CN102657787B - Compound lonicera and forsythia ammonia-sensitive capsules and preparation technology thereof - Google Patents
Compound lonicera and forsythia ammonia-sensitive capsules and preparation technology thereof Download PDFInfo
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Abstract
The invention discloses compound lonicera and forsythia ammonia-sensitive capsules. The capsules comprise polyacrylic resin II, vitamin C, citric acid, paracetamol, chlorpheniramine maleate, dry lonicera and forsythia paste, starch, weeping forsythia volatile oil, schizonepeta volatile oil, mint oil and beta cyclodextrin. The invention also discloses a preparation technology for the capsules. The technology comprises the following steps of: (A), preparing the dry lonicera and forsythia paste; (B), weighing raw materials; (C), dissolving the polyacrylic resin II; (D), coating the vitamin C and the citric acid with resin liquid; (E), coating the paracetamol with the resin liquid; (F), mixing the chlorpheniramine maleate, the dry lonicera and forsythia paste and the starch; (G), coating the weeping forsythia volatile oil, the schizonepeta volatile oil and the mint oil with the beta cyclodextrin; and (H), putting the obtained fine powder into a mixer, adding the coated weeping forsythia volatile oil, schizonepeta volatile oil and mint oil, mixing and packing. The invention has the advantages that stable content of the raw materials is ensured, the validity period of the capsules is prolonged, the production efficiency is improved, the quality performance of the capsules is stable, and the yield of the capsules is improved.
Description
Technical field
The present invention relates to pharmaceutical technology field, particularly a kind of compound Yinqiao Anmin capsule and preparation technology thereof.
Background technology
Compound Yinqiao Anmin capsule is the good remedy for a cold of Chinese medicine and western medicine combination, side effect is little, determined curative effect, western medicine composition is mitigation symptoms timely and effectively, the antagonism flu that Chinese medicine ingredients can be permanently effective, be applicable to the symptoms such as heating that relieve common colds and influenza cause, headache, extremities aching pain, sneeze, rhinorrhea, nasal obstruction, pharyngalgia, cough xerostomia, this kind determined curative effect, toxic and side effects is low, and tool is portable again, demand is large, and development prospect is wide.Domestic market demand is huge, and annual requirement is 1～500,000,000, and growth potential is inestimable.
Comprise vitamin C and acetaminophen in this medicine, vitamin C has decomposability: high temperature, decompose when temperature is higher, and oxidation, easily oxidized in air; Acetaminophen is got by the p-aminophenol acetylation, contacts with air oxidation reaction easily occurs under illumination.
There is the phenomenon that easily produces the Vc content loss in production process in existing technique, causes that expiration date of drug is long, curative effect is inadequate.There is the unsettled phenomenon of content in production process in the existing technique of p-aminophenol acetyl, also causes pharmaceutical effectiveness inadequate.
Also comprise Forsythia volatile oil, Herba Schizonepetae volatile oil and Oleum menthae in this medicine, needing to have volatile Forsythia volatile oil, Herba Schizonepetae volatile oil and Oleum menthae with these three kinds in production process sprays in granule, easily produce the phenomenon of this oils composition volatilization loss in existing technique in production process, cause stability of drug products poor, and exist the capsule of producing to be difficult to guarantee before the deadline the problem of product quality: Forsythia volatile oil, Herba Schizonepetae volatile oil and Oleum menthae have exudative and volatility, easily cause the capsule hygroscopicity, character changes.
Summary of the invention
The object of the invention is to overcome the shortcoming of prior art, provide that a kind of content of drug is more stable, the compound Yinqiao Anmin capsule that effect duration is longer, curative effect of medication is more definite and the preparation technology thereof of product.
