CN102846620B - Composition with alcohol dispelling and sobering effects and preparation method thereof - Google Patents
Composition with alcohol dispelling and sobering effects and preparation method thereof Download PDFInfo
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- CN102846620B CN102846620B CN201210403641.2A CN201210403641A CN102846620B CN 102846620 B CN102846620 B CN 102846620B CN 201210403641 A CN201210403641 A CN 201210403641A CN 102846620 B CN102846620 B CN 102846620B
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- riboflavin
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Abstract
The invention relates to a composition with alcohol dispelling and sobering effects and a preparation method thereof. The composition is prepared from the following raw materials in parts by weight: 100-400 parts of orazamide, 0.1-0.5 part of folic acid, 1-15 parts of riboflavin and 1-150 parts of vitamin E. The invention further comprises a preparation method of the composition. The composition prepared by the invention has an exclusive prescription, is mainly used for alcohol dispelling and sobering, and has the efficacy of protecting the stomach, is suitably taken before and after drinking and during overdrinking, is capable of remarkably increasing capacity for alcohol and alleviating dizziness and headache after overdrinking and uncomfortableness of the stomach and the belly, and has active preventive effects on complications caused by alcoholism, and the preparation method is simple to operate.
Description
Technical field
The present invention relates to a kind of composition and method of making the same with Dealcoholic sobering-up effect.
Background technology
According to interrelated data, show, China has people up to ten thousand to die from alcoholism every year, because the drunk vehicle accident occurring reaches up to ten thousand, have at least 60 various diseases directly related with alcoholism, medical research shows: 90% ethanol is by liver metabolism, ethanol enters after hepatocyte, through enzyme effect, form acetaldehyde, acetaldehyde has obvious toxicity to hepatocyte, make its metabolism generation obstacle, cause hepatocellular degeneration and necrosis, long-term heavy drinking not only can cause brain, the irreversible damage of nervous system and heart, also can cause alcoholic liver, hepatic fibrosis, the multiple symptom such as liver cirrhosis, China has become one of drinks consumption big country at present, the unordered extension of spirits culture, make alcohol user more and more, more and more rejuvenation, China thinks little of relieving the effect of alcohol when drinking publicity simultaneously, the prevention of relieving alcoholic intoxication product and importing, after alcoholism, deliver to often hospital by Drug therapy, and really have, relieve the effect of alcohol, wake up and spill effect, the product of prevention ethylism is few, cause alcoholic cirrhosis disease to increase, become between twenty and fifty main causes of death.Therefore, alcohol user is taked to the actively preventive measure of safety, effectively alleviate drink after dizziness headache, and the sense of discomfort of stomach abdominal part, prevention ethylism, relieves the effect of alcohol in time, relieving alcoholic intoxication, protects stomach, improves people's health level, has been the task of top priority.
The product of existing Dealcoholic sobering-up, of a great variety, Chinese patent literature report only, reach hundreds of more than.The composition and method of making the same as CN101380433A is disclosed with Dealcoholic sobering-up effect, the disclosed Dealcoholic sobering-up health food of CN1193769C, the relieving alcoholism and protecting the liver composition and method of making the same of the disclosed prevention chemical liver injury of CN1257736C, the disclosed alcohol-dissolving liver-protecting healthy food of CN100364450C, CN102293980A is disclosed for relieving alcoholism and protecting the liver pharmaceutical composition and preparation method thereof, the disclosed health-care alcoholic intoxication dispelling tea of CN101990963A, CN102274381A is disclosed for blood fat reducing, hepatoprotective and Chinese medicine composition of relieving the effect of alcohol and preparation method thereof, CN102274381A is disclosed for blood fat reducing, hepatoprotective and Chinese medicine composition of relieving the effect of alcohol and preparation method thereof, glossy ganoderma-three flower tea its preparation method of the disclosed liver-protecting sober-up clearing heat and moistening lung of CN102258098A etc., their multiplex animal-plant materials or/and other biological product make, fill a prescription mostly very complicated, component is mostly more than 7 kinds, manyly also to pass through numerous and diverse leaching process, and function is main mainly with health-care liver protecting, how unintelligible Dealcoholic sobering-up principle is, effect is mostly slow.
