CN102698219A - Drug for treating hyperplasia of prostate and preparation method thereof - Google Patents

Abstract

The invention discloses a drug for treating hyperplasia of prostate and a preparation method of the drug, belonging to the scope of stubborn disease in the field of traditional Chinese medicine. The prescription is composed of 18 drugs including white prepared lateral root of aconite, astragalus mongholicus and pseudo-ginseng. The hyperplasia of prostate is the most common in the old people, the clinical manifestation of hyperplasia of prostate is: frequent micturition, urgent urination, difficult painful urination, thin urine, oliguria, interruption of urinary stream, uroclepsia, nocturnal polyuria or uroschesis, and other symptoms; the disease is caused by kidney-Yang deficiency, insufficiency of middle-warmer energy, disorder bladder qi transformation, and multiple deficiency syndromes; but the symptom of asthenia with sthenia such as abdominal mass is formed as bladder and urinary tract are blocked by damp turbidity, blood stasis and leukorrhagia, the secretion and excretion of prostate are not smooth. The hormonotherapy of western medicine has big side effect, and most of the old people can not accept the operation treatment due to weak physique. The pathological elaboration and the clinical treatment effect of traditional Chinese medicine about the hyperplasia of prostate get the approval and attention of the medical domain at home and abroad. This drug is careful in compatibility, precise and appropriate in drug selection, and remarkable in treatment effect after the clinical therapy for a long term; and no pure traditional Chinese medicine prescription similar to the invention is found at present.

Description

A kind of medicine of treating hyperplasia of prostate and preparation method thereof

One, technical field

The present invention is a kind of medicine of treating hyperplasia of prostate and preparation method thereof, belongs to tcm field difficult disease category.

Two, background technology

1, hyperplasia of prostate is claimed prostate hyperplasia again, is commonly encountered diseases, the frequently-occurring disease of elderly men, and age of onset is many after 50 years old; Lower urinary tract obstruction mainly appears, show as frequent micturition, urgent micturition, urine thin, urine amount less, urine interrupts, puckery pain not to the utmost, dysuria and urine retention symptom such as polyuria at night, the patient goes out because of row's urinary stuttering difficulty; Lower abdomen and radix penis part distending pain unbearably, normal scream person of outstanding talent cry, bend over crisp knee joint, the crown head of a bed or collision wall, moan ceaselessly, and rub extruding distending pain position with hands, attempt to extrude urine and can not; Uneasy round the clock, the diet difficulty is advanced, and is agonizing; So tragic that one cannot bear to look at it; Old patient finally causes renal function injury because of blocking for a long time, uremia, or concurrent other disease is depleted dead.

Normal and the old testicular function decline of the pathogenesis of external report prostatic hyperplasia; And the sex hormone metabolism disorder has substantial connection, and sickness rate is up to 75%, and China's sickness rate is lower than the America and Europe; About about 50%; Someone adds up the 60-70 human body data in year, is as the criterion with macroscopy, and 75% has prostatic hyperplasia.The northern area sickness rate is higher than south, and along with the growth of human average life, its sickness rate is and increases trend gradually.Chinese medicine is just causing the approval and the attention of domestic and international medical circle to the theoretical explanation and the clinical efficacy of prostatic hyperplasia.

