CN102895132B - Composition for detoxifying and purifying skin - Google Patents
Composition for detoxifying and purifying skin Download PDFInfo
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- CN102895132B CN102895132B CN201210459452.7A CN201210459452A CN102895132B CN 102895132 B CN102895132 B CN 102895132B CN 201210459452 A CN201210459452 A CN 201210459452A CN 102895132 B CN102895132 B CN 102895132B
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Abstract
The invention discloses a composition for detoxifying and purifying skin, and aims to provide a composition (SOPC-O for short) which can effectively clear away free radicals produced by the skin of a human body and reduces the free radicals in the skin and residual heavy metal toxics. The composition is characterized by consisting of the following components by weight percent: 30 to 70 percent of super procyanidins and 30 to 70 percent of oat beta-glucosan. The composition belongs to the technical field of skin care products.
Description
Technical field
The present invention discloses a kind of compositions, specifically, is a kind of compositions purifying for skin toxin expelling, belongs to technical field of skin care.
Background technology
Skin care item and clean skin product are one of the article of everyday use that must use every day of modern female.It is pale that Chinese women is liked, and most of women used whitening product.And a part of women is because skin long pox, acne and other reasons, can use skin care item or skin-cleaning articles that product for resolving poxes etc. has certain function.
China cosmetic development time is not long, the supervision in early stage is in the blank stage, in whitening product, the interpolation of the materials such as lead, hydrargyrum and hormone, the adding of hormone and some antibiotic raw material in product for resolving poxes, the needs of consumer to effect have been met at short notice, life-time service, the heavy metals such as plumbous hydrargyrum, in the deposition of skin surface, make the black speck on skin more and more.Lead is a kind of heavy metal element of serious harm human health, affects the nerves, each organoid such as hemopoietic, digestion, immunity, skeleton.Can affect growth and the brain function such as intelligent development, neurobehavioral and learning and memory of infant, serious caused dementia simultaneously.Plumbous hydrargyrum, also can be along with blood enters in body not only in skin surface deposition, hydrargyrum energy heavy damage people's nervous system, hinder brain normal function, be difficult to excrete simultaneously, Corticosteroids is of a specified duration can cause allergic dermatitis, there is erythema, need could recover the health status of skin for a long time.
The infringement of the radical pair human body in human body skin mainly contains three aspects:
(1) make cell membrane destroyed.Free radical can lipid oxide, if the lipid on cell membrane is oxidized, can make cell membrane circulation change, and nutrient cannot enter cell Inner, causes necrocytosis.When the destroyed speed of cell membrane is greater than the speed of cell regeneration, the function of histoorgan will be affected and produce aging.
(2) serum protease inhibitor is lost activity.Free radical is attacked albumen, makes albumen lose function, or forms macromole, even fracture causes pathological changes.Occur in subcutaneous collagen tissue, can make skin follow the string, muscles and bones is stiff etc.
(3) lesioned gene causes the appearance of cytometaplasia and accumulates.The destruction of radical pair DNA is mainly to cause the cut-out of DNA thigh or the modification of base.Once DNA is cut off, human body, in the process of repairing, may produce because of cannot normally repairing sudden change.Free radical can derive some side-products after attacking base, and these side-products can make heredity make a mistake and have carcinogenic possibility.
Summary of the invention
For the problems referred to above, the present invention discloses a kind of compositions purifying for skin toxin expelling, the free radical self producing in super procyanidin opposing human body, the macromole of avenabeta glucosan adheres to the mode of heavy metal ion, the free radical in minimizing skin and residual heavy metal toxin.
Technical scheme of the present invention is such: the compositions that should purify for skin toxin expelling, said composition is comprised of the component of following mass ratio: the super procyanidin SOPC of 30-70% and the avenabeta glucosan of 30-70%, each component sum is 100%.
Further, the above-mentioned compositions purifying for skin toxin expelling, said composition is comprised of the component of following mass ratio: the super procyanidin SOPC of 40-60% and the avenabeta glucosan of 40-60%, each component sum is 100%.
Further, the above-mentioned compositions purifying for skin toxin expelling, the CAS of described avenabeta glucosan is numbered 9041-22-9.
