CN102911076A - Processing device and processing method for refined acetaminophen - Google Patents
Processing device and processing method for refined acetaminophen Download PDFInfo
- Publication number
- CN102911076A CN102911076A CN2012104410260A CN201210441026A CN102911076A CN 102911076 A CN102911076 A CN 102911076A CN 2012104410260 A CN2012104410260 A CN 2012104410260A CN 201210441026 A CN201210441026 A CN 201210441026A CN 102911076 A CN102911076 A CN 102911076A
- Authority
- CN
- China
- Prior art keywords
- fluidized bed
- vibrated fluidized
- lower discharging
- loading device
- crystallizer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Disintegrating Or Milling (AREA)
- Crushing And Grinding (AREA)
Abstract
The invention provides a processing device and a processing method for refined acetaminophen. The processing device comprises a feeding tank and a lower discharging centrifugal machine, a charging device, a vibrated fluidized bed and a grinder, wherein the feeding tank is connected with an outlet of a crystallizing tank and used for containing and stirring materials produced from the crystallizing tank; the lower discharging centrifugal machine is connected with an outlet of the feeding tank; the charging device is arranged below the lower discharging centrifugal machine, and the lower discharging centrifugal machine is used for discharging the centrifuged materials to the charging device; the vibrated fluidized bed is connected with the charging device and used for drying the materials from the charging device; and the grinder is connected with the vibrated fluidized bed and used for grinding the materials introduced by the vibration of the vibrated fluidized bed. According to the processing device and the processing method provided by the invention, the continuous production is realized, the requirement on cleaning production is achieved, the cross contamination is avoided, the labor intensity of workers is lowered, the manpower is saved, the batch sizes of finished products are increased, and the test cost is lowered.
Description
Technical field
The present invention relates to the devices and methods therefor in a kind of paracetamol production process, particularly treatment unit and the treatment process thereof after a kind of acetparaminosalol phenol treating.
Background technology
In the production treating process of present paracetamol, because the output of paracetamol is generally all larger, often more than one in refining crystallization tank, but a plurality of, in traditional mode, after the material of refining crystallization dries through a plurality of little whizzers, pack in the truck, be transported to the drying plant place by the workman again and carry out drying through artificial loading, dry good material reinstalls truck and is transported to the pulverizer place and is pulverized by artificial loading, then packing.Workman's labour intensity is large in this process, and can not non-stop run, and the dust environmental pollution of dry good material is very large, can not reach the requirement of cleaner production, and crossed contamination is inevitable.
Moreover the finished product that single refining crystallization tank goes out is smaller in batches, and will chemically examine separately the finished product that each refining crystallization tank goes out, because general more than one but a plurality of of the quantity of refining crystallization tank, caused like this chemical examination often, expense is high, thereby cost is not easy control.
Summary of the invention
The object of the invention is to overcome above-mentioned technical problem, treatment unit and treatment process thereof after a kind of acetparaminosalol phenol treating are provided, the present invention passes through the improvement of equipment and the optimization of flow process, realize serialization production, reached the requirement of cleaner production, avoided crossed contamination, reduced again workman's labour intensity, saved manually, and improved the batch of finished product, reduced laboratory fee usefulness.
Treatment unit after the acetparaminosalol phenol treating provided by the invention comprises:
Be connected, take in the outlet of crystallizer and stir from the feed tank of the material of described crystallizer output;
The lower discharging centrifuge that is connected with the outlet of described feed tank;
Be arranged at the loading device of described lower discharging centrifuge below, described lower discharging centrifuge will the material discharging after centrifugal described loading device extremely;
Be connected with described loading device, the material from institute's loading device is carried out dry vibrated fluidized bed; And
Be connected the pulverizer that the material that the vibration by described vibrated fluidized bed is introduced is pulverized with described vibrated fluidized bed.
Material in the described crystallizer can be by being pumped into feed tank.
Described loading device can be to be connected by the seal for pipe joints that is arranged on described loading device top with described vibrated fluidized bed.Such as using flexible pipe to be tightly connected.
Described vibrated fluidized bed and described pulverizer can be tightly connected, and can be tightly connected by stainless steel tube.Be tightly connected and reduce crossed contamination, reach the requirement of cleaner production.
