CN102736043A - Method and structure capable of forming conical and dome-shaped gradient magnetic field as well as targeting therapy equipment - Google Patents
Method and structure capable of forming conical and dome-shaped gradient magnetic field as well as targeting therapy equipment Download PDFInfo
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- CN102736043A CN102736043A CN2012101760084A CN201210176008A CN102736043A CN 102736043 A CN102736043 A CN 102736043A CN 2012101760084 A CN2012101760084 A CN 2012101760084A CN 201210176008 A CN201210176008 A CN 201210176008A CN 102736043 A CN102736043 A CN 102736043A
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Abstract
The invention discloses a method and a structure capable of forming a conical and dome-shaped gradient magnetic field as well as targeting therapy equipment. The method comprises the following steps of: step 1, using a square permanent magnet as a main magnet body, and using two square permanent magnets which are lower than the main magnet body as auxiliary magnet bodies, wherein the auxiliary magnet bodies are arranged at both sides of the main magnet body; and a magnetic moment direction of the main magnet body is the same as that of a first auxiliary magnet body and a second auxiliary magnet body; and step 2, respectively arranging wedged ferromagnetic blocks on the top surfaces of the two auxiliary magnet bodies by means that the inclined surfaces of the wedged ferromagnetic blocks face upwards, one square surface of each wedged ferromagnetic block is adhered to the top surface of the corresponding auxiliary magnet body, and the other square surface of each wedged ferromagnetic block is adhered to the side surface of the main magnet body, so that the two wedged ferromagnetic blocks are symmetrically distributed at both sides of the main magnet body in a splayed manner; and the conical and dome-shaped gradient magnetic field is formed at the top of the main magnet body. The magnet structure provided by the invention can be used as a magnetic drug targeting guide magnet body, so that magnetic drug grains are controlled within a smaller space according to the distribution of a compact magnetic field and gradient of the magnetic field; and the positioning accuracy of targeting therapy is improved.
Description
Technical field
The present invention relates to a kind of method that can form the dome-shaped gradient magnetic of taper, also relate to a kind of permanent-magnet structure that can form the dome-shaped gradient magnetic of taper simultaneously, and the equipment that adopts this permanent-magnet structure.
Background technology
Treatment of diseases such as tumour, tuberculosis, osteomyelitis mainly rely on the administration of chemicals whole body clinically at present, certain result of treatment is arranged, but dosage are big, and the whole body toxic and side effect is serious.
The malignant neoplastic disease philtrum; Lung cancer patient about 80% is the non-small cell lung cancer that comprises squama cancer, gland cancer etc.; These patients have about 85% to be middle and advanced stage when making a definite diagnosis; It is also not satisfactory that about 75% non-small cell lung cancer patient in late period has lost the clinical effectiveness of the meeting of surgical radical treatment property therapy apparatus, conventional chemicotherapy, and very strong toxic and side effect usually occurs.And the treatment of tuberculosis patient mainly relies on antituberculotic such as isoniazid, rifampin, pyrazinamide, streptomysin etc., adopts three or the chemotherapy regimen of tetrad more, and dosage is many, and the course of treatment is long.Particularly tuberculous cavity remains one of difficult problem of tuberculosis treatment; Because tuberculous cavity lacks blood supply; Medicine be difficult to arrive empty position performance curative effect, and the tuberculous cavity patient is the important infection sources lungy, so the treatment of tuberculous cavity has very big meaning for the propagation of control tuberculosis.
But the magnetic target medicine treatment can overcome the existing deficiency of above treatment.The characteristics of targeted therapy at first target property are good, only play a role to specific target position, thereby reduce drug dose, improve result of treatment, alleviate toxic and side effect; Secondly can alleviate the patient suffering, obtain patient's cooperation easily.We can say that magnetic target treatment has brought new revolution for treatment of diseases, will become this century PUD D treat in tool potentiality, methods of treatment the most likely.
