CN100464802C - High gradient magnetic field generator - Google Patents
High gradient magnetic field generator Download PDFInfo
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- CN100464802C CN100464802C CNB021541892A CN02154189A CN100464802C CN 100464802 C CN100464802 C CN 100464802C CN B021541892 A CNB021541892 A CN B021541892A CN 02154189 A CN02154189 A CN 02154189A CN 100464802 C CN100464802 C CN 100464802C
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Abstract
The high gradient magnetic field generator features that it consists of three-pawl magnetic field instrument and capacitive discharge pulse magnetic field. The three-pawl magnetic field instrument consists of upper three-pawl magnetic field magnetic path device and lower fixing base board with central hole; and the electric pulse magnetic field consists of pulse power source for capacitor discharge and exciting winding on the S1-N1 pole head in the three-pawl magnetic field magnetic path device. The present invention has raised magnetic field gradient and strength and is suitable for use in the magnetic target treatment of superficial and deep tumor and animal experiment. The present invention has the advantages of high magnetic field gradient, long magnetic action distance, convenient operation, etc.
Description
Technical field
The present invention relates to malignant tumor cancer magnetic drug targeting with the external target assembly of leading.
Background technology
Treatment for cancer is mainly taked operative treatment, chemotherapy, radiotherapy at present, the while Biotherapeutics, and targeted drug and gene therapy development are rapid, and each state all attaches great importance to.Chemotherapy remains the important means of cancer treatment, but chemotherapeutics such as amycin etc., toxic and side effects is very big, and clinical practice is subjected to strict restriction as injected dose, number of times etc.Very cause when serious toxic and side effects occurring the therapy discontinued of having to.In latter stage in last century, a kind of targeted drug has appearred---and antibody drug connects thing.Can make medicine gather target site by the specificity of antibody, improve curative effect, but because antibody and medicine linking intensity are not high, under the physiologic barrier effect, " disintegration " easily, clinical effectiveness is unsatisfactory.
Anticarcinogen,, be attached to magnetic carrier as amycin, nucleic etc., as magnetic micro-beads, behind intravenous injection or tremulous pulse local injection, under the external magnetic field effect, medicine is located at target site, slowly tumor is treated in release, is chemotherapy one big impressive progress, and this class preparation claims magnetic targeted drug again, experiment shows: the target area drug level can improve 30～100 times, chemotherapeutic index improves 10～100 times, has not only improved curative effect, and has reduced the toxic and side effects of medicine to the patient.At present, this medicine and medication have begun to enter clinical trial, as all having begun to be applied to interventional therapy, thromboembolism therapy etc. both at home and abroad; States such as U.S., moral, day reported the successful example to breast carcinoma, esophageal carcinoma, skin carcinoma, bladder cancer magnetic target therapy in succession; Magnetic target therapy need solve two basic technologies: 1. the manufacturing of the magnetic medicine carrier of good magnetic responsiveness is arranged; 2. high gradient is led the structure in target magnetic field.What the present invention relates to is 2. individual technical problem.
After magnetic medicine carrier injects in the body, must have under the external effect of leading target magnetic field, just can make it magnetization, magnetic navigation is delivered to target site, i.e. tumor locus, and reorientation, the slow release of magnetic microsphere of carrying anticarcinogen then.This medication relates to magnetic control theoretical basis and some basic technologies.
