CN102657838A - Application of traditional Chinese medicine composition in preparation of medicine for treating alcoholic hepatitis - Google Patents
Application of traditional Chinese medicine composition in preparation of medicine for treating alcoholic hepatitis Download PDFInfo
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- CN102657838A CN102657838A CN2012101757058A CN201210175705A CN102657838A CN 102657838 A CN102657838 A CN 102657838A CN 2012101757058 A CN2012101757058 A CN 2012101757058A CN 201210175705 A CN201210175705 A CN 201210175705A CN 102657838 A CN102657838 A CN 102657838A
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- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229960004245 silymarin Drugs 0.000 description 1
- 235000017700 silymarin Nutrition 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Abstract
The invention provides an application of a traditional Chinese medicine composition in preparation of a medicine for treating alcoholic hepatitis. The traditional Chinese medicine composition is prepared by traditional Chinese medicines such as Tibetan caragana, phyllanthus emblica, lagotis brevituba, sandalwood padauk, swertia chirata, medicine terminalia fruit, seabuckthorn paste and rhubarb. Clinical experiments show that the traditional Chinese medicine composition has significant clinical curative effects on the alcoholic hepatitis.
Description
Technical field
The present invention relates to the application of a kind of Chinese medicine composition in preparation treatment alcoholic hepatitis medicine, belong to the Chinese herbal medicine application.
Background technology
Alcoholic hepatitis is because the hepatic disease that long-term heavy drinking causes can bring out popularity hepatic necrosis even liver failure when seriously indulging in excessive drinking.This disease is one of common hepatic disease of China.The serious harm people health.Alcoholic hepatitis also is a Clinical typing of alcoholic liver disease; It is one group of clinical pathology syndrome that a large amount of necrosis of hepatocyte in a short time cause; Can occur in or not have on the basis of liver cirrhosis; Mainly show as Serum ALT, AST rising and serum total bilirubin and obviously increase, can raise with heating, peripheral blood neutrophil.The serious symptom alcoholic hepatitis is meant that the performance of liver failure appears in the alcoholic hepatitis patient, like disturbances of blood coagulation, jaundice, hepatic encephalopathy, acute renal failure, upper gastrointestinal hemorrhage etc., often with endotoxemia.
The topmost clinical manifestation of alcoholic hepatitis is to occur jaundice rapidly, and other sings and symptoms comprises that heating, ascites, near-end are of flaccid muscles etc., and hepatic encephalopathy can appear in serious symptom alcoholic hepatitis patient.Usually, alcoholic hepatitis patient's liver increases, liver is touched a tender spot the positive.Laboratory research shows that the sex expression of alcoholic hepatitis patient characteristic is: AST is normal>2 times of normal value upper limits, but seldom 300U/ml.And Serum ALT is lower, and AST/ALT is common>2, but this characteristic is not had specificity and a susceptiveness.PBL, neutrophilic granulocyte counting, serum total bilirubin and INR (intemationalnormalized ratio.INR) raise simultaneously.Serum creatinine level raises, and the indication prognosis mala is because this is usually indicating the generation of hepatorenal syndrome and even dead closing on.
