CN102895008B - The medical closure device delivery system and - Google Patents

The medical closure device delivery system and Download PDF

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Publication number
CN102895008B
CN102895008B CN 201210370963 CN201210370963A CN102895008B CN 102895008 B CN102895008 B CN 102895008B CN 201210370963 CN201210370963 CN 201210370963 CN 201210370963 A CN201210370963 A CN 201210370963A CN 102895008 B CN102895008 B CN 102895008B
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CN 201210370963
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CN102895008A (en )
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崔凯
李辉
赵昆
张昱欣
杨明
蒲忠杰
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上海形状记忆合金材料有限公司
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Abstract

本发明涉及医疗器械领域,尤其涉及一种可降解的医用封堵器。 The present invention relates to the field of medical devices, particularly to a biodegradable medical occluder. 该医用封堵器包括封堵器支架(1)、设置在所述封堵器支架(1)上的膜、以及固定于封堵器支架远端(5)的心轴(2);所述心轴(2)穿过所述封堵器支架(1),所述心轴(2)一端与封堵器支架远端(5)固定连接,另一端设置有与封堵器支架近端(4)相配合的卡合结构,使封堵器支架(1)在展开时所述封堵器支架近端(4)与所述心轴(2)另一端卡合锁定,所述医用封堵器由可降解聚合物制成。 The occluder includes a medical occluder holder (1), the occluder is provided on the film holder (1), and a mandrel (2) fixed to the bracket distal occluder (5); said the mandrel (2) through the occluder holder (1), the spindle (2) is connected with the stent distal occluder (5) is fixed and the other end is provided with a proximal end of the occluder holder ( 4) cooperating engaging structure, so that occluder holder (1) at the proximal end of the stent upon deployment of the occluder device (4) and the spindle (2) engaging the other end of the lock, the medical blocking It is made of a biodegradable polymer. 该医用封堵器在进入人体后能够自行降解,消除了封堵器残留在人体内会造成的副作用的隐患。 The medical occluder capable of self-degradation after entering the body, eliminating the occluder body will remain in the side effects caused by the hazard.

Description

医用封堵器及其输送系统 The medical closure device delivery system and

技术领域 FIELD

[0001] 本发明涉及医疗器械领域,尤其涉及一种可降解的医用封堵器及其输送系统。 [0001] The present invention relates to the field of medical devices, particularly to a biodegradable medical closure device and its delivery system.

背景技术 Background technique

[0002] 先天性心脏病介入治疗已经很普遍了,封堵器是介入治疗的主要器械。 [0002] interventional treatment of congenital heart disease is very common, occluder is the main instrument of intervention. 目前国内外的很多公司都有产品上市,然而这些产品都是使用镍钛记忆合金丝编制,然后热定型;利用镍钛合金的超弹性,制备成自膨胀式封堵器。 At present, many domestic and foreign companies have market, but these products are using nitinol wire preparation and heat setting; use of superelastic Nitinol, prepared as a self-expanding occluder. 但是人体对器械的需求不是长期的,在3个月左右内膜就会被全部覆盖,此时,封堵器就是一个无用的异物,并且伴随有各种副作用,如镍离子溶出、破坏人体组织等。 But the needs of the body of the instrument is not a long-term, will be covered in about three months endometrial all of this time, the occluder is a useless foreign body, and accompanied by various side effects, such as nickel ion release, destroy human tissue Wait.

[0003] 最理想的封堵器应该是满足封堵作用的同时,在病变治愈后封堵器能够自行降解。 [0003] Ideally occluder blocking effect should be satisfied at the same time, after the lesion healing occluder can be self-degradation. 但是除了镍钛合金,目前还找不到合适的超弹性材料,更不用说可降解的超弹性材料。 But in addition to nickel-titanium alloy, there is not find a suitable superelastic material, not to mention the degradable superelastic material.

发明内容 SUMMARY

[0004](—)要解决的技术问题 [0004] (-) technical problem to be solved

[0005] 本发明的目的在于提供一种可降解的封堵器,用以解决封堵器在病变治愈后不能自行降解的问题。 [0005] The object of the present invention to provide a degradable occluder, the occluder to solve the problem can not be self healing lesions after degradation.