Magnetic control theoretical basis is that Japanese scientist Ben Jianjiwen sets up (Japan's " cancer therapeutics meeting will " 1980,15 (5): 881) use till today.The magnetic medicine carrier targeting is assembled external Surface field intensity and the magnetic field gradient of leading target magnetic field of dependence, and carrier is to target position guiding and the power of aggregation extent and the gradient of external magnetic field
Be directly proportional, target site is far away more from pole surface, and suffered magnetic field gradient effect is more little.Therefore, the Dai Zhiqiang of Shanghai Pharmaceutical Inst., Chinese Academy of Sciences professor thinks in " cancer therapy drug magnetic carrier progress " paper: " the speciality allocation outside the magnetic pole strength is made magnetic field gradient to be focused on; make magnetic carrier be trapped in the tumor target tissue as much as possible, and reduce the hold-up of non-target position ... " is the research direction of a novelty.Magnetic carrier is led the target mode at present roughly has following several: 1. adopt rare-earth permanent magnet, the magnetic pole strength magnetic field intensity is at 0.6～0.8T, the body surface of being close to target site, simple and convenient, but magnetic field intensity and gradient are very limited, are applicable to the little target site of table distance that exsomatizes, as skin carcinoma, breast carcinoma, esophageal carcinoma etc., and the darker target site of table that exsomatizes just is difficult to reach the satisfied target effect of leading as hepatocarcinoma, pulmonary carcinoma, gastric cancer etc.2. professor Wang Pingkang of Luoyang Specialized School of Medical Science proposes the method that target is led in the deep, and promptly " earlier the permanent magnetism fine particle is made half mobile colloid, promptly magnet under B ultrasonic or X line machine monitoring, is implanted target site.Behind intravascular administration or topical, magnetic carrier will be adsorbed on inside tumor and periphery securely ".The magnet of this artificial growth is intended to solve the deep and leads target, but needs operation to finish, and is cumbersome.3. adopt bipolar electric magnet, but magnetic field gradient is difficult to still improve.
Summary of the invention
The purpose of this invention is to provide a kind of external target assembly of leading, lead target magnetic field relatively with above-mentioned bar permanent magnet and artificial growth magnet, make its have magnetic field gradient height, magnetic action distance, easy to operate, adjustability is big, is suitable for characteristics such as shallow harmony in the exterior deep tumor magnetic target therapy.
Provided by the invention being used for carried out external high-gradient magnetic field generating means of leading target to magnetic targeted drug, constitute by three-jaw magnetic field instrument and capacitor discharge pulsed magnetic field, three-jaw magnetic field instrument is made up of superposed three-jaw magnetic field magnetic circuit device and the fixed base plate that has centre bore (8) that is positioned at the bottom, three-jaw magnetic field magnetic circuit device is by the S1-N1 cartridge (3) of cuboid, (2) three magnets of S2-N2 magnetic inductive block (1) and S3-N3 magnetic inductive block are formed, form, they are on the plane that three claw-likes are distributed on the fixed base plate (8) that has centre bore, the N end of S1-N1 cartridge (3) and the S end of S2-N2 magnetic inductive block (1) and S3-N3 magnetic inductive block (2) are towards the center, S1-N1 cartridge (3) in its three-jaw magnetic field magnetic circuit is formed by 2 strip permanent magnets and bar shaped pure iron bonding, and the bar shaped pure iron is positioned at the centre of 2 strip permanent magnets; S2-N2 magnetic inductive block (1) and the bar shaped magnetic conductor that S3-N3 magnetic inductive block (2) is a shape, size is identical with S1-N1 cartridge (3); The capacitor discharge pulsed magnetic field is by the capacitor discharge pulse power (13) and be wound on the formation of the magnetizing coil (4) on the S1-N1 cartridge (3) in the magnetic circuit of three-jaw magnetic field; The bar shaped magnetic conductor of S2-N2 and S3-N3 is that electrical pure iron or No. 10 steel are made in the magnetic circuit of formation three-jaw magnetic field;
Between three-jaw magnetic field magnetic circuit device and fixed base plate (8), have and be used for magnetic circuit device is played holder fixing and regulating action, this holder by be positioned at the bottom slide rail (6), be positioned at the slide block (11) on the slide rail (6), the magnet fixed block (5) that is positioned on the slide block (11) is formed, the bottom of slide rail (6) is fixed on the fixed base plate (8), the side that magnet fixed block (5) is gone up centre bore towards fixed base plate (8) is useful on places and the fixing square hole that caves inward of cuboid magnet (1,2,3), and an end of cuboid magnet (1,2,3) is positioned at wherein; Rear-mounted installation at slide block (11) is useful on along the adjusting screw(rod) (10) of orbital direction adjusting slider (11) relative position of slide rail (6); On slide block (11), be useful on the up-down adjustment screw rod (12,14) of up-down adjustment magnet relative position; The base plate (8) of band centre bore by processing characteristics preferably carbon constructional quality steel constitute as No. 25, No. 35 or No. 45 steel.
