CN102813700B - Medicine composition for treating chronic nephritis and preparation method thereof - Google Patents
Medicine composition for treating chronic nephritis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a medicine composition for treating chronic nephritis. The medicine composition is a pellet prepared from the following raw materials and accessory in parts by weight: Chinese medicine herb raw materials: 4,166 parts of lespedeza virgata, 750 parts of radix scutellariae, 1,000 parts of folium pyrrosiae and 1,000 parts of radix astragali; and accessory: 39-98 parts of filler, wherein the filler is one of starch, soluble starch and dextrin or the mixture of more than two thereof. The invention also provides a preparation method of the medicine composition. In the invention, according to the physicochemical characteristics of the raw material extract of 'Shenyansiwei tablets', the raw materials are prepared into pellets and then encapsulated, thus relatively large drug loading capacity is ensured, and the problem that the medicine can not be prepared into hard capsules on the premise of reducing the dose of the patent medicine of the original dosage form is solved; and meanwhile, in the preparation process of pellets, by observing the pill forming method, the type of adhesive and wetting agent and the drying method, the dosage of the accessory and the drying time are further reduced, the production cost is effectively saved, and industrial production is possible.
Description
Technical field
The present invention relates to a kind of chronic nephritis pharmaceutical composition and preparation method thereof for the treatment of.
Background technology
" SHENYAN SIWEI PIAN " is a kind of Chinese patent medicine of classics.Record in the 12nd of national standard for traditional Chinese medicines, 86 pages, standard number is WS
3-B-2345-97, makes tablet by Lespedeza virgata (Thunb. ex Murray) DC., Radix Scutellariae, Folium Pyrrosiae, Radix Astragali four Chinese medicine thing.SHENYAN SIWEI PIAN has blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, and the function of tonifying Qi of the kidney, is mainly used in treating chronic nephritis, and therefore its bitter in the mouth, adopts coated tablet more.Said preparation is tablet, and recipe quantity is: Lespedeza virgata (Thunb. ex Murray) DC. 2083g, Radix Scutellariae 375g, Folium Pyrrosiae 500g, Radix Astragali 500g, and preparation method is: four tastes in writing out a prescription, except Radix Scutellariae, its excess-three taste decocts with water respectively secondary, each 2 hours, collecting decoction, filters, and filtrate is concentrated in right amount, add ethanol and make to be 70%, to stir evenly containing alcohol amount, standing, get supernatant and reclaim ethanol, concentrating under reduced pressure becomes thick paste shape, dry, pulverize; Radix Scutellariae powder is broken into coarse powder, adds water in 80 ℃ of warm macerating three times, each 2 hours, filter while hot, merging filtrate, adds 15% alum solution in filtrate, addition is 5% of medicinal liquid cumulative volume, stir, standing, filter, precipitate washes with water to neutrality, in 75 ℃, dry, pulverize, merge above-mentioned fine powder, add right amount of auxiliary materials, granulation, be pressed into 1000, sugar coating, obtains.The tablet of being prepared by the method, each serving with 8, tablet, takes 24, tablet every day, and patent medicine dose is large, and patient compliance is poor; And disintegrate slow (approximately needing 20～50 minutes), dissolution rate are slow, absorb, effective slow, preparation is sugary, clinical application has certain limitation.
Capsule, mostly its Chinese medicine is to be present in softgel shell with powder, graininess, the impact of the factor such as be not stressed, so dispersion rapidly, stripping and absorption in gastrointestinal tract, its onset speed is faster than tablet.The softgel shell of capsule can also be covered bad taste, the raising medicine stability smelt of medicine.If by SHENYAN SIWEI PIAN capsule, not only can accelerate stripping and the absorption of medicine, can also avoid using sweeting agent adjuvant, save preparation cost.
Summary of the invention
The object of the present invention is to provide a kind of chronic nephritis pharmaceutical composition and preparation method thereof for the treatment of.
The invention provides a kind of chronic nephritis pharmaceutical composition for the treatment of, it is the micropill that the supplementary material by following weight percentage ratio is prepared into:
Herbal raw material:
1000 parts of 1000 parts of Radixs Astragali of 750 parts of Folium Pyrrosiaes of 4166 parts of Radix Scutellariaes of Lespedeza virgata (Thunb. ex Murray) DC.
Adjuvant:
Filler 39-98 part
Described filler is one or more the mixing in starch, soluble starch, dextrin.
Further, described filler is 39-59 part; Described filler is starch.
