is PVDF, number-average molecular weight 100,000～400,000.
In described functional layer, biodegradable polymer accounts for the 80%～100% of oeverall quality, and macromolecule is submissive
Agent accounts for the 1%～20% of oeverall quality.
Described functional layer also includes small-molecule drug.
Described small-molecule drug accounts for the 0.05%～10% of biodegradable polymer quality.
Described biodegradable polymer is PLGA, number-average molecular weight 30,000～500,000, and segment mol ratio
L: G=90: 10～40: 60.
Described macromolecule softener is one or more in polycaprolactone, Merlon and PLA-b-PEG, and number is divided equally
Son amount 5,000～100,000.
Described small-molecule drug be Aminomethylbenzoic Acid, tranamic acid, 6-aminocaprolc acid, reptilase, thrombin, metronidazole,
One or more in tinidazole, ornidazole.
The preparation method of the preparation method of the absorbable double layer fibre film hernia paster of part, comprises the steps:
(1) preparation macromolecular solution: being dissolved in corresponding cosolvent by non-degradable macromolecular material, being configured to concentration is 10
～the solution of 60wt%；Biodegradable polymer is dissolved in corresponding cosolvent to macromolecule softener and small-molecule drug
In, it is configured to the solution of concentration 5～50wt%, wherein biodegradable polymer accounts for the 80%～100% of gross mass, high
Molecule softener accounts for the 1%～20% of gross mass, small-molecule drug account for biodegradable polymer quality 0.05%～
10%；
(2) support basic unit is spun: controlling spinning environment temperature is 25～50 DEG C, and the non-degradable macromolecule (1) obtained is molten
Liquid is placed in the feed injector of electrospinning device, and the distance between regulation spinning head and roller is 7～15cm, in environment
Air velocity controls 0.5～0.8m3/ hr, opens high voltage power supply and feed injector pump, regulation voltage to 10～35KV,
The delivery rate of solution is 10～30 μ l/min, obtains the support basic unit spun on rotating drum；
(3) functional layer is spun: controlling spinning environment temperature is 25～50 DEG C, the biodegradable high score then (1) obtained
Sub-material, macromolecule softener, small-molecule drug mixed solution are placed in the feed injector of electrospinning device, obtain in (2)
To support basic unit on carry out spinning, the distance between regulation spinning head and roller is 7～15cm, the air velocity control in environment
System is 0.5～0.8m3/ hr, opens high voltage power supply and feed injector pump, regulation voltage to 10～35KV, the feed of solution
Speed is 10～30 μ l/min, obtains electrospun fibers composite membrane on a rotating drum.
Described cosolvent is DMF, acetone, trifluoroethanol, hexafluoroisopropanol, THF, dimethyl acetylamide, dichloromethane
In one or more.
Described electrospinning device is many spinning heads electrostatic spinning machine.
Beneficial effects of the present invention: use PVDF as material of main part so that support basic unit have excellence mechanical strength,
Well compliance, has good biocompatibility and histocompatibility within the implantation phase, and can well assist tissue weight
Mould；Use PLGA and add macromolecule softener so that functional layer has good cellular affinity and histocompatibility, adding
Small-molecule drug makes functional layer have hemostasis, the antibacterial and effect of anti；Preparation means easily operates, low cost, can scale
Changing, end properties is excellent, can extensively be used as internal hernia paster material.
Detailed description of the invention:
Hereinafter describe the preferred embodiment of the present invention, but be not limited to the present invention.