Can be useful on the rotation adjustment disk (7) that holder is regulated in rotation by device between said slide rail (6) and fixed base plate (8), it can drive S1-N1 and rotate on the inherent base plate of ± 10 ° of scopes, to regulate the direction of N1 pole-face to target position; The input voltage of capacitor discharge pulsed magnetic field is 220V ± 10%, input power is 500W, charging voltage is 350V/450V, capacitance is 1 * 104 μ f, discharge current 5 * 103～8 * 103A, single line magnetic field 4 * 103KA/M (5T), magnetizing coil (4) linear diameter is 2.5～3.0mm (cotton covered wire), coil turn 100～130.
Can produce powerful pulsating field after connecting unidirectional current.According to the magnetic circuit principle of stacking, this magnetic field and S
1-N
1In the permanent magnetic field stack of two blocks of bar magnets (2).The magnetic line of force forms high gradient and leads target magnetic field through the poly-magnetic of wedge shape pole shoe.
Pulsating field of the present invention is made up of capacitor discharge Pulased power supply unit and magnetizing coil.Its key technical indexes is: input voltage (AC) 220V ± 10%, input power 500W, charging voltage (DC) 350V/450V, capacitance 1 * 10
4μ f, discharge current 5 * 10
3～8 * 10
3A, single line magnetic field 4 * 10
3KA/M (5T).Coil winding is at S
1-N
1On the strip permanent magnet, line straight line 2.5～3.0mm (cotton covered wire), coil turn 100～130; Consider the leakage field factor, this has only permanent magnetic field, its Surface field intensity be 〉=0.6T when installing not the input pulse electric current, adds after the pulsating field stack of (DC:400V) magnetic and gather magnetic field, magnetic rear surface to be 〉=3.1T magnetic field gradient
Lead target magnetic field EFFECTIVE RANGE 〉=6cm.S among the present invention
1-N
1, S
2-N
2, S
3-N
3Three pole orientation, positions can be regulated by the adjusting screw(rod) on the holder, to select suitable magnetic action target position.
Magnetic field intensity of the present invention and gradient are controlled, promptly control ampere-turn (AN) number of magnetizing coil by control charging voltage or discharge current, and number of ampere turns is big more, and the pulsating field that is produced is big more, and magnetic field gradient is high more.But the essential safety of noting first accessory in manufacturing and designing, the insulating properties of circuit, and the action of a magnetic field safety magnetic action dosage that can bear of organism.
The target magnetic field of leading that the present invention applied is safe.Each state was all studied, and had proposed the safety criterion of magnetic action dosage.At present, the field intensity of the NMR (Nuclear Magnetic Resonance)-imaging that clinical medicine adopted has been taked 0.6T, 15T, 4.7T and the animal system of 9.4T has begun imaging research.The target the action of a magnetic field of leading of the present invention should be in 30min (following)/day in time of target site, and should avoid cardia.
