CN102908159B - Radiotherapy with superposition-free 3D computerized tomography imaging - Google Patents

Radiotherapy with superposition-free 3D computerized tomography imaging Download PDF

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CN102908159B
CN102908159B CN201210276129.6A CN201210276129A CN102908159B CN 102908159 B CN102908159 B CN 102908159B CN 201210276129 A CN201210276129 A CN 201210276129A CN 102908159 B CN102908159 B CN 102908159B
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image data
data set
raw image
computer tomography
radiotherapy equipment
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CN102908159A (en
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T.弗洛尔
M.格拉斯鲁克
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Siemens Healthineers AG
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Siemens AG
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/02Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03Computerised tomographs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/02Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03Computerised tomographs
    • A61B6/032Transmission computed tomography [CT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/48Diagnostic techniques
    • A61B6/486Diagnostic techniques involving generating temporal series of image data
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/52Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5205Devices using data or image processing specially adapted for radiation diagnosis involving processing of raw data to produce diagnostic data
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/52Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5258Devices using data or image processing specially adapted for radiation diagnosis involving detection or reduction of artifacts or noise
    • A61B6/5264Devices using data or image processing specially adapted for radiation diagnosis involving detection or reduction of artifacts or noise due to motion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/52Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5288Devices using data or image processing specially adapted for radiation diagnosis involving retrospective matching to a physiological signal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048Monitoring, verifying, controlling systems and methods
    • A61N5/1064Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
    • A61N5/1065Beam adjustment
    • A61N5/1067Beam adjustment in real time, i.e. during treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048Monitoring, verifying, controlling systems and methods
    • A61N5/1049Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1061Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using an x-ray imaging system having a separate imaging source

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Pulmonology (AREA)
  • Theoretical Computer Science (AREA)
  • Physiology (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

The invention relates to a radiotherapy apparatus, comprising: a therapeutic radiation source; a image capturing apparatus used for computerized tomography 3D image data sets, containing the radiation sources and an oppositely positioned radiation detector used for recording original image data for the superposition-free computerized tomography 3D image data sets; a reconstruction apparatus used for reconstructing the superposition-free computerized tomography 3D image data sets from the original image data; and a control device for the coordinated control of an irradiation with the therapeutic radiation source, and a recording and reconstruction of the superposition-free computerized tomography 3D image data sets by using the image capturing apparatus and the reconstruction apparatus. The invention further relates to a method for image data recording during a radiotherapy session, comprising the following steps: recording of raw image data for the superposition-free computerized tomography 3D image data sets, and reconstructing the superposition-free computerized tomography 3D image data sets from the raw image before the irradiation is completed.