Described crystallizer is at least two, and the number of crystallizer can be determined according to the volume of feed tank.When being 2.4 times of crystallizer volume such as the volume when feed tank, crystallizer can be two, and the material after can be simultaneously that two crystallizers are refining is introduced in the feed tank, thereby increases the batch of product.
Described lower discharging centrifuge is manual or full automatic, and the present invention is preferably the full-automatic scraper lower discharging centrifuge.
The present invention can utilize vacuum with the described vibrated fluidized bed of material suction on the described loading device.Such as between described vibrated fluidized bed and described loading device, vaccum-pumping equipment being set.
Described loading device can be selected truck commonly used etc.
Treatment process after the acetparaminosalol phenol treating provided by the invention has adopted above-mentioned treatment unit, comprises following operation steps:
Material behind at least one crystallizer refining crystallization is squeezed into the step of feed tank by pump;
Carry out the stirring of described material in described feed tank after, centrifugal and discharging is to the step of the loading device that is arranged on described lower discharging centrifuge below by lower discharging centrifuge;
By vacuum the material in the described loading device is extracted into and carries out drying on the vibrated fluidized bed, utilize afterwards the shake of described vibrated fluidized bed with the step of described mass transport to pulverizer;
Material powder after will pulverizing by described pulverizer is transported to the step that packaging process is packed.
Beneficial effect of the present invention: this device has been realized non-stop run, need not hand charging between the some treatment process after the acetparaminosalol phenol treating, the operation such as material loading and transportation, greatly reduce workman's labour intensity; In addition, avoided dry good material dust to the pollution of environment thereby the interconnecting piece that this device adopts sealing is connected drying plant with pulverizer, made its requirement that has reached cleaner production, but also avoided crossed contamination.In addition, introduced this equipment of feed tank in this device, can make the material in a plurality of crystallizers before centrifugal, just be mixed into a collection of, thereby increased the batch of finished product, also equaled to have saved corresponding mixed batch machine, chemically examined simultaneously number of times and tail off, expense reduces, thereby has reduced production cost.
Description of drawings
Fig. 1 is the synoptic diagram of the treatment unit after the acetparaminosalol phenol treating in the preferred embodiments of the present invention.
Fig. 2 is the mixed structural representation of criticizing machine that prior art adopts.
Wherein, description of reference numerals is as follows:
1: crystallizer; 2: feed tank; 3: the full-automatic scraper lower discharging centrifuge; 4: truck; 41: flexible pipe; 5: vibrated fluidized bed; 51: stainless steel tube; 6: pulverizer.
Embodiment
Below in conjunction with accompanying drawing treatment unit and treatment process thereof after the acetparaminosalol phenol treating of the present invention are described.
At first, treatment unit after the acetparaminosalol phenol treating in the preferred embodiment of the present invention is described.
Fig. 1 is the synoptic diagram of the treatment unit after the acetparaminosalol phenol treating in the preferred embodiment of the present invention.
As shown in Figure 1, the treatment unit after the acetparaminosalol phenol treating in this preferred embodiment comprises: be connected with the outlet of one or more crystallizer 1, take in and stir from the feed tank 2 of the material of described crystallizer 1 output; The unloading under scraper whizzer 3 that is connected with the outlet of described feed tank 2; Be arranged at the truck 4 of the below of described unloading under scraper whizzer 3, described unloading under scraper whizzer 3 with the material discharging of described feed tank 2 to described truck 4; Vibrated fluidized bed 5 is connected with described truck 4, utilizes vacuum with the material suction of 4 li on described truck, carries out drying; Pulverizer 6 is connected with described vibrated fluidized bed 5, by the vibration of described vibrated fluidized bed 5 material is at the uniform velocity introduced pulverizer 6, then material is pulverized, and the material after again pulverizer being pulverized is at last packed, chemically examined.
Material can be to be admitted to feed tank 2 under the effect of pump from the mode that crystallizer 1 enters feed tank 2, also can be other feasible modes.As the unloading under scraper whizzer, can adopt full-automatic model, also can adopt manual model, determine according to actual needs.
