CN102716190A - Extraction method for pomiferin G/H and morusin of cortex mori radicis - Google Patents
Extraction method for pomiferin G/H and morusin of cortex mori radicis Download PDFInfo
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Abstract
The invention relates to the field of pharmaceutical chemistry and discloses a method for pomiferin G/H and morusin of cortex mori radices. The extraction method for the pomiferin G/H and the morusin of the cortex mori radices is characterized in that under the state of 300MPa superhigh pressure, a required alcohol solvent is added at a time; under the airtight state, the pomiferin G/H and the morusin are extracted at normal temperature; the solvent is fully contacted with active constituents in tissue cells of the cortex mori radices to dissolve the active constituents, and the dissolved active constituents are transferred into an extract. The extraction time is short, and the extraction efficiency is high. Moreover, solvent loss is not generated under the airtight state, and meanwhile, residual alcohol is centrifugally collected from extracted dregs, therefore, the consumption of the organic solvent is reduced, and the production cost is saved. Moreover, the extraction method disclosed by the invention is performed at the normal temperature, therefore, the energy consumption is low and the environment is protected.
Description
Technical field
The present invention relates to the pharmaceutical chemistry field, specifically relate to the method for distilling of a kind of Cortex Mori Phellinus igniarius (L. ex Fr.) Quel. ketone G/H, Morusin.
Background technology
Cortex Mori is the moraceae plants Mulberry
Morus albaL. root bark, main product in Henan Province, Anhui Province, Sichuan Province, Hunan Province, Hebei province, Guangdong Province.Big with Henan Province, Anhui Province's output, and good with Bo Cortex Mori quality.Excavate winter, cleans, and scrapes off surperficial yellow rough bark, vertically cuts skin zone open, touches with wooden mallet, and skin zone is separated with woody part, strips skin zone and dry.Cortex Mori is twisted into groove drum, residual cork yellowish-brown, and the tough slit yarn of matter, the eliminating pathogen from the lung for relieving asthma consumer edema, the repair tissue cell calms down the cicatrix effect.Its main chemical compositions is a chromocor compound, comprises Phellinus igniarius (L. ex Fr.) Quel. ketone G, Phellinus igniarius (L. ex Fr.) Quel. ketone H and Morusin etc.Modern pharmacology effect: 1, repair tissue cell: Cortex Mori has the damaged tissues of reparation cell, desalination cicatrix, the effect of inducing diuresis to remove edema.2, hypotensive activity.3, other effects: Cortex Mori decoct 2g/kg irritates in the stomach 6 hours voided volume to rabbit and chloride obviously increases, and recovers normal in 7～24 hours.
Mostly the existing method of extracting Cortex Mori is to adopt hot reflux to extract.The hot reflux method for distilling is to utilize ethanol to be extraction solvent; Leachate is added thermal distillation, be condensed again after wherein volatile solvent distillates, come back to and continue to participate in leaching process in the infuser; Circulation is carried out, and is complete by lixiviate until effective ingredient Cortex Mori flavone component.Concrete operations in the 3 tons of multi-function extractors of packing into, add 10 times of amount 60% ethanol for getting the coarse powder of Cortex Mori 1 ~ 2mm, and hot reflux extracts twice, each 4h.
Hot reflux method for distilling extraction Cortex Mori sanggenon extraction time is many, extraction time long, it is lower to extract content yet utilize.And the hot reflux extraction needs heating continuously, in the reflux process, can cause a large amount of volatilization losses of ethanol, and amount of ethanol is bigger, and also can residual a large amount of alcohol solvents in extracting medicinal residues, causes high amounts of solvents consumption, increased product cost.The hot reflux extraction needs Steam Heating in addition, therefore needs to consume the great amount of heat energy source, produces problem of environmental pollutions such as waste gas, dense smoke, and environmental protection is caused certain burden.
Summary of the invention
In view of this, the present invention seeks to the method for distilling of the high sanggenon of a kind of extraction ratio to be provided to the low defective of prior art Cortex Mori flavone component extraction ratio.