The medicine of treatment alcoholic hepatitis mainly contains glucocorticoid, pentoxifylline and other medicines etc. at present; Wherein glucocorticoid suppresses the activity of transcription factor such as exciting albumen l (AP 1) and NF-KB through part; Stop inflammatory process, can improve the serious symptom alcoholic hepatitis.But the glucocorticoid treatment alcoholic hepatitis remains dispute, and for acute heavy alcoholic hepatitis patient, uses glucocorticoid to have higher mortality rate.And pentoxifylline is the inhibitor of phosphodiesterase, has multiple effect, comprise regulate TNF transcribe, reduce alcoholic hepatitis patient short-term case fatality rate.But multiple untoward reaction is arranged, wherein occur at first with symptom of digestive tract such as diarrhoea, vomiting, epigastrium pain, other untoward reaction symptoms comprise headache, skin erythema, spontaneous bacterial peritonitis, urinary tract infection etc.The other drug treatment mainly is that the composition that directly replenishes cell membrane comprises exogenous additional polyene phosphatidylcholine, promotion endogenous phosphatidylcholine (S one ademetionine) and glutathion generation etc.This type medicine still is the important component of cell membrane courier (like phosphoinositide), and has antioxidation.The glycyrrhizic acid preparation can suppress the CS digestive enzyme, and endogenous CS is increased, and has antiinflammatory, antitoxin, antianaphylactic effect.The active component silymarin (guest) that extracts in the Herba Silybi mariani has stronger antioxidation, the effect of fibrosis.But said medicine all can not fundamentally be cured alcoholic hepatitis.Therefore research and develop low toxicity, safe and effective alcoholic hepatitis medicine is significant.
Hide capsule for descend of blood fat and come from famous Tibetan medicine and pharmacology scholar Supreme Being agate pellet and increase " the doctor's work selected works " that Peng arranges, Tibetan language be called " Ju Rinia ", and the clinical practice history in year surplus in the of existing 300 so far is Tibetan medicine's be used to purify the blood representative prescription of grease removal.Hide capsule for descend of blood fat and be recorded in the national drug standards, standard numbering: WS-10864 (ZD-0864)-2002.Form by ZANGJINJIER, Fructus Phyllanthi, Lagotis brachystachya Maxim, Lignum pterocarpi indici, Indian Herba Swertiae bimaculatae, Fructus Chebulae, Fructus Hippophae extractum, Radix Et Rhizoma Rhei, Corydalis impatiens (Pall.) Fisch., tangut dragonhead, Rhizoma Zingiberis.Function cures mainly and is Tibetan medicine: passage blood vessels, circulation of qi promoting removing heat from blood.Be used for the caused hyperlipemia of heat in blood.The traditional Chinese medical science: phlegm reduction of blood circulation promoting.Be used for the hyperlipemia that the resistance of expectorant blood stasis causes.
Patent CN201110188604.X discloses a kind of method of quality control of hiding blood-fat-reducing preparation, comprises the discrimination method of tangut dragonhead, the content assaying method of aloe-emodin, chrysophanic acid, emodin, chrysophanol, 5 kinds of main components of physcione in the Radix Et Rhizoma Rhei.The application of unexposed this pharmaceutical composition of this patent in preparation treatment alcoholic hepatitis medicine.
Patent CN100389816C discloses a kind of Tibetan medicinal preparation of treating hyperlipemia and preparation method thereof, comprises the superfine powder of crude drug being processed 0.1-50 μ m earlier, and then processes capsule and tablet.The application of unexposed this pharmaceutical composition of this patent in preparation treatment alcoholic hepatitis medicine.
Through in National IP Network, incomparably data base and tie up scientific and technical literature database retrieval such as general data base, visible document 1: Fructus Mume, Liu Youju, Chen Qiuhong. Tibetan medicine is hidden capsule for descend of blood fat toxicologic study [J]. Asia-Pacific traditional medicine, 2012,2.Document 2: Zhu Yanmei, Dorje, Chen Qiuhong. gold is scolded capsule for descend of blood fat to hyperlipidemia rats blood fat and hemorheological influence [J]. Qinghai Medicine College's journal, 2004,25 (2).Document 3: Chen Qiuhong, Zhou Xiaomei, Yang Quanyu. gold is scolded the blood fat and the hemorheology improvement effect research [J] of capsule for descend of blood fat. and contemporary Chinese is used pharmaceutical journal, 2004,21 (4).Document 4: Zhou Xiaomei, Chen Qiuhong, Yang Quanyu. gold is scolded the blood lipid regulation effect research [J] of capsule for descend of blood fat. Chinese patent medicine, 2003,25 (11).Document 5: Zhou Xiaomei, Dorje, Fan Xiuru. gold is scolded capsule for descend of blood fat to the hemorheological influence of hyperlipidemia rats [J]. Shandong journal of Chinese medicine, 2003,22 (8).The application of all unexposed this pharmaceutical composition of above-mentioned document 1-5 in preparation treatment alcoholic hepatitis medicine.