[0006] (二)技术方案 [0006] (ii) Technical Solution

[0007] 本发明技术方案如下: Technical Solution [0007] The present invention is as follows:

[0008] 一种医用封堵器,包括封堵器支架、设置在所述封堵器支架上的膜、以及固定于封堵器支架远端的心轴;其特征在于:所述心轴穿过所述封堵器支架,所述心轴一端与封堵器支架远端固定连接,另一端设置有与封堵器支架近端相配合的卡合结构,使封堵器支架在展开时所述封堵器支架近端与所述心轴另一端卡合锁定,所述医用封堵器由可降解聚合物制成。 [0008] A medical occlusion device, comprising a holder occluder, the occluder is provided on the film holder, and the distal end of the shaft is fixed to the bracket occluder; characterized in that: said mandrel through when the occluder through the stent, the stent distal end of the mandrel is fixedly connected with the occluder, and the other end is provided with a proximal end of the stent engaging structure cooperating occluder, stent occluder is deployed said occluder proximal end of the mandrel holder and the other end engaging the locking, the medical closure device is made of a biodegradable polymer.

[0009] 优选的,所述心轴另一端设置有卡合凸起,所述封堵器支架近端设置有与所述卡合凸起相匹配的卡槽。 [0009] Preferably, the other end of the mandrel is provided with a projection engaging the proximal end of the occluder holder is provided with the engagement projection matched slot.

[0010] 优选的,所述封堵器支架近端设置有卡合凸起,所述心轴另一端设置有与所述卡合凸起相匹配的卡槽。 [0010] Preferably, the proximal end of the occluder holder is provided with an engaging protrusion, the other end of the mandrel is provided with the engaging projections match the slots.

[0011 ] 优选的,所述支架腰为可伸缩结构。 [0011] Preferably, the stent is a telescopic structure waist.

[0012] 优选的,位于所述封堵器支架远端与所述支架腰之间的上盘面,以及位于所述封堵器支架近端与所述支架腰之间的下盘面上均开设有豁口,封堵器支架在展开时,所述上盘面和下盘面在所述豁口处弯折变形。 [0012] Preferably, the disk on the distal end of the stent between the occluder and the bracket waist, and a lower disk positioned between the proximal end of the occluder holder with the holder defines a waist-average gap, occluder stent when deployed, said upper disk and a lower disk surface of the bending deformation at the gap.

[0013] 优选的,位于所述封堵器支架远端与所述支架腰之间的上盘面,以及位于所述封堵器支架近端与所述支架腰之间的下盘面均由至少两段活动串联的支架条组成,封堵器支架在展开时,所述上盘面和下盘面在所述支架条的串联连接处弯折变形。 [0013] Preferably, the disk holder between the distal end of the occluder with the bracket back, and the disk holder between the proximal end of the occluder with the bracket by at least two waist activity stent segment strips of the series, the occluder stent when deployed, said upper disk and lower disk bending deformation at the connection in series of the brace bar.

[0014] 所述的医用封堵器的输送系统,包括内推送杆,所述内推送杆外套有可相对其轴向运动的外推送管,所述外推送管外套有可相对其轴向运动的外管鞘,外推送管与封堵器支架近端活动连接。 [0014] The medical occluder delivery system comprises an inner push rod, the push rod within the outer casing has relative axial movement of the push tube, push tube outer casing has a relative axial movement thereof an outer sheath tube, an outer push tube connected to the proximal end of the occluder bracket activities.

[0015] 优选的,所述内推送杆与心轴端连接头匹配形成轴向方向的连接,横向方向没有或只有部分连接。 [0015] Preferably, the push rod and the inner mandrel end connector mating connector formed in the axial direction, a transverse direction, no or only partially connected.

[0016] 优选的,所述内推送杆和外推送管之间设置有可相对于内推送杆和外推送管轴向运动的内推送杆套管。 [0016] Preferably, provided between the push rod and push the outer tube is movable relative to said inner push rod within the push tube and the outer push rod axially movable sleeve.

[0017] 优选的,所述输送系统还包括手柄,所述手柄用于控制内推送杆相对外推送管以及外推送管相对于外管鞘的运动。 [0017] Preferably, the delivery system further comprises a handle relative to the outer tube and the outer push a push tube relative movement of the push rod for controlling the outer tube sheath.

