CN102860982A - Tilianin microemulsion composition - Google Patents
Tilianin microemulsion composition Download PDFInfo
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- CN102860982A CN102860982A CN2012103851340A CN201210385134A CN102860982A CN 102860982 A CN102860982 A CN 102860982A CN 2012103851340 A CN2012103851340 A CN 2012103851340A CN 201210385134 A CN201210385134 A CN 201210385134A CN 102860982 A CN102860982 A CN 102860982A
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- tiliannin
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- emulsifier
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Abstract
The invention discloses a microemulsion composition containing tilianin. The microemulsion composition comprises tilianin, an emulsifier, a co-emulsifier, oil and water. The microemulsion composition can greatly enhance the solubility of the tlianin.
Description
Technical field
The present invention relates to a kind of tiliannin micro-emulsion composition that can significantly increase the tiliannin dissolubility.
Background technology
Tiliannin is an important flavonoid glycoside compound that extracts from the labiate Herba Dracocephali, has the biological activitys such as atherosclerosis, resisting hypertension, protection cardiac muscle.Tiliannin belongs to weak acid class medicine, is insoluble in water, is soluble in the organic solvents such as acetonitrile, dimethyl sulfoxide, methanol, chloroform, ethyl acetate.The character of the water-soluble difference of tiliannin has limited the effective exploitation utilization of its preparation.
The Chinese patent notification number is the preparation method that CN10178345A discloses tiliannin, and still, the deficiency of the method is, not according to the water-fast character of tiliannin, for disclosed tiliannin provides a kind of method that increases dissolubility for satisfying the preparation needs.
Summary of the invention
The object of the present invention is to provide a kind of micro-emulsion composition that the tiliannin dissolubility can significantly be provided.
The object of the present invention is achieved like this:
The tiliannin micro-emulsion composition is comprised of tiliannin and adjuvant.
The adjuvant of tiliannin micro-emulsion composition is comprised of emulsifying agent, co-emulsifier, oil phase and water.Emulsifying agent in the microemulsion adjuvant comprises at least a of polyoxyethylene hydrogenated Oleum Ricini, polyoxyethylene castor oil, lecithin, fabaceous lecithin, tween 80; Co-emulsifier comprises at least a of PEG-4000, propylene glycol, ethanol, glycerol; Oil phase comprises at least a of ethyl oleate, oleic acid, Miglyol 812, isopropyl palmitate, isopropyl myristate; Microemulsion adjuvant weight portion consists of 1～25 part of emulsifying agent, 2～50 parts of co-emulsifier, and 5～20 parts of oil phases, water are 10-80 part.
The tiliannin weight portion consists of 0.05～1 part in the tiliannin microemulsion.
The present invention compared with prior art, the tiliannin micro-emulsion composition is to adopt the pharmaceutics means, significantly increase the method for tiliannin solubility method take microemulsion as carrier, the dissolubility of tiliannin in microemulsion is 1300～1500 times in the water, the method does not change the physicochemical properties of tiliannin, have the simple characteristics of preparation method, for the tiliannin preparation research is laid a good foundation.
The specific embodiment
Embodiment 1
Tiliannin: 0.2 part, polyoxyethylene hydrogenated Oleum Ricini: 5 parts, PEG-4000: 10 parts, isopropyl myristate: 10 parts, water: 30 parts
Embodiment 2
Tiliannin: 0.2 part, lecithin: 9 parts, ethanol: 9 parts, ethyl oleate: 10 parts, water: 20 parts
Embodiment 3
Tiliannin: 0.4 part, tween 80: 10 parts, propylene glycol: 5 parts, ethyl oleate: 10 parts, water: 10 parts
Embodiment 4
Tiliannin: 0.5 part, tween 80: 20 parts, ethanol: 10 parts, oleic acid: 10 parts, water: 60 parts
Embodiment 5
Tiliannin: 0.6 part, polyethylene glycol hydrogenated alkene Oleum Ricini: 10 parts, PEG-4000: 20 parts, ethyl oleate: 15 parts, water: 50 parts
Embodiment 6
Tiliannin: 0.2 part, polyoxyethylene castor oil: 20 parts, glycerol: 10 parts, isopropyl myristate: 20 parts, water: 30 parts
Embodiment 7
Tiliannin: 0.1 part, polyoxyethylene hydrogenated Oleum Ricini: 20 parts, ethanol: 20 parts, isopropyl palmitate: 15 parts, water: 40 parts
Embodiment 8
Tiliannin: 0.2 part, polyethylene glycol hydrogenated alkene Oleum Ricini: 20 parts, ethanol: 20 parts, Miglyol 812: 10 parts, water: 55 parts
Embodiment 9
Tiliannin: 0.4 part, 10 parts of fabaceous lecithins, 7.5 parts of glycerol, oleic acid: 15 parts, 15 parts of waters
Embodiment 10
Tiliannin: 0.09 part, 25 parts of tween 80s, glycerol: 15 parts, oleic acid: 18 parts, water: 80 parts
Embodiment 11
Tiliannin: 1 part, polyoxyethylene hydrogenated Oleum Ricini: 20 parts, propylene glycol: 30 parts, isopropyl palmitate: 20 parts, water: 65 parts
Embodiment 12
Tiliannin: 0.05 part, 20 parts in lecithin, propylene glycol: 40 parts, ethyl oleate: 10 parts, water: 55 parts
Embodiment 13
Tiliannin: 0.7 part, tween 80: 20 parts, ethanol: 20 parts, isopropyl myristate: 18 parts, water: 60 parts
Embodiment 14
Tiliannin: 0.8 part, polyoxyethylene hydrogenated Oleum Ricini: 20 parts, propylene glycol: 35 parts, ethyl oleate: 10 parts, water: 50 parts
Embodiment 15
Tiliannin: 0.9 part, polyoxyethylene castor oil: 20 parts, PEG-4000: 20 parts, oleic acid: 10 parts, water: 70 parts.