Summary of the invention
The purpose of this invention is to provide the application of a kind of Chinese medicine composition in preparation treatment alcoholic hepatitis medicine.
The application of a kind of Chinese medicine composition in preparation treatment alcoholic hepatitis medicine, this Chinese medicine composition is processed by following bulk drugs:
ZANGJINJIER 20-60 part, Fructus Phyllanthi 15-45 part, Lagotis brachystachya Maxim 10-30 part, Lignum pterocarpi indici 10-30 part, Indian Herba Swertiae bimaculatae 10-30 part, Fructus Chebulae 10-30 part, Fructus Hippophae extractum 10-30 part, Radix Et Rhizoma Rhei 10-30 part, Corydalis impatiens (Pall.) Fisch. 10-30 part, tangut dragonhead 10-30 part, Rhizoma Zingiberis 8-24 part.
The weight ratio of crude drug is preferably in the Chinese medicine composition of the present invention:
39.3 parts of ZANGJINJIERs, 31.4 parts of Fructus Phyllanthis, 23.5 parts of Lagotis brachystachya Maxims, 23.5 parts of Lignum pterocarpi indici, 23.5 parts of Indian Herba Swertiae bimaculataes, 23.5 parts of Fructus Chebulaes, 23.5 parts of Fructus Hippophae extractums, 23.5 parts of Radix Et Rhizoma Rhei, 23.5 parts of Corydalis impatiens (Pall.) Fisch.s, 23.5 parts of tangut dragonheads, 15.8 parts of Rhizoma Zingiberiss.
In the application of the present invention, this Chinese medicine composition active component is processed by following steps:
A) form proportioning by crude drug and get ZANGJINJIER, Lagotis brachystachya Maxim, tangut dragonhead, Fructus Phyllanthi, Fructus Chebulae, Radix Et Rhizoma Rhei totally 6 flavor medical materials; Extracting in water 1-4 time, the amount that at every turn adds water are 6-14 times of 6 flavor medical material gross weights, and extracting temperature is 50-100 ℃; The each extraction 1-4 hour; Filter, merge medicinal liquid, the thick paste A of relative density 1.20-1.40 when medicinal liquid is evaporated to 50 ℃;
B) form proportioning by crude drug and get Indian Herba Swertiae bimaculatae, Corydalis impatiens (Pall.) Fisch. totally 2 flavor medical materials, add percent by volume 50-95% ethanol extraction 1-4 time, add the alcoholic acid amount of 50-95% at every turn and be 8-12 times of 2 flavor medical material gross weights; Extracting temperature is 50-80 ℃; The each extraction 1-3 hour filters, and merges medicinal liquid; The medicinal liquid concentrating under reduced pressure, the thick paste B of relative density 1.20-1.40 when being concentrated into 50 ℃;
C) form proportioning by crude drug and get Fructus Hippophae extractum, Lignum pterocarpi indici, Rhizoma Zingiberis totally 3 flavor medical materials, be ground into fine powder, get medical material fine powder C.
D) the thick paste B that thick paste A that step a) is obtained and step b) obtain merges, and oven dry is ground into fine powder, adds the medical material fine powder C that step c) obtains, and mixing promptly gets Chinese medicine composition of the present invention.
In the application of the present invention; Said Chinese medicine composition can be prepared into a kind of in capsule, tablet, granule, powder or the oral liquid; For above-mentioned dosage form can be realized; Needing in these dosage forms of preparation is to add acceptable accessories; For example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic etc.; Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc., and disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc., lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Binding agent comprises starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc., correctives comprises: sweeting agent and various essence, antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and salt thereof, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene.
