CN102782132A - 正交q-核糖体 - Google Patents

正交q-核糖体 Download PDF

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Publication number
CN102782132A
CN102782132A CN201080064303XA CN201080064303A CN102782132A CN 102782132 A CN102782132 A CN 102782132A CN 201080064303X A CN201080064303X A CN 201080064303XA CN 201080064303 A CN201080064303 A CN 201080064303A CN 102782132 A CN102782132 A CN 102782132A
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CN
China
Prior art keywords
rrna
codon
quadrature
trna
mrna
Prior art date
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Pending
Application number
CN201080064303XA
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English (en)
Chinese (zh)
Inventor
贾森·钦
王凯航
海因茨·诺伊曼
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Medical Research Council
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Medical Research Council
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Application filed by Medical Research Council filed Critical Medical Research Council
Publication of CN102782132A publication Critical patent/CN102782132A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201080064303XA 2009-12-21 2010-12-20 正交q-核糖体 Pending CN102782132A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28842109P 2009-12-21 2009-12-21
US61/288,421 2009-12-21
GB0922351.2 2009-12-21
GBGB0922351.2A GB0922351D0 (en) 2009-12-21 2009-12-21 Orthogonal Q-Ribosomes
PCT/GB2010/002296 WO2011077075A1 (en) 2009-12-21 2010-12-20 Orthogonal q-ribosomes

Publications (1)

Publication Number Publication Date
CN102782132A true CN102782132A (zh) 2012-11-14

Family

ID=41717344

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080064303XA Pending CN102782132A (zh) 2009-12-21 2010-12-20 正交q-核糖体

Country Status (8)

Country Link
US (1) US20120264926A1 (https=)
EP (1) EP2516644A1 (https=)
JP (1) JP2013514799A (https=)
CN (1) CN102782132A (https=)
AU (1) AU2010334671A1 (https=)
CA (1) CA2785266A1 (https=)
GB (1) GB0922351D0 (https=)
WO (1) WO2011077075A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116083378A (zh) * 2022-10-08 2023-05-09 浙江大学杭州国际科创中心 古菌酪氨酰-tRNA合成酶突变体及其应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020247803A2 (en) 2019-06-07 2020-12-10 Massachusetts Institute Of Technology Frameshift suppressor trna compositions and methods of use
GB202110137D0 (en) 2021-07-14 2021-08-25 Res & Innovation Uk Methods for optimising protein production
KR20240176462A (ko) * 2023-06-14 2024-12-24 포항공과대학교 산학협력단 생물자원의 도난 또는 오용 방지를 위한 유전적 생물봉쇄 시스템 및 이의 이용

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008065398A2 (en) * 2006-11-30 2008-06-05 Medical Research Council Evolved orthogonal ribosomes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008065398A2 (en) * 2006-11-30 2008-06-05 Medical Research Council Evolved orthogonal ribosomes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GREGORY W. MUTH ET AL: "Using a Targeted Chemical Nuclease To Elucidate Conformational Changes in the E. coli 30S Ribosomal Subunit", 《BIOCHEMISTRY》 *
KAIHANG WANG ET AL: "Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion", 《NATURE BIOTECHNOLOGY》 *
MARK S. WILSON ET AL: "Novel Archaea and Bacteria Dominate Stable Microbial Communities in North America’s Largest Hot Spring", 《MICROB ECOL》 *
MICHAEL O’CONNOR ET AL: "Decoding fidelity at the ribosomal A and P sites: influence of mutations in three different regions of the decoding domain in 16S rRNA", 《NUCLEIC ACIDS RESEARCH》 *
OLIVER RACKHAM AND JASON W CHIN: "A network of orthogonal ribosome mRNA pairs", 《NATURE CHEMICAL BIOLOGY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116083378A (zh) * 2022-10-08 2023-05-09 浙江大学杭州国际科创中心 古菌酪氨酰-tRNA合成酶突变体及其应用

Also Published As

Publication number Publication date
US20120264926A1 (en) 2012-10-18
AU2010334671A1 (en) 2012-07-12
CA2785266A1 (en) 2011-06-30
EP2516644A1 (en) 2012-10-31
JP2013514799A (ja) 2013-05-02
WO2011077075A1 (en) 2011-06-30
GB0922351D0 (en) 2010-02-03

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Application publication date: 20121114