CN102727584A - Method for extracting flavonoids from camphor tree leaves - Google Patents
Method for extracting flavonoids from camphor tree leaves Download PDFInfo
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- CN102727584A CN102727584A CN2012102237563A CN201210223756A CN102727584A CN 102727584 A CN102727584 A CN 102727584A CN 2012102237563 A CN2012102237563 A CN 2012102237563A CN 201210223756 A CN201210223756 A CN 201210223756A CN 102727584 A CN102727584 A CN 102727584A
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- cinnamomi camphorae
- folium cinnamomi
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- alcohol
- camphor tree
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a method for extracting flavonoids from camphor tree leaves. The method provided by the invention comprises the steps that: (1) camphor tree leaves are dried and are soaked in ethanol; alcohol-soluble substances are extracted by heating and refluxing; heating is stopped, and filtering is carried out, such that camphor tree leaf tincture is obtained; (2) the camphor tree leaf tincture is heated and distilled, such that ethanol is recovered, and a camphor tree leaf extract is obtained; (3) ligroin is added to the camphor tree leaf extract, and stirring is carried out; the mixture is filtered, such that a filtrate and crude flavonoids are obtained; and (4) the crude flavonoids are dried, such that a finished product is obtained. According to the invention, flavonoids in dried camphor tree leaves are extracted by using industrial ethanol. The technological process is simple, and the requirements on equipment are low, such that the method is suitable for industrialized productions. With the method provided by the invention, the efficiency of flavonoid extraction is high. The source of camphor tree leaves adopted by the invention is wide, such that the resource is fully utilized, and the production cost of the flavonoids is reduced.
Description
Technical field
The invention belongs to flavone compound and extract the field, particularly relate to a kind of method of from Folium cinnamomi camphorae, extracting flavone compound.
Background technology
Flavone compound has multiple functions such as antiinflammatory, detumescence, blood pressure lowering, blood fat reducing and removing oxygen-derived free radicals, is the functional components in many Chinese medicines.Lignum cinnamomi camphorae is the aiphyllium plant that Lignum cinnamomi camphorae belongs to, and is one of chief species of China's subtropical zone broad-leaf forest, contains abundant flavonoids in its leaf.
Summary of the invention
The object of the present invention is to provide a kind of method of from Folium cinnamomi camphorae, extracting flavone compound.
Technical scheme of the present invention is following:
A kind of method of from Folium cinnamomi camphorae, extracting flavone compound comprises the steps:
(1) Folium cinnamomi camphorae is immersed after drying in the ethanol, heating and refluxing extraction alcohol soluble substance stops to filter after the heating, gets the Folium cinnamomi camphorae tincture;
(2) gained Folium cinnamomi camphorae tincture is added thermal distillation and reclaim ethanol, get Folium cinnamomi camphorae extractum;
(3) in above-mentioned Folium cinnamomi camphorae extractum, add petroleum ether and stirring, cross and filter filtrating and crude flavonoid powder compounds;
(4) the crude flavonoid powder compounds is drying to obtain finished product.
In a preferred embodiment of the invention, said step (1) is specially: Folium cinnamomi camphorae is dried to water content≤10% back immerses in the ethanol, heating and refluxing extraction alcohol soluble substance stops to filter after the heating, gets filtering residue and alcohol leaching liquid; The gained filtering residue carry out again 0 to alcohol heating reflux repeatedly be extracted into the color of gained alcohol leaching liquid light till; Above-mentioned alcohol leaching liquid mixing is promptly got the Folium cinnamomi camphorae tincture, and above-mentioned filtering residue is thrown aside behind heating recovery ethanol.Above-mentioned Folium cinnamomi camphorae can be fresh Folium cinnamomi camphorae, also can be through the Folium cinnamomi camphorae behind the distillation extraction quintessence oil; Above-mentioned drying means can be Exposure to Sunlight, dry in the shade, and also can be various artificial drying methods such as oven drying method, hot-air seasoning, steam seasoning, boulton process, far-infrared drying method, micro-wave drying method or the like.
In a preferred embodiment of the invention, used ethanol is for containing the industrial alcohol of alcohol amount 93 ~ 96% in the said step (1), and the consumption of this industrial alcohol in each heating and refluxing extraction is 2.5 ~ 6 times of weight of dried Folium cinnamomi camphorae.
In a preferred embodiment of the invention, the total degree of said reflux is 1 to 3 time, and the time of each heating and refluxing extraction is 0.5 ~ 1.5 hour.
In a preferred embodiment of the invention, in the said step (2), gained Folium cinnamomi camphorae tincture heating is distilled to gained Folium cinnamomi camphorae extractum can be 75 ~ 85 ℃ the time till the free-flow.