Summary of the invention
Technical problem to be solved by this invention is, overcome the above-mentioned defect that prior art exists, a kind of Dealcoholic sobering-up effect that has is provided, and can increases the composition and method of making the same of drinking amount, said composition function be take Dealcoholic sobering-up as main, have the effect of protecting stomach concurrently, prescription is simple, edible safety, and effect is remarkable, while being suitable for drinking front and back and insobriety, take, the complication that alcoholism is caused also has positive preventive effect.
The technical scheme that the present invention solves its technical problem employing is, a compositions with Dealcoholic sobering-up effect, it is made by following raw material: Aicamin 100-400 weight portion, folic acid 0.1-0.5 weight portion, riboflavin 1-15 weight portion, vitamin E 1-150 weight portion.
Further, preferred proportioning raw materials is: Aicamin 200-300 weight portion, folic acid 0.2-0.4 weight portion, riboflavin 5-10 weight portion, vitamin E 50-10 weight portion.
Further, preferred proportioning raw materials is: Aicamin 200 weight portions, folic acid 0.4 weight portion, riboflavin 10 weight portions, vitamin e1 00 weight portion.
Further, preferred proportioning raw materials is: Aicamin 300 weight portions, folic acid 0.4 weight portion, riboflavin 10 weight portions, vitamin 100 weight portions.
Further, preferred proportioning raw materials is: Aicamin 200 weight portions, folic acid 0.2 weight portion, riboflavin 5 weight portions, vitamin E 50 weight portions.
Further, preferred proportioning raw materials is: Aicamin 300 weight portions, folic acid 0.2 weight portion, riboflavin 5 weight portions, vitamin E 50 weight portions.
Further, preferred proportioning raw materials is: the health food that also contains convention amount allows the adjuvant adding, and comprises correctives, excipient etc., for example one or more in maltose, Saccharum Sinensis Roxb., pectin, dextrin, kind can need to determine according to dosage form, and quantity can need to be determined according to mouthfeel.
The preparation method of the present invention's the compositions with Dealcoholic sobering-up effect, comprise the steps: the above fineness of Aicamin drying and crushing to 80 order, by predetermined weight proportioning, take described folic acid, riboflavin, vitamin E, according to dosage form or mouthfeel, make needs, then add appropriate amount of auxiliary materials, mix, ultraviolet disinfection, sterilization, packing.
The described dosage form with the compositions of Dealcoholic sobering-up effect is not limit, and can be sugar pill, granule etc.
Described Aicamin has another name called orazamide, orazamide; English AiCaminum, Orazamide by name; Chemical name is 4-amino-5-Methanamide imidazoles Orotate dihydrate; Molecular formula is C
9h
10n
6o
52H
2o.
Folic acid (Folic acid) molecular formula is C
19h
19n
7o
6
Riboflavin (riboflavin), has another name called vitamin B2.
Present inventor's research shows, the effect of Dealcoholic sobering-up depends primarily on the metabolic capacity of liver, Aicamin can resolve into amino-5 Orazamides (AICA) of equimolecular 4-and orotic acid (orotic acid) in gastro-intestinal Fluid, AICA is the precursor substance of purine, it can successfully be incorporated in hepatocyte nucleic acid, the balance that keeps nucleic acid metabolism, correct the abnormal metabolism of protein, fat and carbohydrate, necrosis, fibrosis and the fatty liver of the hepatic parenchymal cells that prevention causes due to ethylism, and can promote liver cell regeneration.Orotic acid is the precursor substance of pyrimidine, and it can improve the ratio of albumin and globulin, and total serum protein level promotes digestion and the absorption of fat and ethanol, and encourages the absorption of vitamin A and K.Adopt Aicamin to process the rat causing because of ethanol poisoning, can make its breath cycle and glycogen level obtain part and recover, can stimulate the metabolism of single phosphorus hexose, and have significant detoxifying effect, on lipid metabolism without impact.Another toxicological experiment shows: with 40 of white mice, intraperitoneal administration, calculates LD50703.0 mg/kg by Guan Shi method, average fiducial limit: 591-815mg/kg(P=0.05).Rabbit, white mice are filled with and raise administration, and continuous 6 moonsets are found the significant difference of monster.