2, primary disease belongs to traditional Chinese medical science stranguria, difficulty in urination category.Stranguria is meant urine anxious difficulty in micturition frequently, Urethra astringent pain, and lower abdomen contracture, dragging pain in the navel are the disease card of principal character." Jing Yue's complete work stranguria with turbid discharge opinion control " pointed out: " pourings for sick, whether the urine pain is puckery, droplet puckery, desire to go or not, it is also that desire is ended more than person ".Think all that with Chao Yuanfang (550-630 A.D.), Tang's Sun Simiao stranguria is a basis to suffer from a deficiency of the kidney, the bladder pathogenic heat are mark." Xue Shi doctor by ": " if old man's sexual impotence is thought color, essence do not go out and in lose, the contrary puckery pain of urine is as drenching "." pen flower doctor mirror " said: " the old pouring is the void of bladder, and kidney qi is not changed yet, is incontinence of urine, for stranguria caused by overstrain, be old pouring." difficulty in urination is meant oliguria, drop and going out, even urinary obstruction is main disease, is one of old common disease, " infirmity " is meant oliguria,, patient's condition is the person slowly." close " and be meant urinary obstruction, desire to separate can not, the sudden and violent anxious person of patient's condition.The Golden Mirror of Medicine cloud: " the lighter is promptly drenched the drop drop and is gone out, and one is tens of time, or duty go out immoderate, so puckery pain is also in the stem." visible stranguria all belongs to the urine difficulty with the difficulty in urination, stranguria is meant the odynuria of urinating, and the difficulty in urination is meant the urine drop not down, all belongs to difficult danger and demonstrate,proves category.

3, the primary disease pathogenesis is: old people's insufficiency of vital energy and blood, decline of the fire from the gate of life, kidney yang loss, weakness of the spleen and stomach, deficiency of QI in middle-JIAO; Functioning of bladder is unfavorable, and deficiency syndrome are in the majority, because of old people's kidney yang deficiency, and the few sexual life of many sexual impotence; It is unable to ejaculate, or bears essence and do not penetrate, or suppresses urine, causes smart road, urethra freely not to block.So the normal deficiency complicated with excess of primary disease is by turbid damp, blood stasis, lose the smart bladder, urethra, prostate of hindering and form persistent ailment.

Theories such as 4, doctor trained in Western medicine is not clear and definite fully as yet to the cause of disease of prostatic hyperplasia, and main etiological study has endocrine theory, arteriosclerosis theory, inflammation theory, testicular function is unusual, sexual life is excessive.Most scholars think the disease of prostatic hyperplasia because of being since male, estrogenic flat permanent the imbalance cause, think in addition and possibly increase relevant with prostate 52-dihydrotestosterone (52-DHT).On pathology, during benign prostatic hyperplasia, can form multiple spherical shape tuberosity on the prostate, its composition is a fibrous tissue, smooth muscle tissue and body of gland itself.Its hypertrophy shows as glandular hyperplasia, and the glandular tube epithelial proliferation is mamillary and charges in the lumen of gland of expansion, and prostate is bigger and soft.If with fibrillar muscle hamartoplasia is main person, then prostate is normal hard and little.The prostate of hypertrophy enlargement is raised back prolonged urethra, bending, pressurized, bladder outlet, causes lower urinary tract obstruction.And outgrowth weight of prostate size is also very inconsistent, can have 10 surplus gram, tens of gram, supreme hectogram or heavier.Follow blocking of prostate-urethra position, urine excretion is not smooth, and detrusor of bladder meeting compensatory hypertrophy is to overcome urethral resistance; Muscular wall is than normally thickening about 2cm, and ureter and trigone of urinary bladder are also plump, because bladder is urinated endless, remaining urine retention are often arranged; Can bring out vesical calculus, can influence the function of ureter and kidney because of the long-term urokinase road-blockage late period; Concurrent ureter and hydronephrosis, final renal function is influenced, can cause critical illnesses such as chronic renal failure, uremia.

5, western medical treatment adopts progestational hormone more, and the estrogens treatment has certain curative effect, but side effect can appear in heavy dose of prolonged application.The androgen treatment also has certain curative effect, but there is the people to think carcinogenic possibility is arranged, so want careful usefulness.Except that Drug therapy, Therapeutic Method such as operative treatment, cryotherapy, microwave, ultrasound wave are arranged still.

