CN102670641A - Liquid composition for contact lenses - Google Patents
Liquid composition for contact lenses Download PDFInfo
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- CN102670641A CN102670641A CN201110339404XA CN201110339404A CN102670641A CN 102670641 A CN102670641 A CN 102670641A CN 201110339404X A CN201110339404X A CN 201110339404XA CN 201110339404 A CN201110339404 A CN 201110339404A CN 102670641 A CN102670641 A CN 102670641A
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- vitamin
- fluid composition
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- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 239000007788 liquid Substances 0.000 title abstract description 5
- 239000011782 vitamin Substances 0.000 claims abstract description 50
- 229940088594 vitamin Drugs 0.000 claims abstract description 49
- 229930003231 vitamin Natural products 0.000 claims abstract description 49
- 235000013343 vitamin Nutrition 0.000 claims abstract description 49
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 47
- 239000004094 surface-active agent Substances 0.000 claims abstract description 17
- 239000007853 buffer solution Substances 0.000 claims abstract description 9
- 239000012530 fluid Substances 0.000 claims description 46
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 18
- 229920002521 macromolecule Polymers 0.000 claims description 17
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 13
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 9
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 7
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 7
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 7
- 229930003427 Vitamin E Natural products 0.000 claims description 7
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 7
- 235000019155 vitamin A Nutrition 0.000 claims description 7
- 239000011719 vitamin A Substances 0.000 claims description 7
- 235000019165 vitamin E Nutrition 0.000 claims description 7
- 229940046009 vitamin E Drugs 0.000 claims description 7
- 239000011709 vitamin E Substances 0.000 claims description 7
- 229940045997 vitamin a Drugs 0.000 claims description 7
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 6
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 5
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 5
- 229930003779 Vitamin B12 Natural products 0.000 claims description 5
- 229930003537 Vitamin B3 Natural products 0.000 claims description 5
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 5
- 229920002674 hyaluronan Polymers 0.000 claims description 5
- 229960003160 hyaluronic acid Drugs 0.000 claims description 5
- 229960003512 nicotinic acid Drugs 0.000 claims description 5
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 5
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 5
- 229920000053 polysorbate 80 Polymers 0.000 claims description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 5
- 235000019163 vitamin B12 Nutrition 0.000 claims description 5
- 239000011715 vitamin B12 Substances 0.000 claims description 5
- 235000019160 vitamin B3 Nutrition 0.000 claims description 5
- 239000011708 vitamin B3 Substances 0.000 claims description 5
- 235000019158 vitamin B6 Nutrition 0.000 claims description 5
- 239000011726 vitamin B6 Substances 0.000 claims description 5
- 229940011671 vitamin b6 Drugs 0.000 claims description 5
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 229910021538 borax Inorganic materials 0.000 claims description 4
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 4
- 239000004327 boric acid Substances 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- -1 hydroxypropyl Chemical group 0.000 claims description 4
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 4
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 4
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 4
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims description 4
- 150000001642 boronic acid derivatives Chemical class 0.000 claims 1
- 125000000627 niacin group Chemical class 0.000 claims 1
- 150000002266 vitamin A derivatives Chemical class 0.000 claims 1
- 150000003697 vitamin B6 derivatives Chemical class 0.000 claims 1
- 150000003712 vitamin E derivatives Chemical class 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000005252 bulbus oculi Anatomy 0.000 description 20
- 238000004140 cleaning Methods 0.000 description 6
- 235000019156 vitamin B Nutrition 0.000 description 4
- 239000011720 vitamin B Substances 0.000 description 4
- 229940046001 vitamin b complex Drugs 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000003204 osmotic effect Effects 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 206010052804 Drug tolerance Diseases 0.000 description 1
- 229920002413 Polyhexanide Polymers 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 208000003464 asthenopia Diseases 0.000 description 1
- 239000003855 balanced salt solution Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000026781 habituation Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
Abstract
A liquid composition for use in contact lenses comprising a concentration of about 1 x 10 weight percent-5% to about 3% of a vitamin, in a concentration of about 5X 10 by weight-3% to about 1.0% of a hydrophilic polymer at a concentration of about 1X 10 by weight-3% to about 1% of a surfactant, and a salt buffer solution.