For realizing the object of the invention, the present invention adopts following technical scheme:
The method for distilling of a kind of Cortex Mori Phellinus igniarius (L. ex Fr.) Quel. ketone G/H, Morusin comprises:
Step 1, get the Cortex Mori coarse powder and add alcohol solution dipping, hyperpressure extraction 8min under the vacuum tightness condition of 300MPa collects extracting solution then, filters, and filtrate for later use, the water content of said alcoholic solution are 30 ~ 50%;
Step 2, get that to filter the gained medicinal residues centrifugal, collect centrifugal gained clear liquid;
Step 3, combining step 1 gained filtrating and step 2 gained clear liquid, being concentrated into does not have the alcohol flavor, adds purified water and fully stirs, centrifugal 20 ~ 30 ℃ of following sedimentations, gets deposition and promptly gets.
The hyperpressure extraction full name is " a superelevation isostatic cool pressing "; Be meant that the hydrostatic pressure of using 100 ~ 1000MPa at normal temperatures is on medicinal liquid; Make and extract solvent and be penetrated in the drug cell, under predetermined pressure, keep a period of time to make effective ingredient reach dissolution equilibrium after release rapidly because the inside and outside osmotic pressure difference of cell increases suddenly; The various films that can make the interior effective ingredient of cell pass cell are transferred in the extracellular extracting solution, have reached the purpose of effective component extracting.
Method for distilling according to the invention adopts the hyperpressure extraction technology, inside and outside boost phase makes Cortex Mori pressed powder histiocyte, forms the pressure differential of superelevation, extracts etoh solvent and promotes down rapid permeability in Cortex Mori inside vascular bundle and glandular cell at hyperpressure.Along with pressure raises rapidly, the Cortex Mori cell volume is compressed, if surpass its deformation limit, can cause the Cortex Mori cell rupture, and intracellular material contacts dissolved with solvent; If do not surpass the deformation limit of cell, ethanol gets in the Cortex Mori powder organization cell under the high pressure effect, and effective ingredient is dissolved in the ethanol.Cause the change in volume of system at packing stage 300MPa hyperpressure, promoted moving of chemical equilibrium, the infiltration of solvent, the dissolving of solute reach balance fast.
Subsequently in the release stage; The histiocytic pressure of Cortex Mori is reduced to normal pressure rapidly from the supertension of hundreds of MPa; Under the effect of opposite direction pressure; The explosion that fluid and drug matrices volume take place is expanded, and the intensive impacts of formation such as the cell wall of Cortex Mori powder organization cell, cell membrane, plasma membrane, nuclear membrane, vacuole, microtubule is caused deform.If distortion has surpassed its deformation limit, cause that loose, hole appears in cellularity, structural change such as break, effective ingredient such as various flavonoids fully contact with alcohol solvent, and the alcoholic solution that has dissolved effective ingredient can spread rapidly to the extracellular; If the distortion at the cell wall of opposite direction pressure effect undertissue cell does not surpass its deformation limit (permeability increases under the high pressure effect); The alcohol solvent that cell interior has dissolved the sanggenon active component is transferred to the extracellular fast under the hyperosmosis difference, reach the purpose of extraction.The compression that applies in the absorption of fluids external world can the situation of certain (pressure is certain) under, the release time is short more, the cell inner fluid is strong more in the produced simultaneously impulsive force to external diffusion; The turbulence effect that causes is strong more, and the hole of formation, fragment are many more, and the effective ratio surface of the drug matrices of certain mass can be big more; The resistance to mass tranfer of effective ingredient diffusion will be more little, contacting with solvent also will be more abundant; Extraction ratio is high more, thus the release time generally within several seconds, accomplish, be preferably＜2s.
Preferably, said hyperpressure extraction be earlier with the Cortex Mori coarse powder with 60% soak with ethanol 4 hours, in 5min, boost to 300MPa afterwards, keep 8min, within several seconds, pressure is reduced to zero then.
Preferably, the water content of the said alcoholic solution of method for distilling step 1 according to the invention is 40%, and promptly using volume fraction is 60% ethanol extraction.
Preferably, the weight of the said alcoholic solution of step 1 is 6 ~ 12 times of Cortex Mori coarse powder weight, more preferably 7 times.
Preferably, the time of the said immersion of step 1 is 3 ~ 5h, more preferably 4h.