6, Chinese medicine: because of primary disease is a basis with decline of the fire from the gate of life, deficiency of spleen-YANG and kidneyYANG, gasification deficiency, it is mark that its hypertrophy, urinary tract block, and method is worked as treating both the principal and secondary aspects of a disease.The sick position of considering this disease simultaneously according to the principle of the six hollow viscera must keep its unobstructed, first heavy regulating fluid apssage, can not be ignored part " disease is long-pending " pathology at bladder, urethra again; The diffusing stasis of blood knot of the then suitable clearing away damp-heat of real example, sharp mechanism of qi waterway, the suitable Wen Yang of asthenic symptoms; The tonifying spleen kidney, help gasification, assistant is with stagnation resolvation, soft heavily fortified point, the crux of loosing; Gasify capablely to reach, urine is from logical purpose.In a word, no matter use what method, its hard masses softening and resolving, the method for blood circulation promoting and blood stasis dispelling for using because this method has stronger dissipation body of gland, organized the effect of lump, hypertrophy.

7, look into the 201st page of Zheng Yongfeng chief editor " the Chinese medicine patent is complete works of ", in please number: P3102831, notification number: 1078900, denomination of invention: the Chinese medicine preparation of treatment prostatic hyperplasia, adopt medicines such as the Radix Astragali, Talcum, Spica Prunellae, Semen Litchi to be prepared as honeyed pill.

Now its curative effect of clinical QIANLIEKANG commonly used (paracetamol), proscar (non-draw male amine sheet) also owes definite.

More than all there is certain defective in the Chinese and western drugs of treatment prostatic hyperplasia, and curative effect is relatively poor, and particularly the side effect of Western medicine hormones is big, and curative effect is not consolidated, so the present invention treats the comparatively ideal medicine of prostatic hyperplasia at present; According to available data, do not find the pure Chinese medicinal preparation of treatment hyperplasia of prostate at present as yet.

Three, summary of the invention

1, the present invention is made up of following medicine and weight proportion thereof:

Radix Aconiti Lateralis Preparata 10-60 part, Radix Astragali 20-100 part, Cortex Cinnamomi 10-40 part, Rhizoma Zingiberis 10-40 part, Semen Cuscutae 15-50 part, Rhizoma Atractylodis Macrocephalae 15-50 part, Poria 15-50 part, Semen Plantaginis 10-50 part, Semen Abutili 10-50 part, Semen Vaccariae 10-50 part, Radix Notoginseng 10-40 part, Rhizoma Curcumae 10-40 part, Radix Paeoniae Rubra 10-40 part, Radix Cyathulae 15-40 part, Sargassum 10-40 part, Thallus Laminariae (Thallus Eckloniae) 10-40 part, Concha Ostreae 15-50 part, Radix Scrophulariae 15-40 part

2, the preferred weight proportioning of medicine of the present invention is:

Radix Aconiti Lateralis Preparata 20-60 part, Radix Astragali 20-100 part, Cortex Cinnamomi 15-40 part, Rhizoma Zingiberis 10-40 part, Semen Cuscutae 15-50 part, Rhizoma Atractylodis Macrocephalae 15-50 part, Poria 15-50 part, Semen Plantaginis 10-40 part, Semen Abutili 10-40 part, Semen Vaccariae 10-40 part, Radix Notoginseng 10-30 part, Rhizoma Curcumae 10-40 part, Radix Paeoniae Rubra 15-40 part, Radix Cyathulae 15-40 part, Sargassum 10-40 part, Thallus Laminariae (Thallus Eckloniae) 10-40 part, Concha Ostreae 15-50 part, Radix Scrophulariae 15-40 part

3, optimum weight proportioning of the present invention is:

50 parts of Radix Aconiti Lateralis Preparatas, 60 parts of the Radixs Astragali, 15 parts of Cortex Cinnamomis, 20 parts of Rhizoma Zingiberiss, 30 parts of Semen Cuscutae, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts in Poria, 30 parts of Semen Plantaginiss, 20 parts of Semen Abutilis, 20 parts of Semen Vaccariae, 15 parts of Radix Notoginseng, 20 parts of Rhizoma Curcumae, 20 parts of Radix Paeoniae Rubra, 20 parts of Radix Cyathulaes, 20 parts of Sargassums, 20 parts of Thallus Laminariae (Thallus Eckloniae)s, 30 parts of Concha Ostreaes, 30 parts of Radix Scrophulariaes

4, the nature and flavor of each medicine of the present invention and effect:

Radix Aconiti Lateralis Preparata: hot, sweet, big heat, GUIXIN, kidney, spleen channel, recuperating depleted YANG and rescuing the patient from collapse, it is supporing yang to mend fire, dispersing cold for relieving pain.The pure sun of these article is dry strong, is the key medicine of recuperating depleted YANG and rescuing the patient from collapse, on help heart-yang promoting blood circulation, middle warming the spleen sun is with cold expelling, the following benefit gate of vitality is with the benefit fire.The Radix Astragali: sweet, tepor is returned spleen, lung meridian, tonifying Qi and lifting yang, and benefit is defended consolidating superficial resistance, inducing diuresis to remove edema, holder skin ulcer granulation promoting.These article are apt to invigorating middle warmer gas, the ability ascending up spleen-Qi and Yang, and tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, qi-supplementing, blood-engendering.Cortex Cinnamomi: hot, sweet, hot, return kidney, spleen, the heart, Liver Channel, be used for syndrome of yang deficiency of spleen and kidney; The kind gate of vitality's fire of mending of these article has the fiery supporing yang effect of benefit, for controlling the main medicine of decline of the fire from the gate of life; Control insufficiency of kidney-YANG, aversion to cold and cold limbs due to the decline of the fire from the gate of life, waist knee joint weakness, sexual impotence, frequent micturition etc.; These article have supporing yang tonify deficiency again, the effect that cold expelling is promoted blood circulation.Rhizoma Zingiberis: hot, hot, return spleen, stomach, the heart, lung meridian, warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, warming the lungization is cold.These article are kind can warming spleen and stomach for dispelling cold, has the logical heart supporing yang again, the effect that recuperating depleted YANG is promoted blood circulation, control deficiency of heart-YANG and kidney-YANG, yin-cold excess due to yang depletion syndrome; See extremity contrary, the faint pulse being about to disappear person that faints, every and Radix Aconiti Lateralis Preparata mutual reinforcement between are usefulness, " book on Chinese herbal medicine is looked for the truth " cloud: " Rhizoma Zingiberis, big heat is nontoxic; keep and do not walk, all deficiency-cold of the stomach, Yuanyang is closed with Radix Aconiti Lateralis Preparata with throwing wild; then can have immediate effect by recuperating depleted YANG, so there is Radix Aconiti Lateralis Preparata not have the not hot sentence of Rhizoma Zingiberis ", the Zhong Jing cold limbs, lead in vain, JIANGFU soup all uses it.Semen Cuscutae: sweet, warm, return liver, kidney spleen channel, tonifying the kidney to consolidate the essence, nourishing the liver to improve visual acuity; Antidiarrheal is antiabortive, and these article can kidney-replenishing, and is again can tonifying YIN smart, not dryly do not stagnate; Good medicine for flat tonifying liver, kidney, spleen three warps has controlling nocturnal emission with astringent drugs, reducing urination, antidiarrheal, an effect such as antiabortive that makes eye bright, and promptly is applicable to lumbago, sexual impotence, seminal emission, frequent micturition, the leukorrhagia of suffering from a deficiency of the kidney; Be applicable to poor vision, the frequent fetal movement of deficiency of the liver and kindey again, quench one's thirst, still can control having loose bowels of weakness of the spleen and kidney.The Rhizoma Atractylodis Macrocephalae: bitter, sweet, warm, return spleen, stomach warp, air making-up and spleen enlivening, the dampness diuretic, strengthening superficial resistance to stop perspiration is antiabortive, is used for weakness of the spleen and stomach, anorexia and loose stool, distension and fullness in the abdomen, for controlling the key medicine of insufficiency of the spleen all cards, these article get final product air making-up and spleen enlivening, again can the dampness diuretic, control the good medicine of phlegm retention edema.Poria: sweet, light, flat, GUIXIN, spleen, kidney channel, promoting diuresis to eliminate damp pathogen, spleen-benefiting mind-tranquilizing is used for edema, dysuria, and good inducing diuresis to remove edema effect is arranged, and these article property of medicine is gentle, and no cold and heat are partially, diuretic and do not hinder healthy energy, and can invigorating spleen and relieving mental stress.Semen Plantaginis: sweet, cold, return kidney, liver, lung meridian, inducing diuresis for treating stranguria syndrome, eliminating dampness by diuresis antidiarrheal, the liver that disappears makes eye bright, and the lung that disappears reduces phlegm.Be used for pyretic stranguria, edema, dysuria, the kind clearing away heat and promoting diuresis of these article is treating stranguria, control damp invasion of lower energizer, and the puckery pain person of dribbling urination due to the accumulation of heat