Confirm thus: Aicamin can be repaired fast because of ethylism or due to acetaldehyde metabolism be obstructed caused hepatocyte injury and necrosis, irritates hepatic parenchymal cells growth, strengthens the metabolic capacity of liver, has the effect of Dealcoholic sobering-up.Toxicological experiment confirms: Aicamin safety, has no side effect.
Study and also show, folic acid has collaborative facilitation to the Dealcoholic sobering-up effect of Aicamin.Folic acid is a kind of coenzyme essential in DNA replication dna process, its major function is to manufacture erythrocyte and leukocyte, it is to manufacture the indispensable material of blood, can accelerate blood flow, ethanol in dilute blood, the content of acetaldehyde, promote to decompose toxin expelling, folic acid is petrin pyridine, a kind of water solublity vitamin B group that para-amino benzoic acid and glutaminic acid residue form, for the necessary material of body cell Growth and reproduction, can help the metabolism of protein, and participate in the synthetic of purine nucleic acid and pyrimidine nucleotide and transform, the necessary material of human body when utilizing sugar and aminoacid.
Another important component of the present invention " riboflavin " (vitamin B2) belongs to water soluble vitamins, easily digestion and absorption, it is the coenzyme of some important oxidoreductasees in body, participate in biological oxidation and energy metabolism in body, improve the utilization rate of human body to protein, participate in the growth metabolism of cell, it is the necessary nutrient of hepatocyte tissue metabolism and reparation, riboflavin can be strengthened liver function, can improve mitochondrial potential in human body brain cell, prevention headache symptom.Riboflavin is the same with folic acid can not accumulated in vivo, so often will lean on food or nutriment to supplement.
Another component of the present invention " vitamin E " is a kind of high-efficiency antioxidant agent, can protect biomembrane to avoid suffering the infringement of peroxide, improves blood circulation, strengthens cell viability and body endurance, lessens fatigue, and improves body immunity.
Usage, consumption: wine is front or take after drinking 1 to 2 ball (or bag), and wine is taken best results for first 15 to 30 minutes, and every ball or bag, containing effective active component 0.25-0.4 gram.
Said composition function be take Dealcoholic sobering-up as main, has the effect of protecting stomach concurrently, reasonable recipe safety, and effect is more remarkable, is more suitable for while drinking front and back and insobriety and takes, and the complication that alcoholism is caused also has positive preventive effect.
Following table is listed the main distinction between composite for disintoxicating and sobering of the present invention and existing market Dealcoholic sobering-up product:
| Classification | The present invention's composite for disintoxicating and sobering | Existing market Dealcoholic sobering-up product |
| Character | Relieve the effect of alcohol, protect stomach double effects | Mostly be animals and plants prescription, health food |
| Function | The effect of relieving the effect of alcohol is remarkable | The effect of relieving the effect of alcohol is general |
| Onset time | The onset of relieving the effect of alcohol in 15-30 minute | The onset of relieving the effect of alcohol after most 1 hour |
| Safety | Long-term taking safety | Safety needs to be investigated |
In sum: the present invention's composite for disintoxicating and sobering, best composition and the proportioning of studying and designing from molecular cytology, molecular biology angle, Aicamin and folic acid, riboflavin combination in prescription, be aided with vitamin E, the hepatocyte injury causing mainly for ethanol is repaired, and irritates the regeneration of hepatic parenchymal cells, accelerated blood circulation metabolism simultaneously, promote the formed harmful substance of ethanol to get rid of, strengthen the metabolic capacity of liver, thereby reach the effect of " Dealcoholic sobering-up "; Often drink and alcoholic; gastrointestinal mucosa all can have infringement in various degree; intestinal illness can be disturbed the absorption of food Folic Acid, and excessive drinking more causes the shortage of riboflavin, adds folic acid and riboflavin in prescription; both protected mucosa; effectively protect stomach, alleviate the sense of discomfort of stomach abdominal part after drinking, can also alleviate the dizziness headache after drinking; accelerate the process of Dealcoholic sobering-up, prevention alcoholism complication.
