CN102735636A - Optical device for biochemical analyzer - Google Patents
Optical device for biochemical analyzer Download PDFInfo
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- CN102735636A CN102735636A CN201210225260XA CN201210225260A CN102735636A CN 102735636 A CN102735636 A CN 102735636A CN 201210225260X A CN201210225260X A CN 201210225260XA CN 201210225260 A CN201210225260 A CN 201210225260A CN 102735636 A CN102735636 A CN 102735636A
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Abstract
The invention discloses an optical device for a biochemical analyzer. The optical device comprises a light source, a front condenser lens, a reaction disc for placing a reaction cup, a constant temperature bath for maintaining the temperature of a reaction solution in the reaction cup, a rear beam splitting lens and an optical collection point. The front condenser lens comprises a biconvex lens and a meniscus lens with the biconvex lens being in the front and the meniscus lens being at the back, and the convex surface of the meniscus lens is a plane of incidence. The rear beam splitting lens comprises two same planoconvex lenses, convex surfaces of which are attached to each other. According to the invention, through redesigning parts of the optical device and adjusting optical path, the minimum reaction volume is reduced such that reagent consumption and blood consumption of the biochemical analyzer are greatly minimized and reagent usage cost in a hospital is decreased.
Description
Technical field
The present invention relates to biologic medical technique with the apparatus field, be meant that especially a kind of Biochemical Analyzer uses optical devices.
Background technology
Minimal reaction volume in the Biochemical Analyzer is a very important parameter, and it is the liquid volume of minimum needs in the primary first-order equation.The minimal reaction volume is the potpourri of the body fluid (being mainly blood) of reagent and human body; The minimal reaction volume is more little; Then the blood of human body of required extraction and needed reagent are just few more; Obviously blood drawing reduces the misery that can reduce patient, and the reducing of required reagent then can be saved the Biochemical Analyzer use cost greatly.
Yet the approach that dwindles of minimal reaction volume dwindles light exactly through reaction cup volume and spot definition, and this has proposed very high requirement for optical devices.
At present, the reaction cup cross-sectional area of general Biochemical Analyzer is 5 * 6mm
2, spot definition is 3 * 1mm
2, the minimal reaction volume is 150 μ l, and if the minimal reaction volume is reduced 50 μ l, just can reduce the painful of patient and save the Biochemical Analyzer use cost greatly.
Summary of the invention
In view of this, the objective of the invention is to propose a kind of Biochemical Analyzer and use optical devices, it can reduce the minimal reaction volume of Biochemical Analyzer.
Use optical devices based on above-mentioned purpose a kind of Biochemical Analyzer provided by the invention, comprising: the reaction tray of light source, preceding collector lens, placing response cup, the calibration cell that keeps said reaction cup internal reaction liquid temp, back beam splitting lens, light collection point; Collector lens comprises a slice biconvex lens and a slice concave-convex lens before said, and the biconvex lens of said preceding collector lens is preceding, concave-convex lens after, and said concave-convex lens convex surface is the plane of incidence; Said back beam splitting lens comprises two identical plano-convex lenss, and the convex surface of two lens pastes mutually; Said incident light sends and passes through successively said biconvex lens, concave-convex lens, calibration cell, constant temperature liquid, reaction cup, reactant liquor from light source; Said emergent light then passes through said reactant liquor, reaction cup, constant temperature liquid, calibration cell successively; And two identical plano-convex lenss pasting mutually of convex surface, be mapped to said light collection point at last.
In one embodiment, described reaction cup is 5mm along the inwall spacing of said reaction tray radial direction, and said reaction cup wall thickness is not more than 0.75mm, and the inwall spacing of the said reaction tray tangential direction in edge is not more than 4mm; Said calibration cell wall thickness is not less than 1mm, and calibration cell is not more than 15.5mm along the outer wall spacing of said reaction tray radial direction.
In another embodiment, described reaction cup is 4mm along the inwall spacing of said reaction tray tangential direction.
In another embodiment, said calibration cell is 15.5mm along the outer wall spacing of said reaction tray radial direction, and said reaction cup wall thickness is 0.75mm, and said calibration cell wall thickness is 1mm.