Description
Technical field
The present invention relates to a kind of fluid composition that is used for contact lens.
Background technology
Along with popularizing and development of human civilization and education, increasing people suffers from myopia.Consider convenience and habituation, the contact lens utilization rate is very high.Use contact lens to clean and to maintain, otherwise possibly make eyeball injured because of the microorganism on the contact lens or pollutant.
Usually the maintenance method of contact lens is to utilize the contact lens cleaning solution that contains surfactant to clean eyeglass.After cleaning, usually contact lens is immersed in the solution so that remove the residue on the eyeglass.In addition, maintenance method comprises that the sterilization eyeglass is to remove microorganism possible on the eyeglass.Known contact lens Precerving liquid can provide good cleaning and antibacterial effect to contact lens.
But wear contact lens for a long time, cause that easily eyestrain is uncomfortable, known contact lens Precerving liquid can't improve said circumstances effectively.Therefore, still need a kind of contact lens Precerving liquid that can eliminate the tired sense of discomfort of eyeball of contact lens user at present.
Summary of the invention
An object of the present invention is to provide a kind of fluid composition that is used for contact lens, it can make user when using contact lens, and the eyeball feeling of fatigue of eliminating or releive has the contact lens moisture-keeping functions simultaneously concurrently.
According to the embodiment of the present invention, the said fluid composition that is used for contact lens comprises concentration expressed in percentage by weight about 1 * 10
-5One or more the vitamin of % to about 3%, concentration expressed in percentage by weight about 5 * 10
-3One or more the hydrophilic macromolecule of % to about 1.0%, concentration expressed in percentage by weight about 1 * 10
-3One or more the surfactant of % to about 1%, and borate buffer solution or PBS.
According to one embodiment of the invention, vitamin comprises vitamin A, and the concentration expressed in percentage by weight of vitamin A is about 0.01% to about 1%.
According to one embodiment of the invention, vitamin comprises vitamin B complex, for example vitamin B3, vitamin B6 or vitamin B12, and the concentration expressed in percentage by weight of vitamin B complex is about 0.01% to about 1.5%.
According to one embodiment of the invention, vitamin comprises vitamin E, and the concentration expressed in percentage by weight of vitamin E is about 0.01% to about 1%.
According to one embodiment of the invention, hydrophilic macromolecule is selected from the group that is made up of polyvinyl alcohol, polyvinylpyrrolidone, hyaluronic acid, hydroxypropyl emthylcellulose and Polyethylene Glycol.The concentration expressed in percentage by weight of hydrophilic macromolecule is about 0.01% to about 0.1%.
According to one embodiment of the invention, surfactant comprises at least one TWEEN 80
TMAnd GEROPON
TMSBFA-30, and the concentration expressed in percentage by weight of surfactant is about 0.001% to about 0.08%.
According to one embodiment of the invention, borate buffer solution comprises boric acid, sodium borate and sodium chloride.PBS comprises disodium-hydrogen, sodium dihydrogen phosphate and sodium chloride.
Embodiment
More detailed and complete for the narration that makes content of the present invention, hereinafter has proposed illustrative description to embodiment of the present invention and specific embodiment; But this is not unique form of implementing or using the specific embodiment of the invention.Below disclosed each embodiment, under useful situation, can make up each other or replace, and need not further record or explanation.In the following description, with being described in detail many specific detail so that the reader can make much of following embodiment.Yet, can under the situation of not having these specific detail, put into practice embodiments of the invention.
The invention discloses a kind of fluid composition that is used for contact lens, this fluid composition can be used for hard contact lenses and Soft contact lens.The Soft contact lens eyeglass can for example be hydrophilic glue eyeglass or polymeric silicon soft contact lens.
Under common operating position, contact lens is soaked in the fluid composition and fully contacts with fluid composition.When contact lens user is desired to wear or is used contact lens, just contact lens is taken out from fluid composition, and then with contact lens wear on eyeball.When contact lens was immersed in fluid composition, the one-tenth branch in the fluid composition adhered to or is adsorbed on the contact lens.When user with contact lens wear eyeball on the time, adhere to or the composition that is adsorbed on the contact lens just can enter into eyeball.
The fluid composition of embodiment of the present invention comprises vitamin, hydrophilic macromolecule, surfactant and at least a borate buffer solution or PBS at least.