Composite for disintoxicating and sobering product efficacy definite ingredients of the present invention, the effect of relieving the effect of alcohol is remarkable, carries instant, and each composition of compositions is collaborative playing a role mutually, better to frequent dinner party alcohol user's physical recovery effect.
the specific embodiment:the invention will be further described by the following examples.
embodiment 1
The present embodiment component and inventory, major ingredient: Aicamin 800g, folic acid 1.6g, riboflavin 40g, vitamin E 400g, adjuvant: maltose 2000g, Saccharum Sinensis Roxb. 1200g, pectin 800g.
Preparation: take at Aicamin 800 g(60 ℃) the above fineness of drying and crushing to 80 order, separately take above-mentioned grams folic acid, riboflavin, mix, add maltose, Saccharum Sinensis Roxb., pectin and the vitamin E of above-mentioned grams, add the yellow agent of Shao Liang Ginger painted, entering blender fully stirs, mix completely, make sugar pill 4000 balls, ultraviolet disinfection, sterilization, with aluminum type composite membrane subpackage (every bag of 1 ball, the heavy 1.3g of every ball).
Usage/consumption: before wine or take after drinking 1 ball (every ball is containing 0.34 gram of effective ingredient); Before wine, within 15-30 minute, take best results.The weight of described effective ingredient refers to the gross weight (lower same) of major ingredient Aicamin, folic acid, riboflavin and vitamin.
embodiment 2
The present embodiment component and inventory, major ingredient: Aicamin 1200g, folic acid 1.6g, riboflavin 40g, vitamin E 400g, adjuvant: Saccharum Sinensis Roxb. 2800g, dextrin 800g.
Preparation: take at Aicamin 1200g(60 ℃) the above fineness of drying and crushing to 80 order, separately takes folic acid, the riboflavin of above-mentioned grams, mixes, 2800g Saccharum Sinensis Roxb. is pulverized to (at 50 ℃), separately, by after the slurrying of 800g dextrin, add in above-mentioned composition, add again vitamin E 400g, add the yellow agent of Shao Liang Ginger painted, enter blender and fully stir, mix completely, dry, granulation agent 5240g, ultraviolet disinfection, sterilization, with aluminum type composite membrane subpackage (every bag of heavy 1.3g of inclusions).
Usage/consumption: before wine or take after drinking 1 bag (every bag containing effective ingredient 0.4g); Before wine, within 15-30 minute, take best results.
embodiment 3
The present embodiment component and inventory, major ingredient: Aicamin 1000g, folic acid 1.0g, Riboflavin Tetrabutyrate 5g, vitamin E2 50g, adjuvant: maltose 2500g, Saccharum Sinensis Roxb. 1500g, pectin 1000g.
Preparation: take at Aicamin 1000g(60 ℃) the above fineness of drying and crushing to 80 order, pulverizes (at 50 ℃) by 1500g Saccharum Sinensis Roxb., takes folic acid, riboflavin, the Saccharum Sinensis Roxb. of above-mentioned grams, mix, add maltose, the pectin of above-mentioned grams, then add vitamin E2 50g, add the yellow agent of Shao Liang Ginger painted, fully stir, mix completely, make sugar pill 5000 balls, ultraviolet disinfection, sterilization, with aluminum type composite membrane subpackage (every bag of 1 ball, the heavy 1.3g of every ball).