Further, described filler is 39-45 part.
Further preferably, described filler is 43 parts.
Wherein, in micropill, every g in baicalin, must not be less than 58.1mg containing Radix Scutellariae.
The present invention also provides the preparation method of aforementioned pharmaceutical compositions, and it comprises following operating procedure:
(1) take by weight ratio supplementary material;
(2) four described taste Chinese herbal medicine, except Radix Scutellariae, its excess-three taste decocts with water respectively secondary, and each 2 hours, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes to be 70%, to stir evenly containing alcohol amount, standing, get supernatant and reclaim ethanol, concentrating under reduced pressure becomes thick paste shape, dry, pulverize; Radix Scutellariae powder is broken into coarse powder, adds water in 80 ℃ of warm macerating three times, each 2 hours, filter while hot merging filtrate, in filtrate, add 15% alum solution, addition is 5% of medicinal liquid cumulative volume, stirs, standing, filter, precipitate washes with water to neutrality, in 75 ℃, dry, pulverize;
(3) merge above-mentioned fine powder, add starch, mix, take 50-80%V/V ethanol as binding agent, wetting agent, adopt coating pan rolling method or extruding-spheronization to be prepared into ball, dry, obtain.
Further, take 70-80%V/V concentration of alcohol as binding agent, wetting agent, adopt extruding-spheronization to be prepared into ball.
Further preferably, concentration of alcohol is 70%V/V.
Wherein, described dry concrete operation step is: first at 40-45 ℃ of dry 1h, then in 60-70 ℃ of dry 1h, finally at 80-85 ℃ of dry 10h.
Further, described dry concrete operation step is: first at 40-45 ℃ of dry 1h, then in 60-65 ℃ of dry 1h, finally at 80-85 ℃ of dry 10h.
The present invention also provides a kind of chronic nephritis hard capsule for the treatment of, and after it is encapsulated by aforesaid pharmaceutical composition, prepares.
The present invention is according to the physicochemical characteristic of " SHENYAN SIWEI PIAN " raw extract, first raw material is prepared after micropill, encapsulated again, guaranteed higher drug loading, solved this medicine and cannot make a difficult problem for hard capsule under the prerequisite that reduces former dosage form patent medicine dose, significantly reduce drug administration amount, strengthened patient's compliance; Meanwhile, in the preparation process of micropill, by becoming the investigation of ball method, binding agent and wetting agent kind, drying means, further reduced supplementary product consumption and drying time, effectively saved production cost, for suitability for industrialized production provides possibility.
Accompanying drawing explanation
Fig. 1 sucting wet curve
The specific embodiment
The preparation method of embodiment 1 pharmaceutical composition of the present invention
Herbal raw material (unit: gram):
Lespedeza virgata (Thunb. ex Murray) DC. 4166g, Radix Scutellariae 750g, Folium Pyrrosiae 1000g, Radix Astragali 1000g
Pharmaceutic adjuvant:
Starch 43g
Its preparation method is, the above 4 taste Chinese herbal medicine, and except Radix Scutellariae, its excess-three taste decocts with water respectively secondary, each 2 hours, collecting decoction, filters, and filtrate is concentrated in right amount, adds ethanol and makes to be 70%, to stir evenly containing alcohol amount, standing, to get supernatant and reclaim ethanol, concentrating under reduced pressure becomes thick paste shape, dry, pulverize; Radix Scutellariae powder is broken into coarse powder, adds water in 80 ℃ of warm macerating three times, each 2 hours, filter while hot merging filtrate, in filtrate, add 15% alum solution, addition is 5% of medicinal liquid cumulative volume, stirs, standing, filter, precipitate washes with water to neutrality, in 75 ℃, dry, pulverize.Merge above-mentioned fine powder, add starch appropriate, mix, using 70%V/V ethanol as binding agent and wetting agent, adopt extrusion-spheronization pill, at 40-45 ℃ of dry 1h, then in 60-65 ℃ of dry 1h, finally at 80-85 ℃ of dry 10h, take out, sterilizing, obtains micropill.
