CN102715893B - Device and method for detecting blood pressure and oxyhemoglobin saturation simultaneously - Google Patents

Abstract

The invention discloses a device and a method for detecting blood pressure and oxyhemoglobin saturation simultaneously, and belongs to the technical field of radial artery detection. By the device and the method, the problems that the blood pressure and the oxyhemoglobin saturation are needed to be detected by using separate sensors at present, so more electronic components of a detection device are needed, and the detection device is complex in structure are solved. The device comprises a cuff, a pulse generator, a photoelectric plethysm sensor, a wave crest retainer, a first high-pass filter, a first low-pass filter, a second high-pass filter, a second low-pass filter, an analog to digital (A/D) converter, a digital to analog (D/A) converter, a computer, an electro-pneumatic converter, an air pump, a power amplifier, and a pressure sensor; and according to the method, the radial artery is used as a detected target, the blood pressure, and the oxyhemoglobin saturation of arterial and venous blood can be detected simultaneously, and the oxyhemoglobin saturation of the venous blood is measured indirectly. The device and the method are suitable for detecting the blood pressure and the oxyhemoglobin saturation simultaneously.

Description

Checkout gear and detection method in the time of blood pressure and blood oxygen saturation

Technical field

Checkout gear and detection method when the present invention relates to a kind of blood pressure and blood oxygen saturation, belong to Radial artery detection technique field.

Background technology

At present, the blood pressure indirect measurement method when clinical or daily health detection has multiple.For example, traditionally take the mercury sphygmomanometer blood pressure measuring method based on Ke Shi method that upper arm brachial artery is detected object; The electric sphygmomanometer blood pressure measuring method based on pressure oscillographic method that the Radial artery at wrist place of take is detected object, and the electric sphygmomanometer blood pressure measuring method based on volume vibratory drilling method; The electric sphygmomanometer blood pressure measuring method based on volume vibratory drilling method that the finger tremulous pulse of take is detected object etc.And normally take for the indirect measurement method of blood oxygen saturation, refer to that tremulous pulse is detected object, adopt dual wave length spectrophotometry method to carry out the oxygen saturation measurement of arterial blood.When the method for stating is in the use measured blood pressure and blood oxygen saturation, the measurement of blood pressure needs independent sphygomanometer, and the measurement of blood oxygen saturation also needs independent blood oxygen saturation detector.Even if come Measure blood pressure and blood oxygen saturation simultaneously with multi-tester, its inner measuring process still adopts respectively independent photoelectric sensor to realize, and both can not dual-purpose.Like this, just caused the many and complex structure and other problems of the electronic component of checkout gear; Meanwhile, this method can not realize the indirect measurement to the blood oxygen saturation of venous blood.

Summary of the invention

The present invention need to adopt respectively independent sensor to realize in order to solve the detection of existing blood pressure and blood oxygen saturation, cause the many and baroque problem of the electronic component of checkout gear, checkout gear and detection method when a kind of blood pressure and blood oxygen saturation are provided.

Checkout gear in the time of blood pressure of the present invention and blood oxygen saturation, it comprises cuff, it also comprises pulse generator, photoelectricity volume sensor, crest keeper, the first high pass filter, the first low pass filter, the second high pass filter, the second low pass filter, A/D converter, D/A converter, the mechanical, electrical space-variant parallel operation of calculating, air pump, power amplifier and pressure transducer

Air pump is cuff air feed by pipeline, electricity space-variant parallel operation is arranged on the pipeline between air pump and cuff, the control signal input of electricity space-variant parallel operation connects the control signal outfan of power amplifier, the control signal input of power amplifier connects the analog signal output of D/A converter, and the digital signal input end of D/A converter connects the control signal outfan of computer;

The pressure acquisition end of pressure transducer is by the pipeline connection between pipeline and electric space-variant parallel operation and cuff, and the pressure signal outfan of pressure transducer connects the pressure signal input of A/D converter;

Photoelectricity volume sensor setting is in cuff, photoelectricity volume sensor is by first wave long hair optical diode, second wave length light emitting diode and photodiode form, the first pulse signal output end of pulse generator connects the pulse signal input terminal of first wave long hair optical diode, the second pulse signal output end of pulse generator connects the pulse signal input terminal of second wave length light emitting diode, the 3rd pulse signal output end of pulse generator connects the first driving signal input of photodiode, the 4th pulse signal output end of pulse generator connects the second driving signal input of photodiode, the first pulse signal of pulse generator and the 3rd pulse signal conducting simultaneously or close, the second pulse signal of pulse generator and the 4th pulse signal are closed or conducting simultaneously, photodiode is respectively used to gather the photoelectricity plethysmogram signal of first wave long hair optical diode and second wave length light emitting diode, the acquired signal outfan of photodiode connects the acquired signal input of crest keeper, the wavelength signals outfan corresponding to first wave long hair optical diode of crest keeper connects the lightwave signal input of the first high pass filter and the lightwave signal input of the first low pass filter simultaneously, the lightwave signal outfan of the first high pass filter connects the first input end of analog signal of A/D converter, the lightwave signal outfan of the first low pass filter connects the second input end of analog signal of A/D converter, the wavelength signals outfan corresponding to second wave length light emitting diode of crest keeper connects the lightwave signal input of the second high pass filter and the lightwave signal input of the second low pass filter simultaneously, the lightwave signal outfan of the second high pass filter connects the 3rd input end of analog signal of A/D converter, the lightwave signal outfan of the second low pass filter connects the 4th input end of analog signal of A/D converter, the digital signal output end of A/D converter connects the acquired signal input of computer.

The emission wavelength of first wave long hair optical diode is 940nm, and the emission wavelength of second wave length light emitting diode is 805nm, and the wavelength photoreceptor center range of photodiode is 805nm to 940nm.

The driving frequency of pulse generator is 500Hz.

The first pulse signal of described pulse generator and the pass of the second pulse signal are: in a cycle period of pulse generator pulse signal, the ON time of the first pulse signal and the second pulse signal was respectively 1/3 cycle, and the first pulse signal and the second pulse signal alternate conduction or the time difference of closing were 1/6 cycle.