Usage/consumption: before wine or take after drinking 1-2 ball, (every ball is containing effective ingredient 0.25g); Before wine, within 15-30 minute, take best results.
embodiment 4
The present embodiment component and inventory, major ingredient: Aicamin 1500g, folic acid 1.0g, Riboflavin Tetrabutyrate 5g, vitamin E2 50g, adjuvant: Saccharum Sinensis Roxb. 3000g, dextrin 800g
Preparation: take at Aicamin 1500g(60 ℃) the above fineness of drying and crushing to 80 order, pulverizes (at 50 ℃) by 3000g Saccharum Sinensis Roxb., and the folic acid, riboflavin, the Saccharum Sinensis Roxb. that take above-mentioned grams mix, separately, by after the slurrying of 800g dextrin, add maltose, the pectin of above-mentioned grams, then add vitamin E2 50g, add the yellow agent of Shao Liang Ginger painted, fully stir, mix completely, dry, granulation agent 5600g, ultraviolet disinfection, sterilization, with aluminum type composite membrane subpackage (every bag of heavy 1.15g of inclusions).
Usage/consumption: before wine or take after drinking 1-2 bag, (every bag containing effective ingredient 0.35g); Before wine, within 15-30 minute, take best results.
Test-meal Dealcoholic sobering-up effect typical case:
1, side * *: man, 48 years old, often dinner party, hobby Chinese liquor can be drunk 52 degree 150ML at every turn, flushed face after drinking, dizziness, has drunkness, checks and has hepatitis history, yellowish complexion, lassitude.Before wine, edible embodiment 3 sugar pill 2 balls, drink the commensurability same number of degrees after drinking, and self-induction is without the signs of getting drunk, and without dizzy phenomenon, hepatic region, also without malaise symptoms, adds after over-drinking amount 100ML, and micro-have drunkness, but second day gets up without being still drank after a night sensation.
2, Zhao * *: man, 52 years old, treat with courtesy and stay up late morely, often drink Chinese liquor, medicated beer, complexion is not red after drinking, has drunkness, without hepatitis history, the nose heave dizziness of normal sense after drinking, time have a vomiting.Before wine, edible embodiment 3 sugar pill is 1, drinks the commensurability same number of degrees after drinking, and self-induction is without the signs of getting drunk, and the accent without a head phenomenon of swoon, repeatedly strengthens drinking amount and accompany multiple wine to mix and drink, micro-having a brick in one's hat, and liver function test is normal without being still drank after a night next day for self-induction.
3, open * *: female, 33 years old, drinks brand promotion person, business entertainment is many, often drinks Chinese liquor, red wine, complexion is micro-red after drinking, without liver gastropathy history, often drunk, normal sense headache after drinking, edible embodiment 1 sugar pill 1 ball before wine, after drinking, self-induction is substantially without the signs of getting drunk for drink dosage, and no headache phenomenon, without being still drank after a night.
4, summer * *: man, 21 years old, drinks brand promotion person, business entertainment is many, often drink Chinese liquor, red wine, medicated beer, after drinking flushed face, without hepatitis history, often drunk, normal sense is dizzy nose heave after drinking, time have a vomiting, through 1 bag of edible embodiment 2 granule after drinking, drink the commensurability same number of degrees after drinking, self-induction, substantially without the signs of getting drunk, without dizzy sensation, repeatedly strengthens drinking amount and accompanies multiple wine to mix and drink, micro-having a brick in one's hat, without being still drank after a night, liver function test is normal.
5, what * *: female, 24 years old, has hepatitis b surface antigen positive medical history, but self-induction is asymptomatic, often dinner party, can drink Chinese liquor, red wine, can drink 52 degree 100ML, complexion is not red after drinking, has drunkness at every turn, while holding a lot of liquor, have vomiting, before wine, edible embodiment 4 granule is 2 bags, drinks the commensurability same number of degrees after drinking, self-induction is without the signs of getting drunk, and without dizzy phenomenon, hepatic region is also without any discomfort symptom, add after over-drinking amount, micro-have a drunkness, without being still drank after a night sensation.
6, week * *: man, 36 years old, work dinner party was stayed up late a lot, without hepatitis history, often drink Chinese liquor, medicated beer, complexion is micro-red after drinking, often drunk, and sensation is dizzy nose heave after drinking, through after drinking, eat 1 bag of embodiment 4 granule, drink the commensurability same number of degrees after drinking, self-induction is substantially without the signs of getting drunk, without dizzy nose heave phenomenon, repeatedly strengthen drinking amount and accompany that multiple wine is assorted to be drunk, micro-have a drunkness, without being still drank after a night.
