CN102764267A - Carbomer cervical gel - Google Patents
Carbomer cervical gel Download PDFInfo
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- CN102764267A CN102764267A CN2011101163661A CN201110116366A CN102764267A CN 102764267 A CN102764267 A CN 102764267A CN 2011101163661 A CN2011101163661 A CN 2011101163661A CN 201110116366 A CN201110116366 A CN 201110116366A CN 102764267 A CN102764267 A CN 102764267A
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- Prior art keywords
- carbomer
- gel
- gram
- triethanolamine
- benzyl alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920002125 Sokalan® Polymers 0.000 title claims abstract description 41
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 title claims abstract description 37
- 229960001631 carbomer Drugs 0.000 title claims abstract description 37
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 33
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims abstract description 21
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract description 20
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000019445 benzyl alcohol Nutrition 0.000 claims abstract description 7
- 230000002421 anti-septic effect Effects 0.000 claims abstract description 5
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims abstract description 5
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 4
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 4
- 238000005461 lubrication Methods 0.000 claims abstract description 4
- 230000001590 oxidative effect Effects 0.000 claims abstract description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 4
- 239000000499 gel Substances 0.000 claims description 39
- 210000003679 cervix uteri Anatomy 0.000 claims description 11
- 230000003260 anti-sepsis Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 239000000080 wetting agent Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 11
- 230000003628 erosive effect Effects 0.000 abstract description 8
- 208000024891 symptom Diseases 0.000 abstract description 7
- 206010061218 Inflammation Diseases 0.000 abstract description 4
- 210000004369 blood Anatomy 0.000 abstract description 4
- 239000008280 blood Substances 0.000 abstract description 4
- 230000035876 healing Effects 0.000 abstract description 4
- 230000004054 inflammatory process Effects 0.000 abstract description 4
- 230000015572 biosynthetic process Effects 0.000 abstract description 3
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 abstract 3
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 abstract 3
- 235000011187 glycerol Nutrition 0.000 abstract 3
- 208000008035 Back Pain Diseases 0.000 abstract 1
- 206010065019 Coital bleeding Diseases 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 24
- 102000003886 Glycoproteins Human genes 0.000 description 20
- 108090000288 Glycoproteins Proteins 0.000 description 20
- 230000000638 stimulation Effects 0.000 description 14
- 210000000170 cell membrane Anatomy 0.000 description 12
- 102000014150 Interferons Human genes 0.000 description 11
- 108010050904 Interferons Proteins 0.000 description 11
- 229940079322 interferon Drugs 0.000 description 11
- 230000005684 electric field Effects 0.000 description 10
- 230000005672 electromagnetic field Effects 0.000 description 10
- 210000001519 tissue Anatomy 0.000 description 9
- 230000009471 action Effects 0.000 description 7
- 230000036982 action potential Effects 0.000 description 7
- 230000004663 cell proliferation Effects 0.000 description 7
- 230000036039 immunity Effects 0.000 description 5
- 241000700605 Viruses Species 0.000 description 4
- 230000004913 activation Effects 0.000 description 4
- 230000000840 anti-viral effect Effects 0.000 description 4
- 230000004069 differentiation Effects 0.000 description 4
- 230000008520 organization Effects 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 230000000284 resting effect Effects 0.000 description 4
- 240000008042 Zea mays Species 0.000 description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 3
- 230000024245 cell differentiation Effects 0.000 description 3
- 238000007385 chemical modification Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 235000005822 corn Nutrition 0.000 description 3
- 210000000981 epithelium Anatomy 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 235000015110 jellies Nutrition 0.000 description 3
- 239000008274 jelly Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000008521 reorganization Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 201000010105 allergic rhinitis Diseases 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229920006037 cross link polymer Polymers 0.000 description 2
- 230000009849 deactivation Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 210000003701 histiocyte Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 208000036284 Rhinitis seasonal Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 208000017022 seasonal allergic rhinitis Diseases 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
A carbomer cervical gel is mainly composed of carbomer, glycerin, triethanolamine, benzyl alcohol, disodium ethylene diamine tetraacetate (EDTA-2Na) and water. In 100 g of the gel, various components comprise: 0.1-10 g of carbomer, 2-10 g of glycerin, 0.1-1.0 g of triethanolamine, 0.01-1.0 g of disodium ethylene diamine tetraacetate, 0.03-5.0 g of benzyl alcohol, and the balance water, wherein the content of -COOH is 0.1-0.3 g. Carbomer is the main component of the gel and is used for the formation of the gel. Glycerin is a humectant and has a lubrication effect. triethanolamine is an antalkali. Benzyl alcohol is an antiseptic and has disinfection and anticorrosion functions. Disodium ethylene diamine tetraacetate (EDTA-2Na) is an anti-oxidant and is used for preventing products from oxidizing and denaturizing. The gel product provided by the invention is used to reduce erosion area, promote healing of cervical erosion area, mitigate degree of local inflammation, minimize leukorrhagia and improve symptoms such as postcoital bleeding, lumbosacral pain, blood and puriform leucorrhea and the like.