[0018](三)有益效果 [0018] (c) beneficial effect

[0019] 本发明提供的医用封堵器通过在心轴和封堵器支架之间设置相配合的卡和结构,摆脱了传统封堵器必须使用记忆合金或超弹性合金的限制;由于使用的是可降解聚合物材质,本发明提供的医用封堵器在进入人体后能够自行降解,消除了封堵器残留在人体内会造成的副作用的隐患。 [0019] The present invention provides a medical card by occluder and occluder structure between the mandrel and the holder cooperating set, get rid of the limitation of traditional occluder memory alloys must be used or superelastic alloy; The use of the biodegradable polymer material, the present invention provides a medical closure device itself can be degraded after entering the body, eliminating the occluder body will remain in the side effects caused by the hazard.

附图说明 BRIEF DESCRIPTION

[0020] 图1是本发明实施例1中封堵器支架变形前示意图; [0020] FIG. 1 is a schematic view of Example 1 before modification of the present embodiment of the invention the occluder holder;

[0021] 图2是本发明实施例1中封堵器示意图; [0021] FIG. 2 is a schematic diagram of an embodiment of the present invention, the occluder;

[0022] 图3是本发明实施例2中针对PDA设计的封堵器示意图; [0022] FIG. 3 is a schematic diagram for a PDA occluder design of the present invention in Example 2;

[0023] 图4是本发明实施例2中针对ASD设计的封堵器示意图; [0023] FIG. 4 is a schematic diagram for ASD occluder designed in Example 2 of the present invention;

[0024] 图5是本发明实施例3中输送系统的示意图。 [0024] FIG. 5 is a schematic diagram of the delivery system according to Example 3 of the present invention.

[0025] 图中:1:封堵器支架;2:心轴;3:支架腰;4:封堵器支架近端;5:封堵器支架远端;6:上盘面;7:下盘面;8:豁口;9:心轴端连接头;10:内推送杆;11:内推送杆端连接头;12:内推送杆套管;13:外推送管。 [0025] FIG: 1: closure bracket; 2: a mandrel; 3: Waist holder; 4: a proximal occluder holder; 5: distal occluder holder; 6: the disk; 7: the disk ; 8: gap; 9: mandrel end connector; 10: push rod; 11: inner push rod end connector; 12: push rod within the sleeve; 13: push the outer tube.

具体实施方式 detailed description

[0026] 下面结合附图和实施例,对本发明的具体实施方式做进一步描述。 [0026] The following embodiments and the accompanying drawings, specific embodiments of the present invention are further described.

[0027] 实施例1 [0027] Example 1

[0028] 如图2所示的一种针对VSD(Ventricular septal defect,心室隔膜缺陷)设计的医用封堵器:包括封堵器支架1、设置在封堵器支架I上的膜、以及固定于封堵器支架一端的心轴2,封堵器支架此端称为封堵器支架远端5,相应的,另一端称为封堵器支架近端4 ;心轴2穿过封堵器支架1,心轴2 —端与封堵器支架远端5固定连接,另一端设置有与封堵器支架近端4相配合的卡合结构,使封堵器支架I在展开时封堵器支架近端4与心轴2另一端卡合锁定,医用封堵器由可降解聚合物制成。 The one shown in [0028] FIG. 2 for VSD (Ventricular septal defect, ventricular septal defects) designed medical occluder: 1 comprises a holder occluder, the occluder is provided on the film holder I, and is fixed to the one end of the mandrel holder 2 occluder, the occluder end of the stent this is called distal occluder holder 5, the respective other end is called the proximal occluder holder 4; spindle 2 through the occluder holder 1, the mandrel 2 - the distal end of the occluder holder 5 is fixed and the other end is provided with a cooperating engaging structure and occluder proximal stent 4, the stent I occluder stent when deployed occluder 4 and the proximal end of the mandrel 2 and the other end engaged with the lock, the medical closure device is made of a biodegradable polymer. 可降解聚合物可以为丝素蛋白、PLA (聚乳酸)、PGA (聚乙醇酸)、PGLA (聚乙丙交酯)或复合材料等。 Degradable polymer may be silk fibroin, PLA (polylactic acid), PGA (polyglycolic acid), PGLA (PLGA) or a composite material.

[0029] 这样的结构设计,摆脱了传统封堵器必须使用记忆合金或超弹性合金的限制;由于使用的是可降解聚合物材质,本发明提供的医用封堵器在进入人体后能够自行降解,消除了封堵器残留在人体内会造成的副作用的隐患。 [0029] Such structural design, to get rid of the limitation of traditional occluder memory alloys must be used or superelastic alloy; The use of the biodegradable polymer material, the present invention provides a medical closure device into the body can self-degradation eliminating the occluder remain in the human body can cause side effects of risks.