Purpose of the present invention is achieved through the following technical solutions:
Its compound Yinqiao Anmin capsule content: it comprises polyacrylic resin Ⅱ, vitamin C, citric acid, acetaminophen, chlorphenamine maleate, the dried cream of YINQIAO, starch, Forsythia volatile oil, Herba Schizonepetae volatile oil, Oleum menthae and beta cyclodextrin; And the weight ratio of following component is:
Polyacrylic resin Ⅱ 0.1～0.3,
Vitamin C 19～20,
Citric acid 0.2～0.5,
Acetaminophen 40～41,
Chlorphenamine maleate 0.35～0.45,
The dried cream 57～59 of YINQIAO,
Starch 26～27,
Beta cyclodextrin 1～2.5,
The vitamin C of every 19～20kg, following each amounts of components is:
Forsythia volatile oil 0.10～0.15L,
Herba Schizonepetae volatile oil 0.05～0.10L,
Oleum menthae 0.35～0.45L;
The preparation technology of compound Yinqiao Anmin capsule, it comprises the following steps:
A, the dried cream of preparation YINQIAO, it comprises following substep:
A, take raw material, described raw material comprises following component, and each components by weight is:
The Fructus Arctii prepared slices of Chinese crude drugs 80～90,
The Fructus Forsythiae prepared slices of Chinese crude drugs 140～150,
The Herba Schizonepetae prepared slices of Chinese crude drugs 50～60,
The Herba Lophatheri prepared slices of Chinese crude drugs 50～60,
The Semen Sojae Preparatum prepared slices of Chinese crude drugs 70～75,
Flos lonicerae decoction pieces 140～150,
The Rhizoma Phragmitis prepared slices of Chinese crude drugs 80～90,
The Radix Platycodonis prepared slices of Chinese crude drugs 80～90,
Chinese medicine of licorice root decoction pieces 70～75,
Starch 8～10;
B, pulverizing are put the Fructus Arctii prepared slices of Chinese crude drugs that take in Chinese medicine grinder, and be broken rear standby;
C, extraction, it comprises following substep:
C1, the Fructus Forsythiae prepared slices of Chinese crude drugs that take are added 1～2 times of amount water with steam distillation 2～3h, collect volatile oil 0.23～0.37L, standby, extract liquid medicine collecting and separately deposit standby;
C2, the Herba Schizonepetae prepared slices of Chinese crude drugs that take are added 1～2 times of amount water with steam distillation 2～3h, collect volatile oil 0.17～0.23L, standby;
After c3, the above two flavor prepared slices of Chinese crude drugs distillating extracting liquids that step c1, c2 are obtained filter, collect filtrate standby;
C4, will take and decoct with water secondary together with the Herba Lophatheri prepared slices of Chinese crude drugs, the Semen Sojae Preparatum prepared slices of Chinese crude drugs, flos lonicerae decoction pieces, the Rhizoma Phragmitis prepared slices of Chinese crude drugs, the Radix Platycodonis prepared slices of Chinese crude drugs, Chinese medicine of licorice root decoction pieces and medicinal residues that step c3 obtains, amount of water is respectively 6～8 times of amounts, 4～6 times of amounts, each 1～3 hour, collecting decoction filters, and is standby;
C5, the Fructus Arctii prepared slices of Chinese crude drugs after step b fragmentation are extracted 2 times with 60% alcohol heating reflux, add amount of alcohol and be respectively 5～7 times of amounts, 3～5 times of amounts, each 1～3 hour, the filtrate merging, standby;
D, concentrated, it comprises following substep:
D1, get and reclaim ethanol in the energy-conservation evaporation concentration device of filtrate suction single-action that step c5 obtains to without the alcohol flavor, temperature is controlled at 50～60 ℃, vacuum degree control-0.06～-0.08MPa between, filter medicinal liquid, standby;
D2, the filtrate that step c4 and steps d 1 are obtained merge, and is concentrated in the triple effect enrichment facility, thickening temperature be not more than 80 ℃ of three vacuum tank reciprocal of duty cycle respectively 0.04MPa, 0.06MPa, 0.08MPa be concentrated into the extractum of relative density 1.25～1.30, receive to get extractum;
E, receipts extractum are received cream in the cream car is received in cleaning, medicinal liquid is put into clean stainless steel cask, change 100,000 grades of clean area inner dryings over to;
F, drying are put the starch and the YINQIAO extractum that take in 300,000 grades of clean area reduced vacuum drying cupboards, and temperature is controlled at 70 ℃～80 ℃, and heat drying obtains the dried cream of YINQIAO to dried paste;
B, take each component by above-mentioned compound Yinqiao Anmin capsule formula, standby;
C, with the polyacrylic resin Ⅱ that takes, polyacrylic resin Ⅱ is added in 95% warm ethanol, standby until completely dissolved;
D, vitamin C, the citric acid that takes is placed in mixer adds above-mentioned resin liquid II to wrap up, after mix homogeneously, sieve with 14～18 order nylon mesh, cold drying below 60 ℃, with 22～26 mesh sieve nylon mesh granulate, standby; Unstable because of vitamin C character, easily degraded is for better protection vitamin C degraded aborning with the purpose of polyacrylic resin Ⅱ parcel, allows the more lasting performance of medicine specially good effect;
E, the acetaminophen that takes is placed in mixer adds above-mentioned resin liquid II to wrap up, after mix homogeneously, sieve with 14～18 order nylon mesh, dry below 60 ℃, with 22～26 mesh sieve nylon mesh granulate, standby, acetaminophen is the interior metabolism product of phenacetin (phenacetin), belong to phenyl amines, by suppressing hypothalamus thermotaxic centre prostaglandin synthetase, reduce the synthetic of Prostaglandin PGE1 Kallidin I and histamine etc. and discharge, PGE1 is to be mainly the effect nerve centre, its minimizing will cause maincenter body temperature set point to descend, it is relatively hot that cutaneous thermoreceptor is felt, and then cause the angiectatic peripheral blood vessel expansion that causes by neuroregulation, perspire and reach analgesic effect, it is similar to aspirin that it suppresses the synthetic effect of central nervous system's prostaglandin, but a little less than suppressing the anabolic effect of periphery prostaglandin, therefore antipyretic effect is strong, purpose with the polyacrylic resin Ⅱ parcel is in order to guarantee that better medicine aborning decomposes, make curative effect of medication more definite,
F, the dried cream of chlorphenamine maleate, YINQIAO, the starch that takes is placed in trough type mixing machine, mixed 20～30 minutes, standby;
G, the Forsythia volatile oil that takes, Herba Schizonepetae volatile oil, Oleum menthae are placed in trough type mixing machine, wrap up with beta cyclodextrin;
H, the fine powder that step D, step e and step F are obtained are placed in two-dimensional motion mixer, and Forsythia volatile oil, Herba Schizonepetae volatile oil, Oleum menthae after adding beta cyclodextrin to wrap up mixed more than 20 minutes, packing, and get final product.
