CN102920947A - Pharmaceutical composition for relieving eyestrain and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for relieving eyestrain and preparation method of pharmaceutical composition Download PDFInfo
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- CN102920947A CN102920947A CN 201210495883 CN201210495883A CN102920947A CN 102920947 A CN102920947 A CN 102920947A CN 201210495883 CN201210495883 CN 201210495883 CN 201210495883 A CN201210495883 A CN 201210495883A CN 102920947 A CN102920947 A CN 102920947A
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- blue berry
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- semen maydis
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Abstract
The invention relates to a pharmaceutical composition for relieving eyestrain and a preparation method of the pharmaceutical composition. According to the invention, natural corn and blueberry are taken as raw materials and matched with vitamin C, thus the pharmaceutical composition not only prevents juvenile myopia but also relieves eyestrain while supplementing anthocyanin and xanthophyll which are required by eyes. The preparation method is simple; and the obtained medicament preparation has no toxic and side effects and great market development prospect.
Description
Technical field
The invention belongs to field of medicine preparations, be specifically related to eye with health care and treatment formulation art, for a kind of alleviation with asthenopic pharmaceutical composition and preparation method thereof.
Background technology
Eyes have the title of " window of soul ", and it is as the organ of human body Chinese medicine, and whether its health directly has influence on people's live and work, along with the progress of science and technology, use with the research and development of radiation product, and people are particularly important for protection and the treatment of eyes.
CN101390874B discloses a kind of eye health preparation, this invents described preparation is Natrii Sulfas, hyaluronic acid, sodium chloride, magnesium sulfate, calcium sulfate and solvent, the method has overcome the shortcoming that prior art is added antiseptic, had toxic and side effects to a certain extent, but its complicated components also is unfavorable for health care and the treatment of eyes.CN100462074C discloses a kind of chewable tablet with function of relieving visual fatigue; this invention is by using multiple different efficacies composition combination, cooperatively interact, synergism eliminates and use the eyestrain, but how and complicated the method component; production cost is high, is not suitable for enterprise scale production.
The inventor finds according to research: be rich in multiple nutritional components common in the fruit in the blue berry, and antioxidant and the bacterial growth inhibitor such as anthocyanin, flavonoid, the fruit that belongs to homoamino acid, high zinc, high ferro, high-copper, homovitamin, have good nutrition health-care functions, comprise vision enhancing, anti-eye strain, prevent that cranial nerve is aging, anticancer, vessel softening, enhancing body immunity texts.And contain abundant phylloxanthin in the Semen Maydis, taking phylloxanthin has mitigation to asthenopia.In conjunction with the phylloxanthin of the anthocyanidin in the blue berry and maize seed, cooperate again vitamin C, splendid with eyestrain's effect for treatment.At present, domesticly make powder as many take blue berry by the method for vacuum lyophilization, Semen Maydis powder is then take direct pulverizing as main, and the product of these two kinds of natural pigment combinations not yet occurred on market.
Summary of the invention
Purport of the present invention is nutritionally more comprehensive, without any antiseptic and additive, is fit to the wide alleviation of crowd with asthenopic pharmaceutical composition and preparation method thereof.
For achieving the above object, a kind of alleviation of the present invention is with asthenopic pharmaceutical composition and preparation method thereof, and its specific embodiments is:
A kind of alleviation of the present invention is with asthenopic pharmaceutical composition and preparation method thereof, it is characterized in that each component of this pharmaceutical composition forms (mass percent) and is: blue berry powder 10-25%, Semen Maydis powder 25-45%, vitamin C 3-5%, starch 20-40%, its preparation method is: each component powders is mixed, in the empty pocket body of the hard capsule of packing into, cover capsule capsule medicated cap, obtain described pharmaceutical composition.
A kind of alleviation of the present invention is characterized in that the method concrete steps are with asthenopic pharmaceutical composition and preparation method thereof:
1) preparation Semen Maydis powder: choose ripe niblet after cleaning, pulverize, lixiviate, filtration, reconcentration, spray drying get Semen Maydis powder, cool off for subsequent use;
2) preparation blue berry powder: take blue berry as raw material, remove rotten fruit, after fruit is cleaned, carry out break process, then enzymolysis, filtration, with Rotary Evaporators with lixiviating solution be concentrated to solid content again spray drying get blue berry powder, cool off for subsequent use;
3) preparation capsule: according to prescription each component powders is mixed, in the empty pocket body of the hard capsule of packing into, cover capsule capsule medicated cap, obtain described a kind of capsule that contains blue berry and Semen Maydis.