Vitamin helps to eliminate the eyeball feeling of fatigue of contact lens user.Vitamin in the fluid composition can adsorb and attached on the contact lens, and along with user is worn contact lens and got into eyeball, and absorbed by eyeball tissue.Said vitamin can be water soluble vitamins or fatsoluble vitamin.Water soluble vitamins can for example be a vitamin B complex; Fatsoluble vitamin can for example be vitamin A or vitamin E.
The concentration expressed in percentage by weight of vitamin in whole fluid composition is about 1 * 10
-5% is to about 3%.When the concentration of vitamin in the fluid composition is higher than certain value, can influences the pH value of fluid composition, and make the osmotic pressure of fluid composition too high.In the case, if fluid composition gets into eyeball, can let the user of contact lens feel that eyeball is uncomfortable.Otherwise, when the vitamine concentration of fluid composition is too low, then can't produces and eliminate the tired effect of eyeball.Therefore, the concentration expressed in percentage by weight of vitamin is about 1 * 10
-5% is to about 3%.From then on viewpoint; The total amount of the vitamin that embodiment of the present invention added; Can make the pH value of fluid composition maintain about 6.0 to about 8.0, the osmotic pressure of fluid composition maintains about 200mOsm/Kg to about 500mOsm/Kg, and preferably about 280mOsm/Kg is about 380mOsm/Kg extremely.
In one embodiment, said vitamin comprises vitamin A, and the concentration expressed in percentage by weight of vitamin A is about 0.01% to about 1%.Among this paper, if do not have to specify, concentration expressed in percentage by weight is to serve as to calculate benchmark with whole fluid composition.
In another embodiment, said vitamin comprises vitamin B complex.In one embodiment, vitamin comprises vitamin B3, and the concentration expressed in percentage by weight of vitamin B3 is about 0.01% to about 1.5%.In another embodiment, vitamin comprises vitamin B6, and the concentration expressed in percentage by weight of vitamin B6 is about 0.01% to about 1.5%.In another embodiment, vitamin comprises vitamin B12, and the concentration expressed in percentage by weight of vitamin B12 is about 0.01% to about 1.5%.
In other embodiments, said vitamin comprises vitamin E, and the concentration expressed in percentage by weight of vitamin E is about 0.01% to about 1%.
Hydrophilic macromolecule can impel contact lens to adsorb more vitamin, avoids the vitamin on the contact lens to run off because of the tear of eyeball is quick simultaneously.Vitamin in the fluid composition, though can be adsorbed on the contact lens, adsorbance is very limited usually.Hydrophilic macromolecule in the fluid composition can effectively improve absorption and the adhesion amount of vitamin on contact lens.In specific words, the hydrophilic macromolecule in the fluid composition is adsorbed on the contact lens, and with vitamin generation adsorption, and increase the adsorbance of vitamin on the contact lens.In addition, hydrophilic macromolecule helps to keep the vitamin that is adsorbed on the contact lens surface, and the tear of avoiding eyeball to produce removes vitamin from the contact lens dissolving, and causes vitamin to run off rapidly.Especially when wearing contact lens; The moment of contact lens contact eyeball often is accompanied by a large amount of tears of secretion; If can not suitably keep on the contact lens vitamin of absorption originally, vitamin will promptly be dissolved in the tear, and along with tear leaves eyeball and do not absorbed by eyeball.From then on viewpoint, the present invention is not only to be merely to add vitamin, and relates to the reciprocal action between vitamin and the hydrophilic macromolecule.More particularly; The technology contents of embodiment of the present invention relates to the formed biochemical system of vitamin, hydrophilic macromolecule, contact lens, eyeball and tear, and this biochemical system can let the eyeball of user effectively absorb vitamin via wearing contact lens.
Hydrophilic macromolecule can for example be polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), hyaluronic acid (Hyaluronic acid, HA), hydroxypropyl emthylcellulose (HPMC) or Polyethylene Glycol (PEG).In one embodiment, the weight average molecular weight of polyvinyl alcohol and polyvinylpyrrolidone is extremely about 50000g/mol of about 2000g/mol, and the weight average molecular weight of hydroxypropyl emthylcellulose and hyaluronic acid is that about 50000g/mol is to about 350000g/mol.Said hydrophilic macromolecule also helps preserving moisture of contact lens.