(Magnetic drug targeting is with medicine and magnetic Fe MDT) to the magnetic target delivery system
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4Nanoparticle combines, and externally under the effect of guiding magnetic field, with its specific zone of leading, and discharges medicine, thereby reaches the purpose of target.The magnetic target administration can obviously reduce drug dose, and the localized rich that reaches medicine gathers, fixes a point to discharge, and not only can improve the curative effect of medicine, can also obviously reduce the bad reaction of medicine.Main magnetic targeting drug delivery system comprises at present: magnetic drug-carrying microballoon, magnetic drug-carrying liposome, magnetic tablet, magnetic capsule, magnetic bio immune formulation etc.Wherein the magnetic drug-carrying microballoon is that medicine and magnetic material are wrapped in type of processing spherical particle shape preparation in the high molecular carrier material, and particle diameter does not generally wait at one to tens micron.Can further be prepared into injection is used for intravenously administrable to the magnetic drug-carrying microballoon on the one hand, and than the injection of common microballoon, the magnetic drug-carrying microballoon can arrive targeting moiety under the guiding of externally-applied magnetic field, improved the drug accumulation amount of targeting moiety.
Research shows that magnetic and medicated particulate mainly receives the towing of blood flow and the sucking action of external magnetic field in blood vessel, and mean particle dia is big more, and magnetic response power is big more, under the effect of externally-applied magnetic field, can directedly assemble; Simultaneously, the character of external magnetic field, intensity, gradient and action time etc. also are the key factors that influences the magnetic steering effect.The factor that influences target property mainly contains: 1. magnetic and medicated character own, like content, medicament contg, stability and the rate of releasing drug etc. of size, magnetic components; 2. magnetic field properties is like type of magnetic field intensity, magnetic field gradient, the action of a magnetic field time and external magnetic field etc.; 3. the character of target site leaves the distance in magnetic field, the distance that target site leaves medicine-feeding part etc. like vascular distribution, permeability, target site.
In order to produce a suitable non-uniform magnetic field, can adopt two types magnet-permanent magnet or electromagnet or superconductor usually with the location magnetic particle.The magnetic field that permanent magnet produces relatively a little less than, for the flow velocity capture ratio of magnetic particle difficulty in the blood vessel faster; Though electromagnet or superconductor can produce more intense magnetic field, need external current source and can produce a large amount of Joule heats, and maintenance cost is huge.The third method is to adopt the implant that can be magnetized, and zone that can be darker in vivo produces strong magnetic field force.
Magnet system is the key equipment of magnetic drug targeting, and its performance is directly connected to magnetic and medicated tropism, thereby has determined the success or not of magnetic drug targeting to a certain extent.The composition form of magnet system is divided into two types substantially: bilateral formula and unilateral.
Bilateral formula has another name called bipolar system, is a kind of closed magnet apparatus.Finger adds magnetic pole in the both sides of tumor locus, last lower magnetic pole is made different shapes make it produce non-uniform magnetic field, and the bipolar system magnet has reduced the leakage field in magnetic field, and the magnetic field in air gap district and gradient are all strengthened, but experimental provision is convenient not as monopolar type.
Unilateral has another name called monopolar type, is a kind of open magnet device.Finger adds magnetic field in a side of tumour or lesions position, according to the shape of tumour magnetic pole is made sizeable shape, is arranged near the tumour; Make it produce gradient magnetic, it is simple in structure, convenient, but the magnetic field leakage field is bigger; Decay is very fast, is unfavorable for the targeted therapy at degree of depth position.
Owing to adopt the above-mentioned advantage of the unilateral target guiding magnet structure of permanent magnet array, be more suitable for using as external target magnet so unilateral is led the target magnet.But; General single permanent magnet blocks or the not permanent magnet array combination of process particular arrangement; Have that field decay is fast, leakage field is more, thereby caused the spatial dimension of magnetic field disperse bigger, so just be difficult in and assemble most magnetic drug-carrying particles near wanting to formulate target spot; And assemble less, so need on certain depth, to appear the guiding magnet of narrow relatively Distribution of Magnetic Field in other position of non-target spot.
Summary of the invention
In view of this; One of the object of the invention provides a kind of method that can form the dome-shaped gradient magnetic of taper; Two of the object of the invention provides a kind of permanent-magnet structure that can form the dome-shaped gradient magnetic of taper, advantages such as Distribution of Magnetic Field compactness that this structure has is simple in structure, the permanent magnet utilization ratio high, produced and low cost of manufacture; Three of the object of the invention is to provide a kind of targeted therapy equipment of permanent-magnet structure.
