CN102920819A - Food-digestion oral liquid and its preparation method - Google Patents
Food-digestion oral liquid and its preparation method Download PDFInfo
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Abstract
The invention provides a food-digestion oral liquid and its preparation method. The food-digestion oral liquid is prepared from 1-10 parts by weight of haw, 1-6 parts by weight of Rhizoma Atractylodis Macrocephalae, 1-10 parts by weight of Chinese magnoliavine, 1-5 parts by weight of dried orange peel, 1-5 parts by weight of chicken's gizzard membrane, 1-8 parts by weight of fructo-oligosaccharide, and 1-10 parts by weight of xylo-oligosaccharide. The food-digestion oral liquid has the advantages of increased food consumption, improved appetite and easy cacation after taking, and good mouthfeel.
Description
Technical field
The invention belongs to the medicines and health protection field of food, be specifically related to a kind of digestion promoting oral liquid and preparation method thereof.
Background technology
The spleen and stomach in children loses that to stop caused anorexia, refusing to eat in fortune, the food stagnation be melancholy, improper feeding or eating and drinking without temperance, or due to for a long time monophagia, eating cold and uncooked food excessively, the feed variable interval, but above-mentioned situation is the normal transportation capabilities of impairing the spleen and stomach also, cause that dysfunction of the spleen in transportation, stomach are not thought to receive, incoordination between the spleen and stomach, thereby produce the anorexia disease, card sees that diet is depressed, anorexia, become thin, and these have become commonly encountered diseases and the frequently-occurring disease of children's's illness.Treatment is whetted the appetite with activating the spleen, and dyspepsia and intestinal stasis relieving is main, and clinically according to state of an illness determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, stomach is transferred in spleen invigorating, when improving clinical symptoms, improves the content of trace element, improves part and general immunity function, strengthens intestinal absorption and pancreatin secretory function.
In aid digestion medication field, in motilium, river the JIANWEI XIAOSHI PIAN, other surging brands temporarily also do not appear, and " the stomach medicine " of motilium new identity has also stoped choosing of dyspepsia consumer, in fact really outshines othersOne branch of the tree is particularly thriving as the JIANWEI XIAOSHI PIAN of just only having in the river of daily aid digestion medication.
Research finds also that simultaneously the medication rate in dyspepsia market is lower, and the consumer of part takes the attitude of ignoring when indigestion symptom occurring, and wherein, the situation that medication rate in child market is low is particularly outstanding.The child is because taste zoon not yet, and dyspeptic sickness rate is higher than other crowds, and the main manifestations symptom is particular about food, anorexia.The child is in the stage of growing up, the head of a family worries that dyspepsia can affect its growth promoter, it is urgent to solve dyspeptic demand, but the head of a family worries that again the toxic and side effects of medicine can injure the healthy of child simultaneously, it is very careful on medication is selected, finally cause child morbidity high, demand is the most urgent, but the low strange figure of medication rate.
Summary of the invention
Therefore, the purpose of this invention is to provide a kind of aid digestion medication, i.e. digestion promoting oral liquid and preparation method thereof.Digestion promoting oral liquid cost of the present invention is low, mouthfeel acid, sweet, and the child is easy to accept.
Technical scheme of the present invention is as follows:
The invention provides a kind of digestion promoting oral liquid, this digestion promoting oral liquid can be prepared from by the raw material of following weight proportion:
Fructus Crataegi 1-10 part, Rhizoma Atractylodis Macrocephalae 1-6 part, Fructus Schisandrae Chinensis 1-10 part, Pericarpium Citri Reticulatae 1-5 part, Endothelium Corneum Gigeriae Galli 1-5 part, oligofructose 1-8 part, oligomeric xylose 1-10 part.
Preferably, above-mentioned digestion promoting oral liquid can be prepared from by the raw material of following weight proportion:
2.67 parts of Fructus Crataegis, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 2.33 parts of Fructus Schisandrae Chinensis, 1 part of Pericarpium Citri Reticulatae, 1 part of Endothelium Corneum Gigeriae Galli, 1.2 parts of oligofructoses, 1.2 parts of oligomeric xyloses.
Digestion promoting oral liquid of the present invention can be prepared from by the raw material of following weight proportion:
Fructus Crataegi 1-10 part, Rhizoma Atractylodis Macrocephalae 1-6 part, Fructus Schisandrae Chinensis 1-10 part, Pericarpium Citri Reticulatae 1-5 part, Endothelium Corneum Gigeriae Galli 1-5 part, oligofructose 1-8 part, oligomeric xylose 1-10 part, Mel 1-10 part, Fructus Crataegi essence 1-3 part.