The preparation method of embodiment 2 pharmaceutical compositions of the present invention
Herbal raw material (unit: gram):
Lespedeza virgata (Thunb. ex Murray) DC. 4166g, Radix Scutellariae 750g, Folium Pyrrosiae 1000g, Radix Astragali 1000g
Pharmaceutic adjuvant:
Starch 39g
Its preparation method is, the above 4 taste Chinese herbal medicine, and except Radix Scutellariae, its excess-three taste decocts with water respectively secondary, each 2 hours, collecting decoction, filters, and filtrate is concentrated in right amount, adds ethanol and makes to be 70%, to stir evenly containing alcohol amount, standing, to get supernatant and reclaim ethanol, concentrating under reduced pressure becomes thick paste shape, dry, pulverize; Radix Scutellariae powder is broken into coarse powder, adds water in 80 ℃ of warm macerating three times, each 2 hours, filter while hot merging filtrate, in filtrate, add 15% alum solution, addition is 5% of medicinal liquid cumulative volume, stirs, standing, filter, precipitate washes with water to neutrality, in 75 ℃, dry, pulverize.Merge above-mentioned fine powder, add starch appropriate, mix, using 70%V/V ethanol as binding agent and wetting agent, adopt extrusion-spheronization pill, at 40-45 ℃ of dry 1h, then in 60-70 ℃ of dry 1h, finally at 80-85 ℃ of dry 10h, take out, sterilizing, obtains micropill.
The preparation method of embodiment 3 pharmaceutical compositions of the present invention
Herbal raw material (unit: gram):
Lespedeza virgata (Thunb. ex Murray) DC. 4166g, Radix Scutellariae 750g, Folium Pyrrosiae 1000g, Radix Astragali 1000g
Pharmaceutic adjuvant:
Starch 45g
Its preparation method is, the above 4 taste Chinese herbal medicine, and except Radix Scutellariae, its excess-three taste decocts with water respectively secondary, each 2 hours, collecting decoction, filters, and filtrate is concentrated in right amount, adds ethanol and makes to be 70%, to stir evenly containing alcohol amount, standing, to get supernatant and reclaim ethanol, concentrating under reduced pressure becomes thick paste shape, dry, pulverize; Radix Scutellariae powder is broken into coarse powder, adds water in 80 ℃ of warm macerating three times, each 2 hours, filter while hot merging filtrate, in filtrate, add 15% alum solution, addition is 5% of medicinal liquid cumulative volume, stirs, standing, filter, precipitate washes with water to neutrality, in 75 ℃, dry, pulverize.Merge above-mentioned fine powder, add starch appropriate, mix, using 70%V/V ethanol as binding agent and wetting agent, adopt extrusion-spheronization pill, at 40-45 ℃ of dry 1h, then in 60-70 ℃ of dry 1h, finally at 80-85 ℃ of dry 10h, take out, sterilizing, obtains micropill.
The preparation method of embodiment 4 pharmaceutical compositions of the present invention
Get the micropill of embodiment 1 preparation, encapsulated, make altogether 1000 of hard capsules, every filling 0.43g.While taking, 3 times on the one, each 4.
The Study on Forming of embodiment 5 pharmaceutical composition hard capsule of the present invention
1, preparation alignment analysis
In the whole production technology of the present invention, relate to alcohol extractum and aqueous extract, its hygroscopicity is extremely strong, and dried cream powder is capsule charge directly, in order to reduce hygroscopicity, determines to add adjuvant first to prepare granule early stage encapsulated again, thereby reduces medicine hygroscopicity.Yet no matter previous experiments discovery, adopt which kind of filler (as starch, dextrin or soluble starch), all must add 1.25 times of above adjuvants of extractum weight, just can make substantially qualified granule.And huge supplementary product consumption like this cannot reduce patent medicine taking dose, it is that capsule has little significance that former tablet is changed to agent.For these reasons, the present invention considers after extractum micropill processed, refills capsule.
2, the one-tenth ball craft screening of micropill
(1) become ball method to select
Adjuvant adopts starch, take water as wetting agent, binding agent, adopts respectively extrusion-spheronization, coating pan rolling method to examine or check into ball method.
Table 1 becomes ball method screening situation
From table 1, coating pan rolling method pill will add 1.2 times of above adjuvants of extractum weight could become ball, and the fluffy unfavorable capsule charge of a ball after one-tenth ball; And adopt extruding-spheronization pill only to need the adjuvant that adds extractum weight 25% just can become ball, and significantly reduced supplementary product consumption, and after becoming ball, ball quality is closely beneficial to capsule charge, therefore, determine with extrusion-spheronization pill.
(2) supplementary product kind screening
To become the situations such as ball difficulty or ease, the adjuvants such as dextrin, starch, microcrystalline Cellulose have been investigated, 25% dextrin, starch, the microcrystalline Cellulose that add respectively extractum amount, take water as wetting agent, binding agent, adopts extruding pill, to becoming ball situation examination screening supplementary product kind, the results are shown in Table 2.
