CN102716039B - Preassembling type dosing instrument - Google Patents
Preassembling type dosing instrument Download PDFInfo
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- CN102716039B CN102716039B CN201210224566.3A CN201210224566A CN102716039B CN 102716039 B CN102716039 B CN 102716039B CN 201210224566 A CN201210224566 A CN 201210224566A CN 102716039 B CN102716039 B CN 102716039B
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- cartridge case
- rotary sleeve
- push rod
- dosing
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Abstract
The invention discloses a preassembling type dosing instrument which comprises a dosing barrel, dosing double needles, a rotating sleeve and a push rod, wherein a guiding groove is axially arranged on the inner wall of the top of the dosing barrel, one end of the rotating sleeve extends into the dosing barrel, and the other end of the rotating sleeve is sealed. A guiding spiral thorough groove is arranged on the rotating sleeve along the circumferential wall of the rotating sleeve, the push rod is axially arranged in the rotating sleeve, and a guiding block penetrating through the guiding spiral through groove and extending into the guiding groove is arranged on the push rod. When the preassembling type dosing instrument is used, a medicine container and the dosing double needles are in a sealing state by means of a membrane in an interface and the rotating sleeve with one end sealed, and thorough sterility in transportation and storage can be achieved. The push rod is driven to move rapidly downwards and push the medicine container by rotating the rotating sleeve, upper needle points of the dosing double needles puncture a sealing plug on the medicine container, and the lower needle points of the dosing double needles puncture the membrane in the interface, so that the medicine container is instantly communicated with a transfusion container, the whole process is in sterile butt jointing, and therefore, sterile sealing in the whole processes of transportation, storage, butt jointing, medicine mixing and transfusion is achieved.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, the medicine adding instrument using while relating in particular to a kind of mixed medicine.
Background technology
For the medicine in medicament reservoir being added in the solution in infusion vessel (being transfusion flexible bag or soft transfusion bottle), then mixed solution is inputted such as the patient in the Clinical Institutions of hospital.In prior art, often adopt medicine adding instrument that medicament reservoir is connected with transfusion flexible bag or soft transfusion bottle.
Medicine adding instrument of the prior art mainly comprises and adds cartridge case and dosing crosspointer, dosing cylinder forms cup-like structure, dosing crosspointer is stuck in and is added in cartridge case by crosspointer supporting seat, for mixed medicine passage is sealed, be provided with barrier film adding on the bottom interior wall cross section of cartridge case, on the top that adds cartridge case, be provided with diaphragm seal, a needle point of dosing crosspointer is corresponding with barrier film, and another needle point of dosing crosspointer is corresponding with the diaphragm seal of top.During use, this is added to cartridge case docks with the interface of transfusion flexible bag or soft transfusion bottle, tear the diaphragm seal adding on cartridge case top, again medicament reservoir is snapped in and added in cartridge case, when medicament reservoir snaps in, also promoting dosing crosspointer moves down, the upper needle point of dosing crosspointer pierces through the sealing-plug on medicament reservoir, the broken barrier film of the lower acupuncture of dosing crosspointer and pierce through transfusion flexible bag or soft transfusion bottle on interface on sealing-plug, extruding transfusion flexible bag or soft transfusion bottle just can be realized mixed medicine.
Adopt the medicine adding instrument of said structure, mainly in mixed medicine process have a following deficiency: at medicament reservoir, snap in while adding in cartridge case, must add the diaphragm seal on cartridge case top by tear initiation, and add cartridge case while snapping in and can contact with the external world, and then pollute.And all closed medicine adding instruments that occur in prior art all can only be realized airtight in mixed medicine process, and " overall process is sterile closed " when can not realize the docking of cillin bottle and medicine adding instrument, mixed medicine and infusing.
Summary of the invention
For above shortcomings in prior art, the invention provides a kind of can under integral asepsis state, dock, mix medicine and the airtight prepackage type medicine adding instrument of transfusion overall process.
