CN102887837A - Method for producing arginine - Google Patents
Method for producing arginine Download PDFInfo
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- CN102887837A CN102887837A CN 201110202722 CN201110202722A CN102887837A CN 102887837 A CN102887837 A CN 102887837A CN 201110202722 CN201110202722 CN 201110202722 CN 201110202722 A CN201110202722 A CN 201110202722A CN 102887837 A CN102887837 A CN 102887837A
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- arginine
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- exchange resin
- mother liquor
- karb
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Abstract
The invention discloses a method for producing arginine. Arginine belongs to the fields of amino acids. The method utilizes a cystine mother liquor, a cation exchange resin, an anion exchange resin, dilute ammonia water, stronger ammonia water and ethanol as raw materials. Through a resin adsorption method, the cation exchange resin is used for adsorption and then the anion exchange resin is used for adsorption so that an arginine finished product is obtained. The method has simple processes, adopts general equipment, does not need additional important equipment, is convenient for operation, can be popularized easily, adopts the raw materials having rich sources and realizes good product quality.
Description
Technical field:
Product of the present invention belongs to chemical field, relates in particular to a kind of arginic production method.
Background technology:
Arginine is a kind of alpha amino acid, and outward appearance is white rhombic system crystal or white crystalline powder, and molecular formula is C
6H
14N
4O
2, molecular weight is 174,244 ℃ of fusing points are water-soluble, are insoluble to ether, are slightly soluble in ethanol.Arginine is one of 20 kinds of general natural amino acid, it is semi-dispensable amino acid in human body and the animal body, it is a moiety in the urea cycle, also be a kind of important intermediate metabolites of organism ornithine cycle, natural arginine is the L-type, and the product of crystallization contains two molecular crystal water from water, crystallization is anhydride in ethanol, because the existence of guanidine radicals, arginine are alkalescence, easy and acid-respons forms salt.Arginine has widely purposes in industries such as medicine, food and feed additives, arginine can be used as one of main ingredient of Hausmam Amin 20, also be widely used as toxinicide and the liver function-promoter of ammonia poisoning hepatic coma, evident in efficacy to viral hepatitis; The diseases such as enteron aisle ulcer, thrombosis and neurasthenia there is result for the treatment of; The Healing that promotes wound is arranged, it can promote the synthetic of collagenous tissue, can be observed the rising of arginase activity in the wound juice, this shows that also near the arginine requirement the wound increases, and impels wound to fully recover early with the microcirculation that promotes wound circumference.Arginic immunoloregulation function can prevent the degeneration (degeneration after especially injured) of thymus gland, and additional arginine can increase the weight of thymus gland, promotes the growth of thymus gland medium size lymphocyte; Arginine is the same with glutamine, when being under the immense pressure, human body just needs, just often be in this state as body-builders, therefore need to replenish arginine, although concerning the adult, be not indispensable amino acid, but in some situation such as body development is immature or under serious stressed condition, if lack arginine, just body can not be kept positive nitrogen balance and normal physiological function.Arginine also can be used as accessory substance, arginine is that a moiety in the urea cycle has extremely important physiological function. eat arginine more, can increase arginic activity in the liver, so help to change the ammonia in the blood into urea and excrete out., arginine is to hyperammonemia, and liver dysfunction etc. has certain curative effect.Arginine or seasonings are the important component parts of sports nutrition drink formula; Also be a kind of important fodder additives, in world's aquaculture, have widely and use.Produce now arginic technique more, relative merits are respectively arranged, such as the proteolysis method, its advantage is that product purity is high, and quality is good, but shortcoming is complex process, raw materials cost is high, and cystine production waste liquid is produced arginine, and its advantage is that raw material sources are abundant, price is low, but quality product purity is influenced.The raw material that the present invention uses is that cystine mother liquor is raw material, by resin adsorption method, uses first Zeo-karb to adsorb, and re-uses resin anion(R.A) and adsorbs to obtain the arginine finished product.The method has the advantages such as technique is simple, raw material sources abundant, price is low, good product quality.
Summary of the invention:
Produce arginine cost defective high, that can not be guaranteed as raw material production arginine quality product take cystine production waste liquid in order to overcome the proteolysis method, the invention provides a kind of take cystine mother liquor as raw material, produce arginic method with resin absorption, the method has: facility investment is few, technique is simple, with short production cycle, and the series of advantages such as product purity height are compared with traditional technology, have pollution-free, reaction temperature and, temperature is low, thereby has further reduced production cost.Producing the raw material that this arginine uses has: cystine mother liquor 65%, Zeo-karb 15%, anionite-exchange resin 20%, weak ammonia are for (cystine mother liquor, Zeo-karb, anionite-exchange resin total amount) 3 times of (cystine mother liquor, Zeo-karb, anionite-exchange resin total amount) 2 times, ethanol for (cystine mother liquor, Zeo-karb, anionite-exchange resin total amount) 2 times, strong aqua.