Method for distilling step 2 according to the invention is centrifugal with extracting liquid filtering gained medicinal residues, from going out residual ethanol extract wherein, avoids losing Cortex Mori flavone component in the ethanol extract, can reduce alcoholic acid consumption greatly simultaneously.Preferably, step 2 said centrifugal be at 3000 ~ 5000r/min, centrifugal 10 ~ 20min, 4000r/min more preferably, centrifugal 15min.
Preferably, the said distilled water volume of step 3 does not have 4 ~ 6 times of concentrated solution cumulative volume that alcohol distinguishes the flavor of, more preferably 5 times for the step 1 gained filtrating that merges and step 2 gained clear liquid are concentrated into.
Preferably, the said settled time of step 3 is 6 ~ 10h, more preferably 8h.
Preferably, step 3 said centrifugal be at 2000 ~ 4000r/min, centrifugal 10 ~ 20min, 3000r/min more preferably, centrifugal 15min.
Method for distilling step 3 according to the invention also comprises purified water concentrated solution for washing, vacuum drying step.
The method for distilling of sanggenon according to the invention is under 300MPa hyperpressure state, and the required alcohol solvent of disposable adding is under air-tight state; Extract sanggenon, the abundant contact lysis of effective ingredient in solvent and the Cortex Mori histiocyte, and transfer in the extracting solution; Extraction time is short, and extraction ratio is high.And air-tight state do not have the loss of solvent, extracts simultaneously that the back medicinal residues are centrifugal collects remaining ethanol, reduced the consumption of organic solvent, practiced thrift production cost.Method for distilling according to the invention in addition is temperature required lower, and energy consumption is low, energy-conserving and environment-protective.
The specific embodiment
The embodiment of the invention discloses a kind of method for distilling of sanggenon.Those skilled in the art can use for reference this paper content, suitably improve technological parameter and realize.Special needs to be pointed out is that all similarly replace and change apparent to those skilled in the art, they all are regarded as and are included in the present invention.Method of the present invention is described through preferred embodiment, and the related personnel obviously can change or suitably change and combination method as herein described in not breaking away from content of the present invention, spirit and scope, realizes and use technology of the present invention.
For realizing the object of the invention, the present invention adopts following technical scheme:
The method for distilling of a kind of Cortex Mori Phellinus igniarius (L. ex Fr.) Quel. ketone G/H, Morusin comprises
Step 1, get the coarse powder of Cortex Mori medical material 1 ~ 2mm; 60% ~ 70% ethanol that adds 7 ~ 12 times of weight, sealing was soaked 3 ~ 5 hours, placed hyperpressure extraction equipment inner bag; Under the room temperature state; Be raised to 300MPa in 5min time internal pressure, keep about 8min, moment is reduced to zero with pressure within 2 seconds then.Collect hyperpressure extraction liquid, with extracting liquid filtering, filtrate for later use;
Step 2, remaining medicinal residues are packed into filter in the cloth bag, 3000 ~ 5000r/min, centrifugal 10 ~ 20min collects centrifugal gained clear liquid;
Step 3, step 1 gained filtrating and step 2 gained supernatant are merged, 60 ℃ of recover ethanol, vacuum concentration is to there not being the alcohol flavor; Add 4 ~ 6 times of amount purified water and fully stir, under 20 ~ 25 ℃, sedimentation 6 ~ 10 hours; Centrifugal 10 ~ the 20min of 2000 ~ 4000r/min gets sediment, and vacuum drying promptly gets.
In order further to understand the present invention, the present invention is elaborated below in conjunction with embodiment.
Embodiment 1:
Get coarse powder 100 g of Cortex Mori medical material 1 ~ 2mm, in the medicinal vacuum complex pocket of packing into, add 7 times of amount 60% ethanol; Sealing was soaked 4 hours, placed hyperpressure extraction equipment inner bag; At 5min in the time; Pressure is raised to 300MPa, keeps about 8min, and moment is reduced to zero with pressure within 2 seconds then.Collect hyperpressure extraction liquid, with extracting liquid filtering, filtrate for later use.Remaining medicinal residues 100 orders of packing into are filtered in the cloth bag, 5000r/min, centrifugal 15min collects centrifugal gained clear liquid and merges with filtrating; 60 ℃ of recover ethanol, vacuum concentration add 5 times of amount purified water and fully stir to there not being the alcohol flavor; Under 20 ~ 25 ℃, sedimentation 8 hours, the centrifugal 15min of 3000r/min; Get sediment, vacuum drying promptly gets Cortex Mori extract 5.4 g, and yield is 5.4%.Sanggenon content is: 35.6%.Phellinus igniarius (L. ex Fr.) Quel. ketone G13.01% wherein, Phellinus igniarius (L. ex Fr.) Quel. ketone H9.22%, Morusin 13.37%.