In order to solve the problems of the technologies described above, the present invention has adopted following technical scheme:
Prepackage type medicine adding instrument, comprises and adds cartridge case, dosing crosspointer, rotary sleeve and push rod, described dosing crosspointer is located at and adds in cartridge case;
Described one end that adds cartridge case is interface link, and a needle point of described dosing crosspointer is corresponding with interface link; At the other end inwall that adds cartridge case, be provided with vertically gathering sill;
One end of described rotary sleeve put in add in the other end of cartridge case and with add cartridge case axial restraint, radially rotatably coordinate, and rotary sleeve and add cartridge case and be sealed and matched; Described rotary sleeve arranges guiding spiral groove along its circumferential wall;
Described push rod is axially disposed within rotary sleeve along rotary sleeve, on the outer wall of push rod, is provided with guide pad, and described guide pad passes guiding spiral groove and puts in gathering sill.
Further, the other end of described rotary sleeve is sealed end.
Further, the described inwall that adds the other end of cartridge case is arranged with two gathering sills that arrange vertically, described rotary sleeve is symmetrical arranged two guiding spiral grooves along its circumferential wall, on the outer wall of described push rod, be arranged with two guide pads, one of them guide pad passes a guiding spiral groove and puts in a gathering sill, and another guide pad passes another guiding spiral groove and puts in another gathering sill.
Further, the outer wall of described rotary sleeve is along being circumferentially with pressure ring, and described pressure ring is pressed on the other end that adds cartridge case and with it and is sealed and matched.
Further, described pressure ring is sealed and matched by sealing ring and the other end that adds cartridge case.
Further, described in add on the inwall of cartridge case and near interface link annular rubber cushion be set, the needle point that described dosing crosspointer is corresponding with interface link passes annular rubber cushion.
Further, the inwall that adds the interface link of cartridge case described in is a throat structure.
Further, a segment distance is extended in the opposite direction adding in the two ends of described gathering sill on the circumference of cartridge case, and the direction that extend on the circumference of rotary sleeve the bottom of described gathering sill direction of rotation of rotary sleeve when promoting is consistent.
Further, the bottom of described interface link is provided with the clip assembly for the interface of infusion vessel is connected with interface link.
Further again, described in add on the inwall of cartridge case and be symmetrically arranged with at least two near interface link and be barb-like skid-prevention button.
The invention has the beneficial effects as follows: while using this prepackage type medicine adding instrument, first by adding cartridge case, dock with the interface on transfusion flexible bag or soft transfusion bottle, medicament reservoir is pre-loaded into and is added in cartridge case, again rotary sleeve is arranged on and is added on cartridge case, rotary sleeve by the barrier film in interface and one end sealing makes medicament reservoir and dosing crosspointer in sealing state, therefore, can reach transportation and store absolute aseptic.During mixed medicine, rotating rotary sleeve drives push rod to move down rapidly along the gathering sill that adds drug cylinder, press on medicament reservoir, and then promote dosing crosspointer and move down, the upper needle point of dosing crosspointer pierces through the sealing-plug on medicament reservoir, and the lower needle point of dosing crosspointer punctures the barrier film in interface, medicament reservoir was communicated with moment in transfusion flexible bag or soft transfusion bottle, whole process is all in aseptic docking, and therefore, it is sterile closed that this prepackage type medicine adding instrument can be realized the overall process of transportation, storage, docking, mixed medicine and transfusion.
Accompanying drawing explanation
Fig. 1 is the structural representation of prepackage type medicine adding instrument;
Fig. 2 is the cross-sectional view that adds cartridge case;
Fig. 3 is the front view of rotary sleeve;
Fig. 4 is along the cross section view of A-A direction in Fig. 3;
Fig. 5 is the cross-sectional view of push rod;
Fig. 6 is the perspective view of push rod;
Fig. 7 is that prepackage type medicine adding instrument is connected to the structural representation on infusion vessel and before using;
Fig. 8 is that prepackage type medicine adding instrument is connected to the structural representation on infusion vessel and after using.
In accompanying drawing: 1-add cartridge case; 2-dosing crosspointer; 4-rotary sleeve; 5-push rod; 6-interface link; 7-guiding spiral groove; 8-gathering sill; 9-guide pad; 10-pressure ring; 11-sealing ring; 12-annular rubber cushion; 13-suspension ring; 14-infusion vessel; 15-crosspointer supporting seat; 16-skid-prevention button; 17-medicament reservoir; 18-annular snap; 19-annular groove; 20-annular slot; 21-passage; 22-interface; 23-barrier film; 24-clip assembly.