A kind of alleviation of the present invention is characterized in that with asthenopic pharmaceutical composition and preparation method thereof the colour fixative that adds in the Semen Maydis powder preparation process is the 0.3%-0.6% citric acid, and extracted corn concentrated solution additive is mass fraction 8-10% beta-schardinger dextrin-.
A kind of alleviation of the present invention is with asthenopic pharmaceutical composition and preparation method thereof, it is characterized in that extraction temperature is 85-90 ℃ in the Semen Maydis powder preparation process, each lixiviate 20-30min, lixiviate twice, it is mass percent 50-65% that lixiviating solution is concentrated to solid content.
A kind of alleviation of the present invention is with asthenopic pharmaceutical composition and preparation method thereof, and inlet temperature is 115-130 ℃ when it is characterized in that the concentrated solid content of Semen Maydis is dry, and outlet temperature is 80-90 ℃, and charging rate is 15-20ml/min.
A kind of alleviation of the present invention is characterized in that with asthenopic pharmaceutical composition and preparation method thereof the colour fixative that adds in the blue berry powder preparation process is 0.5%-0.6%VC, and blue berry lixiviate concentrated solution additive is mass fraction 15%-20% maltodextrin.
A kind of alleviation of the present invention is with asthenopic pharmaceutical composition and preparation method thereof, it is characterized in that adding in the blue berry powder preparation process pectase of 0.4%-0.5%, enzymolysis time 90-95min, hydrolysis temperature are 45-50 ℃, and it is mass percent 20%-35% that lixiviating solution is concentrated to solid content.
A kind of alleviation of the present invention is with asthenopic pharmaceutical composition and preparation method thereof, and inlet temperature is 110-120 ℃ when it is characterized in that the concentrated solid content of blue berry is dry, and outlet temperature is 80-90 ℃, and charging rate is 15-20ml/min.
The present invention has the following advantages:
1. this product is without any antiseptic and additive, comprehensive nutrition, and it is wide to be fit to the crowd.
2. this product is with capsule form, transportation, easy to carry and use.
3. this product adopts spray drying technology technically, and its powder delivery is fine and smooth, is conducive to absorption of human body;
4. this product preparation technology is simple, and production cost is lower than Vacuum Freezing ﹠ Drying Technology, and does not destroy effective ingredient in the raw material.
The specific embodiment
Below enforcement only for more detailed description the present invention, but do not limit in any form the present invention.
Embodiment
Prescription forms (mass percent) by following component:
Blue berry powder: 10-25%
Semen Maydis powder: 25-45%
Vitamin C: 3-5%
Starch: 20-40%
Preparation method:
A. prepare Semen Maydis powder
Choose the niblet of mature and plump after cleaning, pulverize, add the 0.3%-0.6% citric acid and carry out color fixative, 85 ℃-90 ℃, each lixiviate 25-30min, twice of lixiviate, after the filtration, with Rotary Evaporators lixiviating solution being concentrated to solid content is mass percent 50%-65%, and selecting mass fraction is that the 8%-10% beta-schardinger dextrin-adds in the extracted corn concentrated solution spray drying to, inlet temperature is 115-130 ℃, outlet temperature is 80-90 ℃, and charging rate is 15-20ml/min, and the Semen Maydis powder cooling is for subsequent use;
B. prepare blue berry powder
Take blue berry as raw material, remove rotten fruit, after the fruit cleaning, carry out break process, add 0.5%-0.6%VC and carry out color fixative, with the fruit behind the color fixative, after smashing with beater, the pectase that adds 0.4%-0.5%, with enzymolysis time 90-95min, hydrolysis temperature is 45-50 ℃ and is condition enzymolysis in thermostat water bath, after the filtration, with Rotary Evaporators lixiviating solution being concentrated to solid content is mass percent 20%-35%, and selecting mass fraction is that the 15%-20% maltodextrin adds in the concentrated solution spray drying to, inlet temperature is 110-120 ℃, outlet temperature is 80-90 ℃, and charging rate is 15-20ml/min, and the blue berry powder cooling is for subsequent use;
C. prepare capsule
Blue berry powder: 10-25%
Semen Maydis powder: 25-45%
Vitamin C: 3-5%
Starch: 20-40%
According to above-mentioned prescription each component powders is mixed, in the empty pocket body of the hard capsule of packing into, cover capsule capsule medicated cap, obtain described a kind of capsule that contains blue berry and Semen Maydis.Every quality of capsule is 0.80 ± 0.01g, and blue berry powder content is 0.08 ~ 0.20g, and the content of Semen Maydis powder is 0.20 ~ 0.35g.