Embodiment 1:
It is prepared as follows and partly can absorb double layer fibre film hernia paster:
(1) preparation of solution: PVDF (molecular weight 250000) is dissolved in DMF molten with the mixing of acetone (volume ratio is 7: 3)
In agent, it is configured to the electrospun solution that PVDF concentration is 15wt%；By PLGA (molecular weight 50000), polycaprolactone (molecular weight
50000) and metronidazole is dissolved in DMF, it is configured to the electrospun solution that concentration is 45wt%, wherein PLGA: PCL=85: 15, PLGA
: metronidazole=100: 5；
(2) support basic unit is spun: the PVDF solution (1) obtained is placed in the feed injector of many spinning heads electrostatic spinning machine
In, controlling spinning environment temperature is 50 DEG C, and the distance between regulation spinning head and roller is 7～15cm, the air stream in environment
Speed controls 0.5～0.8m3/hr；Open high voltage power supply and feed injector pump, regulation voltage to 10～35KV, solution
Delivery rate is 10～30 μ l/min, obtains the support basic unit spun on rotating drum；
(3) functional layer is spun: the PLGA that (1) obtained, polycaprolactone, metronidazole mixed solution are placed in many spinning heads Static Spinning
In the feed injector of silk machine, controlling spinning environment temperature is 25 DEG C, carries out spinning in the support basic unit that (2) obtain, regulation
Distance between spinning head and roller is 7～15cm, and the air velocity in environment controls 0.5～0.8m3/hr；Open high pressure
Power supply and feed injector pump, regulation voltage is to 10～35KV, and the delivery rate of solution is 10～30 μ l/min, is rotating rolling
Electrospun fibers composite membrane is obtained on Tong.
Embodiment 2:
It is prepared as follows and partly can absorb double layer fibre film hernia paster:
(1) preparation of solution: PVDF (molecular weight 200000) is dissolved in DMF molten with the mixing of acetone (volume ratio is 5: 5)
In agent, it is configured to the electrospun solution that PVDF concentration is 20wt%；By PLGA (molecular weight 80000), polycaprolactone (molecular weight
80000), metronidazole, 6-aminocaprolc acid be dissolved in DMF, be configured to the electrospun solution that concentration is 40wt%, wherein PLGA: PCL=
90: 10, PLGA: metronidazole: 6-aminocaprolc acid=100: 2: 2；
(2) support basic unit is spun: the PVDF solution (1) obtained is placed in the feed injector of many spinning heads electrostatic spinning machine
In, controlling spinning environment temperature is 50 DEG C, and the distance between regulation spinning head and roller is 7～15cm, the air stream in environment
Speed controls 0.5～0.8m3/hr；Open high voltage power supply and feed injector pump, regulation voltage to 10～35KV, solution
Delivery rate is 10～30 μ l/min, obtains the support basic unit spun on rotating drum；
(3) functional layer is spun: the PLGA that (1) obtained, polycaprolactone, metronidazole, 6-aminocaprolc acid mixed solution are placed in many
In the feed injector of spinning head electrostatic spinning machine, controlling spinning environment temperature is 50 DEG C, and the support basic unit obtained in (2) is enterprising
Row spinning, the distance between regulation spinning head and roller is 7～15cm, and the air velocity in environment controls 0.5～0.8m3/
hr；Opening high voltage power supply and feed injector pump, regulation voltage is to 10～35KV, and the delivery rate of solution is 10～30 μ l/
Min, obtains electrospun fibers composite membrane on a rotating drum.
Claims (4)
1. part can absorb the preparation method of double layer fibre film hernia paster, it is characterised in that:
Described part can absorb double layer fibre film hernia paster by supporting basic unit, functional layer forms；Described support basic unit is with can not
Degraded macromolecular material is material of main part；Described functional layer, with biodegradable polymer as material of main part, adds high score
Sub-softener, wherein biodegradable polymer accounts for the 80%～100% of gross mass, and macromolecule softener accounts for oeverall quality
1%～20%；Also including small-molecule drug in described functional layer, described small-molecule drug accounts for biodegradable polymer
The 0.05%～10% of quality；
(1) preparation macromolecular solution: non-degradable macromolecular material is dissolved in corresponding cosolvent, be configured to concentration be 10～
The solution of 60wt%；Biodegradable polymer is dissolved in corresponding cosolvent to macromolecule softener and small-molecule drug
In, it is configured to the solution that concentration is 5～50wt%；
(2) support basic unit is spun: controlling spinning environment temperature is 25～50 DEG C, and the non-degradable macromolecular solution (1) obtained is put
In the feed injector of electrospinning device, the distance between regulation spinning head and roller is 7～15cm, the air in environment
Flow speed control is 0.5～0.8m3/ hr, opens high voltage power supply and feed injector pump, regulation voltage to 10～35KV, solution
Delivery rate be 10～30 μ l/min, rotating drum obtains the support basic unit spun；
(3) functional layer is spun: controlling spinning environment temperature is 25～50 DEG C, the Biodegradable high-molecular material then (1) obtained
Material, macromolecule softener, small-molecule drug mixed solution are placed in the feed injector of electrospinning device, obtain in (2)
Supporting and carry out spinning in basic unit, the distance between regulation spinning head and roller is 7～15cm, and the air velocity in environment controls
0.5～0.8m3/ hr, opens high voltage power supply and feed injector pump, regulation voltage to 10～35KV, the delivery rate of solution
It is 10～30 μ l/min, obtains electrospun fibers composite membrane on a rotating drum；Described non-degradable macromolecular material is
PVDF, number-average molecular weight 100,000～400,000；Described biodegradable polymer is PLGA, number-average molecular weight
30,000～500,000, segment mol ratio L: G=90: 10～40: 60；Described macromolecule softener is polycaprolactone, poly-carbon
One or more in acid esters and PLA-b-PEG, number-average molecular weight 5,000～100,000.