The blood pressure of checkout gear and the Simultaneous Detection of blood oxygen saturation in the time of based on above-mentioned blood pressure and blood oxygen saturation, it comprises the following steps:

Step 1: by photoelectricity volume sensor setting between cuff inner surface and the contact surface of skin;

Step 2: by regulating electric space-variant parallel operation to regulate the air inflow entering in cuff, make pressure in cuff increase with the speed of 5mmHg/S, until reach the pressure of regulation;

Step 3: four pulse signals of clamp-pulse generator output, when making the first pulse signal of pulse generator and the conducting simultaneously of the 3rd pulse signal, the second pulse signal and the 4th pulse signal are closed simultaneously; In the time of the conducting simultaneously of the second pulse signal of pulse generator and the 4th pulse signal, the first pulse signal and the 3rd pulse signal are closed simultaneously, realize driving the intermittence of two light emitting diodes, photodiode, when each light emitting diode is lighted respectively, gathers the photoelectricity plethysmogram signal of corresponding light emitting diode simultaneously;

Step 4: the reflected light signal that crest keeper detects by photodiode two kinds of wavelength that obtain according to the pulse logic of pulse generator is exported respectively, by computer, all image data are processed, obtained blood pressure and the blood oxygen saturation numerical value at detected position.

The method that step 4 Computer is processed acquisition blood pressure values to image data is: the pressure signal in the cuff that the lightwave signal of the second high pass filter that computer obtains A/D converter collection and pressure transducer collection obtain adopts volume vibratory drilling method to calculate, obtain the numerical value of mean blood pressure and systolic pressure, and calculate the numerical value of diastolic pressure.

The method that step 4 Computer is processed acquisition blood oxygen saturation numerical value to image data is:

First, when detected position is not subject to cuff compressing, its absorbance A ^{λ i}for:

$A^{\mathrm{\λi}}=\log (I_0^{{\mathrm{\λ}}_i}/I^{{\mathrm{\λ}}_i})=({\mathrm{\ϵ}}_{\mathrm{Hb}}^{{\mathrm{\λ}}_i}{C}_{\mathrm{Hb}}^a+{\mathrm{\ϵ}}_{\mathrm{Hbo}}^{{\mathrm{\λ}}_i}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\ϵ}}_{\mathrm{Hb}}^{{\mathrm{\λ}}_i}{C}_{\mathrm{Hb}}^v+{\mathrm{\ϵ}}_{\mathrm{Hbo}}^{{\mathrm{\λ}}_i}{C}_{\mathrm{Hbo}}^v)d_v+{\mathrm{\ϵ}}_t^{{\mathrm{\λ}}_i}{C}_t{d}_t+B^{{\mathrm{\λ}}_i},$

for incident light quantity,

for reflection light quantity, λ _i=λ ₁, λ ₂, λ ₁for the lightwave signal corresponding to first wave long hair optical diode, λ ₂for the lightwave signal corresponding to second wave length light emitting diode,

for the specific absorbance of reduced hemoglobin Hb,

for the reduced hemoglobin Hb concentration of arterial blood,

for the specific absorbance of HbO2 Oxyhemoglobin Hbo, for the HbO2 Oxyhemoglobin Hbo concentration of arterial blood,

D _afor the optical path length of arterial blood, for the reduced hemoglobin Hb concentration of venous blood,

for the HbO2 Oxyhemoglobin Hbo concentration of venous blood,

D _vfor the optical path length of venous blood,

for the specific absorbance of muscular tissue, C _tfor the concentration of muscular tissue,

D _tfor the optical path length of muscular tissue,

absorption for light at random;

The cuff compressing being subject to when detected position does not change arteries, while only having vein blood vessel to change, corresponding to the wavelength X of first wave long hair optical diode ₁wavelength X with second wave length light emitting diode ₂respectively at v ₁absorbance under state

and v ₂absorbance under state with

be respectively:

$A_{{\mathrm{<figure-callout\; id="1"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_1}^{{\mathrm{\&lambda;}}_1}=\log (I_0^{{\mathrm{\&lambda;}}_1}/I_{v_1}^{{\mathrm{\&lambda;}}_1})=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^v)d_{v1}+{\mathrm{\&epsiv;}}_t^{{\mathrm{\&lambda;}}_1}{C}_t{d}_t+B^{{\mathrm{\&lambda;}}_1},$

${\mathrm{<figure-callout\; id="1"\; label="A\; v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">A</figure-callout>}}_{v_{}}^{{}_1}=\log (I_0^{{\mathrm{\&lambda;}}_2}/I_{v_1}^{{\mathrm{\&lambda;}}_2})=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^v)d_{v1}+{\mathrm{\&epsiv;}}_t^{{\mathrm{\&lambda;}}_2}{C}_t{d}_t+B^{{\mathrm{\&lambda;}}_2},$

${\mathrm{<figure-callout\; id="2"\; label="A\; v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">A</figure-callout>}}_{v_{}}^{{}_2}=\log (I_0^{{\mathrm{\&lambda;}}_1}/I_{v_2}^{{\mathrm{\&lambda;}}_1})=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^v)d_{v2}+{\mathrm{\&epsiv;}}_t^{{\mathrm{\&lambda;}}_1}{C}_t{d}_t+B^{{\mathrm{\&lambda;}}_1},$

${\mathrm{<figure-callout\; id="2"\; label="A\; v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">A</figure-callout>}}_{v_{}}^{{}_2}=\log (I_0^{{\mathrm{\&lambda;}}_2}/I_{v_2}^{{\mathrm{\&lambda;}}_2})=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^v)d_{v2}+{\mathrm{\&epsiv;}}_t^{{\mathrm{\&lambda;}}_2}{C}_t{d}_t+B^{{\mathrm{\&lambda;}}_2},$

Due at v ₁, v ₂blood under state in arteries and the absorbance of muscular tissue do not change, and supposition is constant from the absorption of light at random in the small interval of cuff pressurization, and the absorbance of venous blood two wavelength light is poor

with be respectively:

$\mathrm{\&Delta;}{A}_{v_1-v_2}^{{\mathrm{\&lambda;}}_1}=A_{v_1}^{{\mathrm{\&lambda;}}_1}-A_{v_2}^{{\mathrm{\&lambda;}}_1}=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^v)\mathrm{\&Delta;}{d}_{v_1-v_2},$

$\mathrm{\&Delta;}{A}_{v_1-v_2}^{{\mathrm{\&lambda;}}_2}=A_{v_1}^{{\mathrm{\&lambda;}}_2}-A_{v_2}^{{\mathrm{\&lambda;}}_2}=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^v)\mathrm{\&Delta;}{d}_{v_1-v_2},$