Above-described medicine capsule, its preparation method are to be processed by following steps:
A) form proportioning by crude drug and get ZANGJINJIER, Lagotis brachystachya Maxim, tangut dragonhead, Fructus Phyllanthi, Fructus Chebulae, Radix Et Rhizoma Rhei totally 6 flavor medical materials; Extracting in water 2 times, the amount that at every turn adds water are 10 times of 6 flavor medical material gross weights, reflux, extract; The each extraction 2 hours; Filter, merge medicinal liquid, the thick paste A of relative density 1.30 when medicinal liquid is evaporated to 50 ℃;
B) form proportioning by crude drug and get Indian Herba Swertiae bimaculatae, Corydalis impatiens (Pall.) Fisch. totally 2 flavor medical materials, add percent by volume 70% ethanol extraction 2 times, the 70% alcoholic acid amount that at every turn adds is 10 times of 2 flavor medical material gross weights; Reflux, extract; The each extraction 2 hours filters, and merges medicinal liquid; The medicinal liquid concentrating under reduced pressure, the thick paste B of relative density 1.25 when being concentrated into 50 ℃;
C) form proportioning by crude drug and get Fructus Hippophae extractum, Lignum pterocarpi indici, Rhizoma Zingiberis totally 3 flavor medical materials, be ground into fine powder, get medical material fine powder C.
D) the thick paste B that thick paste A that step a) is obtained and step b) obtain merges, and oven dry is ground into fine powder, adds the medical material fine powder C that step c) obtains, and mixing incapsulates, and promptly gets.
The relation of weight portion of the present invention and parts by volume is g/ml or kg/L.
The present invention has following advantage:
1. the present invention takes into full account the character of ingredient; Clinical disease needs; And physiological conditions of medication object, pathologic condition etc., adopt new extraction method for preparing, be prepared from; Compare with the preparation of traditional method preparation; Overcome prior art with the pharmaceutical composition of method of the present invention preparation and be crude drug and pulverize and be used as medicine, be not suitable for the shortcoming of modern formulation, adopted the pharmaceutical composition of the present invention's technology gained to can be used for preparing various modern dosage forms such as capsule, granule, tablet, powder and various oral liquids.
2. the invention provides the application of a kind of Chinese medicine composition in the medicine of preparation treatment alcoholic hepatitis, prove that through clinical trial this pharmaceutical composition is applied to the alcoholic hepatitis patient, total effective rate 87.3% can be used for the treatment of alcoholic hepatitis.
Essence for a better understanding of the present invention, below through this pharmaceutical composition of clinical observation in " treatment alcoholic hepatitis " result of the test, its new application at pharmaceutical field is described.
Test Example 1: the clinical observation of treatment alcoholic hepatitis
Case is gone into the group standard
Group is gone in the diagnostic criteria of the alcoholic liver disease that China's medical association's hepatopathy branch fatty liver and alcoholic liver disease group are formulated according in October, 2010:
1) long-term history of drinking history generally surpasses 5 years, amounts to ethanol amount >=40g/d, women >=20g/d, or interior heavy drinking history (> 80g/d of 2 weeks);
2) aspartate aminotransferase (AST) rising amplitude is obviously greater than alanine aminotransferase (ALT) rising amplitude, and AST/ALT >=2;
3) hepatitis that other causes of disease cause except;
4) treatment preceding 1 monthly not with excessively obviously falling the enzyme medicine.
Test is divided into groups
MethodsThe cases enrolled successively is divided into two groups at random according to being admitted to hospital: test group 63 examples, and matched group 63 examples, GP TH all obtains the patient and family members agree, liver zymetology index difference not statistically significant before two groups sex, age, the course of disease, iconography and the treatment.