Description

There is the radiotherapy of non-overlapping 3D-CT imaging
Technical field
The present invention relates to and a kind of there is the radiotherapy equipment of CT (computer tomography) imaging device and a kind of method of recording image data in radiotherapy.
Background technology
Radiotherapy is a kind of main stream approach, which uses ionizing radiation, is used for the treatment of pathological tissue, such as tumor tissues.Radiocurable target is the surrounding tissue of irradiating tissue to be treated and simultaneously not damage healthy with sufficient therapeutic dose.In addition, therapeutic effect depends on: ionizing radiation acts on different on health tissues with pathological tissue.
When using radiotherapy equipment to irradiate patient, due to have a mind to and unintentionally patient moving (such as breathe, gastrointestinal peristalsis) position to be illuminated can move.Thus, the radiation plan determined before departing from of irradiation.
US6778850 describes a kind of radiocurable enforcement, wherein have recorded the radioscopic image of multiple diagnosis, therefrom to reconstruct the tomography synthetic image (Tomosynthese-Abbildung) of low resolution, then described tomography synthetic image is used to irradiation to focus in target volume.
US7684647 describes a kind of radiocurable enforcement, wherein 2D radiography captured in radiation and 3D rendering data set captured is before exposure connected each other.
Summary of the invention
The technical problem to be solved in the present invention is, provides a kind of a kind of method of radiotherapy equipment and recording image data when radiotherapy, and it accurately can contrast and injects row supervision and wherein can contrast with view data recorded before simply.
Radiotherapy equipment according to the present invention comprises:
-treating radiation source,
-for the filming apparatus of CT (computer tomography) 3D rendering data set, its radiation monitor comprising diagnosis radiation source and be positioned at opposite, can record raw image data for non-overlapping CT (computer tomography) 3D rendering data set by described radiation monitor,
-reconstructing device, can reconstruct non-overlapping CT (computer tomography) 3D rendering data set by described reconstructing device from raw image data, and
-control device, for controlling in phase: the radioactive source by treatment irradiates, and uses filming apparatus and reconstructing device to record non-overlapping CT (computer tomography) 3D rendering data set and rebuild.
Therefore, can to install in radiotherapy equipment or the filming apparatus of the integrated CT image data set (CT represents CT (computer tomography)) for three-dimensional.Three-dimensional non-overlapping CT (computer tomography) image data set can be recorded by described filming apparatus.The non-overlapping image data set of described three-dimensional can be rebuild from recorded raw image data by general CT algorithm for reconstructing.The station diagram picture to be illuminated describing position to be illuminated with high contrast resolution can be obtained thus.
Compared with the radiography of two dimension, three-dimensional CT image data can describe more accurately with obvious higher contrast resolution and locate position (soft tissue particularly to be illuminated) to be illuminated.Only use and only can describe region to be illuminated with limited three-dimensional information from the multiple two-dimentional radiography of different directions.If now should be associated, so because different image types has been not easy the foundation of this association technically with planning CT data set between these radiographies.
Although the object that only tomography is comprehensively taken for examine on the cross section through object carries out imaging, the described cross section through object is not described with having complete zero lap.Tomography is comprehensively taken has that certain is fuzzy because be positioned in object structure before and after cross section similarly (if also obviously faintly) be imaged and show together with the cross-sectional image information of reality in the picture thus superimposedly.Correspondingly, comprehensively take neither be non-overlapping for tomography.Thus, not only limit contrast resolution, and limit three-dimensional information.
When setting up now with when planning the associating of CT data set, be technically also not easy to realize this point, because different image types is compared to each other.
On the other hand, the three-dimensional CT image data set recorded by current radio therapeutic equipment is the three-dimensional data group of object structure being carried out to complete zero lap imaging.Such as cross-sectional image can be generated from the CT data set of described three-dimensional, its only on this cross section object described in video picture and not by superpose destination object other regions come " dilution " this image information.Three-dimensional image data sets has low contrast detectivity typically good CT image.
Due to the similarity between the image data set of the CT (computer tomography) of three-dimensional and planning CT image data set, contrast and/or the association of these two data sets easily can be implemented with relatively little technology overhead.
Radiation monitor can comprise array, and this array has one or more and is arranged in the detector row for detecting x-ray in patient's longitudinal direction.Can arrange detector row like this, make it perpendicular to axle, the radioactive source for the treatment of rotates around this axle.Each detector row of CT detector can comprise hundreds of detector elements respectively.Array can comprise the plane of the stretching, extension had in length, and its stretching, extension is in the vertical at least 2 times of stretching, extension in the horizontal, or or even 3 times or 5 times.
Thus, detector can be like this, make the symmetrical centre of measurement field at radiotherapy equipment in patient's cross-sectional direction have 50cm at least, and measurement field is in the vertical at symmetrical centre maximal cover 20cm.Therefore, detector is obviously different from so-called flat panel detector (Flat-Panel-Detektor), and described flat panel detector is such as used in conical beam CT (Cone-Beam-CT) or is used to generate radiography, X-ray examination or tomography comprehensively and usually have obvious square shape thus.Therefore, filming apparatus can be single file CT (computer tomography) or multirow CT (computer tomography).
Filming apparatus can be rotatively supported.In this case, in order to record raw image data, filming apparatus can at least rotate with the fan angle sum of 180 ° and radiation monitor.Such as the radioactive source of filming apparatus and treatment can be fixed on the rotary apparatus of radiotherapy equipment like this, the radioactive source for the treatment of and filming apparatus are rotated around central shaft jointly.This achieve compact structure mode.By this way also can irradiate time and irradiate terminate before take complete raw image data, described raw image data is necessary for CT image reconstruction data set.
Control device can be configured like this in form of implementation, irradiation is activated.Control record raw image data like this for non-overlapping CT (computer tomography) 3D rendering data set at this, make to start record after starting to irradiate.Partly (or even fully) raw image data can be recorded when application for the treatment of ray, namely when treatment ray is registered to patient by the radioactive source for the treatment of.The rotation for this reason required if desired of filming apparatus can similarly (at least in part) carry out when application for the treatment of ray.
In form of implementation, control device has input, by this input, the external signal of the motion characterizing object to be imaged is transferred to control device.External signal such as can carry out record by the motion sensor of outside, such as, by the optical shooter of monitoring patient surface or the pressure zone (Druckg ü rtel) by the monitoring pleural pressure when breathing.
Control device can be configured to control the record to raw image data like this, and make only in the interval determined, to record raw image data, in described interval, object to be imaged is in the kinestate determined.The record of raw image data can be triggered by external signal.The respiration phase record raw image data such as can only determined.Thus, in the view data of the CT (computer tomography) of rebuilding, motion blur is reduced.