The magnetic field intensity of earth surface is about 0.05mT, as benchmark, if far above the magnetic field in earth's magnetic field, refers generally to 10mT or stronger magnetic field claims high-intensity magnetic field.If the magnetic field far below the earth's magnetic field claims low-intensity magnetic field as biological magnetic field.Lead in the target technology in magnetic field, adopt permanent magnet magnet magnetic field intensity (B) such as Sm-Co usually, if then to be considered as greater than 0.8T be the highfield to magnetic field intensity generally at 0.5～0.7T.Electromagnetic field comprises that its intensity of pulsed magnetic field (B) can reach more than the 1T even up to tens of T, so all be the highfield.All there is the magnetic field intensity (B) of certain numerical value in each permanent magnet surfaces (pole-face), and low more from pole-face B far away more is zero until B, and promptly magnetic field intensity B decays with the increase of distance (cm or m),
Be defined as magnetic field gradient, unit: (mT/cm or T/m) is preceding to be stated, carrier is subjected to magneto motive size to put to death size in magnetic field gradient, generally lead target magnetic field, the about 0.6～0.7T of Surface field with bar magnet, the about 0.05T/cm of gradient, and magnetic field intensity of the present invention can reach 3.1T, and gradient can be greater than 0.58T/cm.Obviously magnetic force is much bigger through the former, and the action of a magnetic field distance is also much bigger, both has been suitable for shallow table target position and has led target, also can be used for the deep target position and leads target.The present invention can change magnetic field intensity and gradient, better adaptability by changing pulse current system.If for skin carcinoma etc., unbalanced pulse magnetic field does not only depend on two Sm-Co5 permanent magnets on the S1-N1 can realize leading target yet.The present invention has broken through bar-shaped magnet and has attached shortcomings such as the limitation of epidermis and artificial growth magnet and operation wound, can be applied to the targeted therapy of magnetic target cancer therapy drug to malignant tumor such as human body skin cancer, breast carcinoma, esophageal carcinoma, bladder cancer; Can be to laboratory animal, carry out magnetic as Mus, rabbit, Canis familiaris L. etc. and lead target test, also can be applicable to orthopaedics, particularly locality disease such as extremity is carried out magnetic target Drug therapy, also can be applicable to magnetic therapy, have magnetic field gradient height, magnetic action distance, easy to operate, characteristics such as adjustability is big.
Description of drawings
Fig. 1 is a high-gradient magnetic field generating means structural representation of the present invention;
Fig. 2 is a magnetic structure sketch map of the present invention.
1---S
2-N
2Cartridge
2---S
3-N
3Magnetic conductor
3---S
1-N
1Magnetic conductor
4---magnetizing coil
5---the magnet fixed block
6---slide rail
7---the rotation adjustment disk
8---fixed base plate
9---fixed block
10---the slide block adjusting screw(rod)
11---slide block
12---the up-down adjustment screw rod
13---the capacitor discharge pulse power
14---the up-down adjustment screw rod
Specific implementation method
Embodiment 1:
Amycin---bovine serum albumin magnetic microsphere preparation is led the target inhibition test to S180 magnetic field:
1, preparation: 1. amycin---bovine serum albumin magnetic microsphere suspension: contain amycin 7mg, albumin 70mg, Fe among the 15ml
3O
4(20nm) 14mg.2. normal saline.
2, tumor strain and experimental technique: (body weight 21～22g) is inoculated the strain of S180 tumor routinely with 30 male mice in kunming, divide 3 groups, when the tumor volume is bred to the 20mm3 left and right sides, distinguish quiet notes 0.2ml normal saline, 0.2ml amycin---bovine serum albumin magnetic microsphere fluid, 0.2ml amycin---bovine serum albumin magnetic microbody fluid and apply high gradient three and grab vortex magnetic field 30min at target site.Disposable administration was put to death animal after five days, got tumor and weighed, and relatively each group is different with the tumor method of double differences of blank group.Experimental result shows: the amycin that does not add magnetic field---the heavy suppression ratio of tumor of bovine serum albumin magnetic microsphere group only 19.02%; And the heavy suppression ratio of the tumor that applies the high-gradient magnetic field group is 39.26% (with matched group P＜0.001 relatively) latter is produce effects.Originally execute example one explanation injection with a kind of magnet carrier, apply magnetic field of the present invention and do not apply magnetic field, its therapeutic effect is different, and the former is produce effects.
Embodiment 2:
Lead target theory and experimental model based on (day) simple radical Wen are led the target test to ferritin (commercial goods, reddish brown color depth liquid, iron content 30%).