Description
Technical field
The present invention relates to a kind of carbomer cervix uteri gel; Be main material specifically with the carbomer, be used to dwindle the cervical erosion face, promote the healing of cervical erosion face; Alleviate the local inflammation degree; Reduce leucorrhoea grow in quantity, improve haemorrhagia sub coitu, the gel products of lumbus sacrum pain, blood sample and the inferior symptom of pus belt transect.
Background technology
The purposes (number of patent application-200810127163.0) of carbomer gel on Polyglucan property rhinitis discloses a kind of collocation method of carbomer gel, discloses its purposes on allergic rhinitis.The concrete grammar that contains carbomer, correctives Oleum menthae, nertralizer such as sodium bicarbonate configuration gel is provided; Find and verified that this carbomer gel spreads upon the nasal cavity mouth and can adsorb irritated things such as pollen, dirt demodicid mite, the generation that prevents and alleviate perennial, seasonal allergic rhinitis.
A kind of instant jelly glue of carbomer for eyes (application number-200710122688.0) the invention discloses a kind of instant jelly glue of carbomer for eyes and preparation method thereof; Contain in 1000 milliliters of instant jelly glue of carbomer for eyes of the present invention: carbomer 10-40 gram; Antiseptic 0.05-1 gram; Osmotic pressure regulator 1.0-7.5 gram, gel-type vehicle 30-150 gram, surplus is acid-base buffer agent and water for injection.The present invention has enriched the pharmaceutical dosage form of carbomer through the optimization of adjuvant and the improvement of technology, has prolonged medicine greatly in the eye holdup time, has improved curative effect, and does not have the pessimal stimulation reaction.
The employing carbomer is that the gel products of main material is varied, and the present invention provides a kind of gel products to the cervix uteri symptom.
Summary of the invention
The object of the present invention is to provide a kind of carbomer gel product to the cervix uteri symptom.。
The objective of the invention is to realize through following technical scheme:
Carbomer cervix uteri gel; Mainly form by carbomer, glycerol, triethanolamine, benzyl alcohol, disodiumedetate (EDTA-2Na), water; The content of various compositions is to contain carbomer 0.1-10 gram, glycerol 2-10 gram, triethanolamine 0.1-1.0 gram, disodiumedetate 0.01-1.0 gram, benzyl alcohol 0.03-5.0 gram in per 100 gram gels; All the other are water, wherein-and the content of COOH group is 0.1～0.3g.Carbomer is the gel main component, forms gel; Glycerol is wetting agent, plays lubrication; Triethanolamine is an antalkali; Benzyl alcohol is an antiseptic, plays the sterilization antisepsis; Disodiumedetate (EDTA-2Na) is an antioxidant, prevents the product oxidative deformation.
