CN102749232A - Supercritical CO2 fluid extraction method for volatile components in hawthorn - Google Patents
Supercritical CO2 fluid extraction method for volatile components in hawthorn Download PDFInfo
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- CN102749232A CN102749232A CN2011103842968A CN201110384296A CN102749232A CN 102749232 A CN102749232 A CN 102749232A CN 2011103842968 A CN2011103842968 A CN 2011103842968A CN 201110384296 A CN201110384296 A CN 201110384296A CN 102749232 A CN102749232 A CN 102749232A
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- hawthorn
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- extraction method
- fluid extraction
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Abstract
The present invention discloses a supercritical CO2 fluid extraction method for volatile components in hawthorn. The method comprises: crushing dried hawthorn into particles with a particle size of 10-100 meshes by using a crusher; filling the particles into a sealed bag; placing in a drier, then placing in an extraction kettle, and sealing the extraction kettle; and introducing CO2 at a supercritical state and a co-solvent to obtain an extract. According to the present invention, a supercritical CO2 fluid extraction technology is adopted to extract volatile components in hawthorn; and the extraction method of the present invention has the following characteristics that: the extraction temperature is low, no active ingredient in the hawthorn extract is destroyed, and the variety of the obtained volatile compounds is more.
Description
Technical field
The invention belongs to the analytical chemistry field, relate to the supercritical CO of volatile ingredient in a kind of hawthorn
2The fluid extraction method.
Background technology
Hawthorn is the fruit of the drying and ripening of rosaceous plant large-fruited Chinese hawthorn Crataegus Pinnatifida Bge.var.major N.E. Br. or hawthorn Crataegus Pinnatifida Bge..The abundant nutrients of hawthorn has very high medical value and health-care effect.Hawthorn is a good medicine simply, and oral administration, external application have multiple medical science function, and ancient medicine and pharmacology man research in modern age all permit branch sure to its medical value; Hawthorn has unique sour-sweet local flavor, can produce food and essence with hawthorn local flavor.
At present; Disclosed method in this technical field; The methods of distillation-extraction that adopt are extracted volatile ingredient in the hawthorn more, and this method realizes through while heated sample liquid phase and organic solvent to boiling, when vapo(u)rizing temperature is too high; Hydrolysis, oxidation, esterification or thermal decomposition possibly take place in volatile ingredient in the hawthorn, are destroyed.Simultaneously, high boiling component also is difficult to steam with water vapor, so be not very comprehensive to the extraction of volatile ingredient.
Summary of the invention
In view of above-mentioned present situation, the purpose of this invention is to provide the supercritical CO of volatile ingredient in a kind of hawthorn
2The fluid extraction method is through adopting supercritical CO
2The fluid extraction method is extracted volatile ingredient in the hawthorn.
Based on above-mentioned purpose, technical solution provided by the invention is: the supercritical CO of volatile ingredient in a kind of hawthorn
2The fluid extraction method comprises:
1, get haw raw material, through dry, pulverize, sieve, obtain granularity 10～100 purpose raw materials, behind the sealing bag of packing into, it is subsequent use to put into exsiccator;
2, above-mentioned dried hawthorn is put into extraction kettle, the sealing extraction kettle feeds the CO that is in supercriticality
2And carry agent, supercritical CO
2The condition of abstraction instrument is: regulates and extracts pressure 20～40MPa, 30 ℃～60 ℃ of temperature are set, and extraction time 0.5 h～2 h, carrying the agent ratio is 0.5L/Kg～5L/Kg, promptly obtains extract.
In the present invention, indication carries methyl alcohol, ethanol, acetone, ethyl acetate, the chloroform organic solvent that agent is the different volumes mark or the proportioning of each organic solvent different proportion.
Distinguishing feature of the present invention: mainly be to have adopted supercritical CO
2The fluid extraction method is extracted volatile ingredient in the hawthorn.Therefore, supercritical CO
2Fluid extraction technology is compared the distillation-extraction method, and it is low to have extraction temperature, the characteristics that extraction component is many.In addition, carbon dioxide has the coefficient of diffusion of similar gas, the dissolving power of liquid under supercriticality, and surface tension is zero, can advance among the solid matter by rapid permeability, extracts its elite, has efficiently, is difficult for characteristics such as oxidation.Supercritical CO
2The fluid extraction method has been used to the extraction of active ingredient of natural product, especially volatility and heat-sensitive substance.Simultaneously, also have characteristics simple to operate.