The specific embodiment
Below in conjunction with the drawings and specific embodiments, the present invention is described in further detail.
As shown in Figure 1, prepackage type medicine adding instrument, comprises and adds cartridge case 1, dosing crosspointer 2, rotary sleeve 4 and push rod 5.
Wherein, add the structure of cartridge case as shown in Figure 2, the bottom that adds cartridge case 1 is interface link 6, and the inwall of interface link 6 is a throat structure, and being more conducive to like this with infusion vessel 14(is transfusion flexible bag or soft transfusion bottle) interface size mate.Add the inwall of cartridge case 1 and be provided with annular rubber cushion 12 near interface link 6, the dosing crosspointer 2 of dosing crosspointer 2(the present embodiment adopts cross needle, be that the upper pin of dosing crosspointer 2, lower pin and crosspointer supporting seat 15 are one-body molded) be located at and add in cartridge case 1, the lower needle point of dosing crosspointer 2 passes annular rubber cushion 12 and is stuck on annular rubber cushion 12, and the crosspointer supporting seat 15 of dosing crosspointer 2 is positioned at the top of annular rubber cushion 12.On the inwall that adds cartridge case 1, being symmetrically arranged with at least two is in barb-like skid-prevention button 16(the present embodiment, on the inwall that adds cartridge case 1, be provided with four skid-prevention buttons), medicament reservoir 17 pack into add cartridge case 1 interior after, when medicament reservoir 17 mixes medicine with infusion vessel 14 (as shown in Figure 8), the bottle cap of medicament reservoir 17 is stuck in the below of skid-prevention button 16, this skid-prevention button 16 can stop medicament reservoir 17 to retreat effectively, ensures that mixed medicine carries out smoothly.The upper inside wall that adds cartridge case 1 is provided with gathering sill 8 vertically, in the present embodiment, adds and on the inwall of cartridge case 1, is arranged with two gathering sills 8 that arrange vertically.A segment distance is extended in the opposite direction at the two ends of gathering sill 8 on the circumference that adds cartridge case 1, forms the gathering sill 8 of " z " font, the direction that extend on the circumference of rotary sleeve 4 bottom of gathering sill 8 during with promotion the direction of rotation of rotary sleeve 4 consistent.Before medicament reservoir 17 and infusion vessel 14 mix medicine (as shown in Figure 7), guide pad 9 on push rod 5 is positioned at the groove of gathering sill 8 top circumferencial directions, effectively stoped push rod 5 along it axially from lower movement, thereby avoided push rod 5 to promote medicament reservoir 17 before mixed medicine, move down; When medicament reservoir 17 mixes medicine with infusion vessel 14 (as shown in Figure 8), guide pad 9 on push rod 5 is positioned at the groove of gathering sill 8 bottom circumferencial directions, effectively stoped push rod 5 along it axially from upper movement, thereby effectively stop medicament reservoir 17 to retreat, further ensure that mixed medicine carries out smoothly.At the inwall top that adds cartridge case 1, along being circumferentially with annular snap 18, on the top end face that adds cartridge case 1, be along the circumferential direction provided with annular groove 19.
As rotary sleeve 4 with add cartridge case 1 fit structure be a kind ofly equal to replacement, can adopt following structure: one end of rotary sleeve 4 be enclosed within add the other end of cartridge case 1 outer and with add cartridge case 1 axial restraint, radially rotatably coordinate, and rotary sleeve 4 and add cartridge case 1 and be sealed and matched.The inwall of rotary sleeve 4 arranges gathering sill vertically, and at the other end inwall that adds cartridge case 1, guiding spiral groove is set, guide pad 9 on push rod 5, through adding the guiding spiral groove on cartridge case 1 and putting in the gathering sill of rotary sleeve 4, rotates rotary sleeve 4 and can drive equally push rod 5 to move down.