The present invention has the following advantages:
The present invention has extended the effect duration of product, and effective ingredient wherein is more stable; Product yield brings up to 95% by original less than 85%; Product qualified rate brings up to 100% by original less than 85%; Improve production efficiency, reduced fuel consumption, thereby reduced production cost; Thick paste content improves 5%, makes the product of Chinese and Western medicine mixture can guarantee the content of Western medicine and the composition of Chinese medicine, and product quality stable performance, qualification rate improve, and have extended keeping life, has solved Character instability, has easily made moist, is difficult for a difficult problem of storing.
The present invention adds appropriate amount of starch in YINQIAO extractum, carry out drying, pulverizes, and sieves, and makes its steady quality, has solved YINQIAO extractum and has made the softgel shell deliquescing, produces the problem of infiltration;
Cold drying is decomposed when avoiding temperature higher, is for better protection vitamin C degraded aborning with the polyacrylic resin Ⅱ parcel, allows the more lasting performance of medicine specially good effect;
Acetaminophen is put with polyacrylic resin Ⅱ and is wrapped up, and is in order better to guarantee acetaminophen medicine decomposition aborning, to make curative effect of medication more definite;
Polyacrylic resin Ⅱ is a kind of novel coating material and release blocker, respectively vitamin C and acetaminophen is wrapped up with polyacrylic resin Ⅱ, and character is more stable, and expiry date is longer, better drug curative effect;
Forsythia volatile oil, Herba Schizonepetae volatile oil and Oleum menthae wrap up with beta cyclodextrin, prevent the exudative and volatility of oil, have solved the capsule hygroscopicity, avoid character to change, and wrap up with beta cyclodextrin, prevent seepage, make EDD longer.
Add the chlorphenamine maleate mixing, overweight sieve dehumidifies to room and granule with dehumidifier, in moisture Control≤1% again; Because Forsythia volatile oil, Herba Schizonepetae volatile oil and Oleum menthae have permeability and volatility, so the present invention adopts beta cyclodextrin that volatile oil is wrapped up, itself and air and metal are isolated, do not interfere with each other, but also can not reduce the content of vitamin C and acetaminophen, guarantee the stable of material content with polyacrylic resin Ⅱ parcel vitamin C and acetaminophen, thereby reached efficacy stability; Wherein Forsythia volatile oil, Herba Schizonepetae volatile oil and Oleum menthae have exudatively, wrap up with beta cyclodextrin, prevent seepage, energy-saving and emission-reduction are also had great significance, the present invention is annual can save energy and reduce the cost 500,000 yuan, reduces discharging 500 tons, waste residue, reduces discharging totally 100 tons of waste water CODs.
The existing technic index comparing result of the key technical indexes of the present invention and industry is as shown in the table.
| Unit | Existing technique | The present invention | Save | |
| Power consumption | Degree | 36000 | 18000 | 18000 |
| The consumption coal | Ton | 960 | 460 | 500 |
| Water consumption | Ton | 3500 | 3400 | 100 |
| Workman's configuration | Name | 8 | 4 | 4 |
The specific embodiment
The present invention will be further described below in conjunction with embodiment:
Embodiment 1: the present embodiment is most preferred embodiment of the present invention.
Compound Yinqiao Anmin capsule, it comprises polyacrylic resin Ⅱ, vitamin C, citric acid, acetaminophen, chlorphenamine maleate, the dried cream of YINQIAO, starch, Forsythia volatile oil, Herba Schizonepetae volatile oil, Oleum menthae and beta cyclodextrin; And the consumption of each component is:
Polyacrylic resin Ⅱ 0.1kg,
Vitamin C 19.16kg,
Citric acid 0.4kg,
Acetaminophen 40.68kg,
Chlorphenamine maleate 0.407kg,
The dried cream 58kg of YINQIAO,
Starch 26kg,
Beta cyclodextrin 2kg,
Forsythia volatile oil 0.12L,
Herba Schizonepetae volatile oil 0.09L,
Oleum menthae 0.42L.