Table 2 pill molding supplementary product kind screening situation
Therefore, tentatively determine and take inexpensive starch as adjuvant.
(3) wetting agent, binding agent and supplementary product consumption screening
Take starch as filler in the situation that determining, existing to take water, 50% ethanol, 60% ethanol, 70% ethanol, 80% ethanol be wetting agent, binding agent, adopts extruding pill, and wetting agent, binding agent and filler loading are screened, and the results are shown in Table 3.
From table 3, while making wetting agent, binding agent with 70% ethanol, 80% ethanol, only add 0.1 times of amount starch of extractum can well become ball, and ball surface color is even, dissolve scattered time limit meets the requirements.Consider that concentration of alcohol is higher, workshop safety coefficient is lower, so select 70% ethanol to make wetting agent, binding agent; Meanwhile, consider the profit and loss in materials variance and preparation process, can select the starch of 0.11 times of amount left and right of extractum weight.
Table 3 wetting agent, binding agent and supplementary product consumption screening
(4) baking temperature
Micropill mechanism ball for the soft material making, wet feed pushed 0.8 ㎜ sieve aperture, and the wet grain of strip cuts off round as a ball, and drying and moulding is crossed 16～20 mesh sieves and is selected ball.But baking temperature often has considerable influence to the character of pill, due to extractum of the present invention, some is alcohol extractum, so tackle dry mode and temperature should be made high spot reviews.
Table 4 baking temperature and time screening table
By the visible optimum drying temperature and time of table 4, be: 70～75 ℃ are dried 20 hours.But the method is longer drying time, therefore, consider different temperatures stage drying, stage drying conditional filtering sees the following form.
Table 5 stage drying temperature and time screening table
As shown in Table 5, adopt two ends dry, although can make micropill molding good, same consuming time oversize; If adopt three sections to be dried, (40～45 ℃ of first stage, dry 1 hour under specific drying condition, 60～65 ℃ of second stage, dry 1 hour, 80～85 ℃ of phase IIIs, dry 10 hours), the dry used time is the shortest, it is minimum to consume energy, and smooth, the moisture of ball outward appearance rounding meets pharmacopeia requirement simultaneously.Therefore, in the present invention, select three sections to be dried.
3, dose determination
Because former nephritis tablet recipe usage and dosage is: oral, a daily dose primary crude drug 82.992g(Radix Scutellariae 9g, Lespedeza virgata (Thunb. ex Murray) DC., Folium Pyrrosiae and Radix Astragali 73.992g).Now make hard capsule, relate to formulation usage and dosage, inevitable relevant with Chinese medical concrete amount and supplementary product consumption.One daily dose primary crude drug 82.992g(Radix Scutellariae 9g, Lespedeza virgata (Thunb. ex Murray) DC., Folium Pyrrosiae and Radix Astragali 73.992g), paste volume is the dry cream 0.99g of 4.5896g(Radix Scutellariae, the dry cream 3.6996g of Lespedeza virgata (Thunb. ex Murray) DC., Folium Pyrrosiae and the Radix Astragali)), by taking every day 3 times, each 4, specification is 0.43g/ grain, and adjuvant need add 0.4704g.According to upper calculating, preparation prescription is:
Extract medical material 6916g(SHENYAN SIWEI PIAN recipe quantity 2 times), paste volume is about the dry cream 82.5g of 390g(Radix Scutellariae, the dry cream 308.3g of Lespedeza virgata (Thunb. ex Murray) DC., Folium Pyrrosiae and the Radix Astragali), make altogether 1000, consider that preparation has certain profit and loss adjuvant need add about 43g.Each 4, every filling 0.43g, 3 times on the one.
