CN102764267B - Carbomer cervical gel - Google Patents
Carbomer cervical gel Download PDFInfo
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- CN102764267B CN102764267B CN201110116366.1A CN201110116366A CN102764267B CN 102764267 B CN102764267 B CN 102764267B CN 201110116366 A CN201110116366 A CN 201110116366A CN 102764267 B CN102764267 B CN 102764267B
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- carbomer
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- triethanolamine
- benzyl alcohol
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Abstract
A carbomer cervical gel is mainly composed of carbomer, glycerin, triethanolamine, benzyl alcohol, disodium ethylene diamine tetraacetate (EDTA-2Na) and water. In 100 g of the gel, various components comprise: 0.1-10 g of carbomer, 2-10 g of glycerin, 0.1-1.0 g of triethanolamine, 0.01-1.0 g of disodium ethylene diamine tetraacetate, 0.03-5.0 g of benzyl alcohol, and the balance water, wherein the content of -COOH is 0.1-0.3 g. Carbomer is the main component of the gel and is used for the formation of the gel. Glycerin is a humectant and has a lubrication effect. triethanolamine is an antalkali. Benzyl alcohol is an antiseptic and has disinfection and anticorrosion functions. Disodium ethylene diamine tetraacetate (EDTA-2Na) is an anti-oxidant and is used for preventing products from oxidizing and denaturizing. The gel product provided by the invention is used to reduce erosion area, promote healing of cervical erosion area, mitigate degree of local inflammation, minimize leukorrhagia and improve symptoms such as postcoital bleeding, lumbosacral pain, blood and puriform leucorrhea and the like.
Description
Technical field
The present invention relates to a kind of carbomer cervix uteri gel, the carbomer of take is specifically main material, be used for dwindling cervical erosion face, promote the healing of cervical erosion face, alleviate local inflammation degree, reduce leucorrhoea grow in quantity, improve haemorrhagia sub coitu, the gel products of lumbus sacrum pain, blood sample and the inferior symptom of pus belt transect.
Background technology
The purposes (number of patent application-200810127163.0) of carbomer gel in Polyglucan rhinitis discloses a kind of collocation method of carbomer gel, discloses its purposes in allergic rhinitis.Provide containing carbomer, correctives Oleum menthae, nertralizer as the concrete grammar of sodium bicarbonate configuration gel, find and verified that this carbomer gel spreads upon nasal cavity mouth and can adsorb the irritated things such as pollen, dirt demodicid mite, prevent and alleviate perennially, the generation of seasonal allergic rhinitis.
A kind of instant jelly glue of carbomer for eyes (application number-200710122688.0) the invention discloses a kind of instant jelly glue of carbomer for eyes and preparation method thereof, in 1000 milliliters of instant jelly glue of carbomer for eyes of the present invention, contain: carbomer 10-40 gram, antiseptic 0.05-1 gram, osmotic pressure regulator 1.0-7.5 gram, gel-type vehicle 30-150 gram, surplus is acid-base buffer agent and water for injection.The present invention, by the optimization of adjuvant and the improvement of technique, has enriched the pharmaceutical dosage form of carbomer, has greatly extended medicine in the eye holdup time, has improved curative effect, and there is no pessimal stimulation reaction.
Adopt the gel products that carbomer is main material varied, the invention provides a kind of gel products for cervix uteri symptom.
Summary of the invention
The object of the present invention is to provide a kind of carbomer gel product for cervix uteri symptom.。
The object of the invention is to be achieved through the following technical solutions:
Carbomer cervix uteri gel, mainly by carbomer, glycerol, triethanolamine, benzyl alcohol, disodiumedetate (EDTA-2Na), water, formed, the content of various compositions is in every 100 grams of gels, to contain carbomer 0.1-10 gram, glycerol 2-10 gram, triethanolamine 0.1-1.0 gram, disodiumedetate 0.01-1.0 gram, benzyl alcohol 0.03-5.0 gram, all the other are water, and the content of wherein-COOH group is 0.1～0.3g.Carbomer is gel main component, forms gel; Glycerol is wetting agent, plays lubrication; Triethanolamine is antalkali; Benzyl alcohol is antiseptic, plays sterilization antisepsis; Disodiumedetate (EDTA-2Na) is antioxidant, prevents product oxidative deformation.