in the urinary bladder is particularly suitable.Semen Abutili: sweet, cold, return intestine and small intestine, urinary bladder channel, relieving stranguria by diuresis, stimulating milk secretion, loosening bowel to relieve constipation, these article have the relieving stranguria by diuresis effect, control the puckery pain of pyretic stranguria, stranguria with blood, consumer edema is used for lack of lactation after delivery again, distending pain of the breast.Semen Vaccariae: bitter, flat, return liver, stomach warp, promoting blood circulation to restore menstrual flow, stimulating milk secretion, eliminating carbuncle, relieving stranguria by diuresis, these article be apt to promoting blood circulation, and are capable and do not live, and the merit of promoting blood circulation to restore menstrual flow arranged, lack of lactation after delivery, or one-tenth acute mastitis.Be used for cards such as pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, the merit of inducing diuresis for treating stranguria syndrome is arranged.Radix Notoginseng: sweet, little hardship, temperature, return liver, stomach warp, removing stasis to stop bleeding; Reducing swelling and alleviating pain, these article can stop blooding, kind again blood stasis dispelling; Hemostasis is arranged and do not stay the stasis of blood, blood stasis dispelling not to hinder characteristics just, good promoting blood circulation and detumescence analgesic therapy effect is arranged; Being widely used in cards such as coronary heart disease, angina pectoris, apoplexy sequela 、 mass in the abdomen, blood stasis amenorrhea, stasis of blood resistance pain, really is blood disorder good medicine.Curcuma zedoary: hot, bitter, warm, return liver, the spleen channel, broken blood promoting the circulation of qi, the long-pending pain relieving that disappears, this product is broken blood eliminating mass key medicine, all stagnation of QI and blood severes are commonly used, treat blood stasis depressed a lump in the abdomen causing distension and pain, through closing, or trusted subordinate's stasis of blood has piece pain.Radix Paeoniae Rubra: bitter, be slightly cold, return Liver Channel, clearing away heat and cooling blood, stasis-dispelling and pain-killing, these article are specially gone into Liver Channel, are apt to away blood system, can clearing away heat and cooling blood, again can stasis-dispelling and pain-killing, for controlling due to the stagnation of blood stasis good medicine, like traumatic injury 、 lumps in the chest and abdomen, sore, carbuncle and painful swelling, liver-fire conjunctival congestion at disease.Radix Cyathulae: bitter, sour, sweet, flat, return liver, kidney channel, promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, ignite (blood) is descending, inducing diuresis for treating stranguria syndrome, this moral character is kind descending, gives birth to kind blood circulation promoting and blood stasis dispelling, decreases the pain of injuring, kind again inducing diuresis for treating stranguria syndrome, the blood of igniting is descending, controls stranguria.Descending because of drawing all medicines, be the descending guiding drug of priming so use always.Sargassum: salty, cold, return liver, stomach, kidney channel, eliminating phlegm and softening indurated mass, inducing diuresis to remove edema is used for goiter, scrofula, painful and swollen testis, and the heat clearing away expectorant is arranged, the effect of hard masses softening and resolving.Thallus Laminariae (Thallus Eckloniae): salty, cold, return liver, stomach, kidney channel, vanishing sputum and dispelling knot, inducing diuresis to remove edema is used for stagnate meridians, pent-up of goiter, scrofula, expectorant and becomes all cards of lump, and hard masses softening and resolving is also controlled painful and swollen testis.Concha Ostreae: salty, puckery, be slightly cold, return liver, kidney channel, suppressing the hyperactive liver and subsiding YANG; Hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweatingly, is used for excessive rising of liver-YANG, the vertigo; Sucutaneous nodule scrofula 、 lumps in the chest and abdomen, the kind multiple weakened body resistance all cards of slippage of not consolidating such as spermatorrhea, the enuresis, frequent micturition, metrorrhagia, leukorrhagia, spontaneous perspiration, night sweat of controlling.Radix Scrophulariae: sweet, bitter, salty, cold, return lung, stomach, kidney channel, clearing away heat and cooling blood, YIN nourishing detoxifcation; These article are the kind heat of letting out nutrient blood of bitter cold, control the heat blood disorder of joining the army, sweet again cold yin nourishing pathogenic fire reducing; Promote the production of body fluid and moisturize, control the cloudy chronic cough that loses, hectic fever due to YIN-deficiency, quench one's thirst, card such as constipation; And ability hard masses softening and resolving is controlled laryngopharynx swelling and pain, the scrofula carbuncle sore.

