CN102895270A - Application of composition of red yeast rice and ginkgo leaves in aspect of controlling diabetic complications - Google Patents
Application of composition of red yeast rice and ginkgo leaves in aspect of controlling diabetic complications Download PDFInfo
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- CN102895270A CN102895270A CN2012104578295A CN201210457829A CN102895270A CN 102895270 A CN102895270 A CN 102895270A CN 2012104578295 A CN2012104578295 A CN 2012104578295A CN 201210457829 A CN201210457829 A CN 201210457829A CN 102895270 A CN102895270 A CN 102895270A
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Abstract
The invention relates to the new application field of composition of red yeast rice and ginkgo leaves in the aspect of controlling diabetic complications, belonging to the fields of medicines and health foods. In order to solve the technical problems, the invention provides the application of the composition of red yeast rice and ginkgo leaves in the aspect of controlling diabetic complications. The composition of red yeast rice and ginkgo leaves has remarkable effects in controlling diabetic complications such as dyslipidemia, diabetic vascular complications, diabetic cardio-cerebrovascular diseases and diabet acompanied by coronary heart disease.
Description
Technical field
The present invention relates to the new application aspect diabetic complication of Monas cuspurpureus Went, compositions extracted from gingko biloba leaves, belong to medicine, health food technology field.
Background technology
Because growth in the living standard, the change of dietary structure, the rhythm of life that day is becoming tight and few moving factors such as life style of sitting more, global onset diabetes rate rapid development, diabetes have become the third-largest disease of the serious harm human health after tumor, cardiovascular pathological changes.China recent years onset diabetes rate has increased more than 5 times, is one of global fastest-rising country, and wherein type 2 diabetes mellitus accounts for more than 90% of all patients.Diabetes are not only carbohydrate metabolism disturbance, also cause thus the disorder of albumen, fat, vitamin, water and salt metabolism, thereby have influence on the metabolism of whole body, the complication that causes almost involves each system and the internal organs of whole body, is the major reason that diabetics is disabled and caused death.
Western medicine and medical practitioners still lacks safely and effectively means treatment diabetic complication at present, and the Chinese medicine that in recent years screening exploitation prevents and treats diabetes and complication thereof has become one of focus of diabetes control drug research.
Summary of the invention
Technical problem solved by the invention provides the Monas cuspurpureus Went of mentioning in 200510041265.7 patents, the new purposes of compositions extracted from gingko biloba leaves.
Above-mentioned new purposes is Monas cuspurpureus Went, the application of compositions extracted from gingko biloba leaves aspect diabetic complication that 200510041265.7 patents are mentioned.
Above-mentioned application is mainly Monas cuspurpureus Went, compositions extracted from gingko biloba leaves is being prevented and treated diabetes merging dyslipidemia, great vessels complication in diabetic patients, the application of diabetic cardiovascular and cerebrovascular disease and several diabetic complications of diabetes complicated coronary heart disease aspect.
Monas cuspurpureus Went, compositions extracted from gingko biloba leaves are the original creation compositionss of granted patent 200510041265.7 of my company, and have been developed to and are Chinese medicine 6 kind new medicines, are transferring the clinical experimental study of blood fat at present.
Monas cuspurpureus Went, compositions extracted from gingko biloba leaves that the present invention adopts, its drug weight proportioning and preparation method are all consistent with patent 200510041265.7.Said composition is formulated take Monas cuspurpureus Went and Folium Ginkgo as effective ingredient, and in dry, Monas cuspurpureus Went wherein: the weight ratio of Folium Ginkgo is 1-5: 5-1.
Wherein Monas cuspurpureus Went refer to Hongqu powder (red colouring agent), Monas cuspurpureus Went extract the two one of, perhaps the two any mixing.
Wherein Folium Ginkgo refer to ginkgo leaf powder, Folium Ginkgo extract the two one of, or any mixing of the two.
The preparation of making as: select by weight Hongqu powder (red colouring agent) (65 order) and ginkgo leaf powder (65 order) in 1:1 ratio mix homogeneously as active ingredient, make capsule, be called Yinqu Capsule, specification 0.27 g/ grain (active ingredient: the weight ratio of adjuvant is 3:1), 2 tablets/times, 1 times/day.This Yinqu Capsule dosage form is namely adopted in the following application of the present invention.