One of the object of the invention is realized through following technical scheme:
This kind can form the method for the dome-shaped gradient magnetic of taper, may further comprise the steps:
Step 1: with a square permanent magnet as main magnet; With two square permanent magnets that highly are lower than this main magnet as auxilliary magnet; Said auxilliary magnet is arranged on the both sides of this main magnet; The Surface field of main magnet and auxilliary magnet is approaching, and the three presses close to parallel placement with the mode of adjacent edge alignment, and main magnet is identical with the magnetic moment direction of the said first auxilliary magnet, the second auxilliary magnet;
Step 2: a wedge shape ferromagnetic block is set respectively on the end face of two auxilliary magnets; Said wedge shape ferromagnetic block comprises that two are oppositely arranged and the right-angle triangle side of vertical projection each other, forms a dip plane between two hypotenuses of two triangle sides, forms two square respectively between two groups of corresponding sides of two triangle sides; When being provided with; With the dip plane of wedge shape ferromagnetic block up, one of them square face is close to auxilliary magnet end face, and another square face is pressed close to main magnet side; Thereby two wedge shape ferromagnetic block are symmetrically distributed in the both sides of main magnet with " eight " word shape, form the dome-shaped gradient magnetic of taper at the top of main magnet.
Further, square top pressing close to mutually of said wedge shape ferromagnetic block and main magnet is concordant with the square bottom surface of main magnet;
Further, the square end face of said main magnet is provided with one and additional has a structure that can form a contraction summit;
Further, said structure is semicircle sphere, wedge shape, square taper or taper shape, and when adopting semicircle spherical, the radius of this dome is half that the minor face of main magnet horizontal section is grown; When adopting other shapes, the height of this structure is half that the minor face of main magnet horizontal section is grown.
Further, the permanent magnetic material of main magnet, auxilliary magnet adopts neodymium iron boron, SmCo or ferrite, and described wedge shape ferromagnetic block adopts iron, cobalt or nickel, or iron content, cobalt, nickel one or more alloy wherein, or the oxide of iron content;
Two of the object of the invention is realized through following technical scheme:
This kind can form the permanent-magnet structure of the dome-shaped gradient magnetic of taper, comprises the main magnet, the first auxilliary magnet, second auxilliary magnet, the first wedge shape ferromagnetic block and the second wedge shape ferromagnetic block that adopt permanent-magnet;
The main body of said main magnet, the first auxilliary magnet and the second auxilliary magnet is square; The first auxilliary magnet and the second auxilliary magnet place main magnet both sides respectively; And three magnets are pressed close to parallel placement with the mode of adjacent edge alignment; The height of the first auxilliary magnet and the second auxilliary magnet is less than main magnet, and the Surface field of main magnet and auxilliary magnet is approaching, and the height span of said main magnet is 0.1 ~ 100cm;
The similar of the said first wedge shape ferromagnetic block and the second wedge shape ferromagnetic block; Including two is oppositely arranged and the right-angle triangle side of vertical projection each other; Form a dip plane between two hypotenuses of two triangle sides, form two square respectively between two groups of corresponding sides of two triangle sides, two wedge shape ferromagnetic block are placed on the first auxilliary magnet and the second auxilliary magnet top respectively; The dip plane of wedge shape ferromagnetic block up; One of them square face is close to auxilliary magnet end face, and another square face is pressed close to main magnet side, thereby two wedge shape ferromagnetic block are symmetrically distributed in the both sides of main magnet with " eight " word shape; The dome-shaped gradient magnetic of taper is formed on the top at main magnet; Two assemblys that the first auxilliary magnet and the first wedge shape ferromagnetic block, the second auxilliary magnet and the second wedge shape ferromagnetic block constitute respectively, its whole height is consistent, and concordant with the end face of main magnet.
Further, the square end face of said main magnet is provided with one and additional has a structure that can form a contraction summit, the identical permanent magnetic material of main magnet employing of said dome structure and below, and magnetic moment direction is identical with main magnet;
Further, said structure is semicircle sphere, wedge shape, square taper or taper shape, and when adopting semicircle spherical, the radius of this dome is half that the minor face of main magnet horizontal section is grown;
Further; The permanent magnetic material of main magnet, the first auxilliary magnet and the second auxilliary magnet adopts neodymium iron boron, SmCo or ferrite; The first wedge shape ferromagnetic block and the second wedge shape ferromagnetic block adopt iron, cobalt or nickel, or iron content, cobalt, nickel one or more alloy wherein, or the oxide of iron content.
Three of the object of the invention is realized through following technical scheme:
Should
Targeted therapy equipmentAdopt foregoing permanent-magnet structure.