The structure of rotary sleeve 4 as shown in Figure 3 and Figure 4, the bottom of rotary sleeve 4 from add the top of cartridge case 1 put in add in cartridge case 1 and with add cartridge case 1 axial restraint, radially rotatably coordinate, and rotary sleeve 4 and add cartridge case 1 and be sealed and matched, the top of rotary sleeve 4 is sealed end.In the present embodiment, on the outer wall edge of rotary sleeve 4, be circumferentially with pressure ring 10, below pressure ring 10, edge is circumferentially with annular slot 20.After rotary sleeve 4 is arranged on and adds on cartridge case 1, annular snap 18 is positioned at annular slot 20, and sealing ring 11 is installed in annular groove 19, and pressure ring 10 is pressed on the top that adds cartridge case 1 and with it and is sealed and matched by sealing ring 11.When rotating rotary sleeve 4, annular snap 18, in the interior rotation of annular slot 20, because of the sealing function of sealing ring 11, makes rotary sleeve 4 both rotatable within adding cartridge case 1, can realize again the outer wall and the top seal that adds cartridge case 1 of rotary sleeve 4.Rotary sleeve 4 arranges in guiding spiral groove 7(the present embodiment along its circumferential wall, and rotary sleeve 4 is arranged with two guiding spiral grooves 7 along its circumferential wall).
As shown in Figure 5 and Figure 6, push rod 5 is axially disposed within rotary sleeve 4 along rotary sleeve 4 the structure of push rod 5, and push rod 5 is the hollow structure of upper end open, lower end sealing, and push rod 5 forms the hollow structure that top diameter of bore is large, bottom diameter of bore is little.In the base wall of top endoporus, be evenly equipped with the passage 21 arranging vertically, when push rod 5 moves down process, this passage 21 is conducive to the gas flow upper space in lower space, reduces the air drag that push rod 5 moves down.On the outer wall of push rod 5, be arranged with two guide pads 9, one of them guide pad 9 passes a guiding spiral groove 7 and puts in a gathering sill 8, and another guide pad 9 passes another guiding spiral groove 7 and puts in another gathering sill 8.Push rod 5 is arranged in rotary sleeve 4 along the axis of rotary sleeve 4, the upper needle point of dosing crosspointer 2 is corresponding with push rod 5, medicament reservoir 17 be placed on add cartridge case 1 interior after, the center, top of the bottom of push rod 5 and medicament reservoir 17 is corresponding, the upper needle point of dosing crosspointer 2 is corresponding with the bottle cap of medicament reservoir 17.
The bottom of interface link 6 is provided with the clip assembly 24 for the interface of infusion vessel 14 is connected with interface link 6.The interface link 6 that adds cartridge case 1 need just can be realized and being tightly connected by clip assembly 24 with 22, interface on infusion vessel 14.On the sealed end of rotary sleeve 4, (being the top of rotary sleeve 4) is provided with suspension ring 13, can be by this medicine adding instrument and the infusion vessel 14(connecting with medicine adding instrument as shown in Figure 7 by these suspension ring 13) together be suspended on transfusion bracing frame used.
When this prepackage type medicine adding instrument and infusion vessel assembling (as shown in Figure 7), first the interface link 6 that adds cartridge case 1 is tightly connected by clip assembly 24 with the interface 22 on infusion vessel 14, then medicament reservoir 17 is placed on and is added in cartridge case 1; Again push rod 5 is arranged in rotary sleeve 4, and the guiding spiral groove 7 that the guide pad 9 on push rod 5 is passed on rotary sleeve 4, finally that the guide pad on push rod 59 is corresponding with the gathering sill 8 adding on cartridge case 1, after rotary sleeve 4 is arranged on and adds on cartridge case 1, guide pad 9 puts in gathering sill 8.