In formula

for v ₁with v ₂the optical path difference of venous blood under state,

The cuff compressing being subject to when detected position makes artery and vein vascular locking, and the extinction characteristic of muscular tissue and light at random is constant, only has the light path of the blood in arteries to change, and supposes the wavelength X corresponding to first wave long hair optical diode ₁wavelength X with second wave length light emitting diode ₂be respectively a ₁and a ₂during state, the absorbance of arterial blood two wavelength light poor

with

be respectively:

$\mathrm{\&Delta;}{A}_{a_1-{\mathrm{<figure-callout\; id="2"\; label="a"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">a</figure-callout>}}_2}^{{\mathrm{\&lambda;}}_1}=A_{a_1}^{{\mathrm{\&lambda;}}_1}-A_{a_2}^{{\mathrm{\&lambda;}}_1}=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^a)\mathrm{\&Delta;}{d}_{a_1-a_2},$

$\mathrm{\&Delta;}{A}_{a_1-{\mathrm{<figure-callout\; id="2"\; label="a"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">a</figure-callout>}}_2}^{{\mathrm{\&lambda;}}_2}=A_{a_1}^{{\mathrm{\&lambda;}}_2}-A_{a_2}^{{\mathrm{\&lambda;}}_2}=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^a)\mathrm{\&Delta;}{d}_{a_1-a_2},$

for a ₁and a ₂the optical path difference of arterial blood under state,

Use SvO ₂represent Svo2, SaO ₂represent arterial oxygen saturation,

${\mathrm{<figure-callout\; id="2"\; label="SvO"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">SvO</figure-callout>}}_2=C_{\mathrm{Hbo}}^v/(C_{\mathrm{Hbo}}^v+C_{\mathrm{Hb}}^v),$

${\mathrm{<figure-callout\; id="2"\; label="SaO"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">SaO</figure-callout>}}_2=C_{\mathrm{Hbo}}^a/(C_{\mathrm{Hbo}}^a+C_{\mathrm{Hb}}^a),$

Above-mentioned all formula are solved and obtain Svo2 SvO ₂with arterial oxygen saturation SaO ₂:

${\mathrm{<figure-callout\; id="2"\; label="SvO"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">SvO</figure-callout>}}_2=\frac{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}}{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}-{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}}-\frac{\mathrm{\&beta;}}{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}-{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}}\&times;\frac{\mathrm{\&Delta;}{A}_{v_1-{\mathrm{<figure-callout\; id="2"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_2}^{{\mathrm{\&lambda;}}_1}}{\mathrm{\&Delta;}{A}_{v_1-{\mathrm{<figure-callout\; id="2"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_2}^{{\mathrm{\&lambda;}}_2}},$

${\mathrm{<figure-callout\; id="2"\; label="SvO"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">SvO</figure-callout>}}_2=\frac{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}}{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}-{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}}-\frac{\mathrm{\&beta;}}{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}-{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}}\&times;\frac{\mathrm{\&Delta;}{A}_{a_1-{\mathrm{<figure-callout\; id="2"\; label="a"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">a</figure-callout>}}_2}^{{\mathrm{\&lambda;}}_1}}{\mathrm{\&Delta;}{A}_{a_1-{\mathrm{<figure-callout\; id="2"\; label="a"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">a</figure-callout>}}_2}^{{\mathrm{\&lambda;}}_2}},$

In formula, β is λ ₂the absorptance of reduced hemoglobin Hb and HbO2 Oxyhemoglobin Hbo when selective reduction Hb H b and HbO2 Oxyhemoglobin Hbo have isobestic point wavelength.

The isobestic point wavelength that described reduced hemoglobin Hb and HbO2 Oxyhemoglobin Hbo have is 805nm.

Advantage of the present invention is: the present invention in use be take Radial artery as detected object, can realize the blood oxygen saturation of blood pressure and plasma viscosity is detected simultaneously, and it has realized the indirect measurement to the blood oxygen saturation of venous blood.The present invention can use in the situation that the lower and peripheral circulation of blood oxygen saturation is very poor, and the precision of detection is high, has realized the non-invasive detection of Svo2, has improved detection stability, simplifies the structure, and has reduced cost, and miniaturization that can implement device.

Accompanying drawing explanation

Fig. 1 is the electrical principle block diagram of apparatus of the present invention;

Fig. 2 is detection schematic diagram of the present invention;

Fig. 3 is the absorbance curve chart corresponding to Fig. 2;

Fig. 4 is reduced hemoglobin Hb and the absorption curve figure of HbO2 Oxyhemoglobin Hbo to HONGGUANG and infrared light.

The specific embodiment

The specific embodiment one: present embodiment is described below in conjunction with Fig. 1, checkout gear when blood pressure and blood oxygen saturation described in present embodiment, it comprises cuff 1, it also comprises pulse generator 2, photoelectricity volume sensor 3, crest keeper 4, the first high pass filter 5-1, the first low pass filter 5-2, the second high pass filter 5-3, the second low pass filter 5-4, A/D converter 6, D/A converter 7, computer 8, electric space-variant parallel operation 9, air pump 10, power amplifier 11 and pressure transducer 12

Air pump 10 is cuff 1 air feed by pipeline, on the pipeline that electricity space-variant parallel operation 9 is arranged between air pump 10 and cuff 1, the control signal input of electricity space-variant parallel operation 9 connects the control signal outfan of power amplifier 11, the control signal input of power amplifier 11 connects the analog signal output of D/A converter 7, and the digital signal input end of D/A converter 7 connects the control signal outfan of computer 8;

The pressure acquisition end of pressure transducer 12 is by the pipeline connection between pipeline and electric space-variant parallel operation 9 and cuff 1, and the pressure signal outfan of pressure transducer 12 connects the pressure signal input of A/D converter 6;