The invention has the beneficial effects as follows:
1. the magnetic field intensity and the magnetic field gradient that make winner magnet top of two auxilliary magnets described in the present invention have all obtained enhancing; And the use of wedge shape ferromagnetic block has further reduced leakage field; Make that the DISTRIBUTION OF MAGNETIC FIELD in the perform region, top of whole magnet mechanism is compact more, trend towards the shape of taper dome;
2. magnet structure of the present invention can be used as lung's magnetic and medicated target guiding magnet and uses; The magnetic field of described compactness and the distribution of magnetic field gradient can be controlled magnetic and medicated particulate on littler spatial dimension, have also just improved the accurate positioning property of targeted therapy;
3. magnet structure of the present invention also has advantages such as structure is simple relatively, permanent magnet utilization ratio height, low cost of manufacture.
Other advantages of the present invention, target and characteristic will be set forth in instructions subsequently to a certain extent; And to a certain extent; Based on being conspicuous to those skilled in the art, perhaps can from practice of the present invention, obtain instruction to investigating of hereinafter.Target of the present invention and other advantages can realize and obtain through following instructions and claims.
Description of drawings
In order to make the object of the invention, technical scheme and advantage clearer, will combine accompanying drawing that the present invention is made further detailed description below, wherein:
Fig. 1 is the arrangement synoptic diagram of magnet structure of the present invention;
Fig. 2 is the structural representation of wedge shape ferromagnetic block;
Fig. 3 is the magnet structure of embodiment one, the magnetic induction density distribution schematic diagram that the perform region, top is produced;
Fig. 4 is the magnet structure vertical view that embodiment two adopts dome structure;
Fig. 5 is the magnet structure of embodiment two, the magnetic induction density distribution schematic diagram that the perform region, top is produced;
Fig. 6 is the magnet structure schematic top plan view of embodiment three.
Fig. 7 is that the magnet structure of embodiment four is formed synoptic diagram;
Fig. 8 is that the magnet structure of embodiment five is formed synoptic diagram;
Fig. 9 is that the magnet structure of embodiment six is formed synoptic diagram.
In above-mentioned accompanying drawing, represent the direction of permanent magnet magnetic moment with arrow.
Embodiment
Below will carry out detailed description to the preferred embodiments of the present invention with reference to accompanying drawing.Should be appreciated that preferred embodiment has been merely explanation the present invention, rather than in order to limit protection scope of the present invention.
The present invention has at first proposed a kind of method that can form the dome-shaped gradient magnetic of taper, may further comprise the steps:
Step 1: with a square permanent magnet as main magnet; With two square permanent magnets that highly are lower than this main magnet as auxilliary magnet; Said auxilliary magnet is arranged on the both sides of this main magnet; The three presses close to parallel placement with the mode of adjacent edge alignment, and main magnet is identical with the magnetic moment direction of the said first auxilliary magnet, the second auxilliary magnet;
Step 2: a wedge shape ferromagnetic block is set respectively on the end face of two auxilliary magnets; Said wedge shape ferromagnetic block comprises that two are oppositely arranged and the right-angle triangle side of vertical projection each other, forms a dip plane between two hypotenuses of two triangle sides, forms two square respectively between two groups of corresponding sides of two triangle sides; When being provided with; With the dip plane of wedge shape ferromagnetic block up, one of them square face is close to auxilliary magnet end face, and another square face is pressed close to main magnet side; Thereby two wedge shape ferromagnetic block are symmetrically distributed in the both sides of main magnet with " eight " word shape, form the dome-shaped gradient magnetic of taper at the top of main magnet.
Based on the thought of above method, the present invention proposes a kind of permanent-magnet structure that can form the dome-shaped gradient magnetic of taper, the related embodiment division is following:
Embodiment one
As shown in Figure 1, this magnet structure comprises main magnet 1, first auxilliary magnet 2, second auxilliary magnet 3, the first wedge shape ferromagnetic block 4 and the second wedge shape ferromagnetic block 5 that adopts permanent-magnet;
The main body of main magnet 1, the first auxilliary magnet 2 and the second auxilliary magnet 3 is square; The main body of the first auxilliary magnet 2 and the second auxilliary magnet 3 is identical; And three's end face and bottom surface all are set to square, and wherein, the first auxilliary magnet 2 and the second auxilliary magnet 3 place main magnet 1 both sides respectively; And three magnets are pressed close to parallel placement with the mode of adjacent edge alignment, and the height of the first auxilliary magnet 2 and the second auxilliary magnet 3 is less than main magnet 1; Both differences in height are h, and h can suitably increase, and just the height of two auxilliary magnets reduces, and can increase the magnetic field gradient of perform region, top so to a certain extent, but can reduce magnetic field intensity simultaneously.