5, pharmaceutical formulation side of the present invention separates:

This prescription adopts Radix Aconiti Lateralis Preparata, the Radix Astragali, Cortex Cinnamomi, Rhizoma Zingiberis, Semen Cuscutae, the Rhizoma Atractylodis Macrocephalae, the sun of Poria warming the spleen kidney, helps fire from the gater of life; The spleen invigorating QI invigorating helps the functioning of bladder function, disease such as remove frequent micturition, urgency, can't help; With Semen Plantaginis, Semen Abutili, Semen Vaccariae, inducing diuresis for treating stranguria syndrome; Sliding sharp unobstructed urinary tract is removed the puckery pain of urine, urine retention, is surplusly drowned endless, disease such as urine interruption, with blood circulation promoting and blood stasis dispelling such as Radix Notoginseng, Rhizoma Curcumae, Radix Paeoniae Rubra; With Sargassum, Thallus Laminariae (Thallus Eckloniae), Concha Ostreae hard masses softening and resolving, play altogether and eliminate damp and hot, blood stasis and lose the Zeng Sheng mass in the abdomen lump due to the essence; Use the Radix Scrophulariae clearing away heat and cooling blood, the YIN nourishing detoxifcation is promoted the production of body fluid and is moisturized, with all descending through sick institutes of medicine of Radix Cyathulae guiding; Full side's strengthening vital QI to eliminate pathogenic factors, reinforcement and elimination in combination, treatment must aim at the pathogenesis of disease, compatibility is careful, selects YAOJING to work as, and is evident in efficacy through clinical prolonged application, any side effect do not occur.

Four, method for preparing

1, press the optimum weight proportioning of the 3rd various medicines of summary of the invention, with various drug purifications, claim sufficient deal, splendid attire respectively.

2, the Radix Aconiti Lateralis Preparata coarse sand is stirred to little yellow hair bubble the nothing of chewing fiber crops flavor.

3, with Semen Cuscutae, be the Herba cuscutae cake by the boiling of prepared slices of Chinese crude drugs concocted specification, drying for standby.

4, various medicines are closed even, Exposure to Sunlight or drying room drying for standby.

5, be fine powder with drying for standby medicine micronizing.

6, micropowders is pressed the conventional method for preparing of the watered pill, be prepared into the watered pill, like the Semen phaseoli radiati size, every 100g is bottled, ultraviolet disinfection.

7, micropowders is divided encapsulated, the heavy 0.5g of grain, ultraviolet disinfection, per 100 bottled sealings.

8,, add compressed with adhesive such as starch and become tablet, the heavy 0.5g of sheet, ultraviolet disinfection, per 100 bottled sealings with micropowders.

9, the watered pill of medication preparation of the present invention, capsule, tablets and other formulations are said dosage forms on any pharmaceutics.

10, medicine of the present invention source is easy to get, and method for preparing is easy, taking convenience, and determined curative effect, pure Chinese medicinal preparation, without any side effects.