Photoelectricity volume sensor 3 is arranged in cuff 1, photoelectricity volume sensor 3 is by first wave long hair optical diode, second wave length light emitting diode and photodiode form, the first pulse signal output end of pulse generator 2 connects the pulse signal input terminal of first wave long hair optical diode, the second pulse signal output end of pulse generator 2 connects the pulse signal input terminal of second wave length light emitting diode, the 3rd pulse signal output end of pulse generator 2 connects the first driving signal input of photodiode, the 4th pulse signal output end of pulse generator 2 connects the second driving signal input of photodiode, the first pulse signal of pulse generator 2 and the 3rd pulse signal conducting simultaneously or close, the second pulse signal of pulse generator 2 and the 4th pulse signal are closed or conducting simultaneously, photodiode is respectively used to gather the photoelectricity plethysmogram signal of first wave long hair optical diode and second wave length light emitting diode, the acquired signal outfan of photodiode connects the acquired signal input of crest keeper 4, the wavelength signals outfan corresponding to first wave long hair optical diode of crest keeper 4 connects the lightwave signal input of the first high pass filter 5-1 and the lightwave signal input of the first low pass filter 5-2 simultaneously, the lightwave signal outfan of the first high pass filter 5-1 connects the first input end of analog signal of A/D converter 6, the lightwave signal outfan of the first low pass filter 5-2 connects the second input end of analog signal of A/D converter 6, the wavelength signals outfan corresponding to second wave length light emitting diode of crest keeper 4 connects the lightwave signal input of the second high pass filter 5-3 and the lightwave signal input of the second low pass filter 5-4 simultaneously, the lightwave signal outfan of the second high pass filter 5-3 connects the 3rd input end of analog signal of A/D converter 6, the lightwave signal outfan of the second low pass filter 5-4 connects the 4th input end of analog signal of A/D converter 6, the digital signal output end of A/D converter 6 connects the acquired signal input of computer 8.

In present embodiment, be provided with power amplifier 11, because the command signal of D/A converter 7 outputs is generally less, be difficult to control the action of electric space-variant parallel operation 9.Therefore, between D/A converter 7 and electric space-variant parallel operation 9, power amplifier 11 is set, the voltage signal of output is carried out to power amplification, reach and control the air capacity that electric space-variant parallel operation 9 moves, adjusting enters cuff, the object that makes the pressure in cuff increase with certain speed.

The specific embodiment two: present embodiment is further illustrating embodiment one, the emission wavelength of first wave long hair optical diode is 940nm, the emission wavelength of second wave length light emitting diode is 805nm, and the wavelength photoreceptor center range of photodiode is 805nm to 940nm.

Photoelectricity volume sensor 3 is comprised of LED and a photodiode PD of two different wave lengths.Two wavelength LED can adopt integral structure as light source.Absorb the scope that its wavelength photoreceptor of catoptrical PD need cover 805nm and 940nm, can effectively absorb the reflected light of two wavelength LED.

The specific embodiment three: present embodiment is for to the further illustrating of embodiment one or two, and the driving frequency of pulse generator 2 is 500Hz.

The specific embodiment four: present embodiment is further illustrating embodiment one, two or three, the first pulse signal of described pulse generator 2 and the pass of the second pulse signal are: in a cycle period of pulse generator 2 pulse signals, the ON time of the first pulse signal and the second pulse signal was respectively 1/3 cycle, and the first pulse signal and the second pulse signal alternate conduction or the time difference of closing were 1/6 cycle.

The specific embodiment five: below in conjunction with Fig. 1 to Fig. 4, present embodiment is described, present embodiment is the blood pressure of checkout gear and the Simultaneous Detection of blood oxygen saturation based on blood pressure described in embodiment one and blood oxygen saturation time, and it comprises the following steps:

Step 1: photoelectricity volume sensor 3 is arranged between cuff 1 inner surface and the contact surface of skin;

Step 2: by regulating electric space-variant parallel operation 9 to regulate the air inflow entering in cuff 1, make pressure in cuff 1 increase with the speed of 5mmHg/S, until reach the pressure of regulation;

Step 3: four pulse signals of clamp-pulse generator 2 output, when making the first pulse signal of pulse generator 2 and the conducting simultaneously of the 3rd pulse signal, the second pulse signal and the 4th pulse signal are closed simultaneously; In the time of the conducting simultaneously of the second pulse signal of pulse generator 2 and the 4th pulse signal, the first pulse signal and the 3rd pulse signal are closed simultaneously, realize driving the intermittence of two light emitting diodes, photodiode, when each light emitting diode is lighted respectively, gathers the photoelectricity plethysmogram signal of corresponding light emitting diode simultaneously;

Step 4: the reflected light signal that crest keeper 4 detects by photodiode two kinds of wavelength that obtain according to the pulse logic of pulse generator 2 is exported respectively, by 8 pairs of all image data of computer, processed, obtain blood pressure and the blood oxygen saturation numerical value at detected position.

In present embodiment, in the cuff pressure regulating system being comprised of electric space-variant parallel operation 9 and air pump 10, air pump 10 is normal air feed, therefore enter air capacity in cuff number be to regulate the size of self electromagnetism valve openings to determine by electric space-variant parallel operation 9.Meanwhile, the pressure variation that in cuff, air inflow is brought detects by pressure transducer 12.

Authorized pressure described in the step 2 of present embodiment can be decided to be on the normal pressure of user and add 30～50mmHg for user.

The specific embodiment six: present embodiment is further illustrating embodiment five, the method that 8 pairs of image data of step 4 Computer are processed acquisition blood pressure values is: the pressure signal employing volume vibratory drilling method that computer 8 gathers A/D converter 6 in the lightwave signal of the second high pass filter 5-3 obtaining and the cuff 1 of pressure transducer 12 collection acquisitions is calculated, obtain the numerical value of mean blood pressure and systolic pressure, and calculate the numerical value of diastolic pressure.

Computational methods about blood pressure values: for a light emitting diode in photoelectricity volume sensor 3, by detecting its photoelectricity volume PGac signal, or catoptrical variation delta I ^λsignal, utilizes volume vibratory drilling method to determine peak SBP and the meansigma methods MBP of indirect blood pressure

The specific embodiment seven: below in conjunction with Fig. 1 to Fig. 4, present embodiment is described, present embodiment is for to the further illustrating of embodiment five or six, and the method that 8 pairs of image data of step 4 Computer are processed acquisition blood oxygen saturation numerical value is:

First, when detected position is not subject to cuff 1 compressing, its absorbance A ^{λ i}for:

$A^{\mathrm{\&lambda;i}}=\log (I_0^{{\mathrm{\&lambda;}}_i}/I^{{\mathrm{\&lambda;}}_i})=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_i}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_i}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_i}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_i}{C}_{\mathrm{Hbo}}^v)d_v+{\mathrm{\&epsiv;}}_t^{{\mathrm{\&lambda;}}_i}{C}_t{d}_t+B^{{\mathrm{\&lambda;}}_i},$

for incident light quantity,

for reflection light quantity, λ _i=λ ₁, λ ₂, λ ₁for the lightwave signal corresponding to first wave long hair optical diode, λ ₂for the lightwave signal corresponding to second wave length light emitting diode,

for the specific absorbance of reduced hemoglobin Hb,

for the reduced hemoglobin Hb concentration of arterial blood,

for the specific absorbance of HbO2 Oxyhemoglobin Hbo,

for the HbO2 Oxyhemoglobin Hbo concentration of arterial blood,

D _afor the optical path length of arterial blood,

for the reduced hemoglobin Hb concentration of venous blood,

for the HbO2 Oxyhemoglobin Hbo concentration of venous blood,

D _vfor the optical path length of venous blood,

for the specific absorbance of muscular tissue, C _tfor the concentration of muscular tissue,