7, Lee * *: man, 30 years old, business entertainment was many, often drink Chinese liquor, medicated beer, flushed face after drinking, without hepatitis history, usually hold a lot of liquor, be difficult to make drunk, this mixes after drinking a large amount of, sensation stomach abdominal part is accompanied dizziness like a hen on a hot girdle, in time edible embodiment 3 sugar pill 2 balls in wine, about 20 minutes, self-induction symptom alleviates a lot, before walking, drunk again a little Chinese liquor, next day is without the sensation of being still drank after a night.
8, Yuan * *: female, 21 years old, red wine promoter, business entertainment is many, often drinks red wine, complexion is not red after drinking, without liver gastropathy history, time have vomiting, the sense of drinking is often dizzy, through after drinking, eat embodiment 1 sugar pill 1 ball, after drink dosage red wine, self-induction is substantially without dizzy phenomenon, without being still drank after a night.
9, Yin * *: female, 42 years old, smoke that it is more to stay up late, often have the beer, red wine, without hepatitis history, in the time of after drinking, there is the dizziness symptom of having a stomach upset, 2 bags of edible embodiment 4 granules after drinking several times, the drink of staying up late is after drinking commensurability, self-induction dizziness and stomach abdominal discomfort symptom are improved obviously, the meaning that is occasionally under the weather, next day, liver function test was normal without being still drank after a night.
Claims (9)
1. a compositions with Dealcoholic sobering-up effect, is characterized in that, by following raw material, is made: Aicamin 200-300 weight portion, folic acid 0.2-0.4 weight portion, riboflavin 5-10 weight portion, vitamin E 50-100 weight portion.
2. the compositions with Dealcoholic sobering-up effect according to claim 1, is characterized in that, by following raw material, is made: Aicamin 200 weight portions, folic acid 0.4 weight portion, riboflavin 10 weight portions, vitamin e1 00 weight portion.
3. the compositions with Dealcoholic sobering-up effect according to claim 1, is characterized in that, by following raw material, is made: Aicamin 300 weight portions, folic acid 0.4 weight portion, riboflavin 10 weight portions, vitamin 100 weight portions.
4. the compositions with Dealcoholic sobering-up effect according to claim 1, is characterized in that, by following raw material, is made: Aicamin 200 weight portions, folic acid 0.2 weight portion, riboflavin 5 weight portions, vitamin E 50 weight portions.
5. the compositions with Dealcoholic sobering-up effect according to claim 1, is characterized in that, by following raw material, is made: Aicamin 300 weight portions, folic acid 0.2 weight portion, riboflavin 5 weight portions, vitamin E 50 weight portions.
6. according to the compositions with Dealcoholic sobering-up effect one of claim 1-5 Suo Shu, it is characterized in that, the health food that also contains convention amount allows the adjuvant adding.
7. the compositions with Dealcoholic sobering-up effect according to claim 6, is characterized in that, dosage form is sugar pill or granule.
8. a preparation method as claimed in claim 1 with the compositions of Dealcoholic sobering-up effect, it is characterized in that, comprise the steps: the above fineness of Aicamin 200-300 weight portion drying and crushing to 80 order, take described folic acid 0.2-0.4 weight portion, riboflavin 5-10 weight portion, vitamin E 50-100 weight portion, mixes.
9. there is according to claim 8 the preparation method of the compositions of Dealcoholic sobering-up effect, it is characterized in that, comprise the steps:, by the above fineness of Aicamin drying and crushing to 80 order, by predetermined weight proportioning, to take described folic acid, riboflavin, vitamin E, add the health food of convention amount to allow the adjuvant adding, mix, make sugar pill or granule, ultraviolet disinfection, sterilization, packing.
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| Title |
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| 合理使用"保肝药";张泽宇;《健康》;19941231(第12期);13 * |
| 张泽宇.合理使用"保肝药".《健康》.1994,(第12期),13. |
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