This gel is to develop according to " bio-electricity of cell principle " and " the compatible scientific principle opinion of biomolecule ".When the glycoprotein cell membrane did not receive any stimulation, also there was resting potential in the relative transfixion in film both sides, shows neutrality.Carbomer gel is because it has a large amount of negative charges, and the positive charge outer with organizing the glycoprotein cell membrane interacts, and there is a natural attraction between the sexes; After the glycoprotein cell membrane received the stimulation of certain intensity, resting potential will become action potential, and the charged particle of film both sides reconfigures; Formed and assembled positive charge in the film and film is assembled the electric field of negative charge outward, when stimulate disappear after, cell membrane is adjusted again; Assemble negatively charged membrane in the film and assemble positive charge outward this moment; The change of twice directivity just takes place in electric field in glycoprotein cell membrane both sides like this, and the electric field of variation produces magnetic field, forms electromagnetic field.Stimulation all passes the energy that the glycoprotein cell applies.This stimulates the variation that on the glycoprotein cell membrane, has caused current potential; Produce an excitement, electric potential difference occurs between the electric field of the electric field of excitement and contiguous not excited glycoprotein cell, charged particle will move; Make contiguous not excited glycoprotein cell excitement, form new excitement.Under the continuous stimulation of carbomer gel; This new excited glycoprotein cell is again successively to the not excited glycoprotein cell propagation electromagnetic field of the next one; Activate and low molecular saccharides albumen---the endogenous interferon of induced tissue cell generation, augment endogenous property interferon is brought into play the antiviral effect of endogenous interferon in the partial concentration of cervix uteri; Deactivation causes HPV, the HSV virus of cervical erosion; Regulate body immunity, because this physical reactions is a continually varying process, so have after effect.
Polyacrylic acid crosslinked polymer (having another name called: carbomer, carbopol, Ka Baibo etc.) is modified through chemical technology, forms the negative charge current potential, with the action potential of the mutual continuous action of the intermolecular formation of histiocyte, generates an electromagnetic field.Under the effect of electromagnetic field, product has been given play to unique biological and has been induced activation and stimulate cellular proliferation differentiation two big characteristics.
One, biotic induce activation characteristic
This gel is through after the chemical modification; Form the electromagnetic field of continuous action; Directly act on cervix uteri local organization cell, the endogenous interferon of cervical tissue cell is induced in indirect stimulation, and its concentration is increased; Show its activity, and then bring into play effects such as interferon anti-reflecting virus, adjusting immunity of organisms.
Two, the differentiation characteristic that stimulates cellular proliferation
This gel through and the cervical tissue cell between each other the continuous action reorganization generate action potential, electromagnetic stimulation squamous cell proliferation and differentiation, and then replace columnar epithelium.
Gel products provided by the invention is used to dwindle rotten to the corn face, promotes the healing of cervical erosion face, alleviates the local inflammation degree, reduces leucorrhoea grow in quantity, improves haemorrhagia sub coitu, lumbus sacrum pain, blood sample and the inferior symptom of pus belt transect.
The specific embodiment
The carbomer cervix uteri gel that this patent proposes; Mainly form by carbomer, glycerol, triethanolamine, benzyl alcohol, disodiumedetate (EDTA-2Na), water; The content of various compositions is to contain carbomer 0.1-10 gram, glycerol 2-10 gram, triethanolamine 0.1-1.0 gram, disodiumedetate 0.01-1.0 gram, benzyl alcohol 0.03-5.0 gram in per 100 gram gels; All the other are water, wherein-and the content of COOH group is 0.1～0.3g.Carbomer is the gel main component, forms gel; Glycerol is wetting agent, plays lubrication; Triethanolamine is an antalkali; Benzyl alcohol is an antiseptic, plays the sterilization antisepsis; Disodiumedetate (EDTA-2Na) is an antioxidant, prevents the product oxidative deformation.