In another embodiment, the bob amount sum that rotates a circle of said reaction tray is not more than 1.5mm.
In another embodiment, the biconvex lens plane of incidence radius-of-curvature of said preceding collector lens is 15.4mm, and the exit facet radius-of-curvature is 23.6mm, and thickness is 1.7mm; The concave-convex lens plane of incidence radius-of-curvature of collector lens is 4.7mm before said, and the exit facet radius-of-curvature is 11mm, and thickness is 2mm.
In another embodiment, the spacing of the concave-convex lens plane of incidence of the biconvex lens exit facet of said preceding collector lens and said preceding collector lens is 6.6mm, and the concave-convex lens exit facet of said preceding collector lens and the spacing of said calibration cell outer wall are 2mm.
In another embodiment, the convex surface radius of the plano-convex lens of said back beam splitting lens is 9.1mm, and thickness is 3mm.
In another embodiment, the preceding plano-convex lens plane of incidence of said back beam splitting lens and the spacing of said calibration cell outer wall are 5mm.
In another embodiment, the biconvex lens plane of incidence of said preceding collector lens and the spacing of optical devices light source are 30mm, and the spacing of the back plano-convex lens exit facet of said back beam splitting lens and the light collection point of optical devices is 24mm.
In another embodiment, the manufacturing materials of said reaction cup, calibration cell, preceding collector lens, back beam splitting lens is optical glass.
Saidly can find out from top; A kind of Biochemical Analyzer provided by the invention is used optical devices, through the parts in the optical devices are designed and adjust light path again, thereby has reduced the minimal reaction volume; Make this kind Biochemical Analyzer significantly reduce reagent consumption and blood using amount; Reduce the cost that hospital uses reagent, and then reduce the amount of clinical waste discharging, reduce the difficulty of MEDICAL WASTE TREATMENT; Reducing assay office simultaneously needs blood volume, reduces patient's misery, improves patient's level of comfort, reduces patient's blood drawing pressure.
Description of drawings
Fig. 1 by Biochemical Analyzer disclosed by the invention with light path among the optical devices embodiment the each several part front view of process;
Fig. 2 is a reaction cup vertical view in the embodiment of the invention.
Embodiment
For making the object of the invention, technical scheme and advantage clearer, below in conjunction with specific embodiment, and with reference to accompanying drawing, to further explain of the present invention.
The disclosed a kind of Biochemical Analyzer of the present invention is used optical devices, comprising: light source, preceding collector lens, the reaction tray of placing said reaction cup, the calibration cell that keeps said reaction cup internal reaction liquid temp, back beam splitting lens, light collection point; Collector lens comprises a slice biconvex lens and a slice concave-convex lens before said, and the biconvex lens of said preceding collector lens is preceding, concave-convex lens after, and said concave-convex lens convex surface is the plane of incidence; Said back beam splitting lens comprises two identical plano-convex lenss, and the convex surface of two lens pastes mutually.
Said incident light sends and passes through successively said biconvex lens, concave-convex lens, calibration cell, constant temperature liquid, reaction cup, reactant liquor from light source; Said emergent light then passes through said reactant liquor, reaction cup, constant temperature liquid, calibration cell successively; And two identical plano-convex lenss pasting mutually of convex surface, be mapped to said light collection point at last.
With reference to figure 1, Biochemical Analyzer disclosed by the invention with light path among the optical devices embodiment the each several part front view of process; The light path of only having drawn among Fig. 1 the part of each parts of process because the incident light sectional area is little, the emergent light sectional area is big, so the varying in size of two-part part, the left and right sides.
Wherein, said optical devices comprise: light source, preceding collector lens 1, reaction cup 2, calibration cell 4, back beam splitting lens 6, light collection point; Wherein, reaction cup 2 is arranged in the calibration cell 4.
Said incident light sends and passes through successively biconvex lens, concave-convex lens, calibration cell 4, constant temperature liquid 5, reaction cup 2, the reactant liquor 3 of said preceding collector lens 1 from light source; Said emergent light then passes through said reactant liquor 3, reaction cup 2, constant temperature liquid 5, calibration cell 4 successively, and two identical plano-convex lenss pasting mutually of the convex surface of back beam splitting lens 6, is mapped to said light collection point at last.