In simulated blood vessel, inject 50ml distilled water (two boil) in advance, the 10ml liquor ferri albuminati reinjects, make above-mentioned diluent liquid in simulated blood vessel, circulate target site and apply the high-gradient magnetic field that the present invention makes up, bore is 0.5mm, and flow velocity is respectively the 30min of 10cm/s and 3cm/s the action of a magnetic field time.From target site and non-target site sampling censorship, survey Fe content with atomic absorption spectrophotometry luminosity degree meter (HITACH180-80).
The result:
Non-target site iron content: target site iron content=1:1.26～1.54 illustrate that high strength of the present invention and high-gradient magnetic field have the magnetic preparation of weak magnetic to lead the target effect preferably.Even the carrier of this weak magnetic of present embodiment explanation ferritin, magnetic field device of the present invention is led target also obvious congregational rate, but leads target with common permanent magnet, and ferritin almost can not be assembled at target position.
Embodiment 3:
High-gradient magnetic field generating means of the present invention, constitute by three-jaw magnetic field instrument and capacitor discharge pulsed magnetic field, three-jaw magnetic field instrument is made up of superposed three-jaw magnetic field magnetic circuit device and the fixed base plate that has centre bore (8) that is positioned at the bottom, three-jaw magnetic field magnetic circuit device is by the S1-N1 cartridge (3) of cuboid, S2-N2 magnetic inductive block (1) and S3-N3 magnetic inductive block (2) are formed, they are on the plane that three claw-likes are distributed on the fixed base plate (8) that has centre bore, the N end of S1-N1 cartridge (3) and the S end of S2-N2 magnetic inductive block (1) and S3-N3 magnetic inductive block (2) are towards the center, S1-N1 cartridge (3) in its three-jaw magnetic field magnetic circuit is formed by 2 strip permanent magnets and bar shaped pure iron bonding, and the bar shaped pure iron is positioned at the centre of 2 strip permanent magnets; S2-N2 magnetic inductive block (1) and the bar shaped magnetic conductor that S3-N3 magnetic inductive block (2) is a shape, size is identical with S1-N1 cartridge (3); The capacitor discharge pulsed magnetic field is by the capacitor discharge pulse power (13) and be wound on the formation of the magnetizing coil (4) on the S1-N1 cartridge (3) in the magnetic circuit of three-jaw magnetic field.2 strip permanent magnets that constitute S1-N1 rectangular magnets in the magnetic circuit of three-jaw magnetic field are samarium one cobalt (Sm-Co) or neodymium-ferrum-boron (Na-Fe-B), and strip permanent magnet adopts S
mC
O5Permanent magnetism, its saturation magnetization Ms are 1.07T (10700Gs), are XG240/46 as the trade mark, and magnetic energy product (β H) max is 28～31Moe altogether, also can adopt Nb-Fe-B neodymium-ferrum-boron permanent magnetism, is N48 as the trade mark; The bar shaped magnetic conductor of S2-N2 and S3-N3 is that electrical pure iron or No. 10 steel are made in the magnetic circuit of formation three-jaw magnetic field; Between three-jaw magnetic field magnetic circuit device and fixed base plate (8), have and be used for magnetic circuit device is played holder fixing and regulating action, this holder by the slide rail (6) that is positioned at the bottom, be positioned at slide block (11), the fixed block (9) on the slide rail (6) and the magnet fixed block (5) that is positioned on the slide block (11) is formed, the bottom of slide rail (6) is fixed on the fixed base plate (8), the side that magnet fixed block (5) is gone up centre bore towards fixed base plate (8) is useful on places and the fixing square hole that caves inward of square magnet, and square magnet is positioned at wherein; Rear-mounted installation at slide block (11) is useful on along the adjusting screw(rod) (10) of orbital direction adjusting slider (11) relative position of slide rail (6); On slide block (11), be useful on the up-down adjustment screw rod (12,14) of up-down adjustment magnet relative position; The base plate (8) of band centre bore by processing characteristics preferably carbon constructional quality steel constitute as No. 25, No. 35 or No. 45 steel.Can be useful on the rotation adjustment disk (7) that holder is regulated in rotation by device between said slide rail (6) and fixed base plate (8), it can drive S1-N1 and rotate on the inherent base plate of ± 10 ° of scopes, to regulate the direction of N1 pole-face to target position.The input voltage of capacitor discharge pulsed magnetic field is 220V ± 10%, and input power is 500W, and charging voltage is 350V/450V, and capacitance is 1 * 10