This gel is to develop according to " bio-electricity of cell principle " and " the compatible scientific principle opinion of biomolecule ".When the glycoprotein cell membrane did not receive any stimulation, also there was resting potential in the relative transfixion in film both sides, shows neutrality.Carbomer gel is because it has a large amount of negative charges, and the positive charge outer with organizing the glycoprotein cell membrane interacts, and there is a natural attraction between the sexes; After the glycoprotein cell membrane received the stimulation of certain intensity, resting potential will become action potential, and the charged particle of film both sides reconfigures; Formed and assembled positive charge in the film and film is assembled the electric field of negative charge outward, when stimulate disappear after, cell membrane is adjusted again; Assemble negatively charged membrane in the film and assemble positive charge outward this moment; The change of twice directivity just takes place in electric field in glycoprotein cell membrane both sides like this, and the electric field of variation produces magnetic field, forms electromagnetic field.Stimulation all passes the energy that the glycoprotein cell applies.This stimulates the variation that on the glycoprotein cell membrane, has caused current potential; Produce an excitement, electric potential difference occurs between the electric field of the electric field of excitement and contiguous not excited glycoprotein cell, charged particle will move; Make contiguous not excited glycoprotein cell excitement, form new excitement.Under the continuous stimulation of carbomer gel; This new excited glycoprotein cell is again successively to the not excited glycoprotein cell propagation electromagnetic field of the next one; Activate and low molecular saccharides albumen---the endogenous interferon of induced tissue cell generation, augment endogenous property interferon is brought into play the antiviral effect of endogenous interferon in the partial concentration of cervix uteri; Deactivation causes HPV, the HSV virus of cervical erosion; Regulate body immunity, because this physical reactions is a continually varying process, so have after effect.
Polyacrylic acid crosslinked polymer (having another name called: carbomer, carbopol, Ka Baibo etc.) is modified through chemical technology, forms the negative charge current potential, with the action potential of the mutual continuous action of the intermolecular formation of histiocyte, generates an electromagnetic field.Under the effect of electromagnetic field, product has been given play to unique biological and has been induced activation and stimulate cellular proliferation differentiation two big characteristics.
One, biotic induce activation characteristic
This gel is through after the chemical modification; Form the electromagnetic field of continuous action; Directly act on cervix uteri local organization cell, the endogenous interferon of cervical tissue cell is induced in indirect stimulation, and its concentration is increased; Show its activity, and then bring into play effects such as interferon anti-reflecting virus, adjusting immunity of organisms.
Two, the differentiation characteristic that stimulates cellular proliferation
This gel through and the cervical tissue cell between each other the continuous action reorganization generate action potential, electromagnetic stimulation squamous cell proliferation and differentiation, and then replace columnar epithelium.
Gel products provided by the invention is used to dwindle rotten to the corn face, promotes the healing of cervical erosion face, alleviates the local inflammation degree, reduces leucorrhoea grow in quantity, improves haemorrhagia sub coitu, lumbus sacrum pain, blood sample and the inferior symptom of pus belt transect.
The characteristic that this product has comprises:
1, antiviral, enhancing local organization immunoregulation capability
This gel stimulates induces the cervical tissue cell to produce endogenous interferon, the biological activity of activated macrophage, NK cell, the antiviral of enhancing local organization (HSV etc.) and the immunity of organism regulating power.
2, promote squamous cell to increase
This gel through and the cervical tissue cell between each other the continuous action reorganization generate action potential, electromagnetic stimulation squamous cell proliferation and differentiation, and then replace columnar epithelium.
3, biological barrier, exudation
This gel is through chemical modification; Its biocompatibility is strengthened greatly, have the favorable tissue compatibility, at first form insulation blocking to rotten to the corn wound surface; Play the biological barrier effect; Gel has stronger adsorption simultaneously, can adsorb a large amount of transudates of organizing, for histiocytic reparation provides good growing environment.
4, self purification
This gel is an acidic polymer, is released to the intravaginal confluent monolayer cells, regulates the vagina PH value level; And has good bacteriostatic activity in intravaginal; Several diseases substances such as staphylococcus aureus, Candida albicans all there is the obvious suppression effect, can be used for prevention and treatment bacterial vaginitis disease, and reduce the pudendum abnormal flavour; Symptom such as relieving itch, pain makes women's vaginal environment injury-free.