[0030] 进一步的,心轴2另一端设置有卡合凸起,封堵器支架近端4设置有与卡合凸起相匹配的卡槽。 [0030] Further, the other end of the mandrel 2 is provided with engaging projections, a proximal occluder holder 4 is provided with a projection engaging slot match. 或者封堵器支架近端4设置有卡合凸起,心轴2另一端设置有与卡合凸起相匹配的卡槽。 Or occluder holder 4 is provided with a proximal end of the engaging protrusion, the other end of the spindle 2 is provided with engaging projections match the slots. 目的是为了保证封堵器支架近端4到达心轴2上相应位置时能够得到有力的束缚,确保封堵器支架I展开后无法自由回弹而保持封堵状态。 Purpose is to ensure occluder holder 4 reaches the proximal end of the mandrel can be obtained a strong position on the corresponding shackles 2, I ensure that the expanded occluder holder can not freely resilient sealing state is maintained.

[0031] 进一步的,支架腰3为可伸缩结构,其长度和直径可以根据需要而定,目的是为了保证封堵器能够扩张到治疗需要的长度和直径,在本实施例中采用的是菱形结构。 [0031] Further, the holder 3 is a waist telescopic structure, its length and diameter can be determined according to need, is to ensure that the occluder can be expanded to a diameter and length need of such treatment, in the present embodiment uses a diamond structure.

[0032] 进一步的,位于封堵器支架远端5与支架腰3之间的上盘面6,以及位于封堵器支架近端4与支架腰3之间的下盘面7上均开设有豁口8,豁口8用于方便定型,变形后形成上盘面6和下盘面7的折点。 [0032] Further, between the distal end of the disk holder 5 and the holder 3 is located in the waist closure device 6, and is located at the proximal end of the disk occluder holder between the holder 4 and the waist 3 defines a notch on average 7 8 , for easy styling gap 8, the folding point forming the disk 6 and 7 of the disk after deformation. 或者位于封堵器支架远端5与支架腰3之间的上盘面6,以及位于封堵器支架近端4与支架腰3之间的下盘面7均由至少两段活动串联的支架条组成,封堵器支架I在展开时,上盘面6和下盘面7在支架条的串联连接处弯折变形,方便定型。 Or brace bar between the distal end of the disk holder 5 and the holder 3 is located in the waist closure device 6, and is located at the proximal end of the occluder disk holder 34 between the waist and the bracket 7 by at least two series of active composition , I occluder stent when deployed, the disk 6 and the disk 7 is bent at the junction of the series deformable brace bar to facilitate the setting.

[0033] 实施例2 [0033] Example 2

[0034] 一种针对PDA (Patent ductus arter1sus,动脉导管未闭)设计的封堵器,如图3所示;一种针对ASD (Atrial septal defect,心房隔膜缺陷)设计的封堵器,如图4所示。 [0034] one for PDA (Patent ductus arter1sus, patent ductus arteriosus) occluder design, shown in Figure 3; one for ASD (Atrial septal defect, atrial septal defects) occluder design as Fig. 它们与实施例1仅是外观上有所区别:针对PDA和针对ASD设计的封堵器的下盘面相对上盘面较扁。 Example 1. They differ only in appearance: for the disk for ASD and PDA occluder design of the disk is relatively more flat.

[0035] 实施例3 [0035] Example 3

[0036] 如图5所示的医用封堵器的输送系统,包括内推送杆10,内推送杆10外套有可相对其轴向运动的外推送管13,外推送管13外套有可相对其轴向运动的外管鞘,外推送管13通过绳索与封堵器支架近端4连接,也可以通过连接槽连接,主要是为了实现展开和回收封堵器;外管鞘主要用于保护封堵器。 [0036] The medical closure device delivery system shown in FIG. 5, the push rod 10 includes an inner, rod 10 pushes the inner casing has its axial movement relative the outer push tube 13, tube 13 pushes the outer casing has its relative axial movement of the outer sheath tube, the outer push tube 134 connecting rope through the proximal occluder holder may be connected through the connecting groove, mainly in order to achieve expansion and recovery occluder; outer sheath tube used to protect seal blocking device.

[0037] 进一步的,心轴2另一端具有心轴端连接头9 ;内推送杆10与心轴端连接头9匹配形成轴向方向的连接,横向方向没有或只有部分连接,目的是方便封堵器的释放。 [0037] Further, the other end of the spindle 2 having a mandrel end connector 9; pushers 10 and the inner mandrel end connection head 9 is formed to match the axial direction, a transverse direction, no or only a part of the connection, is to facilitate the closure block's release.