Preferably, above-mentioned digestion promoting oral liquid can be prepared from by the raw material of following weight proportion:
2.67 parts of Fructus Crataegis, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 2.33 parts of Fructus Schisandrae Chinensis, 1 part of Pericarpium Citri Reticulatae, 1 part of Endothelium Corneum Gigeriae Galli, 1.2 parts of oligofructoses, 1.2 parts of oligomeric xyloses, 1.33 parts of Mel, 0.03 part in Fructus Crataegi essence.
Above-mentioned digestion promoting oral liquid is mainly used in the symptoms such as incoordination between the spleen and stomach, inappetence, abdominal distention.Wherein, Endothelium Corneum Gigeriae Galli invigorating the spleen and stomach, removing food stagnancy relieving dyspepsia.Fructus Crataegi has consumer product dredge stasis, alleviating distention in middle-JIAO except swollen effect, and it is astringent or styptic treatment for spontaneous sweating that Fructus Schisandrae Chinensis has convergence, supplementing QI for promoting the production of body fluid, the effect that kidney calming is calmed the nerves.Cooperatively interact, can control various food stagnations.The hot temperature of Pericarpium Citri Reticulatae, fragrance is amusing, the benefaction stagnation of QI in spleen and stomach, fast diaphragm in the accent, mechanism of qi is unimpeded, and various masses must disappear.All medicines share, and play the effect of promoting digestion and removing stagnation, appetite promoting and the spleen strengthening.Oligosaccharide can be regulated mouthfeel, and bacillus bifidus is bred at double.The health-care effect of oligosaccharide mainly is by catalysis breeding and protection increase and survival volume and the effect of expansion bacillus bifidus in human body to bacillus bifidus in the human body, significantly reduces the quantity of harmful bacteria.
The effect of each raw material and composition are described as follows in the above-mentioned digestion promoting oral liquid:
Fructus Crataegi: sour in the mouth, sweet, tepor.Return spleen, stomach, Liver Channel.The effect promoting digestion and removing stagnation, promoting blood circulation to remove blood stasis.Being used for greasy meat stagnation does not change.Main component is flavone compound and organic acid, and other contains lactone glycoside, lipase, saccharide, vitamin C, riboflavin and calcium, phosphorus, ferrum etc.The energy facilitating digestion increases the enzyme in the stomach.
Fructus Schisandrae Chinensis: sour in the mouth, warm in nature; Return lung, the heart, kidney channel; Hold back and fall; It is astringent or styptic treatment for spontaneous sweating to have convergence, supplementing QI for promoting the production of body fluid, the effect that kidney calming is calmed the nerves.
The Rhizoma Atractylodis Macrocephalae: the Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, the effect of hidroschesis.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration." medicine origin " record: " the dehumidifying benefit is dry, and middle QI invigorating, and warming middle-JIAO goes to wet in the taste, and except gastric heat, strong taste advance diet, quench the thirst.”
Endothelium Corneum Gigeriae Galli: sweet in the mouth, flat.Return spleen, stomach, large intestine, urinary bladder channel.The effect activating the spleen helps digestion.This product ability that helps digestion is stronger, has fortune in order to do the merit of stomach invigorating, and is all stagnant, no matter meat is long-pending, infantile dyspepsia, paddy is long-pending and other stagnant person all can use.Contain gastric hormone, keratin, and contain pepsin and the ammonium chloride etc. of 17 seed amino acids, trace.Good digestion-aid effect is arranged, and showing as gastric secretion increases, and gastric acidity increases, the obvious enhancing of stomach function etc.
Pericarpium Citri Reticulatae: acrid in the mouth, temperature.Return spleen, lung meridian.During effect is regulated the flow of vital energy and is transferred, drying dampness to eliminate phlegm.Be used for the distension and fullness in the abdomen due to the stagnation of QI in spleen and stomach, belch, vomiting is felt sick etc.Can rise the sun of loose taste.This product contains volatile oil.Volatile oil has the stimulation of mitigation to digestive tract, is conducive to the discharge of gastrointestinal gas, can promote the secretion of gastric juice, helps digestion, and gastrointestinal smooth muscle is had relexation.
Oligosaccharide: i.e. oligofructose and oligomeric xylose, directly improve intestinal microbial population, promote profitable strain propagation, be beneficial to host health.Can promote the absorption of the elements such as calcium, magnesium, ferrum, zinc.The not gastric acid in digested road and enzymic digestion absorbed by human body beneficial's flora bacillus bifidus selectivity, and the profitable strain bacillus bifidus of human body is bred rapidly.Suppress the growth of pernicious bacteria, play the effect of removing intestinal rubbish.Pure natural has no side effect.