This gel is to develop according to " bio-electricity of cell principle " and " the compatible theory of biomolecule ".When glycoprotein cell membrane is not subject to any stimulation, also there is resting potential in the relative transfixion in film both sides, shows neutrality.Carbomer gel is because it is with a large amount of negative charges, interact with organizing the positive charge outside glycoprotein cell membrane, there is a natural attraction between the sexes, glycoprotein cell membrane is subject to after the stimulation of some strength, resting potential will become action potential, the charged particle of film both sides reconfigures, formed and assembled positive charge in film and film is assembled the electric field of negative charge outward, after stimulating disappearance, cell membrane is adjusted again, now in film, assemble negatively charged membrane and assemble positive charge outward, at glycoprotein cell membrane both sides electric field, just there is like this change of twice directivity, the electric field changing produces magnetic field, form electromagnetic field.The energy that stimulation applies glycoprotein cell all passes.This stimulates and on glycoprotein cell membrane, has caused the variation of current potential, produce an excitement, between the electric field of excitement and the electric field of contiguous not excited glycoprotein cell, occur electric potential difference, charged particle will move, make contiguous not excited glycoprotein cell excitement, form new excitement.Under the continuous stimulation of carbomer gel, this new excited glycoprotein cell is again successively to the not excited glycoprotein cell propagation electromagnetic field of the next one, activate and induced tissue cell generation low molecular sugar albumen---endogenous interferon, strengthen endogenous interferon in the concentration of cervix uteri part, the antiviral effect of performance endogenous interferon, deactivation causes HPV, the HSV virus of cervical erosion, regulate body immunity, because this physical reactions is a continually varying process, so there is after effect.
Polyacrylic acid crosslinked polymer (having another name called: carbomer, carbopol, 934 P etc.) is modified through chemical technology, forms negative charge current potential, with the action potential of the mutual continuous action of the intermolecular formation of histiocyte, generates an electromagnetic field.Under the effect of electromagnetic field, product has been given play to unique biotic induce activation and the differentiation two large characteristics that stimulate cellular proliferation.
One, biotic induce activation characteristic
This gel is after chemical modification, form the electromagnetic field of continuous action, directly act on cervix uteri local organization cell, indirectly stimulate the endogenous interferon of induction cervical tissue cell, make its Enrichment, show its activity, and then bring into play the effects such as interferon anti-reflecting virus, adjusting immunity of organisms.
Two, the differentiation characteristic that stimulates cellular proliferation
This gel by and cervical tissue cell between mutually continuous action restructuring generate action potential, electromagnetic stimulation squamous cell proliferation and differentiation, and then replace columnar epithelium.
Gel products provided by the invention, for dwindling rotten to the corn face, promotes the healing of cervical erosion face, alleviates local inflammation degree, reduces leucorrhoea grow in quantity, improves haemorrhagia sub coitu, lumbus sacrum pain, blood sample and the inferior symptom of pus belt transect.
The specific embodiment
The carbomer cervix uteri gel that this patent proposes, mainly by carbomer, glycerol, triethanolamine, benzyl alcohol, disodiumedetate (EDTA-2Na), water, formed, the content of various compositions is in every 100 grams of gels, to contain carbomer 0.1-10 gram, glycerol 2-10 gram, triethanolamine 0.1-1.0 gram, disodiumedetate 0.01-1.0 gram, benzyl alcohol 0.03-5.0 gram, all the other are water, and the content of wherein-COOH group is 0.1～0.3g.Carbomer is gel main component, forms gel; Glycerol is wetting agent, plays lubrication; Triethanolamine is antalkali; Benzyl alcohol is antiseptic, plays sterilization antisepsis; Disodiumedetate (EDTA-2Na) is antioxidant, prevents product oxidative deformation.