The similar of the first wedge shape ferromagnetic block and the second wedge shape ferromagnetic block, as shown in Figure 2, in the present embodiment; Both structures are identical, include two and are oppositely arranged and the right-angle triangle side of vertical projection each other, form a dip plane 2a between two hypotenuses of two triangle sides; Form two square 2b, 2c between two groups of corresponding sides of two triangle sides respectively; Two wedge shape ferromagnetic block are placed on the first auxilliary magnet 2 and second auxilliary magnet 3 tops respectively, the dip plane of wedge shape ferromagnetic block up, one of them square 2b is close to and assists the magnet end face; Another square 2c presses close to main magnet side; Thereby two wedge shape ferromagnetic block are symmetrically distributed in the both sides of main magnet with " eight " word shape, form the dome-shaped gradient magnetic of taper at the top of main magnet, and the first auxilliary magnet 2 and the first wedge shape ferromagnetic block 4, second are assisted two assemblys that magnet 3 and the second wedge shape ferromagnetic block 5 constitute respectively; Its whole height is consistent, and concordant with the end face of main magnet.In the present embodiment, the height of main magnet adopts 0.1cm.
In the present embodiment, the permanent magnetic material trade mark is N44, the remanent magnetism Br=13.0KGs-13.5 KGs of material, HCJ iHc >=10.8KOe, maximum magnetic energy product (BH) max=40MGOe-44MGOe.Using identical permanent magnetic material to sinter cross sectional shape into is foursquare bar-shaped permanent magnet blocks; Because the error when permanent magnet magnetizes; It is well-balanced as far as possible for space magnetic field is distributed; When actual assembled, should from a plurality of permanent magnet blocks, measure three magnets that Surface field is approaching of selection, respectively as main magnet and two auxilliary magnets through gaussmeter.Certainly, in order to guarantee better test effect, the first wedge shape ferromagnetic block and second wedge shape are ferromagnetic also preferably to be selected for use and main magnet and two approaching magnets in auxilliary magnet surface magnetic field soon.
The magnetic field of the magnet structure of present embodiment is formed as follows; Wherein main magnet assists magnet with first respectively and the first wedge shape ferromagnetic block and second is assisted magnet and two assemblys of the second wedge shape ferromagnetic block produce the magnetic field that comprises the following magnetic line of force; The said magnetic line of force is at first most of to be assembled in the first and second wedge shape ferromagnetic block; Then because the magnetic moment direction of main magnet and two auxilliary magnets is identical and difference in height arranged; Above main magnet both sides, auxilliary magnet, can form two uniform fields zones (like Fig. 3) that trend towards horizontal distribution, that is to say that the magnetic field gradient in this piece zone is less, the uniform field zone of this level can be tightened up the magnetic field of magnet of the present invention mechanism top to a certain extent; Play " receipts waist " effect, this also is one of effect of auxilliary magnet.
As shown in Figure 3, present embodiment Distribution of Magnetic Field in the perform region above magnet mechanism is the envelope shape, the perhaps conical distribution of dome, and this is the result of above-mentioned magnetic line of force path profile.
On the other hand; Because the existence of the first wedge shape ferromagnetic block and the second wedge shape ferromagnetic block; Make the magnetic line of force that sends from main magnet top promptly receive and return to get into the wedge shape ferromagnetic block, the diversity of the Distribution of Magnetic Field above field generator for magnetic has obtained partly suppressing like this, has reduced leakage field.
Embodiment two
As shown in Figure 4; Be the top view of present embodiment, the difference of present embodiment and embodiment one is, has also increased hemisphere dome magnet structure 6 among this embodiment; Structure 6 is the semi-round ball shape, and the radius of this semi-round ball is the length of side half the of main magnet horizontal section.Through increasing dome structure, be more conducive to form taper dome gradient magnetic.During the assembling of this dome, place above the main magnet because the result that there is a natural attraction between the sexes can be steadily firm.In addition, in the present embodiment, the height of main magnet is 1cm.
Fig. 5 is the magnet structure of embodiment two, and the synoptic diagram that the magnetic induction density that the perform region, top is produced distributes is as shown in Figure 5, after this figure has disclosed and adopted this kind structure, can form more tangible taper dome gradient magnetic in the perform region, top.