Above-mentioned digestion promoting oral liquid absorbs easily with the oral liquid unit dose package.This oral liquid acid, sweet mouthfeel, child is acceptant, and cost is low.
Above-mentioned digestion promoting oral liquid is taken rear appetite increase, appetite improvement, defecation is light, mouthfeel is also relatively good.
The present invention also provides the preparation method of above-mentioned digestion promoting oral liquid, and this preparation method may further comprise the steps:
(1) raw material except oligofructose and oligomeric xylose is mixed in proportion, soaks, then heating extraction is collected extracting solution, filters;
(2) filtrate that step (1) is obtained is concentrated, obtains the concentrated solution of detection density 〉=1.085 in the time of 50-60 ℃;
(3) concentrated solution with step (2) adds oligofructose, oligomeric xylose, purified water, regulates 10～30 ℃ of lower pH value as 4.0-5.0 take 10%NaOH solution, and is centrifugal, canned, gets final product.
In a preferred embodiment, this preparation method may further comprise the steps:
(1) raw material except oligofructose and oligomeric xylose is mixed in proportion, add 5 times of water gagings and soaked 1 hour, heating is when feed liquid is seethed with excitement, keep that decoction liquor is little boiled 2 hours, decoction liquor is filtered, and adds 4 times of water gagings in the material slag, and continuing to heat up decocts, keeping little boiled 1.5 hours, decoction liquor is filtered, and the material slag discards, and collects filtrate;
(2) filtrate with step (1) is concentrated, obtains the concentrated solution of detection density 〉=1.085 in the time of 50-60 ℃, and the filtrate temperature is no more than 90 ℃ in the concentration process, and is then centrifugal;
(3) when the filtrate temperature is down to 20 ℃, add oligofructose, oligomeric xylose, purified water, regulate 10～30 ℃ of lower pH value as 4.0-5.0 take 10%NaOH solution, centrifugal, canned, get final product.
Experiment showed, that the more traditional XIAOSHI PIAN of digestion promoting oral liquid of the present invention, JIANWEI XIAOSHI PIAN (river Chinese medicinal material industry) can obviously improve peptic activity of stomach.
Description of drawings
Below, describe by reference to the accompanying drawings embodiment of the present invention in detail, wherein:
Fig. 1 is the process chart of preparation digestion promoting oral liquid of the present invention.
The specific embodiment
Below in conjunction with the specific embodiment the present invention is further described in detail, the embodiment that provides is only in order to illustrate the present invention, rather than in order to limit the scope of the invention.
Embodiment 1 digestion promoting oral liquid of the present invention
The prescription of present embodiment is as shown in table 1.
Table 1
| The name of an article | Unit | Every | 100 consumptions |
| Fructus Crataegi | g | 2.67 | 267 |
| The Rhizoma Atractylodis Macrocephalae | g | 2.00 | 200 |
| Fructus Schisandrae Chinensis | g | 2.33 | 233 |
| Pericarpium Citri Reticulatae | g | 1.00 | 100 |
| Endothelium Corneum Gigeriae Galli (stir-fry) | g | 1.00 | 100 |
| Oligofructose | g | 1.20 | 120 |
| Oligomeric xylose | g | 1.20 | 120 |
| Mel | g | 1.33 | 133 |
| Fructus Crataegi essence | ml | 0.03 | 3 |
| The dosing amount | ml | 15 | 1500 |
Specification: every 15ml, every ml medicinal liquid contains the 0.6g crude drug.
Consumption usage: oral.Every day 2 times, each one of child.Be grown up each two.
This product is the health food of making as primary raw material take Fructus Crataegi, the Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, oligosaccharide, proves through function test, has facilitating digestion, improves the health care of intestinal microbial population.
The preparation method of embodiment 2 digestion promoting oral liquids
The preparation technology of digestion promoting oral liquid of the present invention specifically comprises the steps: as shown in Figure 1
(1) extracts
According to the prescription mixed material (except the oligosaccharide) shown in the embodiment 1, add 5 times in water amount and soaked 1 hour, heating when feed liquid seethe with excitement, keeps that decoction liquor is little boiled 2 hours, and decoction liquor is filtered, the reservation of material slag; The material slag adds 4 times of amounts of water, continues to heat up to decoct, and keeps little and boils 1.5 hours, and decoction liquor is filtered, and the material slag discards.