Claims (8)
1. an alleviation is with asthenopic pharmaceutical composition and preparation method thereof, it is characterized in that each component of this pharmaceutical composition forms (mass percent) and is: blue berry powder 10-25%, Semen Maydis powder 25-45%, vitamin C 3-5%, starch 20-40%, its preparation method is: each component powders is mixed, in the empty pocket body of the hard capsule of packing into, cover capsule capsule medicated cap, obtain described pharmaceutical composition.
2. described method according to claim 1 is characterized in that the method concrete steps are:
1) preparation Semen Maydis powder: choose ripe niblet after cleaning, pulverize, lixiviate, filtration, reconcentration, spray drying get Semen Maydis powder, cool off for subsequent use;
2) preparation blue berry powder: take blue berry as raw material, remove rotten fruit, after fruit is cleaned, carry out break process, then enzymolysis, filtration, with Rotary Evaporators with lixiviating solution be concentrated to solid content again spray drying get blue berry powder, cool off for subsequent use;
3) preparation capsule: according to prescription each component powders is mixed, in the empty pocket body of the hard capsule of packing into, cover capsule capsule medicated cap, obtain described a kind of capsule that contains blue berry and Semen Maydis.
3. described method according to claim 2 is characterized in that the colour fixative that adds in the Semen Maydis powder preparation process is the 0.3%-0.6% citric acid, and extracted corn concentrated solution additive is mass fraction 8-10% beta-schardinger dextrin-.
4. described method according to claim 2 is characterized in that extraction temperature is 85-90 ℃ in the Semen Maydis powder preparation process, each lixiviate 20-30min, and lixiviate twice, it is mass percent 50-65% that lixiviating solution is concentrated to solid content.
5. described method according to claim 4, inlet temperature is 115-130 ℃ when it is characterized in that the concentrated solid content of Semen Maydis is dry, and outlet temperature is 80-90 ℃, and charging rate is 15-20ml/min.
6. described method according to claim 2 is characterized in that the colour fixative that adds in the blue berry powder preparation process is 0.5%-0.6%VC, and blue berry lixiviate concentrated solution additive is mass fraction 15%-20% maltodextrin.
7. described method according to claim 2 is characterized in that adding in the blue berry powder preparation process pectase of 0.4%-0.5%, and enzymolysis time 90-95min, hydrolysis temperature are 45-50 ℃, and it is mass percent 20%-35% that lixiviating solution is concentrated to solid content.
8. described method according to claim 7, inlet temperature is 110-120 ℃ when it is characterized in that the concentrated solid content of blue berry is dry, and outlet temperature is 80-90 ℃, and charging rate is 15-20ml/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210495883 CN102920947A (en) | 2012-11-29 | 2012-11-29 | Pharmaceutical composition for relieving eyestrain and preparation method of pharmaceutical composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210495883 CN102920947A (en) | 2012-11-29 | 2012-11-29 | Pharmaceutical composition for relieving eyestrain and preparation method of pharmaceutical composition |
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| CN102920947A true CN102920947A (en) | 2013-02-13 |
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| CN 201210495883 Pending CN102920947A (en) | 2012-11-29 | 2012-11-29 | Pharmaceutical composition for relieving eyestrain and preparation method of pharmaceutical composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107996780A (en) * | 2017-12-16 | 2018-05-08 | 张家界立功旅游农业发展有限公司 | A kind of tea therapy agent for alleviating visual fatigue and preparation method thereof |
| CN108606313A (en) * | 2018-04-12 | 2018-10-02 | 孙卓为 | A kind of combination lozenge and preparation method thereof for alleviating visual fatigue |
-
2012
- 2012-11-29 CN CN 201210495883 patent/CN102920947A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107996780A (en) * | 2017-12-16 | 2018-05-08 | 张家界立功旅游农业发展有限公司 | A kind of tea therapy agent for alleviating visual fatigue and preparation method thereof |
| CN108606313A (en) * | 2018-04-12 | 2018-10-02 | 孙卓为 | A kind of combination lozenge and preparation method thereof for alleviating visual fatigue |
| CN108606313B (en) * | 2018-04-12 | 2021-05-18 | 孙卓为 | Composite buccal tablet for relieving visual fatigue and preparation method thereof |
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Application publication date: 20130213 |