Claims (10)

1. The present invention is a kind of medicine of treating prostatic hyperplasia and preparation method thereof, belongs to tcm field difficult disease category, it is characterized in that, it is because the medicament that following medicine and weight proportion thereof are prepared from.

   1. the present invention is made up of following medicine and weight proportion thereof:

   Radix Aconiti Lateralis Preparata 10-60 part, Radix Astragali 20-100 part, Cortex Cinnamomi 10-40 part, Rhizoma Zingiberis 10-40 part, Semen Cuscutae 15-50 part, Rhizoma Atractylodis Macrocephalae 15-50 part, Poria 15-50 part, Semen Plantaginis 10-50 part, Semen Abutili 10-50 part, Semen Vaccariae 10-50 part, Radix Notoginseng 10-40 part, Rhizoma Curcumae 10-40 part, Radix Paeoniae Rubra 10-40 part, Radix Cyathulae 15-40 part, Sargassum 10-40 part, Thallus Laminariae (Thallus Eckloniae) 10-40 part, Concha Ostreae 15-50 part, Radix Scrophulariae 15-40 part.
2. 2. the preferred weight proportioning of medicine of the present invention is:

   Radix Aconiti Lateralis Preparata 20-60 part, Radix Astragali 20-100 part, Cortex Cinnamomi 15-40 part, Rhizoma Zingiberis 10-40 part, Semen Cuscutae 15-50 part, Rhizoma Atractylodis Macrocephalae 15-50 part, Poria 15-50 part, Semen Plantaginis 10-40 part, Semen Abutili 10-40 part, Semen Vaccariae 10-40 part, Radix Notoginseng 10-30 part, Rhizoma Curcumae 10-40 part, Radix Paeoniae Rubra 15-40 part, Radix Cyathulae 15-40 part, Sargassum 10-40 part, Thallus Laminariae (Thallus Eckloniae) 10-40 part, Concha Ostreae 15-50 part, Radix Scrophulariae 15-40 part.
3. 3. optimum weight proportioning of the present invention is:

   50 parts of Radix Aconiti Lateralis Preparatas, 60 parts of the Radixs Astragali, 15 parts of Cortex Cinnamomis, 20 parts of Rhizoma Zingiberiss, 30 parts of Semen Cuscutae, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts in Poria, 30 parts of Semen Plantaginiss, 20 parts of Semen Abutilis, 20 parts of Semen Vaccariae, 15 parts of Radix Notoginseng, 20 parts of Rhizoma Curcumae, 20 parts of Radix Paeoniae Rubra, 20 parts of Radix Cyathulaes, 20 parts of Sargassums, 20 parts of Thallus Laminariae (Thallus Eckloniae)s, 30 parts of Concha Ostreaes, 30 parts of Radix Scrophulariaes.
4. 4. by medicine optimum weight proportioning of the present invention, with various drug purifications, claim sufficient deal, splendid attire respectively.
5. 5. the Radix Aconiti Lateralis Preparata coarse sand is stirred to little yellow hair bubble the nothing of chewing fiber crops flavor; Semen Cuscutae is pressed prepared slices of Chinese crude drugs concocted specification, and boiling is the Herba cuscutae cake, drying for standby.
6. 6. various medicines are closed evenly, Exposure to Sunlight or drying room are dry, adopt superfine grinding method, pulverize to be micropowders.
7. 7. micropowders is prepared into the watered pill by the conventional method for preparing of the watered pill, like the Semen phaseoli radiati size, every 100g is bottled, ultraviolet disinfection.
8. 8. divide encapsulated, the heavy 0.5g of grain, ultraviolet disinfection, per 100 bottled sealings with micropowders.
9. 9. with binding agents such as the trickle adding starch of ultra micro, be pressed into tablet, the heavy 0.5g of sheet, ultraviolet disinfection, per 100 bottled sealings.
10. 10. the watered pill of medication preparation of the present invention, capsule, tablets and other formulations are said dosage forms on any pharmaceutics, the prescription protection.