(2) centrifugal, concentrated
Feed temperature should not surpass 90 ℃ in the concentration process, and density 〉=1.085 (50～60 ℃), concentrated rear feed liquid is carried out secondary centrifuging.
(3) dosing
When feed temperature is down to about 20 ℃ of left and right sides, add oligosaccharide (being oligofructose and the oligomeric xylose of prescription shown in the embodiment 1), an amount of purified water, adjusting pH value with 10%NaOH liquid is 4.0-5.0 (10～30 ℃), then, carry out centrifugal for the third time, centrifugal after, fill, and get final product.
For the product after the fill, as shown in Figure 1, can suppress according to methods known in the art, sterilize, packing, product inspection, final warehouse-in is to form finished product.
Embodiment 3
1. experiment material
1.1 experimental drug
The A group: digestion promoting oral liquid of the present invention, prescription as described in Example 1.
The B group: traditional XIAOSHI PIAN, formed by medicines such as Fructus Crataegi, the Endothelium Corneum Gigeriae Galli Radixs Astragali, effluent south pharmaceutical factory of the college of traditional Chinese medicine provides.
The C group: JIANWEI XIAOSHI PIAN (river Chinese medicinal material industry) is comprised of Chinese medicines such as Radix Pseudostellariae, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Fructus Hordei Germinatus, Fructus Crataegis.
1.2 experimental animal rat, SD.Mice, the Kunming kind provides by Henan Medical Univ.'s animal center.
2. experimental technique and result
2.1 on the pepsic impact of rat gastric acid
Get 40 of rats, body weight 160～200g, male and female half and half.Evenly be divided at random 4 groups, gavage respectively A group, B group and C group experimental solutions.Administration every day 1 time, successive administration 7 days, in rat fasting (can't help water) in the 6th day, in the end after 1 administration 2h with 20% urethane anesthetized rat (rat fasting 12h), dissect rat abdomen, insert the plastic tube that a diameter is 3mm from the pylorus end to gastric, near the pylorus ball place's ligation fix, to collect gastric juice.And insert glandular stomach through esophagus with a plastic tube by the oral cavity, with the esophagus ligation.With 35 ℃ of left and right sides normal saline, carry out the gastric perfusion with peristaltic pump by the speed of 12ml/h and collect.It is for subsequent use to collect the 1h eluate.
2.1.1 the impact of rat stomach proteinase activity is got the hydrochloric acid 2ml of eluate 2ml and 0.1mol in test tube.Mixing adds three of protein pipe in every test tube.(get interior through 1mm, long 10cm, the capillary tube of even thickness, it is clear to make it fill Fresh Egg with siphonage, without bubble, then is placed in 80 ℃ of left and right sides water heaters and makes protein coagulation in the pipe, takes out for subsequent use).With the good test tube mouth of defat tampon, hatch 24h in 37 ± 1 ℃ of calorstats, the measurement protein pipe is awarded the people and is held the length (mm) of incubating part, gets three end sums and asks its meansigma methods, (pepsin unit=meansigma methods 2 * 16 the results are shown in Table 2. to calculate peptic activity of stomach
Table 2 XIAOSHI PIAN is on the impact of rat stomach prolease activity (X ± s)
Can find out that from upper table the .A group can obviously improve peptic activity of stomach (P＜0.01) than B, C group.
Claims (8)
1. digestion promoting oral liquid, this digestion promoting oral liquid is prepared from by the raw material of following weight proportion:
Fructus Crataegi 1-10 part, Rhizoma Atractylodis Macrocephalae 1-6 part, Fructus Schisandrae Chinensis 1-10 part, Pericarpium Citri Reticulatae 1-5 part, Endothelium Corneum Gigeriae Galli 1-5 part, oligofructose 1-8 part, oligomeric xylose 1-10 part.
2. digestion promoting oral liquid according to claim 1 is characterized in that, described digestion promoting oral liquid is prepared from by the raw material of following weight proportion:
2.67 parts of Fructus Crataegis, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 2.33 parts of Fructus Schisandrae Chinensis, 1 part of Pericarpium Citri Reticulatae, 1 part of Endothelium Corneum Gigeriae Galli, 1.2 parts of oligofructoses, 1.2 parts of oligomeric xyloses.
3. digestion promoting oral liquid, this digestion promoting oral liquid is prepared from by the raw material of following weight proportion:
Fructus Crataegi 1-10 part, Rhizoma Atractylodis Macrocephalae 1-6 part, Fructus Schisandrae Chinensis 1-10 part, Pericarpium Citri Reticulatae 1-5 part, Endothelium Corneum Gigeriae Galli 1-5 part, oligofructose 1-8 part, oligomeric xylose 1-10 part, Mel 1-10 part, Fructus Crataegi essence 1-3 part.