Brief summary:
(1) " SHENYAN SIWEI PIAN " former preparation, calculates by every 0.36g in the accurate word Z42021945 of traditional Chinese medicines, need take 8 at every turn, need take 2.88 grams at every turn; And the present invention only takes 1.72 grams at every turn, dose has reduced by 40%;
(2) " SHENYAN SIWEI PIAN " changed to agent is capsule in the present invention, because dry extract hygroscopicity is strong, must add adjuvant granulate or pill after could be encapsulated; But experiment finds, the required supplementary product consumption of granulating is larger, is unfavorable for the saving of adjuvant and the reduction of medication dose, and therefore, the present invention finally selects, and first prepared by extractum after micropill encapsulated again;
(3) when the present invention adopts extruding-spheronization to prepare micropill, effectively reduce supplementary product consumption to 0.25 times of extractum weight, and become ball better effects if, be significantly better than coating pan rolling method;
(4) the present invention, when selecting 70%-80% ethanol to make wetting agent, binding agent, can further reduce supplementary product consumption to 0.1 times of extractum weight, has further increased drug loading, has reduced cost of supplementary product; Meanwhile, in order to guarantee the safety of production process, preferred alcohol concentration of the present invention is 70%;
(5) the present invention finds, if adopt common drying means, can be completely dry at 20-30h, and become ball effect better; But in order to shorten drying time, reduce costs, finally select syllogic dry: 40～45 ℃ of first stage, dry 1 hour, 60～65 ℃ of second stage, dry 1 hour, 80～85 ℃ of phase IIIs, dry 10 hours.
The quality testing of embodiment 6 capsules of the present invention
1 assay
[assay] measured according to high performance liquid chromatography (appendix VI D of Chinese Pharmacopoeia version in 2010).
Chromatographic condition and system suitability octadecylsilane chemically bonded silica are filler; Methanol-water-phosphoric acid (47:53:0.2) is mobile phase; Detection wavelength is 280nm.Number of theoretical plate calculates and should be not less than 3000 by baicalin peak.
The preparation precision of reference substance solution takes at 60 ℃ of drying under reduced pressure baicalin reference substance of 4 hours appropriate, adds methanol and makes every 1ml containing the solution of 15 μ g, obtains.
The content under content uniformity item is got in the preparation of need testing solution, and porphyrize is got about 0.3g, accurately weighed, put in 100ml measuring bottle, add 70% ethanol 80ml, supersound process 30 minutes, take out, let cool, add 70% ethanol to scale, shake up, filter, the accurate subsequent filtrate 1ml that draws, put in 5ml volumetric flask, add methanol to scale, shake up, filter, get subsequent filtrate, obtain.
Algoscopy is accurate reference substance solution and each 10 μ l of need testing solution of drawing respectively, and injection liquid chromatography, measures, and obtains.
The every capsules of this product contains Radix Scutellariae with baicalin (C
21h
18o
11) meter, must not be less than 25.0mg.Through converting, every g micropill contains Radix Scutellariae with baicalin (C
21h
18o
11) meter, must not be less than 58.1mg.
2 physical property researchs
(1) character
Brownish black or black micropill, bitter and puckery flavor.
(2) bulk density
Take the qualified micropill of constant weight, pack in 10ml graduated cylinder, with certain altitude, fall (controlled condition is consistent as far as possible) for several times, make degree of tightness appropriateness, with weight, divided by volume, obtain bulk density, the results are shown in Table 6.
Table 6 micropill bulk density measurement result
(3) mobility
Get qualified micropill and flow down and be cone shape through funnel, measure its angle of repose, the results are shown in Table 7.
Table 7 micropill angle of repose
(4) micropill critical relative humidity is measured
Get every part of about 2g of micropill, accurately weighed, be placed in the exsiccator of the listed supersaturated solution that fills respectively variable concentrations sulphuric acid in 7 or different salt of table 9 (weighing bottle cap opens), weigh keep 84 hours in 25 ℃ of constant incubators after, calculate moisture absorption percentage rate, it the results are shown in Table 8.
The relative humidity of the supersaturated solution of table 8 variable concentrations sulphuric acid or different salt in the time of 25 ℃
Table 10 critical relative humidity determination data
Take moisture absorption percentage rate as vertical coordinate, and relative humidity is abscissa mapping, the results are shown in Figure 1.
By sucting wet curve, tried to achieve, critical relative humidity is 50%, therefore, when capsule charge, relative humidity should be controlled at below 50%.
In sum, the present invention is according to the physicochemical characteristic of " SHENYAN SIWEI PIAN " raw extract, first raw material is prepared after micropill, encapsulated again, guaranteed higher drug loading, solve this medicine and cannot make a difficult problem for hard capsule under the prerequisite that reduces former dosage form patent medicine dose, significantly reduced drug administration amount, strengthened patient's compliance; Meanwhile, in the preparation process of micropill, by becoming the investigation of ball method, binding agent and wetting agent kind, drying means, further reduced supplementary product consumption and drying time, effectively saved production cost, for suitability for industrialized production provides possibility.