Claims (1)
1. carbomer cervix uteri gel; Mainly form by carbomer, glycerol, triethanolamine, benzyl alcohol, disodiumedetate (EDTA-2Na), water; The content of various compositions is to contain carbomer 0.1-10 gram, glycerol 2-10 gram, triethanolamine 0.1-1.0 gram, disodiumedetate 0.01-1.0 gram, benzyl alcohol 0.03-5.0 gram in per 100 gram gels; All the other are water, wherein-and the content of COOH group is 0.1～0.3g..Carbomer is the gel main component, forms gel; Glycerol is wetting agent, plays lubrication; Triethanolamine is an antalkali; Benzyl alcohol is an antiseptic, plays the sterilization antisepsis; Disodiumedetate (EDTA-2Na) is an antioxidant, prevents the product oxidative deformation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110116366.1A CN102764267B (en) | 2011-05-06 | 2011-05-06 | Carbomer cervical gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110116366.1A CN102764267B (en) | 2011-05-06 | 2011-05-06 | Carbomer cervical gel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102764267A true CN102764267A (en) | 2012-11-07 |
| CN102764267B CN102764267B (en) | 2014-01-29 |
Family
ID=47091997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110116366.1A Active CN102764267B (en) | 2011-05-06 | 2011-05-06 | Carbomer cervical gel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102764267B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188899A (en) * | 2014-09-26 | 2014-12-10 | 天津市聚星康华医药科技有限公司 | Loxoprofen sodium gel and preparation method thereof |
| CN105919926A (en) * | 2016-06-29 | 2016-09-07 | 江苏开源康达医疗器械有限公司 | Carbomer cervical gel and preparation method thereof |
| CN110755602A (en) * | 2019-11-29 | 2020-02-07 | 南京禾瀚医药科技有限公司 | Gel for treating cervicitis and erosion |
| WO2020133136A1 (en) * | 2018-12-26 | 2020-07-02 | 赵春梅 | Catheter drug type tampon for treating vaginitis and preparation method therefor |
| CN114903801A (en) * | 2021-06-17 | 2022-08-16 | 苏州鑫斯达医疗科技有限公司 | Silk protein gynecological gel and preparation method thereof |
| CN115634194A (en) * | 2022-10-20 | 2023-01-24 | 云飞生物药业(吉林)有限公司 | Carbomer gynecological lotion and preparation method thereof |
-
2011
- 2011-05-06 CN CN201110116366.1A patent/CN102764267B/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 无: "《食品医药网》", 8 December 2009 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188899A (en) * | 2014-09-26 | 2014-12-10 | 天津市聚星康华医药科技有限公司 | Loxoprofen sodium gel and preparation method thereof |
| CN105919926A (en) * | 2016-06-29 | 2016-09-07 | 江苏开源康达医疗器械有限公司 | Carbomer cervical gel and preparation method thereof |
| CN105919926B (en) * | 2016-06-29 | 2019-11-05 | 江苏开源康达医疗器械有限公司 | A kind of Carbomer cervical gel and preparation method thereof |
| WO2020133136A1 (en) * | 2018-12-26 | 2020-07-02 | 赵春梅 | Catheter drug type tampon for treating vaginitis and preparation method therefor |
| CN110755602A (en) * | 2019-11-29 | 2020-02-07 | 南京禾瀚医药科技有限公司 | Gel for treating cervicitis and erosion |
| CN114903801A (en) * | 2021-06-17 | 2022-08-16 | 苏州鑫斯达医疗科技有限公司 | Silk protein gynecological gel and preparation method thereof |
| CN115634194A (en) * | 2022-10-20 | 2023-01-24 | 云飞生物药业(吉林)有限公司 | Carbomer gynecological lotion and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102764267B (en) | 2014-01-29 |
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| TR01 | Transfer of patent right |
Effective date of registration: 20171123 Address after: 570311 Hainan city of Haikou province sea Yuzhong Line No. 199 deer Industrial Park C8 building sixth layer Patentee after: Hainan Lide Biological Technology Co. Ltd. Address before: 110006 Yixing street, Shenyang peace zone, Liaoning Province, No. 2-2 3-6-3 Patentee before: Dong Weiqian |