Further, the above-mentioned compositions purifying for skin toxin expelling, described super procyanidin extracts from French VITISVINIFERA Fructus Vitis viniferae, is a kind of oligomer procyanidin; Structural formula is formula 1:
Formula 1
Compared with prior art, the invention provides technical scheme, by the combination of SOPC and avenabeta glucosan, remove free radical, adhere to parcel heavy metal ion, accelerate the disappearance of Skin Cell inflammation, make the skin state of getting well, also remove from because of the impact of harmful substance residual in skin on health, reach the effect that skin surface toxin expelling purifies, use contains SOPC-O emulsion, and after 4 weeks, the detection numerical value of black speck is 13.8, far below not containing 15.2 of SOPC-O composition emulsion.
The specific embodiment
Below in conjunction with the specific embodiment, technical scheme of the present invention is described in further detail, but does not form any limitation of the invention.
Embodiment 1
Take super procyanidin (SOPC) powder 20g, be placed in 250mL beaker, add 80g distilled water, stir, until dissolve completely.With middle density filter paper filtering, obtain the SOPC solution of clear, temporary standby.
Take avenabeta glucosan powder (CAS is numbered 9041-22-9) 20g, be placed in 250mL beaker, add 80g distilled water, stir, until dissolve completely.With middle density filter paper filtering, obtain the avenabeta glucosan solution of clear, temporary standby.
Get SOPC solution 40g and directly mix with avenabeta glucosan solution 60g, obtain super procyanidin (SOPC)/avenabeta glucosan compositions (SOPC-O) of 40%:60%, solid content is 20%.
Also can get SOPC solution 30g and directly mix with avenabeta glucosan solution 70g, obtain super procyanidin (SOPC)/avenabeta glucosan compositions (SOPC-O) of 30%:70%, solid content is 20%.
Or get SOPC solution 40g and directly mix with avenabeta glucosan solution 60g, obtain super procyanidin (SOPC)/avenabeta glucosan compositions (SOPC-O) of 60%:40%, solid content is 20%.
Or get SOPC solution 70g and directly mix with avenabeta glucosan solution 30g, obtain super procyanidin (SOPC)/avenabeta glucosan compositions (SOPC-O) of 40%:60%, solid content is 20%.
This SOPC-O can be used as free radical resisting active matter, for preparing cream frost emulsion class skin care item.
Embodiment 2
Take super procyanidin (SOPC) powder 10g, be placed in 250mL beaker, then take avenabeta glucosan 10g, join in same beaker.In beaker, add 80g distilled water, stir, until dissolve completely.With middle density filter paper filtering, obtain super procyanidin (the SOPC)/avenabeta glucosan compositions (SOPC-O) of clear, solid content is 20%, wherein the ratio of two kinds of materials is 50%:50%.
This SOPC-O can be used as free radical resisting active matter, for preparing cream frost emulsion class skin care item.
Principle of the present invention:
Super procyanidin is to extract and obtain material from French VITISVINIFERA Fructus Vitis viniferae, English name is Super Oligomeric Proantho Cyanidins(SOPC), being a kind of oligomer procyanidin that has special molecular structure, is the current generally acknowledged the most effective Natural antioxidant procyanidin of removing people interior free yl OPC a kind of in the world.Super procyanidin (SOPC) is a kind of high-efficiency antioxidant agent, is the most potent free radical scavenger found so far, has very strong activity in vivo.
Avenabeta glucosan, English name Oat beta glucan, because of its stickiness having, can hinder digestion and the absorption of the materials such as starch, protein, and can breed digestive tract probiotics, so can there are some very favourable physiological functions to human body: there is significant blood fat reducing, blood sugar lowering and improve immunocompetence, maintaining intestine microenvironment etc.In addition, it can also accelerate to determine crowd's immunocyte.The reaction that antibacterial is infected is also controlled the position that antibacterial infects, and infection face is recovered as early as possible; As the effective ingredient of cosmetics, can improve resisting skin allergy ability, activate immunity function, delay skin aging.For the heavy metal remaining in skin, can utilize macromole to adhere to the effect of parcel, macromole is not flowed in human body, enter blood circulation, injury internal organs.Along with the physiology circulation of human body excretes again.
The combination of SOPC and avenabeta glucosan, by removing free radical, adheres to parcel heavy metal ion, accelerate the disappearance of Skin Cell inflammation, make the skin state of getting well, also remove from because of the impact of harmful substance residual in skin on health, reach the effect that skin surface toxin expelling purifies.
Experimental example 1
Super procyanidin SOPC and avenabeta glucosan compositions have the effect of removing the mottle that skin heavy metal deposition causes, and experimental technique and test data are as follows.