In the present embodiment; The magnetic field of perform region trends towards envelope shape or the dome-shaped distribution of taper more; Reason at first is the semisphere nature magnetic field sources of the formation of hemisphere dome magnet structure; Make magnetic field to form the dome-type magnetic field line that waits of hemisphere-taper and to distribute according to the geometric configuration of hemisphere to external radiation; Second reason is; The existence of two auxilliary magnets; Above main magnet both sides, auxilliary magnet, can form two uniform field zones (like Fig. 5) that trend towards horizontal distribution; The magnetic field gradient that is to say this piece zone is less, and the uniform field zone of this level can be tightened up the magnetic field of magnet of the present invention mechanism top to a certain extent, plays " receipts waist " effect.
Embodiment three
As shown in Figure 6, be the top view of present embodiment, the difference of present embodiment and embodiment one is,The main body of main magnet 1, the first auxilliary magnet 2 and the second auxilliary magnet 3 is square, and three's end face all is set to rectangle with the bottom surface, and structure is the semi-round ball shape, and the radius of this dome is long half of the minor face of main magnet horizontal section.In addition, in the present embodiment, the height of main magnet is 20cm.
It is emphasized thatAspect the material selection of main magnet, the first auxilliary magnet and the second auxilliary magnet; Can adopt neodymium iron boron, SmCo or ferrite; And the first wedge shape ferromagnetic block and the second wedge shape ferromagnetic block can adopt iron, cobalt or nickel; Or iron content, cobalt, nickel one or more alloy wherein, or the oxide of iron content.
Embodiment four
It is as shown in Figure 7,The difference of present embodiment and embodiment one is, has also increased wedge-shaped magnets structure 6 among this embodiment, and the height of structure 6 is the length of side half the of main magnet horizontal section.During the assembling of this structure, place above the main magnet because the result that there is a natural attraction between the sexes can be steadily firm.In the present embodiment, the height of main magnet is 50cm.
Embodiment five
It is as shown in Figure 8,The difference of present embodiment and embodiment one is, has also increased conical magnets structure 6 among this embodiment, and the height of structure 6 is the length of side half the of main magnet horizontal section or half a little more than the length of side of main magnet horizontal section.During the assembling of this structure, place above the main magnet because the result that there is a natural attraction between the sexes can be steadily firm.In the present embodiment, the height of main magnet is 80cm.
Embodiment six
It is as shown in Figure 9,The difference of present embodiment and embodiment one is, has also increased square taper magnet structure 6 among this embodiment, and the height of structure 6 is the length of side half the of main magnet horizontal section.During the assembling of this structure, place above the main magnet because the result that there is a natural attraction between the sexes can be steadily firm.In the present embodiment, the height of main magnet is 100cm.
Because the dome-shaped gradient magnetic of taper that magnet structure of the present invention produces; Can in the certain distance scope, present narrow relatively magnetic field gradient profile; Therefore through adopting magnet structure of the present invention; Can be used as the critical component of magnetic drug targeting, be applied on the medical targeted therapy equipment.
Concrete application implementation example
Based on the sedimentation experiment under the magnetic aerosol droplets outside magnetic field effect of trachea-bronchia realistic model
The trachea-bronchia realistic model that adopts glass to process, according to person's windpipe-bronchial anatomical structure, its parameter is following: tracheae section internal diameter 13mm, segmenta bronchopulmonalia internal diameter 9mm, 26 ° of left bronchus bifurcation angles, 36 ° of right bronchus bifurcation angles.The mean grain size that adds the Fe3O4 particle of atomizer is 30 nanometers, and saturation magnetization is for being 21.431emu/g, and remanent magnetization is 0.1016 emu/g.The atomizer that adopts is a U.S. Davis portable atomization device (Pulmo-Aide 3655), and the materialization size droplet diameter of generation is at the 3.6-4.0 micron, and the aerosol output quantity is 0.3cc/min.In the experimentation, two long transparent light plastic pipes of the 10cm that has taken by weighing weight are connected on respectively represents on the bronchial bifurcated glass tube in the left and right sides, can take off the weight difference that weighs up the experiment front and back as prolongation.The magnet array that then embodiment of the invention 1 is adopted is put and is parted on the right side by the breeches pipe prolongation, and magnet surface is apart from tube hub 2cm.Then above-mentioned magnetic Nano fluid is splashed in the reservoir of atomizer, add to the maximum scale place, nozzle is connect with the tracheae glass tube connect, accomplish air tightly, open atomizer, take off the prolongation of both sides bifurcated pipe behind the 15min, take by weighing its weight respectively.