The wall thickness d of said reaction cup 2
3Be 0.75mm, the wall thickness d of said calibration cell 4
6Be 1mm; Said reaction cup 2 is along the inwall spacing d of said reaction tray radial direction (promptly along the light direction of passage)
1Be 5mm, described reaction cup 2 is along the inwall spacing d of said reaction tray tangential direction
2(accompanying drawing 2) is 4mm, and said calibration cell 4 is along the outer wall spacing d of said reaction tray radial direction (promptly along the light direction of passage)
5Be 15.5mm.
The spacing d of the concave-convex lens plane of incidence of the biconvex lens exit facet of collector lens 1 and said preceding collector lens before said
8Be 6.6mm, the concave-convex lens exit facet of said preceding collector lens 1 and the spacing d of said calibration cell outer wall
10Be 2mm.The preceding plano-convex lens plane of incidence of said back beam splitting lens 6 and the spacing d of said calibration cell outer wall
11Be 5mm.
The biconvex lens plane of incidence of collector lens 1 and the spacing of optical devices light source are 30mm before said, and the spacing of the back plano-convex lens exit facet of said back beam splitting lens 6 and the light collection point of optical devices is 24mm.
During test, light penetrates from light source, behind the biconvex lens and concave-convex lens optically focused of preceding collector lens 1; Pass through cell wall, constant temperature liquid 5, the wall of cup of reaction cup 2, the reactant liquor 3 of calibration cell 4 successively, reactant liquor reacts under illumination, emergent light afterwards; Pass through wall of cup, the constant temperature liquid 5 of reaction cup 2, the cell wall of calibration cell 4 more successively; Again through after after two identical plano-convex lenss pasting mutually of the convex surface of beam splitting lens 6 disperse, be mapped to the light collection point, test through after the opto-electronic conversion.
After adopting above-mentioned optical devices, see through the luminous point height d of reaction cup 2
4Narrow down to 1.5mm, spot width (along the reaction tray tangential direction) narrows down to 0.5mm.
Said reaction tray can be wound the axle rotation perpendicular to optical axis in level in test process; But this generally speaking rotation can not be an abswolute level; Therefore will cause in its rotary course and produce bob, jerk value is the maximum bob amount sum that rotates a circle with maximum jerk value sum down on the maximum that reaction tray rotates a circle.Obviously, this beating will impact test process.Generally, described reaction tray is selected through design bearing and manufacturing materials, can guarantee the stability of reaction tray so that its maximum bob amount sum that rotates a circle is no more than 1.5mm.
Consider the surface tension of reactant liquor 3, reactant liquor 3 is risen along wall of cup near the liquid level at reaction cup 2 wall of cup places, reactant liquor 3 then can descend at the liquid level of reaction cup 2 centers accordingly.Because the position that luminous point shone is at the center of reactant liquor 3, reactant liquor 3 center liquid levels descend and then may cause luminous point can't shine fully on the reactant liquor 3, so just can cause the error of testing result.In order to compensate the height of the reactant liquor center liquid level that reduces because of liquid level tension force, when adding reactant liquor, then need consider to increase suitable reactant liquor volume.
Therefore, the theoretical calculation formula of the minimal reaction volume of Biochemical Analyzer is:
The inside surface cross-sectional area of minimal reaction volume=reaction cup 2 * (luminous point height d
4The height that maximum bob amount sum+reactant liquor center liquid level loses because of surface tension that+reaction tray rotates a circle)
Wherein, the inside surface cross-sectional area of reaction cup 2 is d
1* d
2=5mm * 4mm=20mm
2, the maximum bob amount sum that reaction tray rotates a circle is 1.5mm, luminous point height d
4Be 1.5mm, the height that reactant liquor center liquid level loses because of surface tension is 1.5mm (theoretical value), then:
Minimal reaction volume=5 * 4 * (1.5+1.5+1.5) mm
3=90 μ l, if consider the influence of equipment error, then the minimal reaction volume is 100 μ l.