Claims (7)
1. a pharmaceutical composition for the treatment of chronic nephritis, is characterized in that: it is the micropill that the supplementary material by following weight percentage ratio is prepared into:
Herbal raw material:
1000 parts of 1000 parts of Radixs Astragali of 750 parts of Folium Pyrrosiaes of 4166 parts of Radix Scutellariaes of Lespedeza virgata (Thunb. ex Murray) DC.
Adjuvant:
Filler 39-45 part
Described filler is starch;
Microsphere and its preparation comprises following operating procedure:
(1) take by weight ratio supplementary material;
(2) four described taste Chinese herbal medicine, except Radix Scutellariae, its excess-three taste decocts with water respectively secondary, and each 2 hours, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes to be 70%, to stir evenly containing alcohol amount, standing, get supernatant and reclaim ethanol, concentrating under reduced pressure becomes thick paste shape, dry, pulverize; Radix Scutellariae powder is broken into coarse powder, adds water in 80 ℃ of warm macerating three times, each 2 hours, filter while hot merging filtrate, in filtrate, add 15% alum solution, addition is 5% of medicinal liquid cumulative volume, stirs, standing, filter, precipitate washes with water to neutrality, in 75 ℃, dry, pulverize;
(3) merge above-mentioned fine powder, add starch, mix, take 70-80%V/V ethanol as binding agent, wetting agent, adopt extruding-spheronization to be prepared into ball, dry, obtain;
In step (3), described dry concrete operations are: first at 40-45 ℃ of dry 1h, then in 60-70 ℃ of dry 1h, finally at 80-85 ℃ of dry 10h.
2. pharmaceutical composition according to claim 1, is characterized in that: described filler is 43 parts.
3. pharmaceutical composition according to claim 1 and 2, is characterized in that: every g micropill in baicalin, must not be less than 58.1mg containing Radix Scutellariae.
4. the preparation method of pharmaceutical composition described in claim 1-3 any one, is characterized in that: it comprises following operating procedure:
(1) take by weight ratio supplementary material;
(2) four described taste Chinese herbal medicine, except Radix Scutellariae, its excess-three taste decocts with water respectively secondary, and each 2 hours, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes to be 70%, to stir evenly containing alcohol amount, standing, get supernatant and reclaim ethanol, concentrating under reduced pressure becomes thick paste shape, dry, pulverize; Radix Scutellariae powder is broken into coarse powder, adds water in 80 ℃ of warm macerating three times, each 2 hours, filter while hot merging filtrate, in filtrate, add 15% alum solution, addition is 5% of medicinal liquid cumulative volume, stirs, standing, filter, precipitate washes with water to neutrality, in 75 ℃, dry, pulverize;
(3) merge above-mentioned fine powder, add starch, mix, take 70-80%V/V ethanol as binding agent, wetting agent, adopt extruding-spheronization to be prepared into ball, dry, obtain;
In step (3), described dry concrete operations are: first at 40-45 ℃ of dry 1h, then in 60-70 ℃ of dry 1h, finally at 80-85 ℃ of dry 10h.
5. preparation method according to claim 4, is characterized in that: concentration of alcohol is 70%V/V.
6. preparation method according to claim 4, is characterized in that: described dry concrete operation step is: first at 40-45 ℃ of dry 1h, then in 60-65 ℃ of dry 1h, finally at 80-85 ℃ of dry 10h.
7. a hard capsule for the treatment of chronic nephritis, is characterized in that: it is to prepare after the pharmaceutical composition described in claim 1-3 any one is encapsulated.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546108A (en) * | 2003-12-09 | 2004-11-17 | 湖北省医药工业研究院有限公司 | Medicine for treating chronic nephritis and its preparing process |
| CN1813896A (en) * | 2005-11-30 | 2006-08-09 | 王衡新 | Chinese medicine formulation for treating nephroma, and its preparing method and quality control method |
-
2012
- 2012-09-05 CN CN201210324388.1A patent/CN102813700B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546108A (en) * | 2003-12-09 | 2004-11-17 | 湖北省医药工业研究院有限公司 | Medicine for treating chronic nephritis and its preparing process |
| CN1813896A (en) * | 2005-11-30 | 2006-08-09 | 王衡新 | Chinese medicine formulation for treating nephroma, and its preparing method and quality control method |
Non-Patent Citations (2)
| Title |
|---|
| 刘启兵.肾炎四味片质量标准的研究.《中成药》.1988,(第10期), |
| 肾炎四味片质量标准的研究;刘启兵;《中成药》;19881231(第10期) * |
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