In a preferred embodiment of the invention, in the said step (3), the consumption of said petroleum ether is 1 ~ 2 times of weight of gained Folium cinnamomi camphorae extractum, and is stirred to said Folium cinnamomi camphorae extractum and the petroleum ether uniform mixing is dispersion liquid.And the filtrating of step (3) gained can be used for extracting chlorophyll, carotenoid etc.
In a preferred embodiment of the invention, the baking temperature in the said step (4) is lower than 60 ℃.Drying means can be to be lower than 60 ℃ various seasonings, comprises boulton process.
The invention has the beneficial effects as follows:
1, the present invention adopts industrial alcohol to extract the flavone compound in the dry Folium cinnamomi camphorae, and technical process is simple, and equipment requirements is low, is fit to suitability for industrialized production;
2, the efficient of method extraction flavone compound of the present invention is higher.
3, the used Folium cinnamomi camphorae wide material sources of method of the present invention have made full use of resource, have reduced the production cost of flavone compound.
The specific embodiment
Below in conjunction with the specific embodiment, technical scheme of the present invention is further explained and described.
Embodiment 1
(1) fresh Folium cinnamomi camphorae is exposed to the sun one day to water content≤10% under the sun, is dried Folium cinnamomi camphorae; The above-mentioned dried Folium cinnamomi camphorae immersion 300kg of 100kg is contained in the industrial alcohol of alcohol amount 95%, and reflux was extracted pure soluble substance in 1 hour, stopped to filter after the heating, got filtering residue and 262 kilograms of first order alcohol leaching liquids; The gained filtering residue immerses in the industrial alcohol of the fresh alcohol amount of containing 95% of 250kg again, carries out reflux 1.5 hours second time, secondary filtering residue and 259kg second level alcohol leaching liquid, the color of second level alcohol leaching liquid has been light at this moment; The above-mentioned first order and the mixing of second level alcohol leaching liquid are promptly got 521kg Folium cinnamomi camphorae tincture, and above-mentioned filtering residue is made fuel and is used behind heating recovery ethanol;
(2) gained Folium cinnamomi camphorae tincture is added thermal distillation and reclaims ethanol, Folium cinnamomi camphorae extractum 11.2kg, this Folium cinnamomi camphorae extractum can free-flow in the time of 75 ~ 85 ℃;
(3) in above-mentioned Folium cinnamomi camphorae extractum, add petroleum ether 12kg and stir and be dispersion liquid to said Folium cinnamomi camphorae extractum and petroleum ether uniform mixing in 30 minutes, cross then and filter filtrate 17.8kg and crude flavonoid powder compounds 5.2kg;
(4) above-mentioned crude flavonoid powder compounds is placed vacuum drier, be dried to moisture approximately about 3% under 60 ℃ the temperature not being higher than, obtain 4.8 kilograms of finished products.
Through detecting, this finished product contains flavone (calculating by rutin) 25.5%, can directly sell as food additive or feed additive.
Embodiment 2
(1) Folium cinnamomi camphorae behind the distillation extraction quintessence oil is dried to water content≤10%, be dried Folium cinnamomi camphorae; The above-mentioned dried Folium cinnamomi camphorae immersion 400kg of 100kg is contained in the industrial alcohol of alcohol amount 95%, and reflux was extracted pure soluble substance in 1 hour, stopped to filter after the heating, got filtering residue and 361 kilograms of alcohol leaching liquids; This moment, the color of alcohol leaching liquid was light; Above-mentioned alcohol leaching liquid is the Folium cinnamomi camphorae tincture, and above-mentioned filtering residue is made fuel and used behind heating recovery ethanol;
(2) gained Folium cinnamomi camphorae tincture is added thermal distillation and reclaims ethanol, Folium cinnamomi camphorae extractum 10.6kg, this Folium cinnamomi camphorae extractum can free-flow in the time of 75 ~ 85 ℃;
(3) in above-mentioned Folium cinnamomi camphorae extractum, add petroleum ether 11.8kg and stir and be dispersion liquid to said Folium cinnamomi camphorae extractum and petroleum ether uniform mixing in 30 minutes, cross then and filter filtrate 17.3kg and crude flavonoid powder compounds 4.8kg;
(4) above-mentioned crude flavonoid powder compounds is placed vacuum drier, be dried to moisture approximately about 3% under 60 ℃ the temperature not being higher than, obtain 4.5 kilograms of finished products.
Through detecting, this finished product contains flavone (calculating by rutin) 27.6%.
The above is merely preferred embodiment of the present invention, so can not limit the scope that the present invention implements according to this, the equivalence of promptly doing according to claim of the present invention and description changes and modifies, and all should still belong in the scope that the present invention contains.