The theoretical value of the minimal reaction volume of more than measuring for the optical devices that utilize the present invention to adopt under the Theoretical Calculation proves through testing below.
Experiment material: the complete biochemical analysis instrument apparatus of a cover comprises 6 half tables of signal acquisition circuit plate and signals collecting instrument.Reaction tray is to be become by 8 cup joint groups, and each cup is associated with 20 cup positions, and for ease, we only write down the tenth cup position in each glass couplet, have eight data.
Experimental technique: at first with adding potassium dichromate (K to be measured in each reaction cup
2Gr
2+ O
7) solution, the absorbance of this potassium dichromate configures earlier, is about about 1.0.
In 160 all reaction cup, add this kind solution 90 μ l, measure absorbance.Measured value and theoretical value are compared,, then increase 10 μ l liquor capacity to be measured, continue to measure, up to differing in error range with theoretical value if test value and theoretical value differ big (error is beyond 0.02).
The absorbance theoretical value is 0.998.
Experimental data is seen table 1.
Table 1
From data, can draw, when the reactant liquor volume is 100 μ l, can obtain test value with the theoretical value basically identical.
To sum up can draw, the minimal reaction volume that adopts the Biochemical Analyzer of optical devices of the present invention is 100 μ l, has reduced 1/3rd than general Biochemical Analyzer minimal reaction volume 150 μ l.
Can find out from above-mentioned; The disclosed Biochemical Analyzer of the present invention is used optical devices, and said reaction cup still keeps the size of 5mm along the inwall spacing of said reaction tray radial direction (being the direction that light passes through); Through distance, realize good light absorption to guarantee enough light; And along the inwall hypotelorism of said reaction tray tangential direction to 4mm, make the cumulative volume of reaction cup dwindle much, the sectional area of the conventional 5mm * 6mm that selects of contrast, this change of single sectional area just with the minimal reaction volume-diminished 1/3rd.
Preceding collector lens 1 adopts the cooperation of biconvex lens and concave-convex lens, to reduce spherical aberration; In order to dwindle spot definition, calibration cell narrowed down to along the outer wall spacing of said reaction tray radial direction have only 15.5mm, these improve actings in conjunction and have realized dwindling of spot definition.
Back beam splitting lens 6 is for thereafter beam split purpose and usefulness, and has adopted two identical plano-convex lens eyeglasses to save cost.
A kind of Biochemical Analyzer disclosed by the invention is used optical devices, through adopting the reaction cup of littler xsect, the littler luminous point size that sees through reaction cup; And the parts in the optical devices are designed and adjust light path again; Realize littler minimal reaction volume, made and adopt the Biochemical Analyzer of this kind optical devices to significantly reduce reagent consumption and blood using amount, reduced the cost that hospital uses reagent; And then reduce the amount that clinical waste discharges, reduce the difficulty of MEDICAL WASTE TREATMENT; Reducing assay office simultaneously needs blood volume, reduces patient's misery, improves patient's level of comfort, reduces patient's blood drawing pressure.
What need particularly point out is; Reaction cup cross-sectional area in the foregoing description is 5 * 4, wherein can also dwindle along the inwall spacing of said reaction tray tangential direction again, can make the minimal reaction volume littler in theory; Consider the debugging of said optical devices and testing apparatus each several part; And the problem of test result precision, adopt the size of 4mm here, but do not got rid of the possibility that adopts 3.5mm or littler size.
In addition; Calibration cell in the foregoing description is 15.5mm along the outer wall spacing of said reaction tray radial direction, also can dwindle on this distance theory, and is same; Consider the debugging of said optical devices and testing apparatus each several part; And the problem of test result precision, adopt the size of 15.5mm here, but do not got rid of the possibility that adopts 15mm or littler size.
Certainly, the wall thickness design of described reaction cup, calibration cell neither be confined to 0.75mm and 1mm, suitably reduces the reaction cup wall thickness and increases the calibration cell wall thickness, also belongs to protection scope of the present invention.