The scheme of taking medicine
Advise patient's teetotalism during the treatment, suitably reduce heat and take in.Test group patient gives embodiment 1 preparation, and is oral, one time 5,2 times on the one, 4 weeks of the course of treatment.The matched group patient gives former preparation and hides capsule for descend of blood fat, scolds the production and marketing of Tibetan medicine limited company by the Qinghai gold, and is oral, one time 5,2 times on the one, 4 weeks of the course of treatment.
Observation index
Main therapeutic evaluation index
1) sings and symptoms: comprise weak, anorexia, uncomfortable liver area, hepatosplenomegaly etc.
2) liver function: aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), STB (TBiL).
Safety indexes
Hematuria is conventional, renal function
Curative effect judging standard
Produce effects: cardinal symptom and sign disappear, and liver function recovery is normal;
Effectively: cardinal symptom and sign are obviously improved, and ALT, AST, GGT, TBiL descend 75%;
Invalid: as not reach above-mentioned standard.
Obvious effective rate and effective percentage add up to total effective rate.
Statistical procedures:
Use SPSS l7.0 statistical software and carry out statistical analysis, two sample rates relatively use χ
2Check, index determining is the result relatively check with t.
Result of the test
The liver function situation relatively before and after table 1 treatment
Annotate:
*, with the treatment before compare P<0.01
Table 1 result shows: two groups of patients with hepatic functional parameters have obtained obvious improvement before and after the treatment, point out this medical instrument that hepatoprotective effect is arranged.
Table 2 liang group clinical efficacy is [n (%)] relatively
χ
2Check is compared with matched group,
*P<0.05
Table 2 result shows: former preparation 63 routine patients, and produce effects 39 examples, effective 9 examples, invalid 15 examples, total effective rate is 76.2%; Embodiment 1 preparation group 63 routine patients, produce effects 43 examples, effective 12 examples, invalid 8 examples, total effective rate is 87.3%.Compare with former preparation group, embodiment 1 preparation group total effective rate obviously improves.Point out former preparation Tibetan capsule for descend of blood fat and embodiment 1 preparation all to can be used for treating alcoholic hepatitis, and embodiment 1 preparation for treating alcoholic hepatitis clinical efficacy significantly is superior to former preparation.
In addition, renal function, hematuria routine and were not seen tangible untoward reaction all in normal range before and after the patient took medicine, and pointed out this medicine clinical practice safe.
The specific embodiment
Following embodiment is used to illustrate the preparation of Chinese medicine composition of the present invention, but it can not constitute any restriction to scope of the present invention.
Embodiment 1 Chinese medicinal composition capsules agent
Prescription:
ZANGJINJIER 39.3g, Fructus Phyllanthi 31.4g, Lagotis brachystachya Maxim 23.5g, Lignum pterocarpi indici 23.5g, Indian Herba Swertiae bimaculatae 23.5g, Fructus Chebulae 23.5g, Fructus Hippophae extractum 23.5g, Radix Et Rhizoma Rhei 23.5g, Corydalis impatiens (Pall.) Fisch. 23.5g, tangut dragonhead 23.5g, Rhizoma Zingiberis 15.8g.
Method for preparing:
A) form proportioning by crude drug and get ZANGJINJIER, Lagotis brachystachya Maxim, tangut dragonhead, Fructus Phyllanthi, Fructus Chebulae, Radix Et Rhizoma Rhei totally 6 flavor medical materials; Extracting in water 2 times, the amount that at every turn adds water are 10 times of 6 flavor medical material gross weights, reflux, extract; The each extraction 2 hours; Filter, merge medicinal liquid, the thick paste A of relative density 1.30 when medicinal liquid is evaporated to 50 ℃;
B) form proportioning by crude drug and get Indian Herba Swertiae bimaculatae, Corydalis impatiens (Pall.) Fisch. totally 2 flavor medical materials, add percent by volume 70% ethanol extraction 1-4 time, the 70% alcoholic acid amount that at every turn adds is 10 times of 2 flavor medical material gross weights; Reflux, extract; The each extraction 2 hours filters, and merges medicinal liquid; The medicinal liquid concentrating under reduced pressure, the thick paste B of relative density 1.25 when being concentrated into 50 ℃;
C) form proportioning by crude drug and get Fructus Hippophae extractum, Lignum pterocarpi indici, Rhizoma Zingiberis totally 3 flavor medical materials, be ground into 80 order fine powders, get medical material fine powder C;
D) the thick paste B that thick paste A that step a) is obtained and step b) obtain merges, and oven dry is ground into fine powder, adds the medical material fine powder C that step c) obtains, mixing, 1000 capsules of packing into.