Embodiment 2:
Get coarse powder 100 g of Cortex Mori medical material 1 ~ 2mm, in the medicinal vacuum complex pocket of packing into, add 7 times of amount 70% ethanol; Sealing; Soaked 4 hours, and placed hyperpressure extraction equipment inner bag, be raised to 300MPa in 5min time internal pressure; Keep about 8min, moment is reduced to zero with pressure within 2 seconds then.Collect hyperpressure extraction liquid, with extracting liquid filtering, filtrate for later use.Remaining medicinal residues 100 orders of packing into are filtered in the cloth bag, 5000r/min, centrifugal 15min collects centrifugal gained supernatant and merges with filtrating; 60 ℃ of recover ethanol, vacuum concentration add 5 times of amount purified water and fully stir, under 20 ~ 25 ℃ to there not being the alcohol flavor; Sedimentation 8 hours, the centrifugal 15min of 3000r/min gets sediment; Vacuum drying promptly gets Cortex Mori extract 5g, and yield is 5%, and sanggenon content is 33.49 %.Phellinus igniarius (L. ex Fr.) Quel. ketone G12.24% wherein, Phellinus igniarius (L. ex Fr.) Quel. ketone H8.67%, Morusin 12.58%.
Embodiment 3:
Get coarse powder 100 g of Cortex Mori medical material 1 ~ 2mm, in the medicinal vacuum complex pocket of packing into, add 10 times of amount 60% ethanol; Sealing; Soaked 4 hours, and placed hyperpressure extraction equipment inner bag, be raised to 300MPa in 5min time internal pressure; Keep about 8min, moment is reduced to zero with pressure within 2 seconds then.Collect hyperpressure extraction liquid, with extracting liquid filtering, filtrate for later use.Remaining medicinal residues 100 orders of packing into are filtered in the cloth bag, 5000r/min, centrifugal 15min collects centrifugal gained supernatant and merges with filtrating; 60 ℃ of recover ethanol, vacuum concentration add 5 times of amount purified water and fully stir, under 20 ~ 25 ℃ to there not being the alcohol flavor; Sedimentation 8 hours, the centrifugal 15min of 3000r/min gets sediment; Vacuum drying promptly gets Cortex Mori extract 5.4 g, and yield is 5.4%, and sanggenon content is 35.02%.Phellinus igniarius (L. ex Fr.) Quel. ketone G12.8% wherein, Phellinus igniarius (L. ex Fr.) Quel. ketone H9.06%, Morusin 13.16%.
Embodiment 4:
Get coarse powder 100 g of Cortex Mori medical material 1 ~ 2mm, in the medicinal vacuum complex pocket of packing into, add 5 times of amount 60% ethanol; Sealing; Soaked 4 hours, and placed hyperpressure extraction equipment inner bag, be raised to 300MPa in 5min time internal pressure; Keep about 8min, moment is reduced to zero with pressure within 2 seconds then.Collect hyperpressure extraction liquid, with extracting liquid filtering, filtrate for later use.Remaining medicinal residues 100 orders of packing into are filtered in the cloth bag, 5000r/min, centrifugal 15min collects centrifugal gained supernatant and merges with filtrating; 60 ℃ of recover ethanol, vacuum concentration add 5 times of amount purified water and fully stir, under 20 ~ 25 ℃ to there not being the alcohol flavor; Sedimentation 8 hours, the centrifugal 15min of 3000r/min gets sediment; Vacuum drying promptly gets Cortex Mori extract 5.2 g, and yield is 5.2%, and sanggenon content is 33%.Phellinus igniarius (L. ex Fr.) Quel. ketone G12.06% wherein, Phellinus igniarius (L. ex Fr.) Quel. ketone H8.53%, Morusin 12.41%.