Preceding collector lens in the said optical devices designs according to reaction cup size and spot definition with the design of back beam splitting lens; Therefore; After described reaction cup size and spot definition variation; The corresponding variation that also can cause spacing between preceding collector lens and back beam splitting lens and the each several part meets the preceding collector lens of the present invention's design and the design of back beam splitting lens accordingly and also belongs to protection scope of the present invention.
The present invention can adopt design comparatively simple and commonly used; Like said calibration cell is water bath; The manufacturing materials of said reaction cup, preceding collector lens and back beam splitting lens is optical glass; K9 glass particularly, but other materials also is feasible, as long as said optical devices and testing apparatus are carried out corresponding debugging.
The maximum bob amount sum that above-mentioned reaction tray rotates a circle is 1.5mm, certainly, selects through special design bearing and manufacturing materials, and this bob amount sum can also be littler, simultaneously, and can also be with the minimal reaction volume-diminished.
The those of ordinary skill in affiliated field is to be understood that: the above is merely specific embodiment of the present invention; Be not limited to the present invention; All within spirit of the present invention and principle, any modification of being made, be equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (11)
1. a Biochemical Analyzer is used optical devices, it is characterized in that, comprises the reaction tray of light source, preceding collector lens, placing response cup, the calibration cell that keeps said reaction cup internal reaction liquid temp, back beam splitting lens, light collection point; Collector lens comprises a slice biconvex lens and a slice concave-convex lens before said, and the biconvex lens of said preceding collector lens is preceding, concave-convex lens after, and said concave-convex lens convex surface is the plane of incidence; Said back beam splitting lens comprises two identical plano-convex lenss, and the convex surface of two lens pastes mutually; Said incident light sends and passes through successively said biconvex lens, concave-convex lens, calibration cell, constant temperature liquid, reaction cup, reactant liquor from light source; Said emergent light then passes through said reactant liquor, reaction cup, constant temperature liquid, calibration cell successively; And two identical plano-convex lenss pasting mutually of convex surface, be mapped to said light collection point at last.
2. Biochemical Analyzer according to claim 1 is used optical devices; It is characterized in that; Described reaction cup is 5mm along the inwall spacing of said reaction tray radial direction, and said reaction cup wall thickness is not more than 0.75mm, and the inwall spacing of the said reaction tray tangential direction in edge is not more than 4mm; Said calibration cell wall thickness is not less than 1mm, and calibration cell is not more than 15.5mm along the outer wall spacing of said reaction tray radial direction.
3. Biochemical Analyzer according to claim 2 is used optical devices, it is characterized in that, described reaction cup is 4mm along the inwall spacing of said reaction tray tangential direction.
4. Biochemical Analyzer according to claim 3 is used optical devices, it is characterized in that, said calibration cell is 15.5mm along the outer wall spacing of said reaction tray radial direction, and said reaction cup wall thickness is 0.75mm, and said calibration cell wall thickness is 1mm.
5. Biochemical Analyzer according to claim 4 is used optical devices, it is characterized in that, the bob amount sum that said reaction tray rotates a circle is not more than 1.5mm.
6. Biochemical Analyzer according to claim 5 is used optical devices, it is characterized in that, the biconvex lens plane of incidence radius-of-curvature of said preceding collector lens is 15.4mm, and the exit facet radius-of-curvature is 23.6mm, and thickness is 1.7mm; The concave-convex lens plane of incidence radius-of-curvature of collector lens is 4.7mm before said, and the exit facet radius-of-curvature is 11mm, and thickness is 2mm.
7. Biochemical Analyzer according to claim 6 is used optical devices; It is characterized in that; The spacing of the concave-convex lens plane of incidence of the biconvex lens exit facet of collector lens and said preceding collector lens is 6.6mm before said, and the concave-convex lens exit facet of said preceding collector lens and the spacing of said calibration cell outer wall are 2mm.
8. Biochemical Analyzer according to claim 7 is used optical devices, it is characterized in that, the convex surface radius of the plano-convex lens of said back beam splitting lens is 9.1mm, and thickness is 3mm.