Usage and dosage: oral, one time 5,2 times on the one.
Embodiment 2 Chinese medicine composition tablets
Prescription:
ZANGJINJIER 39.3g, Fructus Phyllanthi 31.4g, Lagotis brachystachya Maxim 23.5g, Lignum pterocarpi indici 23.5g, Indian Herba Swertiae bimaculatae 23.5g, Fructus Chebulae 23.5g, Fructus Hippophae extractum 23.5g, Radix Et Rhizoma Rhei 23.5g, Corydalis impatiens (Pall.) Fisch. 23.5g, tangut dragonhead 23.5g, Rhizoma Zingiberis 15.8g.
Method for preparing:
A) form proportioning by crude drug and get ZANGJINJIER, Lagotis brachystachya Maxim, tangut dragonhead, Fructus Phyllanthi, Fructus Chebulae, Radix Et Rhizoma Rhei totally 6 flavor medical materials; Extracting in water 1 time, the amount that at every turn adds water are 14 times of 6 flavor medical material gross weights, and extracting temperature is 50 ℃; The each extraction 4 hours; Filter, merge medicinal liquid, the thick paste A of relative density 1.20 when medicinal liquid is evaporated to 50 ℃;
B) form proportioning by crude drug and get Indian Herba Swertiae bimaculatae, Corydalis impatiens (Pall.) Fisch. totally 2 flavor medical materials, add percent by volume 50% ethanol extraction 1 time, the 50% alcoholic acid amount that at every turn adds is 12 times of 2 flavor medical material gross weights; Extracting temperature is 80 ℃; The each extraction 3 hours filters, and merges medicinal liquid; The medicinal liquid concentrating under reduced pressure, the thick paste B of relative density 1.20 when being concentrated into 50 ℃;
C) form proportioning by crude drug and get Fructus Hippophae extractum, Lignum pterocarpi indici, Rhizoma Zingiberis totally 3 flavor medical materials, be ground into fine powder, get medical material fine powder C.
D) the thick paste B that thick paste A that step a) is obtained and step b) obtain merges, and oven dry is ground into fine powder, adds the medical material fine powder C that step c) obtains, and mixing is processed 1000 according to the conventional formulation method.
Embodiment 3 Chinese medicinal composition granules
Prescription:
ZANGJINJIER 39.3g, Fructus Phyllanthi 31.4g, Lagotis brachystachya Maxim 23.5g, Lignum pterocarpi indici 23.5g, Indian Herba Swertiae bimaculatae 23.5g, Fructus Chebulae 23.5g, Fructus Hippophae extractum 23.5g, Radix Et Rhizoma Rhei 23.5g, Corydalis impatiens (Pall.) Fisch. 23.5g, tangut dragonhead 23.5g, Rhizoma Zingiberis 15.8g.