Embodiment
Embodiment 1
1, with haw raw material, through dry, pulverize with comminutor, sieve, obtain granularity 40 purpose raw materials, behind the sealing bag of packing into, it is subsequent use to put into exsiccator;
2, get above-mentioned dried haw raw material 10Kg and put into extraction kettle, the sealing extraction kettle feeds the CO that is in supercriticality
2, ethanol is for carrying agent 15L, supercritical CO
2The condition of abstraction instrument is: regulate and extract pressure 25MPa, 50 ℃ of temperature are set, extraction time 1.5h promptly obtains extract.
Embodiment 2
1, with haw raw material, through dry, pulverize with comminutor, sieve, obtain granularity 40 purpose raw materials, behind the sealing bag of packing into, it is subsequent use to put into exsiccator;
2, get above-mentioned dried haw raw material 10Kg and put into extraction kettle, the sealing extraction kettle feeds the CO that is in supercriticality
2, methyl alcohol is for carrying agent 15L, supercritical CO
2The condition of abstraction instrument is: regulate and extract pressure 25MPa, 50 ℃ of temperature are set, extraction time 1.5h promptly obtains extract.
Embodiment 3
1, with haw raw material, through dry, pulverize with comminutor, sieve, obtain granularity 40 purpose raw materials, behind the sealing bag of packing into, it is subsequent use to put into exsiccator;
2, get above-mentioned dried haw raw material 10Kg and put into extraction kettle, the sealing extraction kettle feeds the CO that is in supercriticality
2, ethyl acetate is for carrying agent 15L, supercritical CO
2The condition of abstraction instrument is: regulate and extract pressure 25MPa, 50 ℃ of temperature are set, extraction time 1.5h promptly obtains extract.
Claims (2)
1. the supercritical CO of volatile ingredient in the hawthorn
2The fluid extraction method comprises:
(1) get haw raw material, through dry, pulverize, sieve, obtain granularity 10～100 purpose raw materials, behind the sealing bag of packing into, it is subsequent use to put into exsiccator;
(2) above-mentioned dried hawthorn is put into extraction kettle, the sealing extraction kettle feeds the CO that is in supercriticality
2And carry agent, supercritical CO
2The condition of abstraction instrument is: regulates and extracts pressure 20～40MPa, 30 ℃～60 ℃ of temperature are set, and extraction time 0.5 h～2 h, carrying the agent ratio is 0.5L/Kg～5L/Kg, promptly obtains extract.
2. the supercritical CO of volatile ingredient in the hawthorn according to claim 1
2The fluid extraction method is characterized in that, saidly carries methyl alcohol, ethanol, acetone, ethyl acetate, the chloroform organic solvent that agent is the different volumes mark, or the proportioning of each organic solvent different proportion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103842968A CN102749232A (en) | 2011-11-28 | 2011-11-28 | Supercritical CO2 fluid extraction method for volatile components in hawthorn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103842968A CN102749232A (en) | 2011-11-28 | 2011-11-28 | Supercritical CO2 fluid extraction method for volatile components in hawthorn |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102749232A true CN102749232A (en) | 2012-10-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103842968A Pending CN102749232A (en) | 2011-11-28 | 2011-11-28 | Supercritical CO2 fluid extraction method for volatile components in hawthorn |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102757862A (en) * | 2012-08-08 | 2012-10-31 | 广东石油化工学院 | Method for extracting hawthorn essential oil |
| CN105106356A (en) * | 2015-09-11 | 2015-12-02 | 陕西省中医药研究院汉唐制药有限公司 | Preparation method for blood lipid reducing and calming tablets |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1253169A (en) * | 1998-11-03 | 2000-05-17 | 林波 | Extract and refined oil of lotus leaf and preparing process thereof |
| CN102135526A (en) * | 2010-12-10 | 2011-07-27 | 中国农业科学院农产品加工研究所 | Method for extracting characteristic flavor substance of roasted peanuts |
-
2011
- 2011-11-28 CN CN2011103842968A patent/CN102749232A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1253169A (en) * | 1998-11-03 | 2000-05-17 | 林波 | Extract and refined oil of lotus leaf and preparing process thereof |
| CN102135526A (en) * | 2010-12-10 | 2011-07-27 | 中国农业科学院农产品加工研究所 | Method for extracting characteristic flavor substance of roasted peanuts |
Non-Patent Citations (1)
| Title |
|---|
| 礼彤等: "《超临界流体萃取技术在中药生物碱提取中的应用》", 《沈阳药科大学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102757862A (en) * | 2012-08-08 | 2012-10-31 | 广东石油化工学院 | Method for extracting hawthorn essential oil |
| CN105106356A (en) * | 2015-09-11 | 2015-12-02 | 陕西省中医药研究院汉唐制药有限公司 | Preparation method for blood lipid reducing and calming tablets |
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Application publication date: 20121024 |