Reconstructing device can be configured like this, makes recorded raw image data be associated with the external signal of the motion characterizing object to be imaged in time.Also this contact can be used for the image data set implementing reconstructing computer tomography like this, make to reduce or even minimize by kinetic fuzzy.
Reconstructing device can be configured like this, make from the recorded raw image data be associated with external signal, determine multiple difference non-overlapping CT (computer tomography) 3D rendering data set, described 3D rendering data set makes object images to be imaged in the different moment.Such as can record raw image data continuously.Then can rebuild when using the external signal be associated with raw image data, and can in time raw image data be classified.Can generate the temporal sequence of three-dimensional CT (computer tomography) graph data group by this way, wherein each independent image data set dimensionally and zero lap ground imaging subjects structure.
In addition can configure control device, so as the institute when irradiating to be recorded and rebuilds, the 3D rendering data set of non-overlapping, CT (computer tomography) with before relatively control irradiation process according to this compared with the 3D rendering data set (such as with plan CT image data set) that records.
By this contact can determine to be illuminated to as if how to be moved and/or be deformed.Such as can produce this contact by registration related object position that is strict or non-critical, therefrom obtain the information about object move, rotation and/or distortion and irradiate for controlling.
Also the captured CT image data set when irradiating can be associated with the time-resolved CT image data set captured by pre-irradiation of check object at this, wherein CT image shows region to be illuminated in the different moment (such as in different respiration phase) before an examination.
Can irradiate according to relatively controlling.Such as, can interrupt irradiating; Can only irradiate in irradiation object position given in advance, described irradiation object position is by relatively determining; Or can control like this to irradiate, make to follow object motion and irradiate.
According to of the present invention in radiotherapy the method for recording image data comprise following steps:
-after starting to irradiate, record raw image data is used for non-overlapping CT (computer tomography) 3D rendering data set, and,
-before irradiation terminates, from raw image data, rebuild non-overlapping CT (computer tomography) 3D rendering data set.
Can by there is the imaging device of CT (computer tomography) of radiation monitor to record raw image data, described radiation monitor comprises and has the array that one or more is arranged in the detector row in patient's longitudinal direction.Raw image data can be recorded, and method is, radiation monitor at least rotates with the fan angle sum of 180 ° and radiation monitor around patient.
Can record raw image data when using external signal and/or rebuild non-overlapping CT (computer tomography) image, described external signal characterizes the motion of object to be imaged.Such as, only can record raw image data in the interval determined, object to be imaged in described interval is in the kinestate determined.But, raw image data also can continuously or do not rely on object motion be recorded.
That recorded can be associated with external signal for the raw image data rebuild, and wherein, rebuilds multiple difference non-overlapping CT (computer tomography) 3D rendering data set especially, and it is at different moment video pictures object to be imaged.
Non-overlapping CT (computer tomography) 3D rendering data set can with irradiate before the 3D rendering data set that records compare, describedly relatively control irradiation process to depend on especially.
Description to each feature, advantage and effect above-mentioned and below not only relates to device category and also relates to method category, and does not at large set forth separately in each case; Each feature disclosed herein also can be other suitable combination according to the present invention.
Accompanying drawing explanation
Set forth form of implementation of the present invention further according to diagram below, but be but not limited to this.Wherein,
Fig. 1 shows the strong schematic structure of radiotherapy equipment, has the o shape frame being integrated with CT imaging device wherein,
Fig. 2 shows a form of implementation according to the present invention's method of recording image data when irradiating,
Fig. 3 shows another form of implementation according to the present invention's method of recording image data when irradiating.
Detailed description of the invention
Fig. 1 shows the radiotherapy equipment 11 with o shape frame 13.
Frame 13 has central opening 13, locates wherein the patient 17 on patient table 19 to irradiate.
Rotary apparatus 21 is positioned on frame ring, the radioactive source 23 for the treatment of can be made to rotate around patient 17 by described rotary apparatus.Carry out collimation (kollimiert) by the ray of multileaf collimator (Multi-Leaf-Kollimator) to the radioactive source for the treatment of, exposure field is limited in two dimension thus.Accordingly, multileaf collimator be different from one dimension binary collimator ( kollimator), described binary collimator only allows exposure field to change in a dimension.
Similarly, being connected with rotary apparatus 21 and being integrated in radiotherapy equipment 11 is CT-X radioactive source 25 and CT detector 27, can for the CT (computer tomography) record raw image data of non-overlapping three-dimensional by them.
CT detector 27 comprises the array with one or more detector row, and described detector row is disposed in the longitudinal direction of patient 17.In order to record raw image data, image-forming block can rotate with 180 ° of fan angle sums with radiation monitor together with rotary apparatus.
Radiotherapy equipment 11 has control device 29, controls all parts of radiotherapy equipment 11 by described control device in phase.
In addition, control device 29 has input 31, can to control device 29 input signal by described input, described signal by external sensor 33 or movement monitor record and characterize the motion (such as respiratory movement) of patient 17.
In addition, radiotherapy equipment 11 has reconstructing device 35, can generate non-overlapping three-dimensional computer tomographic image data group by described reconstructing device from raw image data.
Control device 29 and reconstructing device 35 can such as be realized by computer unit.
Fig. 2 shows the flow chart described according to the form of implementation of method of the present invention.
First, start to irradiate (step 51).
The respiratory movement of patient is monitored and collected by outside movement monitor.The signal of characterizing motility is recorded and is transferred to radiotherapy equipment (step 53).
Irradiate time and particularly apply useful to irradiation of rays time record raw image data (step 55).Only in the interval determined, carry out record, namely when patient is positioned at the respiration phase determined.Determine whether to be positioned at suitable respiration phase according to external signal.
After have recorded enough raw image datas, before irradiation terminates, from raw image data, generate three-dimensional non-overlapping CT (computer tomography) image data set (step 57).
By this non-overlapping three-dimensional computer tomographic image data group compared with planning CT image data set (Planungs-CT-Bilddatensatz) (step 59).
Depend on described relatively control to irradiate, such as, by reorientation patient or by controlling (step 61) gate illuminating method or tracking radiation method.
Fig. 3 shows another form of implementation according to method of the present invention.Be different from embodiment shown in fig. 2 and record raw image data (step 55') continuously at this.
But when rebuilding, raw image data is associated with the external signal of characterizing motility.Rebuild to time resolution, that is, according to external signal, initial data is classified, and generate the temporal sequence (step 57') of the CT image data set of non-overlapping three-dimensional.
The captured temporal sequence of CT image data set when irradiating is associated with the time-resolved CT image data set of the check object captured by pre-irradiation, so that contrast injects row control (step 59').
List of numerals
11 radiotherapy equipments
13 frames
15 central openings
17 patients
19 patient table
21 rotary apparatuss
The radioactive source of 23 treatments
The radioactive source of 25 diagnosis
27 radiation monitors
29 control device
31 inputs
33 external sensors
35 reconstructing devices
51 steps 51
53 steps 53
55,55' step 55, step 55'
57,57' step 57, step 57'
59,59' step 59, step 59'
61 steps 61