Method for preparing:
A) form proportioning by crude drug and get ZANGJINJIER, Lagotis brachystachya Maxim, tangut dragonhead, Fructus Phyllanthi, Fructus Chebulae, Radix Et Rhizoma Rhei totally 6 flavor medical materials; Extracting in water 4 times, the amount that at every turn adds water are 6 times of 6 flavor medical material gross weights, and extracting temperature is 95 ℃; The each extraction 1 hour; Filter, merge medicinal liquid, the thick paste A of relative density 1.40 when medicinal liquid is evaporated to 50 ℃;
B) form proportioning by crude drug and get Indian Herba Swertiae bimaculatae, Corydalis impatiens (Pall.) Fisch. totally 2 flavor medical materials, add percent by volume 95% ethanol extraction 4 times, the 95% alcoholic acid amount that at every turn adds is 8 times of 2 flavor medical material gross weights; Extracting temperature is 80 ℃; The each extraction 1 hour filters, and merges medicinal liquid; The medicinal liquid concentrating under reduced pressure, the thick paste B of relative density 1.40 when being concentrated into 50 ℃;
C) form proportioning by crude drug and get Fructus Hippophae extractum, Lignum pterocarpi indici, Rhizoma Zingiberis totally 3 flavor medical materials, be ground into fine powder, get medical material fine powder C.
D) the thick paste B that thick paste A that step a) is obtained and step b) obtain merges, and oven dry is ground into fine powder, adds the medical material fine powder C that step c) obtains, and mixing makes the 1000g granule according to the conventional formulation method, and packing promptly gets.
Embodiment 4 Chinese medicinal composition capsules agent
Prescription:
ZANGJINJIER 20g, Fructus Phyllanthi 45g, Lagotis brachystachya Maxim 10g, Lignum pterocarpi indici 30g, Indian Herba Swertiae bimaculatae 10g, Fructus Chebulae 30g, Fructus Hippophae extractum 10g, Radix Et Rhizoma Rhei 30g, Corydalis impatiens (Pall.) Fisch. 10g, tangut dragonhead 30g, Rhizoma Zingiberis 8g.
Method for preparing and usage and dosage are with embodiment 1.
Embodiment 5 Chinese medicinal composition capsules agent
Prescription:
ZANGJINJIER 60g, Fructus Phyllanthi 15g, Lagotis brachystachya Maxim 30g, Lignum pterocarpi indici 10g, Indian Herba Swertiae bimaculatae 30g, Fructus Chebulae 10g, Fructus Hippophae extractum 30g, Radix Et Rhizoma Rhei 10g, Corydalis impatiens (Pall.) Fisch. 30g, tangut dragonhead 10g, Rhizoma Zingiberis 24g.
Method for preparing and usage and dosage are with embodiment 1.
Claims (6)
1. the application of Chinese medicine composition in preparation treatment alcoholic hepatitis medicine; It is characterized in that this Chinese medicine composition is processed by following bulk drugs: ZANGJINJIER 20-60 part, Fructus Phyllanthi 15-45 part, Lagotis brachystachya Maxim 10-30 part, Lignum pterocarpi indici 10-30 part, Indian Herba Swertiae bimaculatae 10-30 part, Fructus Chebulae 10-30 part, Fructus Hippophae extractum 10-30 part, Radix Et Rhizoma Rhei 10-30 part, Corydalis impatiens (Pall.) Fisch. 10-30 part, tangut dragonhead 10-30 part, Rhizoma Zingiberis 8-24 part.
2. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is processed by following bulk drugs:
39.3 parts of ZANGJINJIERs, 31.4 parts of Fructus Phyllanthis, 23.5 parts of Lagotis brachystachya Maxims, 23.5 parts of Lignum pterocarpi indici, 23.5 parts of Indian Herba Swertiae bimaculataes, 23.5 parts of Fructus Chebulaes, 23.5 parts of Fructus Hippophae extractums, 23.5 parts of Radix Et Rhizoma Rhei, 23.5 parts of Corydalis impatiens (Pall.) Fisch.s, 23.5 parts of tangut dragonheads, 15.8 parts of Rhizoma Zingiberiss.