Claims (3)
1. micro-emulsion composition that contains tiliannin, it is characterized in that, this microemulsion is comprised of tiliannin and adjuvant, adjuvant is comprised of emulsifying agent, co-emulsifier, oil phase, water, and emulsifying agent is selected from least a of polyoxyethylene hydrogenated Oleum Ricini, polyoxyethylene castor oil, lecithin, fabaceous lecithin, tween 80; Co-emulsifier is selected from least a of PEG-4000, propylene glycol, ethanol, glycerol; Oil phase be selected from ethyl oleate, oleic acid, Miglyol 812, isopropyl palmitate, isopropyl myristate, at least a.
2. the micro-emulsion composition that contains tiliannin according to claim 1 is characterized in that the tiliannin weight portion consists of 0.05～1 part in the tiliannin microemulsion.
3. the micro-emulsion composition of tiliannin according to claim 1 is characterized in that described microemulsion adjuvant weight portion consists of 1～25 part of emulsifying agent, 2～50 parts of co-emulsifier, and 5～20 parts of oil phases, water are 10-80 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210385134.0A CN102860982B (en) | 2012-10-09 | 2012-10-09 | Tilianin microemulsion composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210385134.0A CN102860982B (en) | 2012-10-09 | 2012-10-09 | Tilianin microemulsion composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102860982A true CN102860982A (en) | 2013-01-09 |
| CN102860982B CN102860982B (en) | 2014-08-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210385134.0A Expired - Fee Related CN102860982B (en) | 2012-10-09 | 2012-10-09 | Tilianin microemulsion composition |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103961316A (en) * | 2014-05-13 | 2014-08-06 | 浙江凯胜科技有限公司 | Micro-emulsion containing enramycin and preparation method thereof |
| CN107115321A (en) * | 2017-04-16 | 2017-09-01 | 新疆维吾尔自治区药物研究所 | Creeping thistle glycosides solid lipid nanoparticle and preparation method thereof |
| CN111603447A (en) * | 2020-06-17 | 2020-09-01 | 新疆维吾尔自治区药物研究所 | Tilianin solid dispersion and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101781345A (en) * | 2010-02-10 | 2010-07-21 | 石河子大学医学院第一附属医院 | Method for preparing tilianin |
| CN102106818A (en) * | 2010-12-14 | 2011-06-29 | 石河子大学医学院第一附属医院 | Isoliquiritigenin micro-emulsion composition |
-
2012
- 2012-10-09 CN CN201210385134.0A patent/CN102860982B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101781345A (en) * | 2010-02-10 | 2010-07-21 | 石河子大学医学院第一附属医院 | Method for preparing tilianin |
| CN102106818A (en) * | 2010-12-14 | 2011-06-29 | 石河子大学医学院第一附属医院 | Isoliquiritigenin micro-emulsion composition |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103961316A (en) * | 2014-05-13 | 2014-08-06 | 浙江凯胜科技有限公司 | Micro-emulsion containing enramycin and preparation method thereof |
| CN103961316B (en) * | 2014-05-13 | 2020-01-07 | 浙江工商大学 | Microemulsion containing enramycin and preparation method thereof |
| CN107115321A (en) * | 2017-04-16 | 2017-09-01 | 新疆维吾尔自治区药物研究所 | Creeping thistle glycosides solid lipid nanoparticle and preparation method thereof |
| CN111603447A (en) * | 2020-06-17 | 2020-09-01 | 新疆维吾尔自治区药物研究所 | Tilianin solid dispersion and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102860982B (en) | 2014-08-20 |
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