This gel is to develop according to " bio-electricity of cell principle " and " the compatible theory of biomolecule ".When glycoprotein cell membrane is not subject to any stimulation, also there is resting potential in the relative transfixion in film both sides, shows neutrality.Carbomer gel is because it is with a large amount of negative charges, interact with organizing the positive charge outside glycoprotein cell membrane, there is a natural attraction between the sexes, glycoprotein cell membrane is subject to after the stimulation of some strength, resting potential will become action potential, the charged particle of film both sides reconfigures, formed and assembled positive charge in film and film is assembled the electric field of negative charge outward, after stimulating disappearance, cell membrane is adjusted again, now in film, assemble negatively charged membrane and assemble positive charge outward, at glycoprotein cell membrane both sides electric field, just there is like this change of twice directivity, the electric field changing produces magnetic field, form electromagnetic field.The energy that stimulation applies glycoprotein cell all passes.This stimulates and on glycoprotein cell membrane, has caused the variation of current potential, produce an excitement, between the electric field of excitement and the electric field of contiguous not excited glycoprotein cell, occur electric potential difference, charged particle will move, make contiguous not excited glycoprotein cell excitement, form new excitement.Under the continuous stimulation of carbomer gel, this new excited glycoprotein cell is again successively to the not excited glycoprotein cell propagation electromagnetic field of the next one, activate and induced tissue cell generation low molecular sugar albumen---endogenous interferon, strengthen endogenous interferon in the concentration of cervix uteri part, the antiviral effect of performance endogenous interferon, deactivation causes HPV, the HSV virus of cervical erosion, regulate body immunity, because this physical reactions is a continually varying process, so there is after effect.
Polyacrylic acid crosslinked polymer (having another name called: carbomer, carbopol, 934 P etc.) is modified through chemical technology, forms negative charge current potential, with the action potential of the mutual continuous action of the intermolecular formation of histiocyte, generates an electromagnetic field.Under the effect of electromagnetic field, product has been given play to unique biotic induce activation and the differentiation two large characteristics that stimulate cellular proliferation.
One, biotic induce activation characteristic
This gel is after chemical modification, form the electromagnetic field of continuous action, directly act on cervix uteri local organization cell, indirectly stimulate the endogenous interferon of induction cervical tissue cell, make its Enrichment, show its activity, and then bring into play the effects such as interferon anti-reflecting virus, adjusting immunity of organisms.
Two, the differentiation characteristic that stimulates cellular proliferation
This gel by and cervical tissue cell between mutually continuous action restructuring generate action potential, electromagnetic stimulation squamous cell proliferation and differentiation, and then replace columnar epithelium.
Gel products provided by the invention, for dwindling rotten to the corn face, promotes the healing of cervical erosion face, alleviates local inflammation degree, reduces leucorrhoea grow in quantity, improves haemorrhagia sub coitu, lumbus sacrum pain, blood sample and the inferior symptom of pus belt transect.
The characteristic that this product has comprises:
1, antiviral, enhancing local organization immunoregulation capability
This gel stimulates induction cervical tissue cell to produce endogenous interferon, and the biological activity of activated macrophage, NK cell strengthens antiviral (HPV HSV etc.) and the Organism immunoregulation ability of local organization.
2, promote squamous cell to increase
This gel by and cervical tissue cell between mutually continuous action restructuring generate action potential, electromagnetic stimulation squamous cell proliferation and differentiation, and then replace columnar epithelium.
3, biological barrier, exudation
This gel is through chemical modification; its biocompatibility is strengthened greatly; there is good histocompatibility; first for rotten to the corn wound surface, form insulation blocking; play biological barrier effect; gel has stronger adsorption simultaneously, can adsorb a large amount of transudates of organizing, for histiocytic reparation provides good growing environment.