3. according to claim 1 or claim 2 application is characterized in that the active component of this Chinese medicine composition is to be processed by following steps:
A) form proportioning by crude drug and get ZANGJINJIER, Lagotis brachystachya Maxim, tangut dragonhead, Fructus Phyllanthi, Fructus Chebulae, Radix Et Rhizoma Rhei totally 6 flavor medical materials; Extracting in water 1-4 time, the amount that at every turn adds water are 6-14 times of 6 flavor medical material gross weights, and extracting temperature is 50-100 ℃; The each extraction 1-4 hour; Filter, merge medicinal liquid, the thick paste A of relative density 1.20-1.40 when medicinal liquid is evaporated to 50 ℃;
B) form proportioning by crude drug and get Indian Herba Swertiae bimaculatae, Corydalis impatiens (Pall.) Fisch. totally 2 flavor medical materials, add percent by volume 50-95% ethanol extraction 1-4 time, add the alcoholic acid amount of 50-95% at every turn and be 8-12 times of 2 flavor medical material gross weights; Extracting temperature is 50-80 ℃; The each extraction 1-3 hour filters, and merges medicinal liquid; The medicinal liquid concentrating under reduced pressure, the thick paste B of relative density 1.20-1.40 when being concentrated into 50 ℃;
C) form proportioning by crude drug and get Fructus Hippophae extractum, Lignum pterocarpi indici, Rhizoma Zingiberis totally 3 flavor medical materials, be ground into fine powder, get medical material fine powder C;
D) the thick paste B that thick paste A that step a) is obtained and step b) obtain merges, and oven dry is ground into fine powder, adds the medical material fine powder C that step c) obtains, and mixing promptly gets Chinese medicine composition of the present invention.
4. according to claim 1 or claim 2 application is characterized in that said Chinese medicine composition is prepared into capsule, tablet, granule, powder or oral liquid.
5. application as claimed in claim 4 is characterized in that, said medicine capsule is to be processed by following steps:
A) form proportioning by crude drug and get ZANGJINJIER, Lagotis brachystachya Maxim, tangut dragonhead, Fructus Phyllanthi, Fructus Chebulae, Radix Et Rhizoma Rhei totally 6 flavor medical materials; Extracting in water 2 times, the amount that at every turn adds water are 10 times of 6 flavor medical material gross weights, reflux, extract; The each extraction 2 hours; Filter, merge medicinal liquid, the thick paste A of relative density 1.30 when medicinal liquid is evaporated to 50 ℃;
B) form proportioning by crude drug and get Indian Herba Swertiae bimaculatae, Corydalis impatiens (Pall.) Fisch. totally 2 flavor medical materials, add percent by volume 70% ethanol extraction 1-4 time, the 70% alcoholic acid amount that at every turn adds is 10 times of 2 flavor medical material gross weights; Reflux, extract; The each extraction 2 hours filters, and merges medicinal liquid; The medicinal liquid concentrating under reduced pressure, the thick paste B of relative density 1.25 when being concentrated into 50 ℃;
C) form proportioning by crude drug and get Fructus Hippophae extractum, Lignum pterocarpi indici, Rhizoma Zingiberis totally 3 flavor medical materials, be ground into 80 order fine powders, get medical material fine powder C;
D) the thick paste B that thick paste A that step a) is obtained and step b) obtain merges, and oven dry is ground into fine powder, adds the medical material fine powder C that step c) obtains, and mixing incapsulates promptly and gets.
6. according to claim 1 or claim 2 application is characterized in that, the application of this Chinese medicine composition in preparation treatment alcoholic hepatitis medicine.
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| CN107007809A (en) * | 2017-05-25 | 2017-08-04 | 山东省疾病预防控制中心 | It is a kind of for pharmaceutical composition of alcoholic hepatitis and its preparation method and application |
| CN108813608A (en) * | 2018-05-25 | 2018-11-16 | 陕西黄龙国寿堂生物工程有限公司 | A kind of production method of sea-buckthorn wilsonii cream |
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