Claims (9)

1. a radiotherapy equipment (11), it comprises:
-treating radiation source (23),
-for the filming apparatus of CT (computer tomography) 3D rendering data set, its radiation monitor (27) comprising diagnosis radiation source (25) and be positioned at opposite, raw image data can be recorded for non-overlapping CT (computer tomography) 3D rendering data set by described radiation monitor
-reconstructing device (35), can reconstruct described non-overlapping CT (computer tomography) 3D rendering data set by described reconstructing device from described raw image data, and
-control device (29), for controlling in phase: the radioactive source (23) by treatment irradiates, and use described filming apparatus and reconstructing device (35) to record described non-overlapping CT (computer tomography) 3D rendering data set and rebuild
Wherein, described control device (29) is configured, so as by the non-overlapping CT (computer tomography) 3D rendering data set recording and rebuild between the light period with before relatively control irradiation process according to described compared with the 3D rendering data set that records.
2. radiotherapy equipment according to claim 1 (11), wherein, described radiation monitor (27) comprises array, and this array has one or more by the detector row for detecting x-ray be arranged in continuously in patient's longitudinal direction.
3. radiotherapy equipment according to claim 2 (11), wherein, described array comprises the plane having and length stretches, and its stretching, extension is in the vertical at least the twice of stretching, extension in the horizontal.
4. radiotherapy equipment according to claim 1 (11), wherein, described filming apparatus is rotatively supported, and with 180 °, it at least can add that the fan angle sum of radiation monitor rotates to record described raw image data.
5. radiotherapy equipment according to claim 1 (11), wherein, the described control device of such configuration (29) starts irradiate and control to record described raw image data for described non-overlapping CT (computer tomography) 3D rendering data set, makes to start record after starting to irradiate.
6. radiotherapy equipment according to claim 1 (11), wherein, described control device (29) has input (31), can be had the external signal of the motion characterizing object (17) to be imaged by described input to this control device (29) input.
7. radiotherapy equipment according to claim 1 (11), wherein, the described control device of such configuration (29) controls the record to described raw image data, described raw image data is only recorded in the interval determined, object (17) to be illuminated in described interval is in the kinestate determined.
8. radiotherapy equipment according to claim 6 (11), wherein, described reconstructing device (35) is configured to for the external signal of recorded raw image data with the motion characterizing object (17) to be imaged being linked to each other in time.
9. radiotherapy equipment according to claim 8 (11), wherein, described reconstructing device (35) is configured to for determining multiple difference non-overlapping CT (computer tomography) 3D rendering data set from the raw image data recorded be associated with described external signal, and described 3D rendering data set is at different moment video pictures object to be imaged.
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