While using this prepackage type medicine adding instrument, to add the interface link 6 of cartridge case 1 and interface 22 on infusion vessel 14 by clip assembly 24 be tightly connected (also can adopt the mode of seam and realize and being tightly connected by the mode being threaded), in the present embodiment, infusion vessel 14 adopts transfusion flexible bag, as shown in Figure 7, medicament reservoir 17 is pre-loaded into and is added in cartridge case 1 under aseptic condition, rotary sleeve 4 by the barrier film 23 in interface 22 and end sealing makes medicament reservoir 17 and dosing crosspointer 2 in sealing state, therefore, can reach transportation and store absolute aseptic.During mixed medicine, rotate rotary sleeve 4, rotary sleeve 4 drives push rod 5 to move down rapidly along the gathering sill 8 adding on cartridge case 1 inwall, directly press on medicament reservoir 17, and then promotion dosing crosspointer 2 moves down, the upper needle point of dosing crosspointer 2 pierces through the sealing-plug on medicament reservoir 17, the lower needle point of dosing crosspointer 2 punctures the barrier film 23 in interface 22, medicament reservoir 17 was communicated with moment in transfusion flexible bag, as shown in Figure 8, whole process is all in aseptic docking, and whole process all drives push rod 5 to move down realization by rotating rotary sleeve 4.And push rod 5 moves down and need rotate and could realize by dependence rotary sleeve 4, so can prevent that, in transportation and storing, push rod 5 is oppressed infusion vessels.When the guide pad 9 on push rod 5 moves down in the groove of gathering sill 8 bottom circumferencial directions, medicament reservoir 17 is pushed to the below that bottle cap is positioned at skid-prevention button 16, effectively stops medicament reservoir 17 to retreat, and ensures that mixed medicine carries out smoothly.Due to this prepackage type medicine adding instrument after be pre-loaded into medicament reservoir until infused, related medicament reservoir with the parts that directly contact with medicine all in aseptic condition, therefore, can realize medicine in transportation, store, the overall process of docking, mixed medicine and transfusion is sterile closed.Before mixed medicine and during mixed medicine, medicament reservoir 17 is all in and adds in cartridge case 1, because adding cartridge case 1, by transparent material, made, operator only need be by the transparent just information of the institute's medicine on observable medicament reservoir 17 of cartridge case 1 that adds, be conducive to operator and grasp in time the drug information of joining, avoid medicine mispairing.
Finally explanation is, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is had been described in detail with reference to preferred embodiment, those of ordinary skill in the art is to be understood that, can modify or be equal to replacement technical scheme of the present invention, and not departing from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of claim scope of the present invention.
Claims (9)
1. prepackage type medicine adding instrument, comprises and adds cartridge case (1) and dosing crosspointer (2), and described dosing crosspointer (2) is located at and adds in cartridge case (1), it is characterized in that: also comprise rotary sleeve (4) and push rod (5);
Described one end that adds cartridge case (1) is interface link (6), and a needle point of described dosing crosspointer (2) is corresponding with interface link (6); At the other end inwall that adds cartridge case (1), be provided with vertically gathering sill (8);
One end of described rotary sleeve (4) put in add in the other end of cartridge case (1) and with add cartridge case (1) axial restraint, radially rotatably coordinate, and rotary sleeve (4) and add cartridge case (1) and be sealed and matched; Described rotary sleeve (4) arranges guiding spiral groove (7) along its circumferential wall;
Described push rod (5) is axially disposed within rotary sleeve (4) along rotary sleeve (4), is provided with guide pad (9) on the outer wall of push rod (5), and described guide pad (9) passes guiding spiral groove (7) and puts in gathering sill (8);
A segment distance is extended in the opposite direction at the two ends of described gathering sill (8) on the circumference that adds cartridge case (1), and the direction of rotation of the direction that extend on the circumference of rotary sleeve (4) bottom of described gathering sill (8) rotary sleeve (4) when promoting is consistent.
2. prepackage type medicine adding instrument according to claim 1, is characterized in that: the other end of described rotary sleeve (4) is sealed end.
3. prepackage type medicine adding instrument according to claim 2, it is characterized in that: described in add the other end of cartridge case (1) inwall be arranged with two gathering sills (8) that arrange vertically, described rotary sleeve (4) is symmetrical arranged two guiding spiral grooves (7) along its circumferential wall, on the outer wall of described push rod (5), be arranged with two guide pads (9), one of them guide pad (9) passes a guiding spiral groove (7) and puts in a gathering sill (8), and another guide pad (9) passes another guiding spiral groove (7) and puts in another gathering sill (8).
4. prepackage type medicine adding instrument according to claim 3, is characterized in that: the outer wall of described rotary sleeve (4) is along being circumferentially with pressure ring (10), and described pressure ring (10) is pressed on the other end that adds cartridge case (1) and with it and is sealed and matched.