[0038] 进一步的,内推送杆10和外推送管13之间设置有可相对于内推送杆10和外推送管13轴向运动的内推送杆套管12,心轴端连接头9与内推送杆端连接头11连接后可以收缩回到内推送杆套管12内,形成横向束缚,这时内推送杆10和封堵器牢固连接,释放时,将心轴端连接头9与内推送杆端连接头11推出内推送杆套管12,解除横向束缚,控制内推送杆10,心轴端连接头9就可以脱离内推送杆端连接头11。 [0038] Further, a push rod disposed between the inner 10 and outer 13 may push relative to the inner tube with a push rod 13 to push the inner axial movement of the tube 10 and the outer push rod sleeve 12, mandrel end is connected to the inner head 9 push rod 11 is connected after the first end connector can be collapsed back into the push rod sleeve 12, is formed laterally bound, then the push rod 10 and the occluder is securely connected, when released, the mandrel end is connected to the push head 9 within the first rod end 11 connected to a push rod sleeve 12 Release, releasing lateral restraint, push the control rod 10, mandrel end connector 9 can be connected from the inner end of the push rod head 11.

[0039] 进一步的,输送系统还包括手柄,手柄用于控制内推送杆10、相对外推送管13以及外推送管13相对于外管鞘的运动。 [0039] Further, the delivery system further comprises a handle for controlling the push rod 10, movement of the outer tube 13 and the outer sheath to push the outer tube 13 relative to the push tube. .

[0040] 实际操作中与扩张管配合使用,到达病变后去掉扩张管,首先通过手柄控制内推送杆10,从而控制封堵器,封堵器从管状变成伞状,封堵病变,同时外推送管13与封堵器断开连接,通过手柄控制内推送杆套管12,解除横向束缚,使内推送杆10和封堵器分离,封堵器完全释放。 [0040] In practice the expansion of the tube used, after reaching the lesion dilation tube removed, first by controlling the push rod within the handle 10, thereby controlling the occluder, the occluder into the tubular umbrella, blocking the lesion, while the outer push tube 13 is disconnected from the occluder, by controlling the push rod sleeve within the handle 12, releasing the lateral restraint, the push rod 10 and the inner separation occluder, the occluder fully released.

[0041] 以上实施方式仅用于说明本发明,而并非对本发明的限制,有关技术领域的普通技术人员,在不脱离本发明的精神和范围的情况下,还可以做出各种变化和变型,因此所有等同的技术方案也属于本发明的保护范畴。 [0041] The above embodiments are merely illustrative of the present invention, and are not restrictive of the invention, relating to ordinary skill in the art, without departing from the spirit and scope of the present invention, can make various changes and modifications , all equivalent technical solutions also fall within the protection scope of the invention.

Claims (7)