D _tfor the optical path length of muscular tissue, absorption for light at random;

Cuff 1 compressing being subject to when detected position does not change arteries, while only having vein blood vessel to change, corresponding to the wavelength X of first wave long hair optical diode ₁wavelength X with second wave length light emitting diode ₂respectively at v ₁absorbance under state

and v ₂absorbance under state

with

be respectively:

$A_{{\mathrm{<figure-callout\; id="1"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_1}^{{\mathrm{\&lambda;}}_1}=\log (I_0^{{\mathrm{\&lambda;}}_1}/I_{v_1}^{{\mathrm{\&lambda;}}_1})=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^v){\mathrm{<figure-callout\; id="1"\; label="d\; v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">d</figure-callout>}}_v+{\mathrm{\&epsiv;}}_t^{{\mathrm{\&lambda;}}_1}{C}_t{d}_t+B^{{\mathrm{\&lambda;}}_1},$

$A_{{\mathrm{<figure-callout\; id="1"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_1}^{{\mathrm{\&lambda;}}_2}=\log (I_0^{{\mathrm{\&lambda;}}_2}/I_{v_1}^{{\mathrm{\&lambda;}}_2})=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^v){\mathrm{<figure-callout\; id="1"\; label="d\; v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">d</figure-callout>}}_v+{\mathrm{\&epsiv;}}_t^{{\mathrm{\&lambda;}}_2}{C}_t{d}_t+B^{{\mathrm{\&lambda;}}_2},$

$A_{{\mathrm{<figure-callout\; id="2"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_2}^{{\mathrm{\&lambda;}}_1}=\log (I_0^{{\mathrm{\&lambda;}}_1}/I_{v_2}^{{\mathrm{\&lambda;}}_1})=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^v){\mathrm{<figure-callout\; id="2"\; label="d\; v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">d</figure-callout>}}_v+{\mathrm{\&epsiv;}}_t^{{\mathrm{\&lambda;}}_1}{C}_t{d}_t+B^{{\mathrm{\&lambda;}}_1},$

$A_{{\mathrm{<figure-callout\; id="2"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_2}^{{\mathrm{\&lambda;}}_2}=\log (I_0^{{\mathrm{\&lambda;}}_2}/I_{v_2}^{{\mathrm{\&lambda;}}_2})=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^v){\mathrm{<figure-callout\; id="2"\; label="d\; v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">d</figure-callout>}}_v+{\mathrm{\&epsiv;}}_t^{{\mathrm{\&lambda;}}_2}{C}_t{d}_t+B^{{\mathrm{\&lambda;}}_2},$

Due at v ₁, v ₂blood under state in arteries and the absorbance of muscular tissue do not change, and supposition is constant from the absorption of light at random in the small interval of cuff pressurization, and the absorbance of venous blood two wavelength light is poor

with

be respectively:

$\mathrm{\&Delta;}{A}_{v_1-{\mathrm{<figure-callout\; id="2"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_2}^{{\mathrm{\&lambda;}}_1}=A_{{\mathrm{<figure-callout\; id="1"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_1}^{{\mathrm{\&lambda;}}_1}-{\mathrm{<figure-callout\; id="2"\; label="A\; v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">A</figure-callout>}}_{v_{}}^{{}_2}=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^v)\mathrm{\&Delta;}{d}_{v_1-{\mathrm{<figure-callout\; id="2"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_2},$

$\mathrm{\&Delta;}{A}_{v_1-{\mathrm{<figure-callout\; id="2"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_2}^{{\mathrm{\&lambda;}}_2}=A_{{\mathrm{<figure-callout\; id="1"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_1}^{{\mathrm{\&lambda;}}_2}-{\mathrm{<figure-callout\; id="2"\; label="A\; v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">A</figure-callout>}}_{v_{}}^{{}_2}=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^v)\mathrm{\&Delta;}{d}_{v_1-{\mathrm{<figure-callout\; id="2"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_2},$

In formula for v ₁with v ₂the optical path difference of venous blood under state,

Cuff 1 compressing being subject to when detected position makes artery and vein vascular locking, and the extinction characteristic of muscular tissue and light at random is constant, only has the light path of the blood in arteries to change, and supposes the wavelength X corresponding to first wave long hair optical diode ₁wavelength X with second wave length light emitting diode ₂be respectively a ₁and a ₂during state, the absorbance of arterial blood two wavelength light poor

with

be respectively:

$\mathrm{\&Delta;}{A}_{a_1-a_2}^{{\mathrm{\&lambda;}}_1}=A_{a_1}^{{\mathrm{\&lambda;}}_1}-A_{a_2}^{{\mathrm{\&lambda;}}_1}=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^a)\mathrm{\&Delta;}{d}_{a_1-a_2},$

$\mathrm{\&Delta;}{A}_{a_1-a_2}^{{\mathrm{\&lambda;}}_2}=A_{a_1}^{{\mathrm{\&lambda;}}_2}-A_{a_2}^{{\mathrm{\&lambda;}}_2}=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^a)\mathrm{\&Delta;}{d}_{a_1-a_2},$

for a ₁and a ₂the optical path difference of arterial blood under state,

Use SvO ₂represent Svo2, SaO ₂represent arterial oxygen saturation,

${\mathrm{<figure-callout\; id="2"\; label="SvO"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">SvO</figure-callout>}}_2=C_{\mathrm{Hbo}}^v/(C_{\mathrm{Hbo}}^v+C_{\mathrm{Hb}}^v),$

${\mathrm{<figure-callout\; id="2"\; label="SaO"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">SaO</figure-callout>}}_2=C_{\mathrm{Hbo}}^a/(C_{\mathrm{Hbo}}^a+C_{\mathrm{Hb}}^a),$

Above-mentioned all formula are solved and obtain Svo2 SvO ₂with arterial oxygen saturation SaO ₂:

${\mathrm{<figure-callout\; id="2"\; label="SvO"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">SvO</figure-callout>}}_2=\frac{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}}{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}-{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}}-\frac{\mathrm{\&beta;}}{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}-{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}}\&times;\frac{\mathrm{\&Delta;}{A}_{v_1-{\mathrm{<figure-callout\; id="2"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_2}^{{\mathrm{\&lambda;}}_1}}{\mathrm{\&Delta;}{A}_{v_1-{\mathrm{<figure-callout\; id="2"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_2}^{{\mathrm{\&lambda;}}_2}},$

${\mathrm{<figure-callout\; id="2"\; label="SvO"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">SvO</figure-callout>}}_2=\frac{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}}{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}-{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}}-\frac{\mathrm{\&beta;}}{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}-{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}}\&times;\frac{\mathrm{\&Delta;}{A}_{a_1-a_2}^{{\mathrm{\&lambda;}}_1}}{\mathrm{\&Delta;}{A}_{a_1-a_2}^{{\mathrm{\&lambda;}}_2}},$

In formula, β is λ ₂the absorptance of reduced hemoglobin Hb and HbO2 Oxyhemoglobin Hbo when selective reduction Hb H b and HbO2 Oxyhemoglobin Hbo have isobestic point wavelength.

Artery and vein blood oxygen saturation detection principle related in the present invention is:

The present invention adopts two wavelength optical spectroscopies to carry out the detection of arteriovenous blood oxygen saturation, the different tissues of considering human detection position is different to seeing through light or catoptrical absorbing state, can be simplified to the optical absorption model being formed by muscular tissue, tremulous pulse and vein by detecting position, as shown in Figure 2.When giving detection position pressurization by cuff 1, because muscular tissue is incompressible, in pressure process, its thickness does not change, and therefore can consider that the optical characteristics of muscular tissue is constant.The locking and vein blood vessel and arteries manage under the effect of cuff pressure that inner volume can constantly be dwindled, the variation that has brought thus extinction characteristic.First, the pressure of vein blood vessel is low, and under sleeve effect with pressure, first distortion is consequently pressed off completely; Then, arteries is pressurized gradually, so that arteries is pressed off completely.The change records of extinction characteristic in cuff 1 pressure process is got off, can find because quiet, arterial vascular mechanical characteristic difference has a flex point, to exist on extinction characteristic curve.That is, the former part of this flex point is the variation of the extinction characteristic of venous blood, and later part is the variation of the extinction characteristic of arterial blood.Like this, just can flex point be boundary, by extinction characteristic by the component separating of quiet, arterial blood out.

In present embodiment when detected position is not subject to cuff 1 compressing, its absorbance A ^{λ i}preparation method according to Beer-Lambert law, obtain.From Fig. 2 and Fig. 3, when cuff, to press hour, arteries does not change, and only has vein blood vessel to change.Therefore its corresponding state is v ₁, v ₂.When detecting position, be pressurized to a shown in Fig. 3 ₁, a ₂during state, vein blood vessel is locking, and the supposition of the extinction characteristic of muscular tissue and light at random is constant, only has the light path of the blood in arteries to change.

By Svo2 SvO ₂with arterial oxygen saturation SaO ₂computing formula can also calculate blood O2 difference after metabolism, that is:

$\mathrm{Sa}-\mathrm{<figure-callout\; id="2"\; label="v\; O"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}{O}_{}{}_2=\frac{\mathrm{\&beta;}}{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}-{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}}\&times;(\frac{\mathrm{\&Delta;}{A}_{v_1-{\mathrm{<figure-callout\; id="2"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_2}^{{\mathrm{\&lambda;}}_1}}{\mathrm{\&Delta;}{A}_{v_1-{\mathrm{<figure-callout\; id="2"\; label="v"\; filenames="HDA00001811805800011.png,HDA00001811805800021.png"\; state="\{\{state\}\}">v</figure-callout>}}_2}^{{\mathrm{\&lambda;}}_2}}-\frac{\mathrm{\&Delta;}{A}_{a_1-a_2}^{{\mathrm{\&lambda;}}_1}}{\mathrm{\&Delta;}{A}_{a_1-a_2}^{{\mathrm{\&lambda;}}_2}}),$

Coefficient in formula

can to the absorption curve of HONGGUANG and infrared light, obtain by the Hb shown in Fig. 4 and Hbo, but consider the discreteness of photo-sensor properties reality, conventionally also will calibrate and determine by experiment.

In present embodiment, by detecting the reflected light I of two LED ^λsignal, and the relevant treatment such as take the logarithm calculates artery and vein blood oxygen saturation.Two wavelength LED adopt pulsed drive, and driving frequency is chosen as 500Hz.In order to obtain each LED to detecting the absorbing state at position, two LED are carried out intermittently and driven.That is, when a LED lights, another LED extinguishes, and vice versa.Corresponding thereto, PD is also intermittent connectivity, detects respectively the reflected light signal of two wavelength LED, and keeps loop to make the signal detecting become continuous curve by sampling.Pressure signal in pressurized cuff is that the pressure transducer amplifying by an in-built temperature-compensating and signal detects, as the foundation of determining internal blood vessel blood pressure.The above-mentioned photosignal detecting and pressure signal are input in computer by 16 A/D converters, and carry out processing, record and the storage of data here; Meanwhile, the control of cuff internal pressure is calculated and is also here carried out, and by assigning instruction to electric space-variant parallel operation 9 here, controls the air capacity that enters cuff, makes the pressure in cuff increase with certain speed.

The specific embodiment eight: present embodiment is for to the further illustrating of embodiment seven, and the isobestic point wavelength that described reduced hemoglobin Hb and HbO2 Oxyhemoglobin Hbo have is 805nm.