Embodiment 5:
Get coarse powder 100 g of Cortex Mori medical material 1 ~ 2mm, in the medicinal vacuum complex pocket of packing into, add 7 times of amount 60% ethanol; Sealing; Soaked 4 hours, and placed hyperpressure extraction equipment inner bag, be raised to 300MPa in 5min time internal pressure; Keep about 8min, moment is reduced to zero with pressure within 2 seconds then.Collect hyperpressure extraction liquid, with extracting liquid filtering, filtrate for later use.Remaining medicinal residues 100 orders of packing into are filtered in the cloth bag 5000r/min, centrifugal 15min; Collect centrifugal gained supernatant and merge 60 ℃ of recover ethanol, vacuum concentration with filtrating; Vacuum drying promptly gets Cortex Mori extract 21.7g, and yield is 21.7 %, and sanggenon content is 17.2%.Phellinus igniarius (L. ex Fr.) Quel. ketone G6.29% wherein, Phellinus igniarius (L. ex Fr.) Quel. ketone H4.45%, Morusin 6.46%.
Embodiment 6:
Get coarse powder 100 g of Cortex Mori medical material 1 ~ 2mm, in the medicinal vacuum complex pocket of packing into, add 7 times of amount 70% ethanol; Sealing; Soaked 4 hours, and placed hyperpressure extraction equipment inner bag, be raised to 300MPa in 5min time internal pressure; Keep about 8min, moment is reduced to zero with pressure within 2 seconds then.Collect hyperpressure extraction liquid, with extracting liquid filtering, filtrate for later use.Remaining medicinal residues 100 orders of packing into are filtered in the cloth bag 5000r/min, centrifugal 15min; Collect centrifugal gained supernatant and merge 60 ℃ of recover ethanol, vacuum concentration with filtrating; Vacuum drying promptly gets Cortex Mori extract 17g, and yield is 17 %, and sanggenon content is 15.8%.Phellinus igniarius (L. ex Fr.) Quel. ketone G5.17% wherein, Phellinus igniarius (L. ex Fr.) Quel. ketone H3.98%, Morusin 6.65%.
Embodiment 7: the hot reflux method for distilling
Get coarse powder 100 g of Cortex Mori medical material 1 ~ 2mm, in the medicinal vacuum complex pocket of packing into, add 10 times of amount 60% ethanol, sealing was soaked 4 hours; Reflux, extract, 4 hours is filtered, and the residue medicinal residues added 7 times of amount 60% alcohol reflux 4 hours again, filtered merging filtrate; Being concentrated into does not have the alcohol flavor, adds 5 times of amount distillation washings, sedimentation 8 hours, abandoning supernatant; Get sediment, vacuum drying promptly gets Cortex Mori extract 5 g, and yield is 5 %, and sanggenon content is 30.56%.Phellinus igniarius (L. ex Fr.) Quel. ketone G11.17% wherein, Phellinus igniarius (L. ex Fr.) Quel. ketone H7.91%, Morusin 11.48%.
The explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof.Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of claim of the present invention.
Claims (10)
1. the method for distilling of a Cortex Mori Phellinus igniarius (L. ex Fr.) Quel. ketone G/H, Morusin is characterized in that, comprising:
Step 1, get the Cortex Mori coarse powder and add alcohol solution dipping, hyperpressure extraction 8min under the vacuum tightness condition of 300MPa collects extracting solution then, filters, and filtrate for later use, the water content of said alcoholic solution are 30 ~ 50%;
Step 2, get that to filter the gained medicinal residues centrifugal, collect centrifugal gained clear liquid;
Step 3, combining step 1 gained filtrating and step 2 gained clear liquid reclaim ethanol, and being concentrated into does not have the alcohol flavor, adds purified water and fully stirs, centrifugal 20 ~ 30 ℃ of following sedimentations, gets deposition and promptly gets.
2. according to the said method for distilling of claim 1; It is characterized in that said hyperpressure extraction is specially earlier the Cortex Mori coarse powder with 60% alcohol at normal temperature immersion 4 hours, in 5min, boosts to 300MPa afterwards; Keep 8min; Within several seconds, pressure is reduced to zero then, whole leaching process is to operate at normal temperatures, need not heating.
3. according to the said method for distilling of claim 1, it is characterized in that the water content of the said alcoholic solution of step 1 is 30 ~ 50%.