The present invention can be achieved through the following technical solutions:
The arginic method of a kind of suitability for industrialized production is characterized in that being made of following steps:
1. once concentration: cystine mother liquor is sent in the once concentration tank, pass into steam, the control temperature concentrates for-0.1Mpa at 100 ℃-110 ℃, air pressure, and concentration time is 7-8 hour, when approximately being concentrated into into tank 3/5ths of liquid volume, obtain crystal solution.
2. decolouring: crystal solution is sent into the decoloring reaction still, start agitator, rotating speed is 25 rev/mins, add Zeo-karb and adsorb this moment, react and add the weak ammonia washing after 2 hours, add again the strong aqua washing, remove the ammonia decolouring after the washing, obtain filtrate after being filtered after decolouring is finished.
3. secondary concentration, filtrate after the decolouring is sent into the neutralization reaction tank, add quantitative anionite-exchange resin absorption and removal of impurities, the liquid after the removal of impurities is sent into concentration tank and is again concentrated, 100 ℃-110 ℃ of control temperature, air pressure is-0.1Mpa, concentration time 4-5 hour, be concentrated into 1/2nd of original volume, be filtered, obtain filtrate and xln, xln is the arginine crude product.
4. refining: as the arginine crude product to be sent into settling vessel, add ethanol and precipitate 8 hours, throw out is sent into dehydrated device, obtain sending into the baker oven dry behind the white arginine finished product packing, warehouse-in after the oven dry after the drying.
Cystine mother liquor described in the above-mentioned steps 1 is Gelucystine one mother liquor.
The bake out temperature of baker is 80 ℃-90 ℃ in the above-mentioned steps 4.
The invention has the beneficial effects as follows: provide a kind of cystine mother liquor that utilizes to produce arginic method, produce arginine, have production technique simple, use general-purpose equipment and need not to increase visual plant, easy to operate, be easy to promote, the advantages such as raw material sources are abundant, good product quality.
Embodiment
Embodiment 1
Cystine mother liquor is sent in the once concentration tank, passed into steam, the control temperature concentrates for-0.1Mpa at 100 ℃, air pressure, and concentration time is 8 hours, when approximately being concentrated into into tank 3/5ths of liquid volume, obtains crystal solution; Crystal solution is sent into the decoloring reaction still, start agitator, rotating speed is 25 rev/mins, add Zeo-karb and adsorb this moment, reacts to add the weak ammonia washing after 2 hours, adds the strong aqua washing again, remove the ammonia decolouring after the washing, obtain filtrate after being filtered after decolouring is finished; The rear filtrate that will decolour is sent into the neutralization reaction tank, add quantitative anionite-exchange resin absorption and removal of impurities, liquid after the removal of impurities is sent into concentration tank and is again concentrated, 100 ℃ of control temperature, air pressure is-0.1Mpa concentration time 5 hours, be concentrated into 1/2nd of original volume, be filtered, obtain filtrate and xln, xln is the L-arginine crude product; The arginine crude product is sent into settling vessel, add ethanol and precipitate 8 hours, throw out is sent into dehydrated device, obtain sending into the baker oven dry behind the white arginine finished product packing, warehouse-in after the oven dry after the drying.
Embodiment 2
Cystine mother liquor is sent in the once concentration tank, passed into steam, the control temperature concentrates for-0.1Mpa at 105 ℃, air pressure, and concentration time is 7.5 hours, when approximately being concentrated into into tank 3/5ths of liquid volume, obtains crystal solution; Crystal solution is sent into the decoloring reaction still, start agitator, rotating speed is 25 rev/mins, add Zeo-karb and adsorb this moment, reacts to add the weak ammonia washing after 2 hours, adds the strong aqua washing again, remove the ammonia decolouring after the washing, obtain filtrate after being filtered after decolouring is finished; The rear filtrate that will decolour is sent into the neutralization reaction tank, add quantitative anionite-exchange resin absorption and removal of impurities, liquid after the removal of impurities is sent into concentration tank and is again concentrated, 105 ℃ of control temperature, air pressure is-0.1Mpa concentration time 4.5 hours, be concentrated into 1/2nd of original volume, be filtered, obtain filtrate and xln, xln is the L-arginine crude product; The arginine crude product is sent into settling vessel, add ethanol and precipitate 8 hours, throw out is sent into dehydrated device, obtain sending into the baker oven dry behind the white arginine finished product packing, warehouse-in after the oven dry after the drying.