According to following proportioning, prepare respectively 5 kinds of super procyanidin SOPC/avenabeta glucosan compositionss:
(1) SOPC: avenabeta glucosan=30%:70%
(2) (2) SOPC: avenabeta glucosan=40%:60%
(3) SOPC: avenabeta glucosan=50%:50%
(4) SOPC: avenabeta glucosan=60%:40%
(5) SOPC: avenabeta glucosan=70%:30%
Using above-mentioned 5 kinds of compositionss as effect thing, use conventional skin care item formulated to become containing the emulsion of effect thing 3% and go speckle contrast experiment.
Selecting 10 that confirm through dermatologist, skin surfaces has the volunteer because of the residual heavy metal pigmentation spots of improper use cosmetics, is divided into 5 groups, one group of two people.Use respectively above-mentioned 5 kinds of emulsions containing SOPC-O compositions, spread upon for one day three times on the skin of black speck.With MC750 melanin detecting head, detect the melanin value of speckle, measure once weekly, tie-in surrounding, evaluates the dispel effect of SOPC-O composition emulsion to heavy metal deposition mottle.
Experiment shows, uses the volunteer of various SOPC-O composition emulsions, and the melanin probe value of facial colour spot is continuous decrease trend, and the test data after surrounding is as shown in table 1:
Table 1 is used the melanin probe value after SOPC/ avenabeta glucosan composition emulsion surrounding
| Compositions | 0 | （1） | （2） | （3） | （4） | （5） |
| Ratio | Blank sample | 30%：70% | 40%：60% | 50%：50% | 60%：40% | 70%：30% |
| Reading | 15.2 | 14.3 | 12.7 | 12.1 | 13.1 | 13.8 |
By above table, can be found out SOPC: the removal of the combination counterweight metal pigmentation mottle that avenabeta glucosan is 50%:50% has best effect.
The heavy metal mottle of visual volunteer's face has desalination in various degree after using 4 weeks, wherein, use (2), (3), (4) volunteer of group solution, after one week, dark color spots starts to shoal, and after 4 weeks, speckle has very significantly desalination, after 2 months, mottle is more difficult perceives, and illustrates that SOPC/ avenabeta glucosan compositions has obvious toxin expelling purifying functions.
Experimental example 2
Super procyanidin SOPC and avenabeta glucosan compositions have the effect of removing free radical.
According to following proportioning, prepare respectively 5 kinds of SOPC/avenabeta glucosan compositionss:
(1) SOPC: avenabeta glucosan=35%:65%;
(2) SOPC: avenabeta glucosan=45%:55%
(3) SOPC: avenabeta glucosan=50%:50%
(4) SOPC: avenabeta glucosan=55%:45%
(5) SOPC: avenabeta glucosan=60%:40%
Adopt 1,1-diphenyl-2-trinitrophenyl-hydrazine (DPPH) is as supplying examination thing, add above-mentioned (1)～(5) to organize the SOPC/ avenabeta glucosan compositions of different proportionings, the absorbance changing value that adds compositions front and back with spectrophotometer quantitative assay, evaluates the scavenging action of SOPC/ avenabeta glucosan compositions to DPPH free radical.Detect data and come together in table 2.
Adopt luminol-pyrogallol chemical luminous system, add above-mentioned (1)～(5) to organize the SOPC/ avenabeta glucosan compositions of different proportionings, with biochemiluminescence instrument, measure SOPC/ avenabeta glucosan compositions to superoxide ion free radical (O
2-) scavenging action.Detect data and come together in table 2.
Employing is to orthophenanthroline/Fe
2+oxidizing process, adds above-mentioned (1)～(5) to organize the SOPC/ avenabeta glucosan compositions of different proportionings, with spectrophotometer quantitative assay, adds the absorbance changing value before and after compositions, evaluate SOPC/ avenabeta glucosan compositions to hydroxy radical (
.oH) scavenging action.Detect data and come together in table 2.
Table 2 SOPC/ avenabeta glucosan compositions free radical resisting experimental data
| Compositions | （1） | （2） | （3） | （4） | （5） |
| Ratio | 35%:65% | 45%：55% | 50%：50% | 55%：45% | 60%：40% |
| Remove DPPH | 41.8 | 59.7 | 63.8 | 66.3 | 65.8 |
| Remove hydroxy radical | 43.3 | 61.8 | 67 | 68.7 | 67.3 |
| Remove superoxide radical | 46.5 | 62.3 | 67.5 | 68.1 | 69.7 |
By above chart, can be found out, the SOPC/ avenabeta glucosan compositions of different proportionings all has extraordinary effect to the removal of various free radicals.