Claims (7)
1. a method of from Folium cinnamomi camphorae, extracting flavone compound is characterized in that: comprise the steps:
(1) Folium cinnamomi camphorae is immersed after drying in the ethanol, heating and refluxing extraction alcohol soluble substance stops to filter after the heating, gets the Folium cinnamomi camphorae tincture;
(2) gained Folium cinnamomi camphorae tincture is added thermal distillation and reclaim ethanol, get Folium cinnamomi camphorae extractum;
(3) in above-mentioned Folium cinnamomi camphorae extractum, add petroleum ether and stirring, cross and filter filtrating and crude flavonoid powder compounds;
(4) the crude flavonoid powder compounds is drying to obtain finished product.
2. a kind of method of from Folium cinnamomi camphorae, extracting flavone compound as claimed in claim 1; It is characterized in that: said step (1) is specially: Folium cinnamomi camphorae is dried to water content≤10% back immerses in the ethanol; Heating and refluxing extraction alcohol soluble substance; Stop to filter after the heating, get filtering residue and alcohol leaching liquid; The gained filtering residue carry out again 0 to alcohol heating reflux repeatedly be extracted into the color of gained alcohol leaching liquid light till; Above-mentioned alcohol leaching liquid mixing is promptly got the Folium cinnamomi camphorae tincture.
3. a kind of method of from Folium cinnamomi camphorae, extracting flavone compound as claimed in claim 2; It is characterized in that: used ethanol is for containing the industrial alcohol of alcohol amount 93 ~ 96% in the said step (1), and the consumption of this industrial alcohol in each heating and refluxing extraction is 2.5 ~ 6 times of weight of dried Folium cinnamomi camphorae.
4. a kind of method of from Folium cinnamomi camphorae, extracting flavone compound as claimed in claim 3, it is characterized in that: the total degree of said reflux is 1 to 3 time, the time of each heating and refluxing extraction is 0.5 ~ 1.5 hour.
5. a kind of method of from Folium cinnamomi camphorae, extracting flavone compound as claimed in claim 1 is characterized in that: in the said step (2), the heating of gained Folium cinnamomi camphorae tincture is distilled to gained Folium cinnamomi camphorae extractum can be 75 ~ 85 ℃ the time till the free-flow.
6. a kind of method of from Folium cinnamomi camphorae, extracting flavone compound as claimed in claim 1; It is characterized in that: in the said step (3); The consumption of said petroleum ether is 1 ~ 2 times of weight of gained Folium cinnamomi camphorae extractum, and is stirred to said Folium cinnamomi camphorae extractum and the petroleum ether uniform mixing is dispersion liquid.
7. a kind of method of from Folium cinnamomi camphorae, extracting flavone compound as claimed in claim 1, it is characterized in that: the baking temperature in the said step (4) is lower than 60 ℃.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012102237563A CN102727584A (en) | 2012-06-29 | 2012-06-29 | Method for extracting flavonoids from camphor tree leaves |
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| CN2012102237563A CN102727584A (en) | 2012-06-29 | 2012-06-29 | Method for extracting flavonoids from camphor tree leaves |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108247790A (en) * | 2018-03-30 | 2018-07-06 | 吕莉 | A kind of preparation method of mould proof finishing glued board |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1369704A (en) * | 2001-02-16 | 2002-09-18 | 中国科学院长春应用化学研究所 | Method for testing quality of acanthopanax leaf |
| CN101016287A (en) * | 2007-02-12 | 2007-08-15 | 西北农林科技大学 | Method of extracting flavone from cabbage leaf |
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- 2012-06-29 CN CN2012102237563A patent/CN102727584A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1369704A (en) * | 2001-02-16 | 2002-09-18 | 中国科学院长春应用化学研究所 | Method for testing quality of acanthopanax leaf |
| CN101016287A (en) * | 2007-02-12 | 2007-08-15 | 西北农林科技大学 | Method of extracting flavone from cabbage leaf |
Non-Patent Citations (2)
| Title |
|---|
| 林翔云: "芳樟叶提取物在化妆品中的应用", 《香料香精化妆品》, no. 2, 30 April 2011 (2011-04-30), pages 44 - 48 * |
| 苏远波等: "芳樟树叶乙醇提取物的抗癌作用", 《化工进展》, vol. 25, no. 2, 28 February 2006 (2006-02-28), pages 200 - 204 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108247790A (en) * | 2018-03-30 | 2018-07-06 | 吕莉 | A kind of preparation method of mould proof finishing glued board |
| CN108247790B (en) * | 2018-03-30 | 2019-07-26 | 江苏梵品新材料有限公司 | A kind of mould proof finishing preparation method of glued board |
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Application publication date: 20121017 |