Claims (8)

1. checkout gear when a blood pressure and blood oxygen saturation, it comprises cuff (1), it is characterized in that: it also comprises pulse generator (2), photoelectricity volume sensor (3), crest keeper (4), the first high pass filter (5-1), the first low pass filter (5-2), the second high pass filter (5-3), the second low pass filter (5-4), A/D converter (6), D/A converter (7), computer (8), electric space-variant parallel operation (9), air pump (10), power amplifier (11) and pressure transducer (12)

Air pump (10) is cuff (1) air feed by pipeline, electricity space-variant parallel operation (9) is arranged on the pipeline between air pump (10) and cuff (1), the control signal input of electricity space-variant parallel operation (9) connects the control signal outfan of power amplifier (11), the control signal input of power amplifier (11) connects the analog signal output of D/A converter (7), and the digital signal input end of D/A converter (7) connects the control signal outfan of computer (8);

The pressure acquisition end of pressure transducer (12) is by the pipeline connection between pipeline and electric space-variant parallel operation (9) and cuff (1), and the pressure signal outfan of pressure transducer (12) connects the pressure signal input of A/D converter (6);

Photoelectricity volume sensor (3) is arranged in cuff (1), photoelectricity volume sensor (3) is by first wave long hair optical diode, second wave length light emitting diode and photodiode form, the first pulse signal output end of pulse generator (2) connects the pulse signal input terminal of first wave long hair optical diode, the second pulse signal output end of pulse generator (2) connects the pulse signal input terminal of second wave length light emitting diode, the 3rd pulse signal output end of pulse generator (2) connects the first driving signal input of photodiode, the 4th pulse signal output end of pulse generator (2) connects the second driving signal input of photodiode, the first pulse signal of pulse generator (2) and the 3rd pulse signal conducting simultaneously or close, the second pulse signal of pulse generator (2) and the 4th pulse signal are closed or conducting simultaneously, photodiode is respectively used to gather the photoelectricity plethysmogram signal of first wave long hair optical diode and second wave length light emitting diode, the acquired signal outfan of photodiode connects the acquired signal input of crest keeper (4), the wavelength signals outfan corresponding to first wave long hair optical diode of crest keeper (4) connects the lightwave signal input of the first high pass filter (5-1) and the lightwave signal input of the first low pass filter (5-2) simultaneously, the lightwave signal outfan of the first high pass filter (5-1) connects the first input end of analog signal of A/D converter (6), the lightwave signal outfan of the first low pass filter (5-2) connects the second input end of analog signal of A/D converter (6), the wavelength signals outfan corresponding to second wave length light emitting diode of crest keeper (4) connects the lightwave signal input of the second high pass filter (5-3) and the lightwave signal input of the second low pass filter (5-4) simultaneously, the lightwave signal outfan of the second high pass filter (5-3) connects the 3rd input end of analog signal of A/D converter (6), the lightwave signal outfan of the second low pass filter (5-4) connects the 4th input end of analog signal of A/D converter (6), the digital signal output end of A/D converter (6) connects the acquired signal input of computer (8).

2. checkout gear when blood pressure according to claim 1 and blood oxygen saturation, it is characterized in that: the emission wavelength of first wave long hair optical diode is 940nm, the emission wavelength of second wave length light emitting diode is 805nm, and the wavelength photoreceptor center range of photodiode is 805nm to 940nm.

3. checkout gear when blood pressure according to claim 1 and 2 and blood oxygen saturation, is characterized in that: the driving frequency of pulse generator (2) is 500Hz.

4. checkout gear when blood pressure according to claim 1 and 2 and blood oxygen saturation, it is characterized in that: the first pulse signal of described pulse generator (2) and the pass of the second pulse signal are: in a cycle period of pulse generator (2) pulse signal, the ON time of the first pulse signal and the second pulse signal was respectively 1/3 cycle, and the first pulse signal and the second pulse signal alternate conduction or the time difference of closing were 1/6 cycle.

5. the blood pressure of checkout gear and a Simultaneous Detection for blood oxygen saturation in the time of based on blood pressure described in claim 1 and blood oxygen saturation, is characterized in that: it comprises the following steps:

Step 1: photoelectricity volume sensor (3) is arranged between cuff (1) inner surface and the contact surface of skin;

Step 2: enter the air inflow in cuff (1) by regulating electric space-variant parallel operation (9) to regulate, make the interior pressure of cuff (1) increase with the speed of 5mmHg/S, until reach the pressure of regulation;

Step 3: clamp-pulse generator (2) is exported four pulse signals, when making the conducting simultaneously of the first pulse signal of pulse generator (2) and the 3rd pulse signal, the second pulse signal and the 4th pulse signal are closed simultaneously; In the time of the conducting simultaneously of the second pulse signal of pulse generator (2) and the 4th pulse signal, the first pulse signal and the 3rd pulse signal are closed simultaneously, realize driving the intermittence of two light emitting diodes, photodiode, when each light emitting diode is lighted respectively, gathers the photoelectricity plethysmogram signal of corresponding light emitting diode simultaneously;

Step 4: the reflected light signal that crest keeper (4) detects by photodiode two kinds of wavelength that obtain according to the pulse logic of pulse generator (2) is exported respectively, by computer (8), all image data are processed, obtained blood pressure and the blood oxygen saturation numerical value at detected position.

6. the Simultaneous Detection of blood pressure according to claim 5 and blood oxygen saturation, it is characterized in that: the method that step 4 Computer (8) is processed acquisition blood pressure values to image data is: the interior pressure signal of cuff (1) that the collections of the lightwave signal of the second high pass filter (5-3) that computer (8) obtains A/D converter (6) collection and pressure transducer (12) obtain adopts volume vibratory drilling method to calculate, obtain the numerical value of mean blood pressure and systolic pressure, and calculate the numerical value of diastolic pressure.

7. according to the Simultaneous Detection of blood pressure described in claim 5 or 6 and blood oxygen saturation, it is characterized in that: the method that step 4 Computer (8) is processed acquisition blood oxygen saturation numerical value to image data is:

First, when detected position is not subject to cuff (1) compressing, its absorbance A ^{λ i}for:

$A^{\mathrm{\&lambda;i}}=\log (I_0^{{\mathrm{\&lambda;}}_i}/I^{{\mathrm{\&lambda;}}_i})=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_i}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_i}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_i}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_i}{C}_{\mathrm{Hbo}}^v)d_v+{\mathrm{\&epsiv;}}_t^{{\mathrm{\&lambda;}}_i}{C}_t{d}_t+B^{{\mathrm{\&lambda;}}_i},$

for incident light quantity, for reflection light quantity, λ _i=λ ₁, λ ₂, λ ₁for the lightwave signal corresponding to first wave long hair optical diode, λ ₂for the lightwave signal corresponding to second wave length light emitting diode,

for the specific absorbance of reduced hemoglobin Hb,

for the reduced hemoglobin Hb concentration of arterial blood,

for the specific absorbance of HbO2 Oxyhemoglobin Hbo,

for the HbO2 Oxyhemoglobin Hbo concentration of arterial blood,

D _afor the optical path length of arterial blood,

for the reduced hemoglobin Hb concentration of venous blood,

for the HbO2 Oxyhemoglobin Hbo concentration of venous blood,

D _vfor the optical path length of venous blood,

for the specific absorbance of muscular tissue, C _tfor the concentration of muscular tissue,