The result:
In the time of atomizer work, part the prolongation of breeches pipe on the left side, adhere to naturally and action of gravity under include magnetic Nano Fe3O4 particle aerosol droplets can on tube wall, deposit; Parting the prolongation of breeches pipe on the right side, owing to there is magnetic field to exist, is that the magnetic aerosol droplets is deposited on the tube wall so under natural deposition, added very big external magnetic field power.With the size of the weight gain Δ M of prolongation can be quantitative show deposition, the result shows, the weight gain Δ MR that the right prolongs pipe (putting the magnet limit) is about 4.6 times of weight gain Δ ML that the left side prolongs pipe.This explains the magnet array as magnetic and medicated target of the present invention, and the magnetic aerosol droplets can well localization be assembled, and present embodiment has explained that too the present invention is particularly suitable for lung and sucks magnetic drug targeting.
Explanation is at last; Above embodiment is only unrestricted in order to technical scheme of the present invention to be described; Although with reference to preferred embodiment the present invention is specified, those of ordinary skill in the art should be appreciated that and can make amendment or be equal to replacement technical scheme of the present invention; And not breaking away from the aim and the scope of present technique scheme, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (10)
1. can form the method for the dome-shaped gradient magnetic of taper, it is characterized in that: said method comprising the steps of:
Step 1: with a square permanent magnet as main magnet; With two square permanent magnets that highly are lower than this main magnet as auxilliary magnet; The Surface field of main magnet and auxilliary magnet is approaching; Said auxilliary magnet is arranged on the both sides of this main magnet, and the three presses close to parallel placement with the mode of adjacent edge alignment, and main magnet is identical with the magnetic moment direction of the said first auxilliary magnet, the second auxilliary magnet;
Step 2: a wedge shape ferromagnetic block is set respectively on the end face of two auxilliary magnets; Said wedge shape ferromagnetic block comprises that two are oppositely arranged and the right-angle triangle side of vertical projection each other, forms a dip plane between two hypotenuses of two triangle sides, forms two square respectively between two groups of corresponding sides of two triangle sides; When being provided with; With the dip plane of wedge shape ferromagnetic block up, one of them square face is close to auxilliary magnet end face, and another square face is pressed close to main magnet side; Thereby two wedge shape ferromagnetic block are symmetrically distributed in the both sides of main magnet with " eight " word shape, form the dome-shaped gradient magnetic of taper at the top of main magnet.
2. the method that can form the dome-shaped gradient magnetic of taper according to claim 1 and 2 is characterized in that: said wedge shape ferromagnetic block is concordant with the square end face of main magnet with square the top that main magnet is pressed close to mutually.
3. the method that can form the dome-shaped gradient magnetic of taper according to claim 2 is characterized in that: the square end face of said main magnet is provided with one and additional has a structure that can form a contraction summit from top to bottom.
4. the permanent-magnet method that can form the dome-shaped gradient magnetic of taper according to claim 3; It is characterized in that: said structure is semicircle sphere, wedge shape, square taper or taper shape; When adopting semicircle spherical, the radius of this dome is half that the minor face of main magnet horizontal section is grown; When adopting other shapes, the height of this structure is half that the minor face of main magnet horizontal section is grown.
5. the permanent-magnet method that can form the dome-shaped gradient magnetic of taper according to claim 1; It is characterized in that: the permanent magnetic material of main magnet, auxilliary magnet adopts neodymium iron boron, SmCo or ferrite; Described wedge shape ferromagnetic block adopts iron, cobalt or nickel; Or iron content, cobalt, nickel one or more alloy wherein, or the oxide of iron content.
6. can form the permanent-magnet structure of the dome-shaped gradient magnetic of taper; It is characterized in that: said device comprises main magnet, the first auxilliary magnet, second auxilliary magnet, the first wedge shape ferromagnetic block and the second wedge shape ferromagnetic block that adopts permanent-magnet, and the Surface field of main magnet and auxilliary magnet is approaching;
The main body of said main magnet, the first auxilliary magnet and the second auxilliary magnet is square; The first auxilliary magnet and the second auxilliary magnet place main magnet both sides respectively; And three magnets are pressed close to parallel placement with the mode of adjacent edge alignment; The height of the first auxilliary magnet and the second auxilliary magnet is less than main magnet, and the height span of said main magnet is 0.1 ~ 100cm;
The similar of the said first wedge shape ferromagnetic block and the second wedge shape ferromagnetic block; Including two is oppositely arranged and the right-angle triangle side of vertical projection each other; Form a dip plane between two hypotenuses of two triangle sides, form two square respectively between two groups of corresponding sides of two triangle sides, two wedge shape ferromagnetic block are placed on the first auxilliary magnet and the second auxilliary magnet top respectively; The dip plane of wedge shape ferromagnetic block up; One of them square face is close to auxilliary magnet end face, and another square face is pressed close to main magnet side, thereby two wedge shape ferromagnetic block are symmetrically distributed in the both sides of main magnet with " eight " word shape; The dome-shaped gradient magnetic of taper is formed on the top at main magnet; Two assemblys that the first auxilliary magnet and the first wedge shape ferromagnetic block, the second auxilliary magnet and the second wedge shape ferromagnetic block constitute respectively, its whole height is consistent, and concordant with the end face of main magnet.