The preparation technology of compound Yinqiao Anmin capsule, it comprises the following steps:
A, the dried cream of preparation YINQIAO, it comprises the following steps:
A, take raw material, described raw material comprises following component, and each composition weight is:
Fructus Arctii prepared slices of Chinese crude drugs 86.4kg,
Fructus Forsythiae prepared slices of Chinese crude drugs 144kg,
Herba Schizonepetae prepared slices of Chinese crude drugs 57.6kg,
Herba Lophatheri prepared slices of Chinese crude drugs 57.6kg,
Semen Sojae Preparatum prepared slices of Chinese crude drugs 72kg,
Flos lonicerae decoction pieces 144kg,
Rhizoma Phragmitis prepared slices of Chinese crude drugs 86.4kg,
Radix Platycodonis prepared slices of Chinese crude drugs 86.4kg,
Chinese medicine of licorice root decoction pieces 72kg,
Starch 9kg;
B, pulverizing are put the Fructus Arctii prepared slices of Chinese crude drugs that take in Chinese medicine grinder, and be broken rear standby;
C, extraction, it comprises following substep:
C1, the Fructus Forsythiae prepared slices of Chinese crude drugs that take are added the water steam distillation 2h of 1 times of amount, collect volatile oil 0.23～0.37L, please test, standby, extract liquid medicine collecting and separately deposit standby;
C2, the Herba Schizonepetae prepared slices of Chinese crude drugs that take are added the water steam distillation 2h of 1 times of amount, collect volatile oil 0.17～0.23L, please test, standby;
After c3, the above two flavor prepared slices of Chinese crude drugs distillating extracting liquids that step c1, c2 are obtained filter, collect filtrate (approximately 900～1100L) separately deposit standby;
C4, will take and decoct with water secondary together with the Herba Lophatheri prepared slices of Chinese crude drugs, the Semen Sojae Preparatum prepared slices of Chinese crude drugs, flos lonicerae decoction pieces, the Rhizoma Phragmitis prepared slices of Chinese crude drugs, the Radix Platycodonis prepared slices of Chinese crude drugs, Chinese medicine of licorice root decoction pieces and medicinal residues that step c3 obtains, amount of water is respectively 7 times of amounts, 5 times of amounts, each 2 hours, collecting decoction filter (approximately 7000～8000L), standby;
C5, the Fructus Arctii prepared slices of Chinese crude drugs after step b fragmentation are extracted 2 times with 60% alcohol heating reflux, add amount of alcohol and be respectively 6 times of amounts, 4 times of amounts, each 2 hours, the filtrate merging (approximately 700～800L), standby;
D, concentrated, it comprises following substep:
D1, get and reclaim ethanol in the energy-conservation evaporation concentration device of filtrate suction single-action that step c5 obtains to without the alcohol flavor, temperature is controlled at 50～60 ℃, vacuum degree control-0.06～-0.08MPa between, filter medicinal liquid (approximately 160～200L), standby;
D2, the filtrate that step c4 and steps d 1 are obtained merge, concentrated in the triple effect enrichment facility, thickening temperature is not more than 80 ℃ of three vacuum tank reciprocal of duty cycle, and 0.04MPa, 0.06MPa, 0.08MPa are concentrated into relative density 1.25～1.30(65～70 ℃ respectively) extractum, receive to get the about 200～300Kg of extractum;
E, receipts extractum are received cream in the cream car is received in cleaning, medicinal liquid is put into clean stainless steel cask, weigh, and stick a barrel writing paper, change 100,000 grades of clean area inner dryings over to;
F, drying are put 300,000 grades of clean area reduced vacuum cabinet inner dryings with the starch and the YINQIAO extractum that take, and temperature is controlled at 70 ℃～80 ℃, and heat drying namely gets the dried cream of YINQIAO to dried paste;
G, receive dried cream, the dried cream of drying is packed in the cleaning bag of band sealing, weighing changes workshop or freezer over to;
B, take each component by above-mentioned compound Yinqiao Anmin capsule formula, standby;
C, with the polyacrylic resin Ⅱ that takes, polyacrylic resin Ⅱ is added in 95% warm ethanol, standby until completely dissolved;
D, the vitamin C that takes and citric acid are placed in mixer add above-mentioned resin liquid to wrap up, after mix homogeneously, sieve with 16 order nylon mesh, cold drying below 60 ℃, with 24 mesh sieve nylon mesh granulate, standby; Unstable because of vitamin C character, easily degraded is for better protection vitamin C degraded aborning with the purpose of polyacrylic resin Ⅱ parcel, allows the more lasting performance of medicine specially good effect;