4, self purification
This gel is acidic polymer, be released to intravaginal confluent monolayer cells, regulate vagina PH value level, and there is good bacteriostatic activity in intravaginal, the multiple pathogens such as staphylococcus aureus, Candida albicans are all had to obvious inhibitory action, can be used for prevention and treatment bacterial vaginitis disease, and reduce pudendum abnormal flavour, the symptom such as relieving itch, pain, makes women's vaginal environment injury-free.
Claims (1)
1. carbomer cervix uteri gel, mainly by carbomer, glycerol, triethanolamine, benzyl alcohol, disodiumedetate (EDTA-2Na), water, formed, the content of various compositions is in every 100 grams of gels, to contain carbomer 0.1-10 gram, glycerol 2-10 gram, triethanolamine 0.1-1.0 gram, disodiumedetate 0.01-1.0 gram, benzyl alcohol 0.03-5.0 gram, all the other are water, and the content of wherein-COOH group is 0.1～0.3g; Carbomer is gel main component, forms gel; Glycerol is wetting agent, plays lubrication; Triethanolamine is antalkali; Benzyl alcohol is antiseptic, plays sterilization antisepsis; Disodiumedetate (EDTA-2Na) is antioxidant, prevents product oxidative deformation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110116366.1A CN102764267B (en) | 2011-05-06 | 2011-05-06 | Carbomer cervical gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110116366.1A CN102764267B (en) | 2011-05-06 | 2011-05-06 | Carbomer cervical gel |
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| CN102764267A CN102764267A (en) | 2012-11-07 |
| CN102764267B true CN102764267B (en) | 2014-01-29 |
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| CN201110116366.1A Active CN102764267B (en) | 2011-05-06 | 2011-05-06 | Carbomer cervical gel |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105919926A (en) * | 2016-06-29 | 2016-09-07 | 江苏开源康达医疗器械有限公司 | Carbomer cervical gel and preparation method thereof |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188899A (en) * | 2014-09-26 | 2014-12-10 | 天津市聚星康华医药科技有限公司 | Loxoprofen sodium gel and preparation method thereof |
| CN109394424A (en) * | 2018-12-26 | 2019-03-01 | 南通市第人民医院 | A kind of Catheter drug type tampon and preparation method thereof for treating vaginitis |
| CN110755602A (en) * | 2019-11-29 | 2020-02-07 | 南京禾瀚医药科技有限公司 | Gel for treating cervicitis and erosion |
| CN114903801A (en) * | 2021-06-17 | 2022-08-16 | 苏州鑫斯达医疗科技有限公司 | Silk protein gynecological gel and preparation method thereof |
| CN115634194A (en) * | 2022-10-20 | 2023-01-24 | 云飞生物药业(吉林)有限公司 | Carbomer gynecological lotion and preparation method thereof |
-
2011
- 2011-05-06 CN CN201110116366.1A patent/CN102764267B/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 无.卡波姆凝胶 美林淑宁（妇科）.《食品医药网》.2009, * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105919926A (en) * | 2016-06-29 | 2016-09-07 | 江苏开源康达医疗器械有限公司 | Carbomer cervical gel and preparation method thereof |
| CN105919926B (en) * | 2016-06-29 | 2019-11-05 | 江苏开源康达医疗器械有限公司 | A kind of Carbomer cervical gel and preparation method thereof |
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| Publication number | Publication date |
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| CN102764267A (en) | 2012-11-07 |
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Inventor after: Yuan Yun Inventor after: Zhou Yingying Inventor after: Dong Weiqian Inventor before: Dong Weiqian |
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Effective date of registration: 20171123 Address after: 570311 Hainan city of Haikou province sea Yuzhong Line No. 199 deer Industrial Park C8 building sixth layer Patentee after: Hainan Lide Biological Technology Co. Ltd. Address before: 110006 Yixing street, Shenyang peace zone, Liaoning Province, No. 2-2 3-6-3 Patentee before: Dong Weiqian |