4μ f, discharge current 5 * 10
3～8 * 10
3A, single line magnetic field 4 * 10
3KA/M (5T), magnetizing coil (4) linear diameter is 2.5～3.0mm (cotton covered wire), coil turn 100～130.Consider the leakage field factor, this has only permanent magnetic field, its Surface field intensity be 〉=0.6T when installing not the input pulse electric current, adds after the pulsating field stack of (DC:400V) magnetic and gather magnetic field, magnetic rear surface to be 〉=3.1T magnetic field gradient
Lead target magnetic field EFFECTIVE RANGE 〉=6cm.S
1-N
1, S
2-N
2, S
3-N
3Three pole orientation, positions can be regulated by the adjusting screw(rod) on the holder, to select suitable magnetic action target position.
Claims (8)
1, a kind of high-gradient magnetic field generating means, it is characterized in that it is made of three-jaw magnetic field instrument and capacitor discharge pulsed magnetic field, three-jaw magnetic field instrument is made up of superposed three-jaw magnetic field magnetic circuit device and the fixed base plate that has centre bore (8) that is positioned at the bottom, and three-jaw magnetic field magnetic circuit device is by the S of cuboid
1-N
1Cartridge (3), S
2-N
2Magnetic inductive block (1) and S
3-N
3(2) three magnets of magnetic inductive block are formed, and they are on the plane that three claw-likes are distributed on the fixed base plate (8) that has centre bore, S
1-N
1The N utmost point and the S of cartridge (3)
2-N
2Magnetic inductive block (1) and S
3-N
3The S of magnetic inductive block (2) holds towards the center, the S in its three-jaw magnetic field magnetic circuit device
1-N
1Cartridge (3) is formed by 2 strip permanent magnets and bar shaped pure iron bonding, and the bar shaped pure iron is positioned at the centre of 2 strip permanent magnets; S
2-N
2Magnetic inductive block (1) and S
3-N
3Magnetic inductive block (2) is shape, size and S
1-N
1The bar shaped magnetic conductor that cartridge (3) is identical; The capacitor discharge pulsed magnetic field is by the capacitor discharge pulse power (13) and be wound on S in the magnetic circuit device of three-jaw magnetic field
1-N
1Magnetizing coil (4) on the cartridge (3) constitutes.
2, high-gradient magnetic field generating means according to claim 1, it is characterized in that between three-jaw magnetic field magnetic circuit device and fixed base plate (8), having and be used for magnetic circuit device is played holder fixing and regulating action, this holder is by the slide rail (6) that is positioned at the bottom, be positioned at the slide block (11) on the slide rail (6), the magnet fixed block (5) that is positioned on the slide block (11) is formed, the bottom of slide rail (6) is fixed on the fixed base plate (8), the side that magnet fixed block (5) is gone up centre bore towards fixed base plate (8) is useful on places and fixing cuboid magnet (1,2,3) the square hole that caves inward, cuboid magnet (1,2,3) a end is positioned at wherein; Rear-mounted installation at slide block (11) is useful on along the adjusting screw(rod) (10) of orbital direction adjusting slider (11) relative position of slide rail (6); On slide block (11), be useful on the up-down adjustment screw rod (12,14) of up-down adjustment magnet relative position.
3, high-gradient magnetic field generating means according to claim 3 is characterized in that being useful on the rotation adjustment disk (7) that holder is regulated in rotation between said slide rail (6) and fixed base plate (8).
4,, it is characterized in that said permanent magnet is samarium one cobalt or neodymium-ferrum-boron according to claim 1,2 or 3 described high-gradient magnetic field generating meanss.