5. prepackage type medicine adding instrument according to claim 4, is characterized in that: described pressure ring (10) is sealed and matched by sealing ring (11) and the other end that adds cartridge case (1).
6. prepackage type medicine adding instrument according to claim 5, it is characterized in that: described in add on the inwall of cartridge case (1) and near interface link (6) annular rubber cushion (12) be set, the needle point that described dosing crosspointer (2) is corresponding with interface link (6) passes annular rubber cushion (12).
7. prepackage type medicine adding instrument according to claim 6, is characterized in that: described in add the interface link (6) of cartridge case (1) inwall be a throat structure.
8. prepackage type medicine adding instrument according to claim 7, is characterized in that: the bottom of described interface link (6) is provided with the clip assembly (24) for the interface of infusion vessel (14) is connected with interface link (6).
9. prepackage type medicine adding instrument according to claim 8, is characterized in that: described in add on the inwall of cartridge case (1) and be symmetrically arranged with at least two near interface link (6) and be barb-like skid-prevention button (16).
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210224566.3A CN102716039B (en) | 2012-04-06 | 2012-07-02 | Preassembling type dosing instrument |
| PCT/CN2012/079609 WO2013149445A1 (en) | 2012-04-06 | 2012-08-02 | Preassembled medicine mixer |
| CA2877515A CA2877515C (en) | 2012-04-06 | 2012-08-02 | Preassembled medicine mixer |
| EP12873551.1A EP2845578B1 (en) | 2012-04-06 | 2012-08-02 | Preassembled medicine mixer |
| US14/415,605 US9839581B2 (en) | 2012-04-06 | 2012-08-02 | Preassembled medicine mixer |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210099108.1 | 2012-04-06 | ||
| CN201210099108 | 2012-04-06 | ||
| CN201210224566.3A CN102716039B (en) | 2012-04-06 | 2012-07-02 | Preassembling type dosing instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102716039A CN102716039A (en) | 2012-10-10 |
| CN102716039B true CN102716039B (en) | 2014-03-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210224566.3A Active CN102716039B (en) | 2012-04-06 | 2012-07-02 | Preassembling type dosing instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102716039B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4936841A (en) * | 1988-03-31 | 1990-06-26 | Fujisawa Pharmaceutical Co., Ltd. | Fluid container |
| CN1250365A (en) * | 1997-01-24 | 2000-04-12 | 史密丝克莱恩比彻姆生物有限公司 | Novel device |
| CN101147821A (en) * | 2006-09-18 | 2008-03-26 | 丁玉英 | Powder injection automatic medicine-mixing device |
| CN202505773U (en) * | 2012-04-06 | 2012-10-31 | 重庆莱美药业股份有限公司 | Preloaded type medicine-adding device |
-
2012
- 2012-07-02 CN CN201210224566.3A patent/CN102716039B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4936841A (en) * | 1988-03-31 | 1990-06-26 | Fujisawa Pharmaceutical Co., Ltd. | Fluid container |
| CN1250365A (en) * | 1997-01-24 | 2000-04-12 | 史密丝克莱恩比彻姆生物有限公司 | Novel device |
| CN101147821A (en) * | 2006-09-18 | 2008-03-26 | 丁玉英 | Powder injection automatic medicine-mixing device |
| CN202505773U (en) * | 2012-04-06 | 2012-10-31 | 重庆莱美药业股份有限公司 | Preloaded type medicine-adding device |
Also Published As
| Publication number | Publication date |
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| CN102716039A (en) | 2012-10-10 |
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Inventor after: Qiu Yu Inventor after: Qian Yangming Inventor after: Zhou Shan Inventor after: Li Ke Inventor after: Yuan Yuan Inventor after: Li Hongyu Inventor before: Qiu Yu Inventor before: Li Ke Inventor before: Yuan Yuan Inventor before: Li Hongyu |
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Free format text: CORRECT: INVENTOR; FROM: QIU YU LI KE YUAN YUAN LI HONGYU TO: QIU YU QIAN YANGMING ZHOU SHAN LI KE YUAN YUAN LI HONGYU |
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