4. digestion promoting oral liquid according to claim 3 is characterized in that, described digestion promoting oral liquid is prepared from by the raw material of following weight proportion:
2.67 parts of Fructus Crataegis, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 2.33 parts of Fructus Schisandrae Chinensis, 1 part of Pericarpium Citri Reticulatae, 1 part of Endothelium Corneum Gigeriae Galli, 1.2 parts of oligofructoses, 1.2 parts of oligomeric xyloses, 1.33 parts of Mel, 0.03 part in Fructus Crataegi essence.
5. the preparation method of a claim 1 or 2 described digestion promoting oral liquids, this preparation method may further comprise the steps:
(1) raw material except oligofructose and oligomeric xylose is mixed in proportion, soaks, then heating extraction is collected extracting solution, filters;
(2) filtrate that step (1) is obtained is concentrated, obtains the concentrated solution of detection density 〉=1.085 in the time of 50-60 ℃;
(3) concentrated solution with step (2) adds oligofructose, oligomeric xylose, purified water, regulates 10～30 ℃ of lower pH value as 4.0-5.0 take 10%NaOH solution, and is centrifugal, canned, gets final product.
6. preparation method according to claim 5, this preparation method may further comprise the steps:
(1) raw material except oligofructose and oligomeric xylose is mixed in proportion, add 5 times of water gagings and soaked 1 hour, heating is when feed liquid is seethed with excitement, keep that decoction liquor is little boiled 2 hours, decoction liquor is filtered, and adds 4 times of water gagings in the material slag, and continuing to heat up decocts, keeping little boiled 1.5 hours, decoction liquor is filtered, and the material slag discards, and collects filtrate;
(2) filtrate with step (1) is concentrated, obtains the concentrated solution of detection density 〉=1.085 in the time of 50-60 ℃, and the filtrate temperature is no more than 90 ℃ in the concentration process, and is then centrifugal;
(3) when the filtrate temperature is down to 20 ℃, add oligofructose, oligomeric xylose, purified water, regulate 10～30 ℃ of lower pH value as 4.0-5.0 take 10%NaOH solution, centrifugal, canned, get final product.
7. the preparation method of a claim 3 or 4 described digestion promoting oral liquids, this preparation method may further comprise the steps:
(1) raw material except oligofructose and oligomeric xylose is mixed in proportion, soaks, then heating extraction is collected extracting solution, filters;
(2) filtrate that step (1) is obtained is concentrated, obtains the concentrated solution of detection density 〉=1.085 in the time of 50-60 ℃;
(3) concentrated solution with step (2) adds oligofructose, oligomeric xylose, purified water, regulates 10～30 ℃ of lower pH value as 4.0-5.0 take 10%NaOH solution, and is centrifugal, canned, gets final product.
8. preparation method according to claim 7, this preparation method may further comprise the steps:
(1) raw material except oligofructose and oligomeric xylose is mixed in proportion, add 5 times of water gagings and soaked 1 hour, heating is when feed liquid is seethed with excitement, keep that decoction liquor is little boiled 2 hours, decoction liquor is filtered, and adds 4 times of water gagings in the material slag, and continuing to heat up decocts, keeping little boiled 1.5 hours, decoction liquor is filtered, and the material slag discards, and collects filtrate;
(2) filtrate with step (1) is concentrated, obtains the concentrated solution of detection density 〉=1.085 in the time of 50-60 ℃, and the filtrate temperature is no more than 90 ℃ in the concentration process, and is then centrifugal;
(3) when the filtrate temperature is down to 20 ℃, add oligofructose, oligomeric xylose, purified water, regulate 10～30 ℃ of lower pH value as 4.0-5.0 take 10%NaOH solution, centrifugal, canned, get final product.
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| CN106692763A (en) * | 2017-03-17 | 2017-05-24 | 广东岭南职业技术学院 | Antipyretic digestion-promoting preparation and preparing method thereof |
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Effective date of registration: 20151209 Address after: 518057 to two floor, Shenzhen pharmaceutical industry building, Nanshan District Fifth Industrial Zone, Guangdong, China Patentee after: Shenzhen Taitai Pharmaceutical Industry Co., Ltd. Patentee after: Jiankangyuan Pharmaceutical Group Co., Ltd. Address before: 518057 to two floor, Shenzhen pharmaceutical industry building, Nanshan District Fifth Industrial Zone, Guangdong, China Patentee before: Shenzhen Taitai Pharmaceutical Industry Co., Ltd. |