Monas cuspurpureus Went of the present invention, compositions extracted from gingko biloba leaves are in the mechanism of action of prevention and treatment diabetic complication:
Monas cuspurpureus Went of the present invention, compositions extracted from gingko biloba leaves are to be based upon on the therapeutical effect basis of Monas cuspurpureus Went, this two flavors medical material of Folium Ginkgo at the preventive and therapeutic effect aspect the diabetic complication.Monas cuspurpureus Went is China's Chinese medicine, has significant accent blood fat, can increase the stability of atheromatous plaque or speckle is dwindled, and reduces the generation of apoplexy or myocardial infarction.The stanin fat-reducing materials such as blood fat reducing chemical constituent lovastatin that contain natural generation in the Monas cuspurpureus Went; can suppress specifically reductase---the activity of HMG-CoA; thereby reduce the level of body inner cholesterol, regulate the blood lipid level that diabetes merge patients with dyslipidemia.In addition, statin substance still has multiple non-lipid effect, as improves vascular endothelial function, improves blood vessel endothelium to expanding the reactivity of angiogenic substance; Suppress propagation and the migration of vascular smooth muscle cell, promote vascular smooth muscle cell apoptosis; Reduce the formation of arterial wall macrophage and foam cell, make atherosclerotic plaque stable and dwindle; Reduce the plasma C reactive protein, alleviate the inflammatory reaction of Atherosclerosis; Anticoagulant and fibrinolytic etc. is provided.
The effective ingredient bilobalide of Folium Ginkgo and flavonoid have unique curative effect to the treatment cardiovascular and cerebrovascular disease; can improve the brain cell metabolism; cerebral blood flow is increased; the protection ischemic myocardium; reduce the generation of arrhythmia, have in addition the effects such as the free radical of removing, anti peroxidation of lipid, anti-platelet activating factor, anticoagulant.Be usually used in clinically obstruction of qi in the chest and cardialgia, apoplexy, hemiplegia, stiff tongue and retardation in speech, Treating Stable Angina Pectoris of Coronary Artery Disease, cerebral infarction are seen above-mentioned patient.
The above-mentioned collaborative and complementary action of Monas cuspurpureus Went, Folium Ginkgo two flavor Chinese medicines, can effectively merge dyslipidemia to diabetes, great vessels complication in diabetic patients, the diabetic complications such as diabetic cardiovascular and cerebrovascular disease and diabetes complicated coronary heart disease are prevented and treated, be conducive to quality of life of delaying the PD of diabetics and improving diabetics, have good social benefit and market value.
The specific embodiment
Representative instance
Example 1, patient Wang Zhen, the man, 51 years old, private storekeeper, the type 2 diabetes mellitus patient, for many years ill, be diet on ordinary days or take all rules relatively of antidiabetic drug that often carry out self-monitoring in the domestic blood glucose meter, glycemic control gets always good.Find the Secondary cases hyperlipidemia that diabetes cause at the beginning of 2012 during to Hospital Physical Examination, T-CHOL 6.35 mmol/L, slightly more higher than normal level, low-density lipoprotein cholesterol 4.12 mmol/L reach the Drug therapy level that needs.Because dyslipidemia is the important risk factor that type 2 diabetes mellitus patient cardiovascular and cerebrovascular complication incidence rate increases, the patient begins to take the described Yinqu Capsule that Monas cuspurpureus Went, compositions extracted from gingko biloba leaves make in February, 2012, take before sleeping every day 1 time, each 2 capsules, take continuously health check-up after 3 months, T-CHOL 5.28 mmol/L, low-density lipoprotein cholesterol 3.50 mmol/L reach normal level.By this example as seen, Monas cuspurpureus Went, compositions extracted from gingko biloba leaves merge dyslipidemia to preventing and treating diabetes, there is certain curative effect diabetes cardiovascular and cerebrovascular complication aspect.
Example 2, patient Liu Aiqin, the woman, 46 years old, the grade teacher, the type 2 diabetes mellitus patient, for many years ill, occur dizzy in October, 2011, numb limbs and tense tendons, cardiopalmus, the symptom of the cardiovascular and cerebrovascular diseases such as distortion of commissure, the health check-up of being admitted to hospital find that its merging suffers from heavier hyperlipidemia, T-CHOL 6.68mmol/L, low-density lipoprotein cholesterol 4.53 mmol/L, triacylglycerol 4.81 mmol/L, this also is the major reason that causes above-mentioned symptom to occur, and finally can cause the severe complications such as coronary heart disease, apoplexy if the state of an illness continues development.