5,, it is characterized in that said condition magnetic conductor made by electrical pure iron or No. 10 steel according to claim 1,2 or 3 described high-gradient magnetic field generating meanss.
6, high-gradient magnetic field generating means according to claim 4 is characterized in that said bar shaped magnetic conductor made by electrical pure iron.
7, according to claim 1,2,3 described high-gradient magnetic field generating meanss, the input voltage that it is characterized in that said capacitor discharge pulsed magnetic field is 220V ± 10%, and input power is 500W, and charging voltage is 350V/450V, and capacitance is 1 * 10
4μ f, discharge current 5 * 10
3～8 * 10
3A, single line magnetic field is 4 * 10
3KA/M (5T), magnetizing coil (4) cotton covered wire diameter is 2.5～3.0mm, coil turn is 100～130.
8, high-gradient magnetic field generating means according to claim 6, the input voltage that it is characterized in that said capacitor discharge pulsed magnetic field is 220V ± 10%, and input power is 500W, and charging voltage is 350V/450V, and capacitance is 1 * 10
4μ f, discharge current 5 * 10
3～8 * 10
3A, single line magnetic field is 4 * 10
3KA/M (5T), magnetizing coil (4) cotton covered wire diameter is 2.5～3.0mm, coil turn is 100～130.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021541892A CN100464802C (en) | 2002-12-31 | 2002-12-31 | High gradient magnetic field generator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021541892A CN100464802C (en) | 2002-12-31 | 2002-12-31 | High gradient magnetic field generator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1511598A CN1511598A (en) | 2004-07-14 |
| CN100464802C true CN100464802C (en) | 2009-03-04 |
Family
ID=34235458
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021541892A Expired - Fee Related CN100464802C (en) | 2002-12-31 | 2002-12-31 | High gradient magnetic field generator |
Country Status (1)
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| CN (1) | CN100464802C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884824A (en) * | 2010-07-02 | 2010-11-17 | 华中科技大学 | Three-dimension scanning large gradient electromagnetic guiding device |
| CN102736043B (en) * | 2012-05-31 | 2014-10-29 | 重庆医科大学附属儿童医院 | Method and structure capable of forming conical and dome-shaped gradient magnetic field as well as targeting therapy equipment |
| CN109842280A (en) * | 2017-11-24 | 2019-06-04 | 彭德正 | Height magnetization high gradient component power supply |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2047966U (en) * | 1989-01-07 | 1989-11-22 | 钱存泽 | Taiji electromagnetic coil |
| EP0797317A1 (en) * | 1996-03-22 | 1997-09-24 | ELA MEDICAL (Société anonyme) | Receiving device for signals sent by an active implanted medical device |
| CN1234745A (en) * | 1996-06-19 | 1999-11-10 | 罗伯特·R·霍尔库姆 | Electromagnetic therapeutic device and using method therefor |
| WO2001010501A1 (en) * | 1999-08-07 | 2001-02-15 | Mfh Hyperthermiesysteme Gmbh | Magnetic field applicator for heating magnetic or magnetizable substances or solids in biological tissue |
-
2002
- 2002-12-31 CN CNB021541892A patent/CN100464802C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2047966U (en) * | 1989-01-07 | 1989-11-22 | 钱存泽 | Taiji electromagnetic coil |
| EP0797317A1 (en) * | 1996-03-22 | 1997-09-24 | ELA MEDICAL (Société anonyme) | Receiving device for signals sent by an active implanted medical device |
| CN1234745A (en) * | 1996-06-19 | 1999-11-10 | 罗伯特·R·霍尔库姆 | Electromagnetic therapeutic device and using method therefor |
| WO2001010501A1 (en) * | 1999-08-07 | 2001-02-15 | Mfh Hyperthermiesysteme Gmbh | Magnetic field applicator for heating magnetic or magnetizable substances or solids in biological tissue |
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|---|---|
| CN1511598A (en) | 2004-07-14 |
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