In addition, described truck 4 is to be connected by the seal for pipe joints that is arranged on described truck 4 tops with described vibrated fluidized bed 5, preferably connects by flexible pipe 41.Why adopting sealing-duct, is because will be by vacuum the material suction vibrated fluidized bed 5 on the truck 4.For this reason, vaccum-pumping equipment need to be set between truck 4 and vibrated fluidized bed be connected with above-mentioned pipeline, facilitate the use vacuum convey materials between truck 4 and vibration vulcanization bed 5.
Certainly, if the draft of blower fan is enough large, also can utilize blower fan that material is transported to vibrated fluidized bed 5 from truck 4.
In addition, described vibrated fluidized bed 5 was tightly connected with being connected by stainless steel tube 51 of described pulverizer 6, thereby had avoided dry good material dust to the pollution of environment, made its requirement that has reached cleaner production, but also had avoided crossed contamination.
Described crystallizer 1 is not limited to one, can for a plurality of, be provided with two crystallizers in the present embodiment.When crystallizer is two or more, that is to say when the material of a plurality of crystallizer outputs all is incorporated in the feed tank 2, feed tank just is equivalent to a transfer tank, thereby the material of a plurality of crystallizer outputs can be mixed therein become a collection of, the batch of finished product becomes large like this, also saved laboratory fee usefulness when having saved a mixed batch of machine, if process in a traditional way the paracetamol after making with extra care, to chemically examine separately the finished product that each refining crystallization tank goes out, and adopt treatment unit of the present invention, since the material that a plurality of refining crystallization tanks are gone out mix first carry out again centrifugal, dry, pulverization process, reduced need chemical examination batch, increased the quantum of output of each batch, so reduced laboratory fee usefulness.
The present invention once of following detailed analysis adopts feed tank to carry out mixing of materials is carried out mixing of materials than the mixed batch machine of available technology adopting advantage.
To utilize mixed batch machine that the material of different batches production is mixed in the back of centrifugal, drying process (namely at vibrated fluidized bed 5) etc. in the prior art, the structural representation of mixed batch machine as shown in Figure 2, exactly diconical stainless steel tank body is placed on the large support, the good material of drying is placed on the inside, then build lid, utilize transmission of crankshaft to move back and forth, thus the dried material of putting into tank body is mixed.
The present invention adopts at a plurality of crystallizer 1 rear directly with feed tank 2 with the mixing of materials of different batches together, then by carrying out the operations such as centrifugal, dry after mixing again.
The prior art that adopts mixed batch machine is that the material to drying mixes, owing to be again that this mode of putting upside down back and forth by tank body makes material reach mixed uniformly, because producing a large amount of dust, friction (cause near the dust in working district of mixed batch machine to increase between the dry material, and when packing dust also can increase, thus operating personnel's Working environment brought detrimentally affect).
And feed tank of the present invention is owing to be the material that directly receives from crystallizer, and the material of this moment is liquid, and be by the mode (being provided with agitator in the tank body) that stirs the object in the tank to be mixed, so reduced the generation of dust, improved workman's operating environment.
And, on the effect that stirs, the liquid from different batches (crystallizer) being mixed the solid of comparing from different batches mix, the effect that the former mixes should be better, namely mixes more even.
And compare with feed tank, mixed batch machine is not only expensive but also need the larger area place, so adopt the mode of feed tank not only to provide cost savings but also reduced requirement to the place.Treatment process after the below adopts treatment unit in the preferred embodiment of the present invention to the acetparaminosalol phenol treating describes.
Material behind two crystallizer 1 refining crystallizations is squeezed into its volume of described feed tank 2(through a pump be equivalent to 2.4 times of crystallizer 1 volume), in described feed tank 2, carry out material stirring, afterwards, (effect of whizzer is exactly the effect of playing solid-liquid separation by described full-automatic scraper lower discharging centrifuge 3 centrifugal, because common link-suspended basket centrifuge needs manually from the top discharging, so in order to reduce labor strength, the whizzer that this place adopts is full automatic, do not need artificial, and automatic bottom discharge) and automatic discharging to the described truck 4 that arranges thereunder, then by vacuum the material in the described truck 4 be extracted into described vibrated fluidized bed 5 carry out drying (why will be through truck 4 and material after directly centrifugal whizzer 3 is sent into fluidized-bed 5, because the material in the feed tank 2 can not disposablely get rid of, need just can get rid of several times, if directly discharging enters fluidized-bed, can not guarantee the work of serialization), utilize afterwards the shake of described vibrated fluidized bed 5 that material at the uniform velocity is transported to described pulverizer 6, the material powder after will pulverizing by described pulverizer at last is transported to packing department and packs.