E, the acetaminophen that takes is placed in mixer adds above-mentioned resin liquid to wrap up, after mix homogeneously, sieve with 16 order nylon mesh, dry below 60 ℃, with 24 mesh sieve nylon mesh granulate, standby; Acetaminophen is the interior metabolism product of phenacetin (phenacetin), belongs to phenyl amines.by suppressing hypothalamus thermotaxic centre prostaglandin synthetase, reduce the synthetic of Prostaglandin PGE1 Kallidin I and histamine etc. and discharge, PGE1 is to be mainly the effect nerve centre, its minimizing will cause maincenter body temperature set point to descend, it is relatively hot that cutaneous thermoreceptor is felt, and then cause the angiectatic peripheral blood vessel expansion that causes by neuroregulation, perspire and reach analgesic effect, it is similar to aspirin that it suppresses the synthetic effect of central nervous system's prostaglandin, but a little less than suppressing the anabolic effect of periphery prostaglandin, therefore antipyretic effect is strong, purpose with the polyacrylic resin Ⅱ parcel is in order to guarantee that better medicine aborning decomposes, make curative effect of medication more definite,
F, the dried cream of chlorphenamine maleate, YINQIAO, the starch that takes is placed in trough type mixing machine, mixed 20～30 minutes, standby;
G, the Forsythia volatile oil with taking, Herba Schizonepetae volatile oil, Oleum menthae are placed in trough type mixing machine, wrap up with beta cyclodextrin;
H, the fine powder that step D, step e and step F are obtained are placed in two-dimensional motion mixer, Forsythia volatile oil after adding beta cyclodextrin to wrap up, Herba Schizonepetae volatile oil, Oleum menthae, mix more than 20 minutes, packing (is namely carried out aluminum-plastic blister with PTP, PVC, add aluminium foil and carry out secondary seal, air-isolation and moisture), and get final product.
Embodiment 2:
Compound Yinqiao Anmin capsule, it comprises polyacrylic resin Ⅱ, vitamin C, citric acid, acetaminophen, chlorphenamine maleate, the dried cream of YINQIAO, starch, Forsythia volatile oil, Herba Schizonepetae volatile oil, Oleum menthae and beta cyclodextrin; And the consumption of each component is:
Polyacrylic resin Ⅱ 0.2kg,
Vitamin C 20kg,
Citric acid 0.5kg,
Acetaminophen 40kg,
Chlorphenamine maleate 0.45kg,
The dried cream 57kg of YINQIAO,
Starch 27kg,
Beta cyclodextrin 2.5kg,
Forsythia volatile oil 0.15L,
Herba Schizonepetae volatile oil 0.10L,
Oleum menthae 0.45L.
The preparation technology of compound Yinqiao Anmin capsule, it comprises the following steps:
A, the dried cream of preparation YINQIAO, it comprises following substep:
A, take raw material, described raw material comprises following component, and each composition weight is:
Fructus Arctii prepared slices of Chinese crude drugs 90kg,
Fructus Forsythiae prepared slices of Chinese crude drugs 140kg,
Herba Schizonepetae prepared slices of Chinese crude drugs 50kg,
Herba Lophatheri prepared slices of Chinese crude drugs 50kg,
Semen Sojae Preparatum prepared slices of Chinese crude drugs 75kg,
Flos lonicerae decoction pieces 140kg,
Rhizoma Phragmitis prepared slices of Chinese crude drugs 90kg,
Radix Platycodonis prepared slices of Chinese crude drugs 80kg,
Chinese medicine of licorice root decoction pieces 75kg,
Starch 10kg;
B, pulverizing are put the Fructus Arctii prepared slices of Chinese crude drugs that take in Chinese medicine grinder, and be broken rear standby;
C, extraction, it comprises following substep:
C1, the Fructus Forsythiae prepared slices of Chinese crude drugs that take are added the water steam distillation 3h of 2 times of amounts, collect volatile oil 0.23～0.37L, please test, standby, extract liquid medicine collecting and separately deposit standby;
C2, the Herba Schizonepetae prepared slices of Chinese crude drugs that take are added the water steam distillation 3h of 2 times of amounts, collect volatile oil 0.17～0.23L, please test, standby;
After c3, the above two flavor prepared slices of Chinese crude drugs distillating extracting liquids that step c1, c2 are obtained filter, collect filtrate (approximately 900～1100L) separately deposit standby;
C4, will take and decoct with water secondary together with the Herba Lophatheri prepared slices of Chinese crude drugs, the Semen Sojae Preparatum prepared slices of Chinese crude drugs, flos lonicerae decoction pieces, the Rhizoma Phragmitis prepared slices of Chinese crude drugs, the Radix Platycodonis prepared slices of Chinese crude drugs, Chinese medicine of licorice root decoction pieces and medicinal residues that step c3 obtains, amount of water is respectively 6 times of amounts, 4 times of amounts, each 1 hour, collecting decoction filters, and is standby;
C5, the Fructus Arctii prepared slices of Chinese crude drugs after step b fragmentation are extracted 2 times with 60% alcohol heating reflux, add amount of alcohol and be respectively 5 times of amounts, 3 times of amounts, each 2 hours, the filtrate merging, standby;
D, concentrated, it comprises following substep:
D1, get and reclaim ethanol in the energy-conservation evaporation concentration device of filtrate suction single-action that step c5 obtains to without the alcohol flavor, temperature is controlled at 50～60 ℃, vacuum degree control-0.06～-0.08MPa between, filter medicinal liquid, standby;
D2, the filtrate that step c4 and steps d 1 are obtained merge, concentrated in the triple effect enrichment facility, thickening temperature is not more than 80 ℃ of three vacuum tank reciprocal of duty cycle, and 0.04MPa, 0.06MPa, 0.08MPa are concentrated into relative density 1.25～1.30(65～70 ℃ respectively) extractum, receive to get the about 200～300Kg of extractum;
E, receipts extractum are received cream in the cream car is received in cleaning, medicinal liquid is put into clean stainless steel cask, weigh, and stick a barrel writing paper, change 100,000 grades of clean area inner dryings over to;
F, drying are put 300,000 grades of clean area reduced vacuum cabinet inner dryings with the starch and the YINQIAO extractum that take, and temperature is controlled at 70 ℃～80 ℃, and heat drying namely gets the dried cream of YINQIAO to dried paste;
G, receive dried cream, the dried cream of drying is packed in the cleaning bag of band sealing, weighing changes workshop or freezer over to;
B, take each component by above-mentioned compound Yinqiao Anmin capsule formula, standby;
C, with the polyacrylic resin Ⅱ that takes, polyacrylic resin Ⅱ is added in 95% warm ethanol, standby until completely dissolved;
D, the vitamin C that takes and citric acid are placed in mixer add above-mentioned resin liquid to wrap up, after mix homogeneously, sieve with 14 order nylon mesh, dry below 60 ℃, with 22 mesh sieve nylon mesh granulate, standby;
E, the acetaminophen that takes is placed in mixer adds above-mentioned resin liquid to wrap up, after mix homogeneously, sieve with 14 order nylon mesh, dry below 60 ℃, with 22 mesh sieve nylon mesh granulate, standby;
F, the dried cream of chlorphenamine maleate, YINQIAO, the starch that takes is placed in trough type mixing machine, mixed 20～30 minutes, standby;
G, the Forsythia volatile oil with taking, Herba Schizonepetae volatile oil, Oleum menthae are placed in trough type mixing machine, wrap up with beta cyclodextrin;
H, the fine powder that step D, step e and step F are obtained are placed in two-dimensional motion mixer, Forsythia volatile oil after adding beta cyclodextrin to wrap up, Herba Schizonepetae volatile oil, Oleum menthae, mix more than 20 minutes, packing (is namely carried out aluminum-plastic blister with PTP, PVC, add aluminium foil and carry out secondary seal, air-isolation and moisture), and get final product.
Embodiment 3:
Compound Yinqiao Anmin capsule, it comprises polyacrylic resin Ⅱ, vitamin C, citric acid, acetaminophen, acetaminophen, chlorphenamine maleate, the dried cream of YINQIAO, starch, Forsythia volatile oil, Herba Schizonepetae volatile oil, Oleum menthae and beta cyclodextrin; And the consumption of each component is:
Polyacrylic resin Ⅱ 0.3kg,
Vitamin C 19kg,
Citric acid 0.2kg,
Acetaminophen 41kg,
Chlorphenamine maleate 0.35kg,
The dried cream 59kg of YINQIAO,
Starch 26kg,
Beta cyclodextrin 1kg,
Forsythia volatile oil 0.10L,
Herba Schizonepetae volatile oil 0.05L,
Oleum menthae 0.35L.
The preparation technology of compound Yinqiao Anmin capsule, it comprises the following steps:
A, the dried cream of preparation YINQIAO, it comprises following substep:
A, take raw material, described raw material comprises following component, and each composition weight is:
Fructus Arctii prepared slices of Chinese crude drugs 80kg,
Fructus Forsythiae prepared slices of Chinese crude drugs 150kg,
Herba Schizonepetae prepared slices of Chinese crude drugs 60kg,
Herba Lophatheri prepared slices of Chinese crude drugs 60kg,
Semen Sojae Preparatum prepared slices of Chinese crude drugs 70kg,
Flos lonicerae decoction pieces 150kg,
Rhizoma Phragmitis prepared slices of Chinese crude drugs 80kg,
Radix Platycodonis prepared slices of Chinese crude drugs 90kg,
Chinese medicine of licorice root decoction pieces 70kg,
Starch 8kg;
B, pulverizing are put the Fructus Arctii prepared slices of Chinese crude drugs that take in Chinese medicine grinder, and be broken rear standby;
C, extraction, it comprises following substep:
C1, the Fructus Forsythiae prepared slices of Chinese crude drugs that take are added the water steam distillation 2h of 1 times of amount, collect volatile oil 0.23～0.37L, please test, standby, extract liquid medicine collecting and separately deposit standby;
C2, the Herba Schizonepetae prepared slices of Chinese crude drugs that take are added the water steam distillation 2h of 1 times of amount, collect volatile oil 0.17～0.23L, please test, standby;
After c3, the above two flavor prepared slices of Chinese crude drugs distillating extracting liquids that step c1, c2 are obtained filter, collect filtrate and separately deposit standby.