4. according to the said method for distilling of claim 1, it is characterized in that the consumption of the said alcoholic solution of step 1 is 7 ~ 12 times of Cortex Mori coarse powder weight.
5. according to the said method for distilling of claim 1, it is characterized in that the time of the said immersion of step 1 is 3 ~ 5h.
6. according to the said method for distilling of claim 1, it is characterized in that the said centrifugal revolution of step 2 is 3000 ~ 5000r/min, centrifugation time is 10 ~ 20min.
7. according to the said method for distilling of claim 1, it is characterized in that the said purified water volume of step 3 does not have 4 ~ 6 times of concentrated solution cumulative volume that alcohol distinguishes the flavor of for the step 1 gained filtrating that merges and step 2 gained clear liquid are concentrated into.
8. according to the said method for distilling of claim 1, it is characterized in that the said settled time of step 3 is 6 ~ 10h.
9. according to the said method for distilling of claim 1, it is characterized in that the said centrifugal revolution of step 3 is 3000 ~ 5000r/min, centrifugation time is 10 ~ 20min.
10. according to the said method for distilling of claim 1, it is characterized in that, centrifugal behind the purified water washing and depositing, the taking precipitate vacuum drying.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435007A (en) * | 2014-12-04 | 2015-03-25 | 东北师范大学 | Method for breaking ganoderma spore wall rapidly and efficiently |
| CN107088206A (en) * | 2017-04-07 | 2017-08-25 | 黄山学院 | A kind of preparation method and applications of mulberry bark extract |
| CN108697685A (en) * | 2015-05-26 | 2018-10-23 | 新树有限公司 | Containing moracin, Phellinus copper G or the root bark of white mulberry, the prevention of muscle disease and treatment is used or muscular function improvement composition |
| CN110051659A (en) * | 2019-06-14 | 2019-07-26 | 贵州理工学院 | Mulberrin is preparing the application in osteosporosis resistant medicament |
| CN111821233A (en) * | 2020-06-30 | 2020-10-27 | 广州伽能生物科技有限公司 | Plant whitening natural active compound composition and preparation method and application thereof |
| CN113292482A (en) * | 2021-05-27 | 2021-08-24 | 湖南德诺贝莱健康产业有限公司 | Method for extracting high-content deoxynojirimycin from cortex mori |
| CN114983893A (en) * | 2022-06-22 | 2022-09-02 | 可可琪可思曼中华有限公司 | Method and apparatus for preparing anti-sugar composition |
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- 2012-07-03 CN CN2012102261115A patent/CN102716190A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435007A (en) * | 2014-12-04 | 2015-03-25 | 东北师范大学 | Method for breaking ganoderma spore wall rapidly and efficiently |
| CN108697685A (en) * | 2015-05-26 | 2018-10-23 | 新树有限公司 | Containing moracin, Phellinus copper G or the root bark of white mulberry, the prevention of muscle disease and treatment is used or muscular function improvement composition |
| CN107088206A (en) * | 2017-04-07 | 2017-08-25 | 黄山学院 | A kind of preparation method and applications of mulberry bark extract |
| CN107088206B (en) * | 2017-04-07 | 2020-07-28 | 黄山学院 | Preparation method and application of cortex mori extract |
| CN110051659A (en) * | 2019-06-14 | 2019-07-26 | 贵州理工学院 | Mulberrin is preparing the application in osteosporosis resistant medicament |
| CN111821233A (en) * | 2020-06-30 | 2020-10-27 | 广州伽能生物科技有限公司 | Plant whitening natural active compound composition and preparation method and application thereof |
| CN111821233B (en) * | 2020-06-30 | 2021-06-15 | 广州伽能生物科技有限公司 | Plant whitening natural active compound composition and preparation method and application thereof |
| CN113292482A (en) * | 2021-05-27 | 2021-08-24 | 湖南德诺贝莱健康产业有限公司 | Method for extracting high-content deoxynojirimycin from cortex mori |
| CN113292482B (en) * | 2021-05-27 | 2022-11-01 | 湖南德诺贝莱健康产业有限公司 | Method for extracting high-content deoxynojirimycin from cortex mori |
| CN114983893A (en) * | 2022-06-22 | 2022-09-02 | 可可琪可思曼中华有限公司 | Method and apparatus for preparing anti-sugar composition |
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Application publication date: 20121010 |