Experimental example 3
Adopt SOPC-O as the preparation of speckle dispelling emulsion and the result of use thereof of active matter.Preparation basic emulsion, fill a prescription as table 3:
Table 3
Compound method: A heat phase is to 80-85 ℃, and B heat phase is to 80-85 ℃, and A is added to B phase, and emulsifying homogeneous is even.Under stirring, be cooled to 45 ℃, add C phase, homogenizing is even, as basic emulsion.
In above-mentioned basic emulsion, room temperature adds the SOPC/ avenabeta glucosan (mass ratio 1:1) of 3% content, and emulsifying is even.
The emulsion obtaining with above-mentioned preparation, contain SOPC-O compositions 3% is gone speckle contrast experiment.
Selecting 10 that confirm through dermatologist, skin surfaces has the volunteer because of the residual heavy metal pigmentation spots of improper use cosmetics, uses respectively the above-mentioned emulsion containing SOPC-O compositions, spreads upon for one day three times on the skin of black speck.With MC750 melanin detecting head, detect the melanin value of speckle, measure once weekly, tie-in surrounding, evaluates the dispel effect of SOPC-O composition emulsion to heavy metal deposition mottle, and the test data of surrounding is as shown in table 4 continuously:
Table 4 is used the mottle probe value after SOPC-O composition emulsion
| Service time | Start | One week | Two weeks | Three weeks | Surrounding |
| Reading | 15.2 | 13.3 | 12.7 | 12.0 | 11.3 |
Experimental data shows, uses the volunteer of SOPC/ avenabeta glucosan composition emulsion, and the melanin probe value of facial colour spot is continuous decrease trend.
Experimental example 4
SOPC, avenabeta glucosan and SOPC/ avenabeta glucosan are dispelled black speck Contrast on effect:
Formulation content is that 3% SOPC, avenabeta glucosan and SOPC/ avenabeta glucosan (mass ratio 1:1) solution is chosen, adopt 1,1-diphenyl-2-trinitrophenyl-hydrazine (DPPH) is as supplying examination thing, add above-mentioned (1)～(5) to organize the SOPC/ avenabeta glucosan compositions of different proportionings, the absorbance changing value that adds compositions front and back with spectrophotometer quantitative assay, evaluate the scavenging action of SOPC/ avenabeta glucosan compositions to DPPH free radical, test result is in Table 5.
Table 5 SOPC, avenabeta glucosan and SOPC/ avenabeta glucosan are dispelled black speck Contrast on effect
| Compositions | 3%SOPC | 3% avenabeta glucosan | 3%SOPC/ avenabeta glucosan |
| Remove DPPH | 28.3 | 10.1 | 43.7 |
| Remove hydroxy radical | 29.6 | 12.5 | 48.9 |
| Remove superoxide radical | 32.4 | 13.3 | 51.6 |
Claims (4)
1. the compositions purifying for skin toxin expelling, is characterized in that, said composition is comprised of the component of following mass ratio: the super procyanidin of 30%-70% and the avenabeta glucosan of 30%-70%, and each component sum is 100%;
The structural formula of described super procyanidin is formula 1:
Formula 1.
2. the compositions purifying for skin toxin expelling according to claim 1, is characterized in that, said composition is comprised of the component of following mass ratio: the super procyanidin of 40%-60% and the avenabeta glucosan of 40%-60%, each component sum is 100%.
3. the compositions purifying for skin toxin expelling according to claim 1 and 2, is characterized in that, the CAS of described avenabeta glucosan is numbered 9041-22-9.
4. the compositions purifying for skin toxin expelling according to claim 1 and 2, is characterized in that, described super procyanidin extracts from French VITISVINIFERA Fructus Vitis viniferae, is a kind of oligomer procyanidin.
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| CN102895132B true CN102895132B (en) | 2014-04-09 |
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| CN102362846B (en) * | 2011-11-14 | 2013-01-23 | 广州孕肤宝日用品有限公司 | Skin radiation-preventing composition |
| CN102488627B (en) * | 2011-12-31 | 2013-06-19 | 上海宝姿化妆品有限公司 | Radiation-resistant and moisture-retention make-up base, lotion and water |
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