C4, will take and decoct with water secondary together with the Herba Lophatheri prepared slices of Chinese crude drugs, the Semen Sojae Preparatum prepared slices of Chinese crude drugs, flos lonicerae decoction pieces, the Rhizoma Phragmitis prepared slices of Chinese crude drugs, the Radix Platycodonis prepared slices of Chinese crude drugs, Chinese medicine of licorice root decoction pieces and medicinal residues that step c3 obtains, amount of water is respectively 8 times of amounts, 6 times of amounts, each 3 hours, collecting decoction filters, and is standby;
C5, the Fructus Arctii prepared slices of Chinese crude drugs after step b fragmentation are extracted 2 times with 60% alcohol heating reflux, add amount of alcohol and be respectively 6 times of amounts, 4 times of amounts, each 3 hours, the filtrate merging, standby;
D, concentrated, it comprises following substep:
D1, get and reclaim ethanol in the energy-conservation evaporation concentration device of filtrate suction single-action that step c5 obtains to without the alcohol flavor, temperature is controlled at 50～60 ℃, vacuum degree control-0.06～-0.08MPa between, filter medicinal liquid, standby;
D2, the filtrate that step c4 and steps d 1 are obtained merge, concentrated in the triple effect enrichment facility, thickening temperature is not more than 80 ℃ of three vacuum tank reciprocal of duty cycle, and 0.04MPa, 0.06MPa, 0.08MPa are concentrated into relative density 1.25～1.30(65～70 ℃ respectively) extractum, receive to get the about 200～300Kg of extractum;
E, receipts extractum are received cream in the cream car is received in cleaning, medicinal liquid is put into clean stainless steel cask, weigh, and stick a barrel writing paper, change 100,000 grades of clean area inner dryings over to;
F, drying are put the starch and the YINQIAO extractum that take in 300,000 grades of clean area reduced vacuum drying cupboards, and temperature is controlled at 70 ℃～80 ℃, and heat drying namely gets the dried cream of YINQIAO to dried paste;
G, receive dried cream, the dried cream of drying is packed in the cleaning bag of band sealing, weighing changes workshop or freezer over to;
B, take each component by above-mentioned compound Yinqiao Anmin capsule formula, standby;
C, with the polyacrylic resin Ⅱ that takes, polyacrylic resin Ⅱ is added in 95% warm ethanol, standby until completely dissolved;
D, the vitamin C that takes and citric acid are placed in mixer add above-mentioned resin liquid to wrap up, after mix homogeneously, sieve with 18 order nylon mesh, dry below 60 ℃, with 26 mesh sieve nylon mesh granulate, standby;
E, the acetaminophen that takes is placed in mixer adds above-mentioned resin liquid to wrap up, after mix homogeneously, sieve with 18 order nylon mesh, dry below 60 ℃, with 26 mesh sieve nylon mesh granulate, standby;
F, the dried cream of chlorphenamine maleate, YINQIAO, the starch that takes is placed in trough type mixing machine, mixed 20～30 minutes, standby;
G, the Forsythia volatile oil with taking, Herba Schizonepetae volatile oil, Oleum menthae are placed in trough type mixing machine, wrap up with beta cyclodextrin;
H, the fine powder that step D, step e and step F are obtained are placed in two-dimensional motion mixer, Forsythia volatile oil after adding beta cyclodextrin to wrap up, Herba Schizonepetae volatile oil, Oleum menthae, mix more than 20 minutes, packing (is namely carried out aluminum-plastic blister with PTP, PVC, add aluminium foil and carry out secondary seal, air-isolation and moisture), and get final product.