Part the most according to claim 1 can absorb the preparation method of double layer fibre film hernia paster, it is characterised in that: institute
The small-molecule drug stated is Aminomethylbenzoic Acid, tranamic acid, 6-aminocaprolc acid, reptilase, thrombin, metronidazole, tinidazole, nitre difficult to understand
One or more in azoles.
Part the most according to claim 1 can absorb the preparation method of double layer fibre film hernia paster, it is characterised in that: step
(1) is used for dissolving non-degradable macromolecular material or biodegradable polymer and macromolecule softener and little point suddenly
The cosolvent of sub-medicine is in DMF, acetone, trifluoroethanol, hexafluoroisopropanol, THF, dimethyl acetylamide, dichloromethane
Plant or multiple.
Part the most according to claim 1 can absorb the preparation method of double layer fibre film hernia paster, it is characterised in that: use
Spin in step (2) and support that to spin the electrospinning device of functional layer in basic unit or step (3) be many spinning heads electrostatic spinning machine.
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| CN104096272A (en) * | 2013-04-03 | 2014-10-15 | 中国科学院化学研究所 | Postoperation anti-infectious composite electrostatic-spinning nanometer fiber-film sheet for repairing hernia and preparation method thereof |
| CN103656741B (en) * | 2013-11-21 | 2016-02-10 | 无锡中科光远生物材料有限公司 | A kind of bacteriostatic film |
| CN103705978B (en) * | 2013-11-21 | 2016-02-10 | 无锡中科光远生物材料有限公司 | A kind of preparation method of bacteriostatic film |
| CN104963092A (en) * | 2015-07-31 | 2015-10-07 | 武汉蓝普医品有限公司 | Preparation device and method for non-woven high polymer material optilene mesh |
| CN107537067A (en) * | 2017-09-15 | 2018-01-05 | 深圳大学 | A kind of composite artificial endocranium and preparation method thereof |
| CN107510520B (en) * | 2017-09-21 | 2020-08-11 | 上海松力生物技术有限公司 | Cruciate ligament regenerative implant and preparation method and application thereof |
| CN111803713A (en) * | 2020-05-29 | 2020-10-23 | 广州新诚生物科技有限公司 | Woven film, woven bag and weaving method |
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| CN100569299C (en) * | 2006-08-29 | 2009-12-16 | 北京华世本全科技有限公司 | Degradable compound biomaterial membrane for medical purpose |
| US7927620B2 (en) * | 2007-05-15 | 2011-04-19 | Boston Scientific Scimed, Inc. | Medical devices having antifouling character |
| CN101530353B (en) * | 2008-04-11 | 2010-08-25 | 北京天助畅运医疗技术股份有限公司 | Anti-adhesion hernia repair patch |
| CN102085122B (en) * | 2011-03-01 | 2013-04-17 | 东华大学 | Polypropylene/polyvinylidene fluoride composite hernia patch and preparation method thereof |
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Effective date of registration: 20170626 Address after: 100027 Beijing City, Dongcheng District No. 40 East Street, Yuanjia Residence Internazionale B block 3 layer Patentee after: TransEasy Medical Tech. Co.,Ltd. Address before: 214192, Jiangsu, Xishan Economic Development Zone, Wuxi science and Technology Park (Furong Road three, 99), Qingyun six Patentee before: Wuxi Zhongke Guangyuan Biomaterial Co., Ltd. |