  1. 1.一种医用封堵器,包括封堵器支架(I)、设置在所述封堵器支架(I)上的膜以及固定于封堵器支架远端(5)的心轴(2);其特征在于:所述心轴(2)穿过所述封堵器支架(1),所述心轴(2) —端与封堵器支架远端(5)固定连接,另一端设置有与封堵器支架近端(4)相配合的卡合结构,使封堵器支架(I)在展开时所述封堵器支架近端(4)与所述心轴(2)另一端卡合锁定,所述医用封堵器由可降解聚合物制成; 其中,位于所述封堵器支架远端(5)与所述支架腰(3)之间的上盘面¢),以及位于所述封堵器支架近端(4)与所述支架腰(3)之间的下盘面(7)上均开设有豁口(8),封堵器支架(I)在展开时,所述上盘面(6)和下盘面(7)在所述豁口(8)处弯折变形;所述支架腰(3)为可伸缩的菱形结构; 其中,位于所述封堵器支架远端(5)与所述支架腰(3)之间的上盘面¢),以及位于所述封堵器支架近端(4)与所述支 1. A medical occlusion device, comprising a closure holder (I), the occluder is provided on the film holder (I) and a mandrel (2) fixed to the bracket distal occluder (5) ; characterized in that: said mandrel (2) through the occluder holder (1), the spindle (2) - the distal end of the occluder holder (5) is fixed and the other end is provided with a (4) cooperating with the proximal end of the occluder holder engaging structure, occluder holder (I) in the deployed proximal end of the occluder holder (4) and the mandrel (2) the other end of the card locked together, the medical closure device is made of a biodegradable polymer; wherein, in said distal occluder holder (5) with the bracket ¢ waist between the disk (3)), and is located in the the lower disk (7) between said proximal occluder holder (4) with the bracket back (3) each defines a gap (8), the occluder holder (I) when deployed, said upper disk (6) and a lower disk (7) (8) is bent at the cutout deformation; the bracket back (3) is a telescopic rhombus structure; wherein the distal end of the stent is located occluder (5) the stent waist ¢ between the disk (3)), and located at the proximal end of the occluder holder (4) and the support 架腰(3)之间的下盘面(7)均由至少两段活动串联的支架条组成,封堵器支架(I)在展开时,所述上盘面(6)和下盘面(7)在所述支架条的串联连接处弯折变形。 Lower lumbar disk holder (7) between (3) by at least two series of activities brace bar composition occluder holder (I) when deployed, said upper disk (6) and a lower disk (7) series connection of said brace bar bending deformation.
  2. 2.根据权利要求1所述医用封堵器,其特征在于:所述心轴(2)另一端设置有卡合凸起,所述封堵器支架近端(4)设置有与所述卡合凸起相匹配的卡槽。 2. The method of claim 1 medical occluder, wherein: said mandrel (2) and the other end is provided with a projection engaging the proximal end of the occluder holder (4) is provided with the card engagement projections match the slots.
  3. 3.根据权利要求1所述医用封堵器,其特征在于:所述封堵器支架近端(4)设置有卡合凸起,所述心轴(2)另一端设置有与所述卡合凸起相匹配的卡槽。 3. The occluder of claim 1 medical device, wherein: said proximal occluder holder (4) is provided with a projection engaging the mandrel (2) and the other end is provided with the card engagement projections match the slots.
  4. 4.一种根据权利要求1所述的医用封堵器的输送系统,包括内推送杆(10),所述内推送杆(10)外套有可相对其轴向运动的外推送管(13),所述外推送管(13)外套有可相对其轴向运动的外管鞘,所述外推送管(13)与所述封堵器支架近端(4)活动连接。 4. A delivery system according to claim medical occlusion device of claim 1, comprising the push rod (10), the inner push rod (10) movable relative to the outer casing has axial movement of the push tube (13) the outer push tube (13) relative to the outer jacket tube of the sheath can have its axial movement, the outer push tube (13) is connected to the proximal end of the occluder holder (4) activity.
  5. 5.根据权利要求4所述的输送系统,其特征在于:所述心轴(2)另一端具有心轴端连接头(9);所述内推送杆(10)与心轴端连接头(9)匹配形成轴向方向的连接。 The delivery system as claimed in claim 4, wherein: the other end of said mandrel (2) having a mandrel end connector (9); a push rod (10) and the inner mandrel end connector ( 9) forming a connection matches the axial direction.
  6. 6.根据权利要求5所述的输送系统,其特征在于:所述内推送杆(10)和外推送管(13)之间设置有可相对于内推送杆(10)和外推送管(13)轴向运动的内推送杆套管(12)。 6. A delivery system as claimed in claim 5, wherein: a push rod (10) of said inner and outer tube is provided between the push (13) has a push rod relative to the inner (10) and an outer push tube (13 ) within the axial movement of the push rod sleeve (12).
  7. 7.根据权利要求4至6中任意一项所述的输送系统,其特征在于:所述输送系统还包括与内推送杆(10)、外推送管(13)连接的手柄,所述手柄用于控制内推送杆(10)相对外推送管(13)以及外推送管(13)相对于外管鞘的运动。 The delivery system of any one of 4 to 6 claim, wherein: the delivery system further includes an inner push rod (10), an outer push tube (13) connected to the handle, the handle with in the control push rod (10) relative to the outer push tube (13) and an outer push tube (13) movement relative to the outer sheath tube.
CN 201210370963 2012-09-28 2012-09-28 The medical closure device delivery system and CN102895008B (en)

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CN104905890A (en) * 2014-03-14 2015-09-16 徐州亚太科技有限公司 Novel degradable stopper implanted through guide pipe and conveying system of novel degradable stopper
US20160345943A1 (en) * 2014-04-30 2016-12-01 Lepu Medical Technology (Beijing) Co., Ltd Medical closure system
WO2017157316A1 (en) * 2016-03-18 2017-09-21 上海微创医疗器械(集团)有限公司 Left auricle occluder and delivery system thereof

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