The concentration of hydrophilic macromolecule in fluid composition can be adjusted according to the kind and the concentration of vitamin.In one embodiment, for making the vitamin of contact lens absorption capacity, the concentration expressed in percentage by weight of hydrophilic macromolecule is about 5 * 10
-3% is to about 0.5%, preferred about 0.01% to about 0.1%.
Can add an amount of surfactant in the fluid composition of contact lens, in order to the cleaning contact lens.Add surfactant kind and concentration only otherwise can stimulate the eyeball of user and not harm health and get final product.For example, TWEEN 20
TM, TWEEN 80
TM, GEROPON
TMSBFA-30 or TETRONIC1107
TM, the surfactant concentration expressed in percentage by weight is about 1 * 10
-3% more clearly is about 1 * 10 to about 1%
-3% is to about 0.1%.
Inventor of the present invention finds that some surfactant not only has the function of cleaning contact lens, and can promote contact lens to adsorb more vitamin simultaneously.In one embodiment, surfactant comprises at least one TWEEN 80
TMAnd GEROPON
TMThe surfactant of SBFA-30, it can further improve the adsorbance of vitamin on the contact lens, and has the function of cleaning contact lens simultaneously concurrently.In the present embodiment, the concentration expressed in percentage by weight of surfactant in whole fluid composition is about 1 * 10
-3% is preferably about 0.002% to about 0.01% to about 0.08%.In addition, TWEEN 80
TMAnd GEROPON
TMThe SBFA-30 surfactant can increase fatsoluble vitamin dissolubility in fluid composition.
Borate buffer solution or PBS are in order to provide stable p H-number environment.For example, borate buffer solution can comprise boric acid, sodium borate and sodium chloride.PBS can comprise disodium-hydrogen, sodium dihydrogen phosphate and sodium chloride.In addition, said balanced salt solution comprises proper amount of sodium chloride, makes the osmotic pressure of above-mentioned fluid composition maintain suitable scope, for example is that about 200mOsm/Kg is to about 500mOsm/Kg.
Comprise in the embodiment of borate buffer solution at said fluid composition; The concentration expressed in percentage by weight of sodium chloride in whole fluid composition is about 0.35% to about 1.05%; The concentration expressed in percentage by weight of boric acid is about 0.20% to about 0.70%, and the concentration expressed in percentage by weight of sodium borate is about 0.01% to about 0.7%.
Comprise in the embodiment of PBS at said fluid composition; The concentration expressed in percentage by weight of sodium chloride in whole fluid composition is about 0.40% to about 1.20%; The concentration expressed in percentage by weight of disodium-hydrogen is about 0.10% to about 0.70%, and the concentration expressed in percentage by weight of sodium dihydrogen phosphate is about 0.01% to about 0.70%.
In other embodiments, said fluid composition can further comprise the antimicrobial of capacity, for example can add be lower than 3ppm gather cyclohexane extraction biguanide (PHMB), it is the present technique known.
Below list several representational embodiment.
Embodiment 1
Embodiment 2
Embodiment 3
Embodiment 4
Embodiment 5
Though the present invention is with embodiment openly as above, so it is not that any those skilled in the art are not breaking away from the spirit and scope of the present invention in order to qualification the present invention, but do various modifications and change, so protection scope of the present invention is as the criterion with claims.
Claims (11)
1. fluid composition that is used for contact lens comprises:
Concentration expressed in percentage by weight about 1 * 10
-5% is about 3% vitamin extremely;
Concentration expressed in percentage by weight about 5 * 10
-3% is about 1.0% hydrophilic macromolecule extremely;
Concentration expressed in percentage by weight about 1 * 10
-3% is about 1% surfactant extremely; And
Borate buffer solution or PBS.
2. fluid composition as claimed in claim 1, wherein this vitamin comprises vitamin A, and the concentration expressed in percentage by weight of this vitamin A is about 0.01% to about 1%.
3. fluid composition as claimed in claim 1, wherein this vitamin comprises vitamin B3, and the concentration expressed in percentage by weight of this vitamin B3 is about 0.01% to about 1.5%.