Embodiment 3
Cystine mother liquor is sent in the once concentration tank, passed into steam, the control temperature concentrates for-0.1Mpa at 110 ℃, air pressure, and concentration time is 7 hours, when approximately being concentrated into into tank 3/5ths of liquid volume, obtains crystal solution; Crystal solution is sent into the decoloring reaction still, start agitator, rotating speed is 25 rev/mins, add Zeo-karb and adsorb this moment, reacts to add the weak ammonia washing after 2 hours, adds the strong aqua washing again, remove the ammonia decolouring after the washing, obtain filtrate after being filtered after decolouring is finished; The rear filtrate that will decolour is sent into the neutralization reaction tank, add quantitative anionite-exchange resin absorption and removal of impurities, liquid after the removal of impurities is sent into concentration tank and is again concentrated, 110 ℃ of control temperature, air pressure is-0.1Mpa concentration time 4 hours, be concentrated into 1/2nd of original volume, be filtered, obtain filtrate and xln, xln is the L-arginine crude product; The arginine crude product is sent into settling vessel, add ethanol and precipitate 8 hours, throw out is sent into dehydrated device, obtain sending into the baker oven dry behind the white arginine finished product packing, warehouse-in after the oven dry after the drying.
Claims (5)
1. arginic production method, it is characterized in that: as (cystine mother liquor, Zeo-karb, anionite-exchange resin total amount) 2 times, ethanol as (cystine mother liquor, Zeo-karb, anionite-exchange resin total amount) 3 times of take cystine mother liquor 65%, Zeo-karb 15%, anionite-exchange resin 20%, weak ammonia as (cystine mother liquor, Zeo-karb, anionite-exchange resin total amount) 2 times, strong aqua obtain finished product as raw material by following steps.
2. a kind of arginic production method according to claim 1, the feature of its first step is: once concentration: cystine mother liquor is sent in the once concentration tank, pass into steam, the control temperature concentrates for-0.1Mpa at 100 ℃-110 ℃, air pressure, concentration time is 7-8 hour, when approximately being concentrated into into tank 3/5ths of liquid volume, obtain crystal solution.
3. a kind of arginic production method according to claim 1, the feature of its second step is: decolouring: crystal solution is sent into the decoloring reaction still, start agitator, rotating speed is 25 rev/mins, add Zeo-karb and adsorb this moment, reacts to add the weak ammonia washing after 2 hours, adds the strong aqua washing again, remove the ammonia decolouring after the washing, obtain filtrate after being filtered after decolouring is finished.
4. a kind of arginic production method according to claim 1, the feature in its 3rd step is: secondary concentration, and the rear filtrate that will decolour is sent into the neutralization reaction tank, adds quantitative anionite-exchange resin absorption and removal of impurities, liquid after the removal of impurities is sent into concentration tank and is again concentrated, 100 ℃-110 ℃ of control temperature, air pressure is-0.1Mpa concentration time 4-5 hour, be concentrated into 1/2nd of original volume, be filtered, obtain filtrate and xln, xln is the L-arginine crude product.
5. a kind of arginic production method according to claim 1, the feature in its 4th step is: refining: that the arginine crude product is sent into settling vessel, add ethanol and precipitate 8 hours, throw out sent into dehydrate device, obtain sending into the baker oven dry behind the white arginine finished product packing, warehouse-in after the oven dry after the drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110202722 CN102887837A (en) | 2011-07-20 | 2011-07-20 | Method for producing arginine |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110202722 CN102887837A (en) | 2011-07-20 | 2011-07-20 | Method for producing arginine |
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| CN102887837A true CN102887837A (en) | 2013-01-23 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106588702A (en) * | 2015-10-14 | 2017-04-26 | 天津工业大学 | Method for extracting arginine from rabbit hair fibers based on ion exchange method |
-
2011
- 2011-07-20 CN CN 201110202722 patent/CN102887837A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106588702A (en) * | 2015-10-14 | 2017-04-26 | 天津工业大学 | Method for extracting arginine from rabbit hair fibers based on ion exchange method |
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Application publication date: 20130123 |