Claims (9)
1. the treatment unit after the acetparaminosalol phenol treating is characterized in that, comprising:
Be connected, take in the outlet of crystallizer and stir from the feed tank of the material of described crystallizer output;
The lower discharging centrifuge that is connected with the outlet of described feed tank;
Be arranged at the loading device of described lower discharging centrifuge below, described lower discharging centrifuge will the material discharging after centrifugal described loading device extremely;
Be connected with described loading device, the material from institute's loading device is carried out dry vibrated fluidized bed; And
Be connected the pulverizer that the material that the vibration by described vibrated fluidized bed is introduced is pulverized with described vibrated fluidized bed.
2. the treatment unit after the acetparaminosalol phenol treating as claimed in claim 1 is characterized in that,
Described loading device is to be connected by the seal for pipe joints that is arranged on described loading device top with described vibrated fluidized bed.
3. the treatment unit after the acetparaminosalol phenol treating as claimed in claim 1 is characterized in that,
Described vibrated fluidized bed and described pulverizer are tightly connected.
4. the treatment unit after the acetparaminosalol phenol treating as claimed in claim 1 is characterized in that,
Described crystallizer is at least two.
5. the treatment unit after the acetparaminosalol phenol treating as claimed in claim 1 is characterized in that,
Described lower discharging centrifuge is the full-automatic scraper lower discharging centrifuge.
6. the treatment unit after the acetparaminosalol phenol treating as claimed in claim 1 is characterized in that,
Material on the described loading device utilizes vacuum to be pumped on the described vibrated fluidized bed.
7. the treatment process after the acetparaminosalol phenol treating is characterized in that, comprises following operation steps:
Material behind at least one crystallizer refining crystallization is squeezed into the step of feed tank by pump;
Carry out the stirring of described material in described feed tank after, centrifugal and discharging is to the step of the loading device that is arranged on described lower discharging centrifuge below by lower discharging centrifuge;
By vacuum the material in the described loading device is extracted into and carries out drying on the vibrated fluidized bed, utilize afterwards the shake of described vibrated fluidized bed with the step of described mass transport to pulverizer;
Material powder after will pulverizing by described pulverizer is transported to the step that packaging process is packed.
8. the treatment process after the acetparaminosalol phenol treating as claimed in claim 7 is characterized in that,
Described lower discharging centrifuge is the full-automatic scraper lower discharging centrifuge.