4. fluid composition as claimed in claim 1, wherein this vitamin comprises vitamin B6, and the concentration expressed in percentage by weight of this vitamin B6 is about 0.01% to about 1.5%.
5. fluid composition as claimed in claim 1, wherein this vitamin comprises vitamin B12, and the concentration expressed in percentage by weight of this vitamin B12 is about 0.01% to about 1.5%.
6. fluid composition as claimed in claim 1, wherein this vitamin comprises vitamin E, and the concentration expressed in percentage by weight of this vitamin E is about 0.01% to about 1%.
7. fluid composition as claimed in claim 1, wherein this hydrophilic macromolecule is selected from the group that is made up of polyvinyl alcohol, polyvinylpyrrolidone, hyaluronic acid, hydroxypropyl emthylcellulose and Polyethylene Glycol.
8. fluid composition as claimed in claim 1, wherein the concentration expressed in percentage by weight of this hydrophilic macromolecule is about 0.01% to about 0.1%.
9. fluid composition as claimed in claim 1, wherein this surfactant comprises at least one TWEEN80
TMAnd GEROPON
TMSBFA-30, and the concentration expressed in percentage by weight of this surfactant is about 0.001% to about 0.08%.
10. fluid composition as claimed in claim 1, wherein this borate buffer solution comprises boric acid, sodium borate and sodium chloride.
11. fluid composition as claimed in claim 1, wherein this PBS comprises disodium-hydrogen, sodium dihydrogen phosphate and sodium chloride.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW100108129A TWI480039B (en) | 2011-03-10 | 2011-03-10 | Aqueous composition for contact lens |
| TW100108129 | 2011-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102670641A true CN102670641A (en) | 2012-09-19 |
Family
ID=46803629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110339404XA Pending CN102670641A (en) | 2011-03-10 | 2011-10-28 | Liquid composition for contact lenses |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP2012189993A (en) |
| CN (1) | CN102670641A (en) |
| TW (1) | TWI480039B (en) |
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| CN107541361A (en) * | 2016-06-27 | 2018-01-05 | 晶硕光学股份有限公司 | Solution for treating contact lenses |
| WO2019041169A1 (en) * | 2017-08-30 | 2019-03-07 | 晶硕光学股份有限公司 | Contact lens with element protection function |
| CN112312791A (en) * | 2018-06-27 | 2021-02-02 | 鲍希与洛姆伯股份有限公司 | Packaging solutions |
| CN115612563A (en) * | 2021-07-16 | 2023-01-17 | 晶硕光学股份有限公司 | Liquid composition for ophthalmic products |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI607768B (en) * | 2017-03-31 | 2017-12-11 | 晶碩光學股份有限公司 | Composition for contact lenses and method for caring contact lenses |
| TWI673315B (en) * | 2018-02-22 | 2019-10-01 | 優你康光學股份有限公司 | Aqueous composition with the ability to release active ingredients and reusable contact lens products |
| JP7133942B2 (en) * | 2018-02-27 | 2022-09-09 | ロート製薬株式会社 | ophthalmic composition |
| TWI798452B (en) * | 2019-06-17 | 2023-04-11 | 晶碩光學股份有限公司 | Contact lens product |
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| CN107541361A (en) * | 2016-06-27 | 2018-01-05 | 晶硕光学股份有限公司 | Solution for treating contact lenses |
| WO2019041169A1 (en) * | 2017-08-30 | 2019-03-07 | 晶硕光学股份有限公司 | Contact lens with element protection function |
| CN112312791A (en) * | 2018-06-27 | 2021-02-02 | 鲍希与洛姆伯股份有限公司 | Packaging solutions |
| US11660370B2 (en) | 2018-06-27 | 2023-05-30 | Bausch & Lomb Incorporated | Ophthalmic device packaging solutions comprising tris(hydroxymethyl)aminomethane and nonionic surfactant |
| CN115612563A (en) * | 2021-07-16 | 2023-01-17 | 晶硕光学股份有限公司 | Liquid composition for ophthalmic products |
Also Published As
| Publication number | Publication date |
|---|---|
| TWI480039B (en) | 2015-04-11 |
| JP2012189993A (en) | 2012-10-04 |
| TW201236676A (en) | 2012-09-16 |
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