CN102670506A

CN102670506A - Non-oral administration for influenza antiviral medicament

Info

Publication number: CN102670506A
Application number: CN2012101164635A
Authority: CN
Inventors: 余秀民
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-04-13
Filing date: 2012-04-13
Publication date: 2012-09-19

Abstract

The invention focuses on an oral cavity administration which changes various oral preparations of influenza antiviral medicament into various preparations for local oral cavity. An influenza antiviral medicament can miss the opportunity of killing invasive influenza in the running process in the body, such as absorption, metabolization, excretion and distribution, after being administrated; and furthermore, few medicament is distributed to concentrated upper respiratory tract where influenza starts to infect along blood flow due to the consumption in the body so as to have no resistance effect. The oral administration has more harm than good. However, the administration to the local oral cavity is equivalent to directly place the medicament at the living area of the influenza, so that all the invasive influenza are killed suddenly; and therefore, the oral cavity administration has more good than harm.

Description

Anti-influenza virus medicament is not answered oral administration

Technical field

The present invention relates to the anti-influenza virus medicament oral administration, very unreasonable, should change oral administration into, just can give full play to the due effect of antiviral drugs.

Background technology

Nearly all medicine, except gastrointestinal reaction serious.Outside stomach degraded inefficacy and the destructive metabolism severe patient, all to use oral administration.Get into blood flow through gastrointestinal absorption, send to the ill position of body to medicine, play therapeutical effect.

Because this oral administration method is simple and convenient, tablet, capsule and oral liquid etc. that its used oral formulations is extensive use.These preparation taking conveniences, good mouthfeel, satisfactory effect.The less initiation anaphylaxis of drug oral almost do not meet oral drugs burst anaphylactic shock, so drug oral is very popular, unmanned blame.

But for the pharmaceutical preparation of resisiting influenza virus, then there is big problem in oral administration, and is very unreasonable.

Summary of the invention

Main purpose of the present invention is through adopting the most effectively dosage form and medication, reaching the influenza virus that strong rapidly elimination of imitating is infected, the rapid healing flu.

As everyone knows, influenza infection duplicates and breeds, and mainly is at the upper respiratory tract epithelial cell.Many acceptor-sialic acids that can combine with the hemagglutinin on the influenza virus coating because upper respiratory tract epithelial cell membrane is distributing are convenient to virus absorption and penetrate duplicate breeding in the cell.

Upper respiratory tract epithelial cell is the most attractive and have the preferendum condition to influenza virus, is that influenza virus likes best life and the movable place of causing a disease.

When virus from the oral cavity, when nasal cavity, eyes get into upper respiratory tract, virus be free in upper respiratory tract or be adsorbed on also do not penetrate in the cell on the epithelial cell membrane before, should have enough medicines there at upper respiratory tract etc., prepare antagonism.But it's a pity and sent drug oral to gastrointestinal tract; Absorbed effective ingredient gets into liver with blood flow; Under the effect of metabolic enzyme system, carried out first-pass effect, drained (discharging and unabsorbed composition from stool behind the enterohepatic circulation) through renal excretion and anus then.Because medicine running loss in vivo; Last effective ingredient be distributed to each histoorgan of whole body seldom, be not distributed to upper respiratory tract then still less, virus is not played any effect at all; And about half an hour after at this time taking medicine; The infective virus of upper respiratory tract is not only eliminated, and has on the contrary much to have penetrated in the epithelial cell the human body activity (see figure 2) of causing a disease.

It is thus clear that the oral administration of anti-influenza virus medicament is not miss the good opportunity of preventing and treating influenza, be a kind of wrong administrated method of shooting at random.

If but, change the following dosage forms of oral administration into dosage form oral liquid, tablet, capsule and the granule etc. of existing antiviral oral administration:

1, makes the dosage form packaged powders after being added with an amount of rare long-pending agent and principal agent mix homogeneously.

2, make the propellant of quantitatively sealing after being added with an amount of rare long-pending agent and principal agent mix homogeneously.

3, with its littleization powder be pressed into hardness moderate suck chewable tablet.

4, be pressed into to collapse and loose and the fast sublingual lozenge of medicine stripping.

5, make oral mucosa or Sublingual paper patch.

More than the preparation of several kinds of oral administrations, no matter that is a kind of all much better than than the curative effect of oral Preparation, because its not only a large amount of rapidly absorption also can directly act on influenza virus.Medicine dissolution gets into blood flow in the oral cavity with absorbing, and all is the life scope in virus, so in case oral cavity medicine will be killed the influenza virus (see figure 1) fast.And can eliminate the influenza virus that runs away to bronchus, lung, heart and brain by absorbing in a large number fast.

The present invention has advantage with original compared with techniques (in fact being exactly that oral administration is compared with oral administration):

1, can escape a large amount of losses of operation process such as oral drugs absorption in vivo, metabolism and drainage and the waste of a large amount of herbal raw material.

2, can eliminate fast infection influenza virus, cure influenza, do not stay sequela.

3, oral cavity and hypogloeeis are the most intensive places of blood vessel and very near with respiratory system and heart and brain, and the oral cavity antiviral drugs is absorbed and eliminates rapidly the virus of respiratory system and heart and brain very soon.

4, can reduce or eliminate the toxicity of antiviral chemical medicine article, improve safety.

Description of drawings

Fig. 1 eliminates the influenza virus sketch map that infects fully between momentariness behind the oral administration

Before the administration: the existing many influenza virus that infect of upper respiratory tract, 2 and 3 for influenza virus is adsorbed on the epithelial cell membrane, and 4 have just duplicated the progeny virus of emitting for upper respiratory tract.

After the administration: the epithelial virus of all upper respiratory tract is eliminated entirely.2 and 3 is that the virus that is adsorbed on the cell membrane does not have 3.4 have just duplicated the progeny virus of emitting and have not also had 3 for the epithelium respiratory tract.1 for the oral cavity is the place of administration, belongs to the area of influenza virus vital movement.

Fig. 2 is turn round the in vivo sketch map of (absorb metabolism, drain and distribute) of oral medication medicine.

1 is upper respiratory tract.2 for being adsorbed on the influenza virus on the epithelial cell membrane.3 is few with the medicine of blood flow distribution entering upper respiratory tract, does not work.4 is oral administration.

The specific embodiment

Why implement? This will make great efforts to accomplish by the manufacturer of existing this antiviral oral drugs simultaneously.

But whether manufacturer admits, whether meets reality, whether reasonable to the problem that you propose, if hold a negating attitude, then implements hopeless.If hold a definite attitude, think the reality that meets that I say, just can smooth implementation.

The different preparations of 5 kinds of oral administrations that the front proposes, all pharmaceutical factories can both well create, and do not have what technical matters, if must do a laboratory or clinical verification data, this should not have any difficulty concerning the pharmaceutical factory.

Claims

1. the oral formulations of all ready-made anti-influenza virus medicaments will change dosage form and medication, it is characterized in that earlier principal agent being made the preparation that is applicable to oral cavity partial, oral administration.