9. Biochemical Analyzer according to claim 8 is used optical devices, it is characterized in that, the preceding plano-convex lens plane of incidence of said back beam splitting lens and the spacing of said calibration cell outer wall are 5mm.
10. Biochemical Analyzer according to claim 9 is used optical devices; It is characterized in that; The biconvex lens plane of incidence of collector lens and the spacing of optical devices light source are 30mm before said, and the spacing of the back plano-convex lens exit facet of said back beam splitting lens and the light collection point of optical devices is 24mm.
11. use optical devices, it is characterized in that the manufacturing materials of said reaction cup, calibration cell, preceding collector lens, back beam splitting lens is optical glass according to any described Biochemical Analyzer of claim 1 to 10.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107831118A (en) * | 2017-12-18 | 2018-03-23 | 杭州凯坤科技有限公司 | A kind of smooth detection module |
| CN111022967A (en) * | 2019-11-25 | 2020-04-17 | 中国科学院苏州纳米技术与纳米仿生研究所 | Regional light source dodging structure applied to fluorescence imaging system and fluorescence imaging system |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4566792A (en) * | 1983-02-04 | 1986-01-28 | Shimadzu Corporation | Multi-channel spectrophotometric measuring device |
| JP2005069980A (en) * | 2003-08-27 | 2005-03-17 | Toyobo Co Ltd | Surface plasmon resonance system |
| US20080024758A1 (en) * | 2006-07-31 | 2008-01-31 | Sysmex Corporation | Optical system for a particle analyzer and particle analyzer using same |
| CN201368878Y (en) * | 2009-01-23 | 2009-12-23 | 北京松上技术有限公司 | Improved spectrometer for full-automatic biochemical analyzer |
| CN101672767A (en) * | 2009-09-01 | 2010-03-17 | 深圳市蓝韵实业有限公司 | Grating spectrophotometer |
| JP2011047797A (en) * | 2009-08-27 | 2011-03-10 | Nippon Telegr & Teleph Corp <Ntt> | Generator type utilizing radio waves |
| CN102507448A (en) * | 2011-11-11 | 2012-06-20 | 深圳市锦瑞电子有限公司 | Detecting system and detecting method for biochemical analyzer |
-
2012
- 2012-06-29 CN CN201210225260.XA patent/CN102735636B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4566792A (en) * | 1983-02-04 | 1986-01-28 | Shimadzu Corporation | Multi-channel spectrophotometric measuring device |
| JP2005069980A (en) * | 2003-08-27 | 2005-03-17 | Toyobo Co Ltd | Surface plasmon resonance system |
| US20080024758A1 (en) * | 2006-07-31 | 2008-01-31 | Sysmex Corporation | Optical system for a particle analyzer and particle analyzer using same |
| CN201368878Y (en) * | 2009-01-23 | 2009-12-23 | 北京松上技术有限公司 | Improved spectrometer for full-automatic biochemical analyzer |
| JP2011047797A (en) * | 2009-08-27 | 2011-03-10 | Nippon Telegr & Teleph Corp <Ntt> | Generator type utilizing radio waves |
| CN101672767A (en) * | 2009-09-01 | 2010-03-17 | 深圳市蓝韵实业有限公司 | Grating spectrophotometer |
| CN102507448A (en) * | 2011-11-11 | 2012-06-20 | 深圳市锦瑞电子有限公司 | Detecting system and detecting method for biochemical analyzer |
Non-Patent Citations (1)
| Title |
|---|
| 解传芬 等: "一种面向基层的全自动生化分析系统的研制", 《中国医疗器械杂志》, vol. 35, no. 5, 31 October 2011 (2011-10-31) * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107831118A (en) * | 2017-12-18 | 2018-03-23 | 杭州凯坤科技有限公司 | A kind of smooth detection module |
| CN107831118B (en) * | 2017-12-18 | 2024-02-09 | 杭州凯坤科技有限公司 | Light detection module |
| CN111022967A (en) * | 2019-11-25 | 2020-04-17 | 中国科学院苏州纳米技术与纳米仿生研究所 | Regional light source dodging structure applied to fluorescence imaging system and fluorescence imaging system |
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