9. the treatment process after the acetparaminosalol phenol treating as claimed in claim 7 is characterized in that,
Described crystallizer is at least two.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210441026.0A CN102911076B (en) | 2012-11-07 | 2012-11-07 | Treatment unit after acetparaminosalol phenol treating and treatment process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210441026.0A CN102911076B (en) | 2012-11-07 | 2012-11-07 | Treatment unit after acetparaminosalol phenol treating and treatment process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102911076A true CN102911076A (en) | 2013-02-06 |
| CN102911076B CN102911076B (en) | 2015-09-02 |
Family
ID=47609682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210441026.0A Active CN102911076B (en) | 2012-11-07 | 2012-11-07 | Treatment unit after acetparaminosalol phenol treating and treatment process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102911076B (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86102837A (en) * | 1986-02-20 | 1987-09-02 | 药品管理公司 | Preparation of stable crystal of sodium acetylsalicylate |
| US20040176233A1 (en) * | 2001-07-19 | 2004-09-09 | Ernst-Ulrich Himmen | Deviation ring for a self-distributing centrifuge |
| CN102030712A (en) * | 2010-11-18 | 2011-04-27 | 大庆井井源油田科技开发有限公司 | Device for producing dimethyl hydantoin |
| CN102382004A (en) * | 2011-08-19 | 2012-03-21 | 河北冀衡（集团）药业有限公司 | Decolorization pre-treatment system and decolorization pre-treatment method of acetaminophen |
| CN202290321U (en) * | 2011-10-20 | 2012-07-04 | 河北冀衡（集团）药业有限公司 | Closed material throwing system for acetaminophen production |
| CN202387546U (en) * | 2012-01-09 | 2012-08-22 | 河北冀衡（集团）药业有限公司 | Device for controlling grain size of paracetamol powder |
-
2012
- 2012-11-07 CN CN201210441026.0A patent/CN102911076B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86102837A (en) * | 1986-02-20 | 1987-09-02 | 药品管理公司 | Preparation of stable crystal of sodium acetylsalicylate |
| US20040176233A1 (en) * | 2001-07-19 | 2004-09-09 | Ernst-Ulrich Himmen | Deviation ring for a self-distributing centrifuge |
| CN102030712A (en) * | 2010-11-18 | 2011-04-27 | 大庆井井源油田科技开发有限公司 | Device for producing dimethyl hydantoin |
| CN102382004A (en) * | 2011-08-19 | 2012-03-21 | 河北冀衡（集团）药业有限公司 | Decolorization pre-treatment system and decolorization pre-treatment method of acetaminophen |
| CN202290321U (en) * | 2011-10-20 | 2012-07-04 | 河北冀衡（集团）药业有限公司 | Closed material throwing system for acetaminophen production |
| CN202387546U (en) * | 2012-01-09 | 2012-08-22 | 河北冀衡（集团）药业有限公司 | Device for controlling grain size of paracetamol powder |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102911076B (en) | 2015-09-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105108924A (en) | Plastic mixed-processing equipment | |
| CN210969516U (en) | Mixing, stirring and feeding system of extruder used in thermoplastic plastic production | |
| CN213557402U (en) | Carbon black powder granulation system | |
| CN206481979U (en) | One seed shrimp crab mixed feed production system | |
| CN202898274U (en) | Device for treatment after acetaminophen refining | |
| CN105481491A (en) | Full-automatic biofertilizer production system | |
| CN209809989U (en) | Novel automatic mixing and weighing system for powder | |
| CN103567045B (en) | Paint kit equipment Environment-friendlyproduction production line | |
| CN210544857U (en) | Chemical fertilizer raw material mixing device | |
| CN102911076A (en) | Processing device and processing method for refined acetaminophen | |
| CN202876725U (en) | V-shaped mixer | |
| CN214915607U (en) | Filter aid automatic reagent feeding device | |
| CN205501149U (en) | Full -automatic production system of bio -feritlizer | |
| CN204779387U (en) | Fertile system of system with good oxygen stirring function of wall is scraped in rotation of heating cloth oxygen | |
| CN211070020U (en) | Powder mixing and stirring system | |
| CN210279430U (en) | Ball-milling, bipyramid blendor, automatic alignment and vacuum feeding integration equipment | |
| CN113353938A (en) | Purification process method of high-purity silicon | |
| CN202700608U (en) | Environmental-friendly production line of coating complete equipment | |
| CN104857890A (en) | Fertilizer production system with functions of steam heating, wall scrapping and stirring | |
| CN207838745U (en) | A kind of batch mixer for powder | |
| CN201999248U (en) | Efficient mixing and metering packaging system for ammonium molybdate effective mixed material | |
| CN218131679U (en) | Drainage sand automated production system of dolly batching | |
| CN214316967U (en) | Fodder modulation system material machine | |
| CN205570205U (en) | Bamboo wood flour agitating unit | |
| CN108421486A (en) | A kind of mixing machine convenient for cleaning |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: 053000 No.1, Weiwu street, high tech Zone, Hengshui City, Hebei Province Patentee after: Hebei Jiheng Pharmaceutical Co.,Ltd. Address before: 053000 No.368 Jianshe North Street, Hengshui City, Hebei Province Patentee before: HEBEI JIHENG (Group) PHARMACEUTICAL Co.,Ltd. |