7. the permanent-magnet structure that can form the dome-shaped gradient magnetic of taper according to claim 6; It is characterized in that: the square end face of said main magnet is provided with one and additional has a structure that can form a contraction summit; Said structure adopts identical permanent magnetic material with the main magnet of below, and magnetic moment direction is identical with main magnet.
8. the permanent-magnet structure that can form the dome-shaped gradient magnetic of taper according to claim 7; It is characterized in that: said structure is semicircle sphere, wedge shape, square taper or taper shape; When adopting semicircle spherical, the radius of this dome is half that the minor face of main magnet horizontal section is grown.
9. the permanent-magnet structure that can form the dome-shaped gradient magnetic of taper according to claim 6; It is characterized in that: the permanent magnetic material of main magnet, the first auxilliary magnet and the second auxilliary magnet adopts neodymium iron boron, SmCo or ferrite; The first wedge shape ferromagnetic block and the second wedge shape ferromagnetic block adopt iron, cobalt or nickel; Or iron content, cobalt, nickel one or more alloy wherein, or the oxide of iron content.
10. adopt like the arbitrary described permanent-magnet structure of claim 6 to 9
Targeted therapy equipment
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103887036A (en) * | 2014-03-13 | 2014-06-25 | 中国计量科学研究院 | Gradient field electromagnet for permanent magnet temperature coefficient open circuit measurement |
| CN103971915A (en) * | 2014-04-21 | 2014-08-06 | 合肥晟辉磁性材料有限公司 | Manufacturing method of capsule endoscope control magnetic ball |
| CN108578895A (en) * | 2018-04-25 | 2018-09-28 | 东莞市星显电子科技有限公司 | A kind of Gyromagnetic device |
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| JPH0838458A (en) * | 1994-06-29 | 1996-02-13 | Siemens Ag | Active shield type plate-form gradient coil for polar plate magnet |
| US6461288B1 (en) * | 1996-09-10 | 2002-10-08 | Holcomb Healthcare Services | Method and apparatus for altering the charge distribution upon living membranes with functional stabilization of the membrane physical electrical integrity |
| CN1511598A (en) * | 2002-12-31 | 2004-07-14 | 华中科技大学同济医学院 | High gradient magnetic field generator |
| CN102429857A (en) * | 2011-11-30 | 2012-05-02 | 重庆大学 | Method and device for performing physical targeting positioning on magnetic medicine by using permanent magnets |
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| JPH0838458A (en) * | 1994-06-29 | 1996-02-13 | Siemens Ag | Active shield type plate-form gradient coil for polar plate magnet |
| US6461288B1 (en) * | 1996-09-10 | 2002-10-08 | Holcomb Healthcare Services | Method and apparatus for altering the charge distribution upon living membranes with functional stabilization of the membrane physical electrical integrity |
| CN1511598A (en) * | 2002-12-31 | 2004-07-14 | 华中科技大学同济医学院 | High gradient magnetic field generator |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103887036A (en) * | 2014-03-13 | 2014-06-25 | 中国计量科学研究院 | Gradient field electromagnet for permanent magnet temperature coefficient open circuit measurement |
| CN103887036B (en) * | 2014-03-13 | 2016-07-06 | 中国计量科学研究院 | A kind of gradient fields electric magnet measured for permanent magnet temperature coefficient open circuit |
| CN103971915A (en) * | 2014-04-21 | 2014-08-06 | 合肥晟辉磁性材料有限公司 | Manufacturing method of capsule endoscope control magnetic ball |
| CN108578895A (en) * | 2018-04-25 | 2018-09-28 | 东莞市星显电子科技有限公司 | A kind of Gyromagnetic device |
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| CN102736043B (en) | 2014-10-29 |
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