D _tfor the optical path length of muscular tissue,

absorption for light at random;

Cuff (1) compressing being subject to when detected position does not change arteries, while only having vein blood vessel to change, corresponding to the wavelength X of first wave long hair optical diode ₁wavelength X with second wave length light emitting diode ₂respectively at v ₁absorbance under state

and v ₂absorbance under state

with

be respectively:

$A_{v_1}^{{\mathrm{\&lambda;}}_1}=\log (I_0^{{\mathrm{\&lambda;}}_1}/I_{v_1}^{{\mathrm{\&lambda;}}_1})=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^v)d_{v1}+{\mathrm{\&epsiv;}}_t^{{\mathrm{\&lambda;}}_1}{C}_t{d}_t+B^{{\mathrm{\&lambda;}}_1},$

$A_{v_1}^{{\mathrm{\&lambda;}}_2}=\log (I_0^{{\mathrm{\&lambda;}}_2}/I_{v_1}^{{\mathrm{\&lambda;}}_2})=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^v)d_{v1}+{\mathrm{\&epsiv;}}_t^{{\mathrm{\&lambda;}}_2}{C}_t{d}_t+B^{{\mathrm{\&lambda;}}_2},$

$A_{v_2}^{{\mathrm{\&lambda;}}_1}=\log (I_0^{{\mathrm{\&lambda;}}_1}/I_{v_2}^{{\mathrm{\&lambda;}}_1})=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^v)d_{v2}+{\mathrm{\&epsiv;}}_t^{{\mathrm{\&lambda;}}_1}{C}_t{d}_t+B^{{\mathrm{\&lambda;}}_1},$

$A_{v_2}^{{\mathrm{\&lambda;}}_2}=\log (I_0^{{\mathrm{\&lambda;}}_2}/I_{v_2}^{{\mathrm{\&lambda;}}_2})=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^a)d_a+({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^v)d_{v2}+{\mathrm{\&epsiv;}}_t^{{\mathrm{\&lambda;}}_2}{C}_t{d}_t+B^{{\mathrm{\&lambda;}}_2},$

Due at v ₁, v ₂blood under state in arteries and the absorbance of muscular tissue do not change, and supposition is constant from the absorption of light at random in the small interval of cuff pressurization, and the absorbance of venous blood two wavelength light is poor

with

be respectively:

$\mathrm{\&Delta;}{A}_{v_1-v_2}^{{\mathrm{\&lambda;}}_1}=A_{v_1}^{{\mathrm{\&lambda;}}_1}-A_{v_2}^{{\mathrm{\&lambda;}}_1}=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^v)\mathrm{\&Delta;}{d}_{v_1-v_2},$

$\mathrm{\&Delta;}{A}_{v_1-v_2}^{{\mathrm{\&lambda;}}_2}=A_{v_1}^{{\mathrm{\&lambda;}}_2}-A_{v_2}^{{\mathrm{\&lambda;}}_2}=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^v+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^v)\mathrm{\&Delta;}{d}_{v_1-v_2},$

In formula

for v ₁with v ₂the optical path difference of venous blood under state,

Cuff (1) compressing being subject to when detected position makes artery and vein vascular locking, and the extinction characteristic of muscular tissue and light at random is constant, only has the light path of the blood in arteries to change, and supposes the wavelength X corresponding to first wave long hair optical diode ₁wavelength X with second wave length light emitting diode ₂be respectively a ₁and a ₂during state, the absorbance of arterial blood two wavelength light poor

with

be respectively:

$\mathrm{\&Delta;}{A}_{a_1-a_2}^{{\mathrm{\&lambda;}}_1}=A_{a_1}^{{\mathrm{\&lambda;}}_1}-A_{a_2}^{{\mathrm{\&lambda;}}_1}=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}{C}_{\mathrm{Hbo}}^a)\mathrm{\&Delta;}{d}_{a_1-a_2},$

$\mathrm{\&Delta;}{A}_{a_1-a_2}^{{\mathrm{\&lambda;}}_2}=A_{a_1}^{{\mathrm{\&lambda;}}_2}-A_{a_2}^{{\mathrm{\&lambda;}}_2}=({\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hb}}^a+{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_2}{C}_{\mathrm{Hbo}}^a)\mathrm{\&Delta;}{d}_{a_1-a_2},$

for a ₁and a ₂the optical path difference of arterial blood under state,

Use SvO ₂represent Svo2, SaO ₂represent arterial oxygen saturation,

${\mathrm{SvO}}_2=C_{\mathrm{Hbo}}^v/(C_{\mathrm{Hbo}}^v+C_{\mathrm{Hb}}^v),$

${\mathrm{SaO}}_2=C_{\mathrm{Hbo}}^a/(C_{\mathrm{Hbo}}^a+C_{\mathrm{Hb}}^a),$

Above-mentioned all formula are solved and obtain Svo2 SvO ₂with arterial oxygen saturation SaO ₂:

${\mathrm{SvO}}_2=\frac{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}}{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}-{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}}-\frac{\mathrm{\&beta;}}{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}-{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}}\&times;\frac{\mathrm{\&Delta;}{A}_{v_1-v_2}^{{\mathrm{\&lambda;}}_1}}{\mathrm{\&Delta;}{A}_{v_1-v_2}^{{\mathrm{\&lambda;}}_2}},$

${\mathrm{SvO}}_2=\frac{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}}{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}-{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}}-\frac{\mathrm{\&beta;}}{{\mathrm{\&epsiv;}}_{\mathrm{Hb}}^{{\mathrm{\&lambda;}}_1}-{\mathrm{\&epsiv;}}_{\mathrm{Hbo}}^{{\mathrm{\&lambda;}}_1}}\&times;\frac{\mathrm{\&Delta;}{A}_{a_1-a_2}^{{\mathrm{\&lambda;}}_1}}{\mathrm{\&Delta;}{A}_{a_1-a_2}^{{\mathrm{\&lambda;}}_2}},$

In formula, β is λ ₂the absorptance of reduced hemoglobin Hb and HbO2 Oxyhemoglobin Hbo when selective reduction Hb H b and HbO2 Oxyhemoglobin Hbo have isobestic point wavelength.

8. the Simultaneous Detection of blood pressure and blood oxygen saturation according to claim 7, is characterized in that: the isobestic point wavelength that described reduced hemoglobin Hb and HbO2 Oxyhemoglobin Hbo have is 805nm.

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