The patient begins to take the described Yinqu Capsule that Monas cuspurpureus Went, compositions extracted from gingko biloba leaves make in the same month, take before sleeping every day 1 time, each 2 capsules, take continuously that the health check-up blood fat reaches normal level substantially after 3 months, T-CHOL 5.35 mmol/L, low-density lipoprotein cholesterol 3.32 mmol/L, triacylglycerol 1.58 mmol/L, above-mentioned dizziness, the symptoms such as numb limbs and tense tendons all disappear, and the diabetic complications such as diabetic cerebrovascular and diabetes complicated coronary heart disease great vessels complication in diabetic patients do not appear so far.By this example as seen, Monas cuspurpureus Went, compositions extracted from gingko biloba leaves have certain curative effect to control great vessels complication in diabetic patients, diabetic cardiovascular and cerebrovascular disease and diabetes complicated coronary heart disease aspect.
Example 3, patient Wu Zhigang, the man, 55 years old, the lawyer, type 2 diabetes mellitus merges patients with dyslipidemia, T-CHOL 6.40mmol/L, low-density lipoprotein cholesterol 3.88 mmol/L, triacylglycerol 3.59 mmol/L.In March, the 2011 heart burst violent constriction of persistence and vexed plug sense, pain involves whole shirtfront, and is extremely weak, and dyspnea continues 30 minutes.Go to see a doctor and be diagnosed as diabetes complicated coronary heart disease, the described Yinqu Capsule that Monas cuspurpureus Went, compositions extracted from gingko biloba leaves make is taken in conventional first aid simultaneously, took continuously 3 months, and took 1 time before sleeping every day, each 2 capsules, above-mentioned symptom disappears, the health check-up blood fat reaches normal level, T-CHOL 5.15 mmol/L, low-density lipoprotein cholesterol 3.24 mmol/L, triacylglycerol 1.56 mmol/L, and above-mentioned coronary heart disease symptom does not appear so far more than a year again.By this example as seen, Monas cuspurpureus Went, compositions extracted from gingko biloba leaves have certain curative effect to preventing and treating diabetes complicated coronary heart disease aspect.
Claims (2)
1. Monas cuspurpureus Went, the application of compositions extracted from gingko biloba leaves aspect the control diabetic complication.
2. application according to claim 1, concrete described Monas cuspurpureus Went, compositions extracted from gingko biloba leaves are being prevented and treated diabetes merging dyslipidemia, great vessels complication in diabetic patients, the application of diabetic cardiovascular and cerebrovascular disease and several diabetic complications of diabetes complicated coronary heart disease aspect.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106722453A (en) * | 2016-11-28 | 2017-05-31 | 张新江 | Functional food composition rich in Organic Selenium and Organic Chromium suitable for diabetic and its preparation method and application |
| CN110477379A (en) * | 2018-08-07 | 2019-11-22 | 美安康质量检测技术（上海）有限公司 | A kind of red yeast rice hypertension and hyperlipemia nutrient powder and preparation method thereof |
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| CN1899342A (en) * | 2006-07-17 | 2007-01-24 | 浙江杭州鑫富药业股份有限公司 | Oral medicine for treating diabetes and its use |
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2012
- 2012-11-15 CN CN2012104578295A patent/CN102895270A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899342A (en) * | 2006-07-17 | 2007-01-24 | 浙江杭州鑫富药业股份有限公司 | Oral medicine for treating diabetes and its use |
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| 吉桂萍等: "血脂康胶囊治疗早期糖尿病肾病32例", 《中国厂矿医学》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106722453A (en) * | 2016-11-28 | 2017-05-31 | 张新江 | Functional food composition rich in Organic Selenium and Organic Chromium suitable for diabetic and its preparation method and application |
| CN110477379A (en) * | 2018-08-07 | 2019-11-22 | 美安康质量检测技术（上海）有限公司 | A kind of red yeast rice hypertension and hyperlipemia nutrient powder and preparation method thereof |
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Application publication date: 20130130 |