Claims (1)
1. the preparation technology of compound Yinqiao Anmin capsule, described capsule comprises polyacrylic resin Ⅱ, vitamin C, citric acid, acetaminophen, chlorphenamine maleate, the dried cream of YINQIAO, starch, Forsythia volatile oil, Herba Schizonepetae volatile oil, Oleum menthae and beta cyclodextrin; And the weight ratio of following component is:
Polyacrylic resin Ⅱ 0.1～0.3,
Vitamin C 19～20,
Citric acid 0.2～0.5,
Acetaminophen 40～41,
Chlorphenamine maleate 0.35～0.45,
The dried cream 57～59 of YINQIAO,
Starch 26～27,
Beta cyclodextrin 1～2.5,
The vitamin C of every 19～20kg, following each amounts of components is:
Forsythia volatile oil 0.10～0.15L,
Herba Schizonepetae volatile oil 0.05～0.10L,
Oleum menthae 0.35～0.45L,
It is characterized in that: the preparation technology of described compound Yinqiao Anmin capsule, it comprises the following steps:
A, the dried cream of preparation YINQIAO, it comprises following substep:
A, take raw material, described raw material comprises following component, and each components by weight is:
The Fructus Arctii prepared slices of Chinese crude drugs 80～90,
The Fructus Forsythiae prepared slices of Chinese crude drugs 140～150,
The Herba Schizonepetae prepared slices of Chinese crude drugs 50～60,
The Herba Lophatheri prepared slices of Chinese crude drugs 50～60,
The Semen Sojae Preparatum prepared slices of Chinese crude drugs 70～75,
Flos lonicerae decoction pieces 140～150,
The Rhizoma Phragmitis prepared slices of Chinese crude drugs 80～90,
The Radix Platycodonis prepared slices of Chinese crude drugs 80～90,
Chinese medicine of licorice root decoction pieces 70～75,
Starch 8～10;
B, pulverizing are put the Fructus Arctii prepared slices of Chinese crude drugs that take in Chinese medicine grinder, and be broken rear standby;
C, extraction, it comprises following substep:
C1, the Fructus Forsythiae prepared slices of Chinese crude drugs that take are added 1～2 times of amount water with steam distillation 2～3h, collect volatile oil 0.23～0.37L, standby, extract liquid medicine collecting and separately deposit standby;
C2, the Herba Schizonepetae prepared slices of Chinese crude drugs that take are added 1～2 times of amount water with steam distillation 2～3h, collect volatile oil 0.17～0.23L, standby;
After c3, the above two flavor prepared slices of Chinese crude drugs distillating extracting liquids that step c1, c2 are obtained filter, collect filtrate standby;
C4, will take and decoct with water secondary together with the Herba Lophatheri prepared slices of Chinese crude drugs, the Semen Sojae Preparatum prepared slices of Chinese crude drugs, flos lonicerae decoction pieces, the Rhizoma Phragmitis prepared slices of Chinese crude drugs, the Radix Platycodonis prepared slices of Chinese crude drugs, Chinese medicine of licorice root decoction pieces and medicinal residues that step c3 obtains, amount of water is respectively 6～8 times of amounts, 4～6 times of amounts, each 1～3 hour, collecting decoction filters, and is standby;
C5, the Fructus Arctii prepared slices of Chinese crude drugs after step b fragmentation are extracted 2 times with 60% alcohol heating reflux, add amount of alcohol and be respectively 5～7 times of amounts, 3～5 times of amounts, each 1～3 hour, the filtrate merging, standby;
D, concentrated, it comprises following substep:
D1, get and reclaim ethanol in the energy-conservation evaporation concentration device of filtrate suction single-action that step c5 obtains to without the alcohol flavor, temperature is controlled at 50～60 ℃, vacuum degree control-0.06～-0.08MPa between, filter medicinal liquid, standby;
D2, the filtrate that step c4 and steps d 1 are obtained merge, and is concentrated in the triple effect enrichment facility, thickening temperature be not more than 80 ℃ of three vacuum tank vacuum respectively 0.04MPa, 0.06MPa, 0.08MPa be concentrated into the extractum of relative density 1.25～1.30, receive to get extractum;
E, receipts extractum are received cream in the cream car is received in cleaning, medicinal liquid is put into clean stainless steel cask, change 100,000 grades of clean area inner dryings over to;
F, drying are put the starch and the YINQIAO extractum that take in 300,000 grades of clean area reduced vacuum drying cupboards, and temperature is controlled at 70 ℃～80 ℃, and heat drying obtains the dried cream of YINQIAO to dried paste;
B, take each component by above-mentioned compound Yinqiao Anmin capsule formula, standby;
C, with the polyacrylic resin Ⅱ that takes, polyacrylic resin Ⅱ is added in 95% warm ethanol, standby until completely dissolved;
D, the vitamin C that takes and citric acid are placed in mixer add above-mentioned resin liquid to wrap up, after mix homogeneously, sieve with 14～18 order nylon mesh, dry below 60 ℃, with 22～26 mesh sieve nylon mesh granulate, standby;
E, the acetaminophen that takes is placed in mixer adds above-mentioned resin liquid to wrap up, after mix homogeneously, sieve with 14～18 order nylon mesh, dry below 60 ℃, with 22～26 mesh sieve nylon mesh granulate, standby;
F, the dried cream of chlorphenamine maleate, YINQIAO, the starch that takes is placed in trough type mixing machine, mixed 20～30 minutes, standby;
G, the Forsythia volatile oil with taking, Herba Schizonepetae volatile oil, Oleum menthae are placed in trough type mixing machine, wrap up with beta cyclodextrin;
H, the fine powder that step D, step e and step F are obtained are placed in two-dimensional motion mixer, and Forsythia volatile oil, Herba Schizonepetae volatile oil, Oleum menthae after adding beta cyclodextrin to wrap up mixed more than 20 minutes, packing, and get final product.
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